Articles tagged with Type 1 Diabetes
For patients with low pre-test probability of PE, applying PERC rule should guide diagnostic strategy. Imaging and testing can be reserved for those with high pre-test probability or contraindications to CT pulmonary angiography.
A/Prof Shane Grey's team aims to make significant improvements in islet transplantation therapy, making it a clinically realistic option for more individuals with type 1 diabetes. They focus on calming the immune response of patients to islet transplantation, which could lead to treated individuals living drug-free in the long term.
Researchers developed a drug that blocks hyaluronan buildup in pancreatic islets, preventing immune cell infiltration and destruction of insulin-producing cells. The study suggests a potential preventive treatment for type 1 diabetes in humans if initiated before the onset of the disease.
Researchers from Penn and Baylor have precisely quantified the loss of insulin-producing beta cells in dogs with diabetes, revealing a key similarity with human type I diabetes. The study also identifies features unique to canine diabetes, highlighting potential insights into treating human patients.
A study published in the British Medical Journal found that insulin pump users had a substantially lower risk of dying from cardiovascular disease than those using multiple daily injections. The researchers believe more frequent monitoring and training may be key to the therapy's benefits.
A new study by Joslin researchers reveals that alterations in the DNA damage checkpoint pathway machinery and higher levels of miR200 are associated with severe complications in type 1 diabetes. This finding holds promise for early detection and treatment of complications through therapeutic interventions targeting miR200.
Researchers have discovered a potential new treatment for type 1 diabetes using the anti-inflammatory cytokine interleukin-35, which can reverse or cure the disease in mice models. The study also found that IL-35 concentrations are lower in T1D patients than healthy individuals.
Researchers found that type 1 diabetes patients have significantly lower levels of four proteins (IL8, IL-1Ra, MCP-1, and MIP-1β) that help protect against immune attack. These findings suggest a potential protein cocktail that could aid in disease diagnosis and management, as well as new therapeutic strategies.
The T1DAL study found that alefacept treatment preserved beta cell function in 30% of participants with new-onset type 1 diabetes. Alefacept also reduced insulin dose requirements and major hypoglycemic events compared to the placebo group.
People diagnosed with type 1 diabetes at older ages have weaker brain connections in midlife compared to those who were diagnosed earlier, according to a new study. The research found that individuals diagnosed later in childhood had the weakest brain connectivity as they aged.
A new laser sensor can continuously monitor blood glucose levels without penetrating the skin, offering a pain-free alternative to traditional methods. The technology has potential to improve the lives of millions by enabling constant monitoring and self-regulation.
A new study published in the Journal of Nutrition Education and Behavior found that healthier food options are more expensive than standard options. The researchers recruited families with children aged 1-6 years with type 1 diabetes and found that a healthier market basket cost 18% more than the standard basket.
Researchers have created an implantable device that continuously measures blood sugar levels and automatically releases insulin as needed, eliminating the need for constant monitoring and daily injections. The artificial pancreas maintained blood glucose within target range nearly 80% of the time in computer simulations.
Researchers found that pet care can significantly improve monitoring of Type 1 diabetes in adolescents, leading to lower blood glucose levels. The study's senior author instructs families to associate regular pet fish care with diabetes care, resulting in improved hemoglobin A1C levels.
A Montréal research team found that the dual-hormone artificial pancreas provides the most benefits by reducing time spent in nocturnal hypoglycaemia. The study also showed that no participant using the system experienced a nocturnal hypoglycaemia event requiring treatment.
Researchers have developed a novel approach using liposomes to prevent the onset of Type 1 Diabetes in mice, offering a promising candidate for human vaccination. The technique avoids damaging insulin-producing pancreatic cells and induces immunological tolerance, providing a potential solution for this incurable disease.
A five-year phase II clinical trial testing the ability of BCG to clinically improve type 1 diabetes in adults will be conducted at Massachusetts General Hospital. The trial aims to create a lasting therapeutic response and has received $19 million out of $25 million needed for the study.
Researchers gave disposable cameras to 40 adolescents with Type 1 diabetes to capture their experiences. The findings reveal key differences in boys and less-affluent young people, which could shape patient care and education. The study also highlights the impact of food on managing the disease.
Researchers developed a 3D printing technique to create scaffolds for insulin-producing cells, which showed full functionality and improved transplantation success rates. The bioplotting method enabled the creation of porous structures that facilitated glucose and insulin exchange, while protecting the cells from the immune system.
Researchers found that larger spheres, at least 1.5 millimeters in diameter, triggered lower immune response and developed less scar tissue on their surface. This breakthrough could lead to a viable cure for type 1 diabetes by eliminating the need for lifelong immunosuppressive drugs.
