Articles tagged with Type 1 Diabetes
Researchers developed a 3D printing technique to create scaffolds for insulin-producing cells, which showed full functionality and improved transplantation success rates. The bioplotting method enabled the creation of porous structures that facilitated glucose and insulin exchange, while protecting the cells from the immune system.
Researchers found that larger spheres, at least 1.5 millimeters in diameter, triggered lower immune response and developed less scar tissue on their surface. This breakthrough could lead to a viable cure for type 1 diabetes by eliminating the need for lifelong immunosuppressive drugs.
A study reveals that almost a quarter of our genes exhibit seasonal variation, impacting immune cells and blood composition. This seasonality may explain why certain conditions worsen in winter, with some genes more active in summer.
Research led by the University of Pittsburgh Graduate School of Public Health shows that people with type 1 diabetes experience accelerated brain aging, correlated with slower information processing and cognitive difficulties. The study suggests clinicians should screen middle-aged patients for cognitive complications to prevent potent...
The Helmsley Charitable Trust has launched a global type 1 diabetes prevention initiative, investing $8.7 million in international grants to support observational studies and clinical trials. The project aims to identify new pathways to prevent the disease through data analysis and intervention clinical trials.
A Swedish study found that maternal overweight and obesity increases the risk of type 1 diabetes in children when neither parent has diabetes. The study, published in Diabetologia, suggests that reducing maternal weight before and during pregnancy could lower the incidence of T1D.
A study found a significant increase in diabetic ketoacidosis rates among Colorado youth with type 1 diabetes, from 39% in 1998 to 46% in 2012. The incidence of this life-threatening complication rose sharply after 2007, coinciding with an increase in child poverty prevalence.
Researchers have successfully completed the first step in developing an insulin vaccine to prevent type 1 diabetes. The Pre-POINT study showed a positive immune response in children at high risk for the disease, with no adverse reactions observed.
A study in Colorado found a 55% increase in diabetic ketoacidosis among youth with type 1 diabetes between 1998 and 2012. Younger age, African American race, and private insurance were associated with higher risk of DKA, while family history and public insurance were protective factors.
A pilot study found that daily oral insulin administration induced an immune response without hypoglycemia, supporting the need for a phase 3 trial to prevent islet autoimmunity and diabetes. The study enrolled genetically at-risk children and showed varying responses to different doses of oral insulin.
Researchers found that children given daily doses of oral insulin developed a protective immune response to the disease, which could lead to the development of a vaccine against type 1 diabetes. The study showed increased immunity with higher doses of oral insulin, suggesting a potential treatment strategy.
A study analyzing Welsh data reveals that children with type 1 diabetes are at a significantly higher risk of hospital admission compared to their non-diabetic peers. The research found that younger children and those from lower socioeconomic backgrounds are most at risk, highlighting the need for improved support and care.
Research published in BMJ Open found that children with type 1 diabetes are almost five times more likely to be hospitalized compared to their peers. The study, which analyzed data from over 1577 Welsh children, also revealed that pre-schoolers and those from disadvantaged backgrounds are most at risk of hospital admission.
Researchers at National Jewish Health found a response in human cells consistent with vaccination response in mice, using a mutated insulin fragment. The finding suggests an immune response in humans could lead to a vaccine and treatment for diabetes.
Scientists at Scripps Research Institute have developed a synthetic compound that prevents type 1 diabetes in animal models by suppressing immune cells. The study suggests Th17 cells play a key role in the disease and that using ROR-specific compounds may be an effective preventative therapy.
Engineers at Oregon State University have developed an improved type of glucose sensor for patients with Type 1diabetes, utilizing electrohydrodynamic jet printing. The new system is more precise, less intrusive, and cost-effective, with the potential to improve diabetes management and treatment.
A research group including a UF expert has located and narrowed down genes that play a role in Type 1 diabetes. The findings will help predict who might develop the disease and how to prevent it, leading to more effective treatments.
The Endocrine Society has selected 22 winners of the Helmsley Charitable Trust Abstract Awards in Type 1 Diabetes, recognizing outstanding work in clinical care and underlying mechanisms. The award winners will present their research at ENDO 2015 and received travel grants to attend.
A new study confirms earlier findings that African-American children have significantly higher HbA1c levels than their white counterparts despite similar average blood glucose levels. The study calls for prioritizing efforts to identify and address the sources of ongoing disparities in young patients with type 1 diabetes.
Researchers have developed a novel imaging technique using ferumoxytol and MRI to visualize pancreatic inflammation in patients with newly diagnosed type 1 diabetes. The study found clear evidence of ongoing inflammation in the pancreas, which could help predict disease progression and identify potential therapeutic targets.