A study reveals that almost a quarter of our genes exhibit seasonal variation, impacting immune cells and blood composition. This seasonality may explain why certain conditions worsen in winter, with some genes more active in summer.
Research led by the University of Pittsburgh Graduate School of Public Health shows that people with type 1 diabetes experience accelerated brain aging, correlated with slower information processing and cognitive difficulties. The study suggests clinicians should screen middle-aged patients for cognitive complications to prevent potent...
The Helmsley Charitable Trust has launched a global type 1 diabetes prevention initiative, investing $8.7 million in international grants to support observational studies and clinical trials. The project aims to identify new pathways to prevent the disease through data analysis and intervention clinical trials.
A Swedish study found that maternal overweight and obesity increases the risk of type 1 diabetes in children when neither parent has diabetes. The study, published in Diabetologia, suggests that reducing maternal weight before and during pregnancy could lower the incidence of T1D.
A study found a significant increase in diabetic ketoacidosis rates among Colorado youth with type 1 diabetes, from 39% in 1998 to 46% in 2012. The incidence of this life-threatening complication rose sharply after 2007, coinciding with an increase in child poverty prevalence.
Researchers have successfully completed the first step in developing an insulin vaccine to prevent type 1 diabetes. The Pre-POINT study showed a positive immune response in children at high risk for the disease, with no adverse reactions observed.
A study in Colorado found a 55% increase in diabetic ketoacidosis among youth with type 1 diabetes between 1998 and 2012. Younger age, African American race, and private insurance were associated with higher risk of DKA, while family history and public insurance were protective factors.
A pilot study found that daily oral insulin administration induced an immune response without hypoglycemia, supporting the need for a phase 3 trial to prevent islet autoimmunity and diabetes. The study enrolled genetically at-risk children and showed varying responses to different doses of oral insulin.
Researchers found that children given daily doses of oral insulin developed a protective immune response to the disease, which could lead to the development of a vaccine against type 1 diabetes. The study showed increased immunity with higher doses of oral insulin, suggesting a potential treatment strategy.
A study analyzing Welsh data reveals that children with type 1 diabetes are at a significantly higher risk of hospital admission compared to their non-diabetic peers. The research found that younger children and those from lower socioeconomic backgrounds are most at risk, highlighting the need for improved support and care.
Research published in BMJ Open found that children with type 1 diabetes are almost five times more likely to be hospitalized compared to their peers. The study, which analyzed data from over 1577 Welsh children, also revealed that pre-schoolers and those from disadvantaged backgrounds are most at risk of hospital admission.
Researchers at National Jewish Health found a response in human cells consistent with vaccination response in mice, using a mutated insulin fragment. The finding suggests an immune response in humans could lead to a vaccine and treatment for diabetes.
Scientists at Scripps Research Institute have developed a synthetic compound that prevents type 1 diabetes in animal models by suppressing immune cells. The study suggests Th17 cells play a key role in the disease and that using ROR-specific compounds may be an effective preventative therapy.
Engineers at Oregon State University have developed an improved type of glucose sensor for patients with Type 1diabetes, utilizing electrohydrodynamic jet printing. The new system is more precise, less intrusive, and cost-effective, with the potential to improve diabetes management and treatment.
A research group including a UF expert has located and narrowed down genes that play a role in Type 1 diabetes. The findings will help predict who might develop the disease and how to prevent it, leading to more effective treatments.
The Endocrine Society has selected 22 winners of the Helmsley Charitable Trust Abstract Awards in Type 1 Diabetes, recognizing outstanding work in clinical care and underlying mechanisms. The award winners will present their research at ENDO 2015 and received travel grants to attend.
A new study confirms earlier findings that African-American children have significantly higher HbA1c levels than their white counterparts despite similar average blood glucose levels. The study calls for prioritizing efforts to identify and address the sources of ongoing disparities in young patients with type 1 diabetes.
Researchers have developed a novel imaging technique using ferumoxytol and MRI to visualize pancreatic inflammation in patients with newly diagnosed type 1 diabetes. The study found clear evidence of ongoing inflammation in the pancreas, which could help predict disease progression and identify potential therapeutic targets.
Researchers are developing an artificial pancreas (AP) to manage pediatric diabetes, aiming to alleviate parents' stress and anxiety. The device will be tailored to consider children's unpredictable eating habits and physical activity, and its safety, efficacy, reliability, and ease of use will be prioritized.
Researchers have developed a long-lasting, glucose-responsive insulin derivative called Ins-PBA-F, which self-activates when blood sugar levels rise. Tests on mouse models show that one injection works for up to 14 hours, automatically lowering blood sugar levels.
A longitudinal study found that infants who developed type 1 diabetes had a significant drop in microbial diversity prior to disease onset, including a decrease in health-promoting bacteria and an increase in potentially harmful ones. The study also revealed stable biological functions served by the microbiome across individuals.
A large meta-analysis involving over 200,000 people with type 1 diabetes found that women face a 40% increased excess risk of death from all causes and have more than twice the risk of dying from heart disease compared to men. Women with type 1 diabetes also face a greater excess risk of strokes and kidney disease.
A new study identifies a DNA biomarker that can detect β cell death and predict type 1 diabetes risk. Unmethylated insulin DNA levels correlate with reduced β cell function and increased risk of clinical onset.
A study found that most teens and young adults with type 1 diabetes are interested in a peer mentoring program to improve diabetes control, despite social barriers. The researchers also found that those with supportive friends and family members were more likely to be interested.
Stephanie Stanford, Ph.D., has been awarded a $1.6 million grant by the American Diabetes Association to investigate the genetic and environmental causes of type 1 diabetes. The grant will support her research on the PTPN22 gene mutation that significantly increases the risk of type 1 diabetes.
A long-term follow-up of patients with type 1 diabetes found that intensive treatment was associated with a modestly lower all-cause rate of death compared to conventional therapy. The study's findings suggest that intensive therapy may reduce mortality risk in type 1 diabetes patients.
A study published in JAMA Network found that patients with type 1 diabetes in Scotland experience a substantially reduced life expectancy, with men losing an average of 11 years and women losing an average of 13 years compared to the general population.
A recent report led by a University of Pittsburgh Graduate School of Public Health investigator found that people with type 1 diabetes who intensively control their blood glucose soon after diagnosis are likely to live longer. The study showed a 33 percent reduction in deaths over the past several decades among participants.
Research funded by the National Institutes of Health found that people with type 1 diabetes who intensively control their blood glucose levels can live longer than those who do not. The study, which followed participants for an average of 27 years, found a 33% reduction in deaths among those who received intensive treatment.
A new study published in the American Journal of Pathology suggests that HLA class I hyperexpression on pancreatic islet cells may not be a crucial step in developing type 1 diabetes. The study found discrepancies between results from immunohistochemistry and quantitative molecular techniques.
A recent study published in Diabetes Care found that approximately one-third of people with type 1 diabetes produce insulin, as measured by C-peptide, even up to 40 years after diagnosis. This challenges the long-held assumption that these patients lose all ability to produce insulin, highlighting potential implications for clinical pr...
A new study published in Diabetes suggests that young children with type 1 diabetes have slower brain growth compared to children without diabetes. The researchers found that abnormal blood glucose levels impact brain structure and function at a young age.
Researchers at the University of Pennsylvania School of Medicine have successfully restored type 1 diabetics' ability to recognize low blood sugar levels after receiving islet cell transplantation. The treatment has nearly abolished time spent in a hypoglycemic state and improved response to experimental insulin-induced hypoglycemia.
A study published in Diabetes Care found that hypoglycaemia significantly increases the risk of cardiovascular events and mortality in insulin-treated patients with diabetes. The research, led by University of Leicester, showed a ~60% higher risk of cardiovascular events following hypoglycaemia.
A clinical trial confirms the external artificial pancreas system improves glucose control and reduces the risk of hypoglycemia compared to conventional diabetes treatment. The dual-hormone artificial pancreas provides additional reduction in hypoglycemia, offering a promising treatment option for type 1 diabetes patients.
A new study published in the journal Diabetes shows that a chemical produced in the pancreas, gamma-aminobutryic acid (GABA), can prevent and reverse Type 1 diabetes in mice with human beta cells transplanted into their bodies. GABA also improved the survival rate of pancreatic cells during transplantation.
A new study links a sweet-smelling chemical marker in the breath of children with type 1 diabetes to a build-up of potentially harmful chemicals in the blood. The researchers hope to develop a diagnostic device to identify children with the disease before serious illness sets in.
Scientists aim to understand immune system factors that influence insulin production in people with type 1 diabetes. They hope to develop biomarkers and a drug combination to help people live with fewer complications and increased ability to manage their disease.
Researchers at Wayne State University are working on a grant-funded project to design molecular vaccines for Type 1 diabetes and other autoimmune diseases. They aim to use a novel approach called 'hitchhiking' to deliver therapeutics to specific sites in the lymph nodes.
A new study found a significant increase in type 1 diabetes rates among non-Hispanic white youth, with the highest rate of increase seen in children aged 5-9. The study, based on data from over 2 million children and adolescents, suggests that these trends will continue to be monitored to identify potential causes.