Researchers are developing an artificial pancreas (AP) to manage pediatric diabetes, aiming to alleviate parents' stress and anxiety. The device will be tailored to consider children's unpredictable eating habits and physical activity, and its safety, efficacy, reliability, and ease of use will be prioritized.
Researchers have developed a long-lasting, glucose-responsive insulin derivative called Ins-PBA-F, which self-activates when blood sugar levels rise. Tests on mouse models show that one injection works for up to 14 hours, automatically lowering blood sugar levels.
A longitudinal study found that infants who developed type 1 diabetes had a significant drop in microbial diversity prior to disease onset, including a decrease in health-promoting bacteria and an increase in potentially harmful ones. The study also revealed stable biological functions served by the microbiome across individuals.
A large meta-analysis involving over 200,000 people with type 1 diabetes found that women face a 40% increased excess risk of death from all causes and have more than twice the risk of dying from heart disease compared to men. Women with type 1 diabetes also face a greater excess risk of strokes and kidney disease.
A new study identifies a DNA biomarker that can detect β cell death and predict type 1 diabetes risk. Unmethylated insulin DNA levels correlate with reduced β cell function and increased risk of clinical onset.
A study found that most teens and young adults with type 1 diabetes are interested in a peer mentoring program to improve diabetes control, despite social barriers. The researchers also found that those with supportive friends and family members were more likely to be interested.
Stephanie Stanford, Ph.D., has been awarded a $1.6 million grant by the American Diabetes Association to investigate the genetic and environmental causes of type 1 diabetes. The grant will support her research on the PTPN22 gene mutation that significantly increases the risk of type 1 diabetes.
A long-term follow-up of patients with type 1 diabetes found that intensive treatment was associated with a modestly lower all-cause rate of death compared to conventional therapy. The study's findings suggest that intensive therapy may reduce mortality risk in type 1 diabetes patients.
A study published in JAMA Network found that patients with type 1 diabetes in Scotland experience a substantially reduced life expectancy, with men losing an average of 11 years and women losing an average of 13 years compared to the general population.
A recent report led by a University of Pittsburgh Graduate School of Public Health investigator found that people with type 1 diabetes who intensively control their blood glucose soon after diagnosis are likely to live longer. The study showed a 33 percent reduction in deaths over the past several decades among participants.
Research funded by the National Institutes of Health found that people with type 1 diabetes who intensively control their blood glucose levels can live longer than those who do not. The study, which followed participants for an average of 27 years, found a 33% reduction in deaths among those who received intensive treatment.
A new study published in the American Journal of Pathology suggests that HLA class I hyperexpression on pancreatic islet cells may not be a crucial step in developing type 1 diabetes. The study found discrepancies between results from immunohistochemistry and quantitative molecular techniques.
A recent study published in Diabetes Care found that approximately one-third of people with type 1 diabetes produce insulin, as measured by C-peptide, even up to 40 years after diagnosis. This challenges the long-held assumption that these patients lose all ability to produce insulin, highlighting potential implications for clinical pr...
A new study published in Diabetes suggests that young children with type 1 diabetes have slower brain growth compared to children without diabetes. The researchers found that abnormal blood glucose levels impact brain structure and function at a young age.
Researchers at the University of Pennsylvania School of Medicine have successfully restored type 1 diabetics' ability to recognize low blood sugar levels after receiving islet cell transplantation. The treatment has nearly abolished time spent in a hypoglycemic state and improved response to experimental insulin-induced hypoglycemia.
A study published in Diabetes Care found that hypoglycaemia significantly increases the risk of cardiovascular events and mortality in insulin-treated patients with diabetes. The research, led by University of Leicester, showed a ~60% higher risk of cardiovascular events following hypoglycaemia.
A clinical trial confirms the external artificial pancreas system improves glucose control and reduces the risk of hypoglycemia compared to conventional diabetes treatment. The dual-hormone artificial pancreas provides additional reduction in hypoglycemia, offering a promising treatment option for type 1 diabetes patients.
A new study published in the journal Diabetes shows that a chemical produced in the pancreas, gamma-aminobutryic acid (GABA), can prevent and reverse Type 1 diabetes in mice with human beta cells transplanted into their bodies. GABA also improved the survival rate of pancreatic cells during transplantation.
A new study links a sweet-smelling chemical marker in the breath of children with type 1 diabetes to a build-up of potentially harmful chemicals in the blood. The researchers hope to develop a diagnostic device to identify children with the disease before serious illness sets in.
Scientists aim to understand immune system factors that influence insulin production in people with type 1 diabetes. They hope to develop biomarkers and a drug combination to help people live with fewer complications and increased ability to manage their disease.
Researchers at Wayne State University are working on a grant-funded project to design molecular vaccines for Type 1 diabetes and other autoimmune diseases. They aim to use a novel approach called 'hitchhiking' to deliver therapeutics to specific sites in the lymph nodes.
A new study found a significant increase in type 1 diabetes rates among non-Hispanic white youth, with the highest rate of increase seen in children aged 5-9. The study, based on data from over 2 million children and adolescents, suggests that these trends will continue to be monitored to identify potential causes.
Research suggests that physical exercise preserves beta cell function, reducing complications and improving blood sugar control. However, large-scale trials are necessary to confirm the benefits of exercise in slowing the onset of type 1 diabetes in children and adults.
A new study published in Diabetologia found that children infected with enterovirus were 48% more likely to develop type 1 diabetes. The study's results suggest a positive correlation between EV infection and the incidence of type 1 diabetes, which may be driven by environmental factors in regions with high EV prevalence.
Researchers at Harvard University have made a breakthrough in producing human insulin-producing beta cells equivalent to normally functioning cells, offering hope for new diabetes treatment. The development involves massive quantities of human embryonic stem cells and could lead to drug discovery and transplantation therapy.
A study of 37,539 children and young adults with type 1 diabetes found that the link between low average glucose blood levels and severe hypoglycemia declined substantially between 1995 and 2012. The relative risk for severe hypoglycemia decreased from 1.28 to 1.05 per 1% decrease in HbA1c levels, corresponding to a drop in risk of 1.2...
A recent study from Tel Aviv University suggests that prenatal exposure to viruses may cause type 1 diabetes and other autoimmune diseases in children. The researchers found a link between winter epidemics and increased levels of damaging antibodies in cord blood, indicating autoimmune damage to islet cells during gestation.
Researchers at UC San Diego aim to bioengineer the irregularly shaped patches of the pancreas called Islets of Langerhans in a dish. This could lead to studying the events that trigger beta cell destruction and developing new drug therapies, as well as understanding the genetic component of the disease.
Researchers have discovered a new mechanism for inhibiting the immunoproteasome, a protein complex involved in autoimmune disorders such as rheumatism and multiple sclerosis. The found mechanism involves a novel compound that selectively targets and deactivates the immunoproteasome without affecting other proteasomes.
A nationwide study of over 18,000 patients with type 1 diabetes found that insulin pump treatment reduces all-cause mortality by 29% and fatal cardiovascular disease risk by 43%. Pump use was also associated with an 18% risk reduction for coronary heart disease.
A new model predicts which type 1 diabetes patients will develop major complications, such as coronary heart disease and blindness. The model uses easily measurable risk factors, allowing healthcare professionals to identify high-risk patients and implement preventative strategies.
Researchers found that closed-loop insulin delivery systems maintained safe blood glucose levels for 53-82% of the time. The study proposed improvements needed for better design and implementation of these systems in adults and adolescents with type 1 diabetes.
The University of Chicago Medicine and Advocate Children's Hospital have received a $1.8 million NIH grant to establish the first Type 1 Diabetes TrialNet Clinical Center in Chicago. The center aims to identify people at risk or early stages of type 1 diabetes through international collaboration.
Researchers at Sanford Burnham Prebys Institute have discovered a promising technique to restore insulin production in people with Type 1 diabetes. A peptide called caerulein was found to convert existing alpha cells into insulin-producing beta cells, potentially freeing patients from daily insulin doses.
Researchers discovered that mice born by natural birth have a stronger immune system due to exposure to their mother's beneficial bacteria. This may lead to the development of autoimmune diseases such as type 1 diabetes and Crohn's disease.
Researchers have identified genetic markers that can predict the development of celiac disease in infants. The study found a significantly higher risk for celiac disease among Swedish children compared to their European counterparts.
A recent NIH-funded study found that children with two copies of a high-risk variant in specific genes have a 26% chance of developing early signs of celiac disease by age 5. The study also revealed higher rates of celiac disease in Sweden compared to the US and other European countries.
A new survey reveals that nearly 70% of adults with Type 1 diabetes do not use their blood glucose self-monitoring devices or insulin pumps to download historical data about their blood sugar levels and insulin doses. Only 12% of patients regularly review their past glucose and insulin pump data at home.
Researchers found that high blood glucose levels increase neurotransmitter associated with depression and alter brain connections in patients with Type 1 diabetes. The study suggests a biological mechanism for the increased risk of depression in these individuals.
A genetic risk component of type 1 diabetes has been shed light on by a study identifying the role of gene Clec16a in faulty cell recycling. Healthy mitochondria are crucial to insulin production and blood sugar control, making this finding a significant step towards treating or preventing both type 1 and type 2 diabetes.