Articles tagged with Type 1 Diabetes
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new study suggests that a combined vaccine therapy using live Salmonella is safe and effective in preventing diabetes in mice. The vaccine works by rebalancing the immune system and preventing the attack on insulin-producing cells. Researchers believe this targeted immunotherapy has great potential for treating type 1 diabetes.
Researchers have discovered a new potential therapy that can protect transplanted human pancreatic islets from dying. The study suggests that pretreating cells with a peptide hormone called cholecystokinin (CCK) may enhance the curative potential of islet transplant for Type 1 diabetes.
Research published in Diabetologia found that people with type 1 diabetes have a three-times increased risk of developing epilepsy later in life. Younger age and severe hypoglycemia are also identified as critical risk factors for brain abnormalities and the development of epilepsy.
Researchers aim to spare people with type 1 diabetes from lifelong insulin therapy by developing three-dimensional cellular structures of insulin-producing cells. The EU-funded project plans to work with pharmaceutical industry partners to mass-produce the cells for transplantation.
Scientists have developed novel insulin mimetopes that can induce regulatory T cells to produce tolerance against insulin, halting the development of type 1 diabetes in young mice. In a humanized mouse model, the new vaccine efficiently stimulates regulatory T cells, which can impede the immune system's attack on insulin-producing cells.
A multicentre study found type 1 diabetes associated with higher cancer incidence, especially for cancers of the stomach, liver, pancreas, endometrium, ovary, and kidney. Women with type 1 diabetes had a smaller but still significant increased risk compared to men.
Researchers have developed a novel therapeutic approach using nanomedicines called Navacims that can reprogram white blood cells to become regulatory cells capable of blunting autoimmune responses. The treatment has shown promising results in preclinical models of diabetes, multiple sclerosis, and rheumatoid arthritis.
Children diagnosed with type 1 diabetes before age seven develop a more aggressive form of the disease compared to teenagers. Researchers found that those diagnosed in childhood retain fewer insulin-producing beta cells than previously thought.
Researchers have identified a new drug target that can restore healthier lipid levels in people with type 1 diabetes. By blocking the growth hormone receptor, MIA-602 has been shown to reduce unhealthy lipids and improve vascular function.
Researchers found a link between pre-kallikrein levels and thickened blood vessels in type 1 diabetes patients. Elevated plasma PK levels are an independent risk factor for whole-body diabetic vascular disease, similar to high triglycerides or high blood pressure.
A study of over 99,000 children found that weight increase during the first year of life is associated with a higher risk of developing type 1 diabetes. The average change in weight from birth to 12 months was linked to an increased risk, while length gain showed no association.
A randomized trial found that metformin did not improve glycemic control after 6 months, despite reducing weight gain and insulin doses. The study included 140 adolescents with type 1 diabetes, aged 12-19 years, and was conducted at 26 pediatric endocrinology clinics.
A large-scale analysis of three diabetes registries found that insulin pump use is associated with lower mean HbA1c levels and better blood sugar control in children and adolescents with type 1 diabetes. Pump use was also more common among certain subgroups, such as girls and non-minority ethnic groups.
Researchers at Helmholtz Munich developed a method to predict the probability of developing postpartum diabetes after childbirth, using BMI and genetic predisposition as key factors. The test showed that women with low-risk scores had an 11% risk of developing diabetes within five years.
Researchers at Monash University discovered that regulatory T cells can function even when their receptors bind to MHC in a completely different orientation, challenging established views on the immune system. This finding opens up new avenues for investigating and potentially treating autoimmune diseases like type 1 diabetes.
Researchers discovered that excess IGFBP3 damages colonic stem cells, leading to intestinal lining damage and chronic gastrointestinal symptoms. A biopharmaceutical blocking circulating levels of the protein has shown promising results in reversing colon damage in diabetic mice.
Researchers have created a new investigational drug that traps IGFBP3, preventing gastrointestinal symptoms and restoring the intestine's mucosal lining structure. The drug may hold promise as a potential treatment for diabetic enteropathy, a common complication of type 1 diabetes.
Researchers create insulin-producing cells using adult tissue and transcription factors, offering a potential cure for type 1 diabetes. The cells can be transplanted into diabetic mice and may lead to clinical trials for human patients.
For patients with low pre-test probability of PE, applying PERC rule should guide diagnostic strategy. Imaging and testing can be reserved for those with high pre-test probability or contraindications to CT pulmonary angiography.
A/Prof Shane Grey's team aims to make significant improvements in islet transplantation therapy, making it a clinically realistic option for more individuals with type 1 diabetes. They focus on calming the immune response of patients to islet transplantation, which could lead to treated individuals living drug-free in the long term.
Researchers developed a drug that blocks hyaluronan buildup in pancreatic islets, preventing immune cell infiltration and destruction of insulin-producing cells. The study suggests a potential preventive treatment for type 1 diabetes in humans if initiated before the onset of the disease.
Researchers from Penn and Baylor have precisely quantified the loss of insulin-producing beta cells in dogs with diabetes, revealing a key similarity with human type I diabetes. The study also identifies features unique to canine diabetes, highlighting potential insights into treating human patients.
A study published in the British Medical Journal found that insulin pump users had a substantially lower risk of dying from cardiovascular disease than those using multiple daily injections. The researchers believe more frequent monitoring and training may be key to the therapy's benefits.
A new study by Joslin researchers reveals that alterations in the DNA damage checkpoint pathway machinery and higher levels of miR200 are associated with severe complications in type 1 diabetes. This finding holds promise for early detection and treatment of complications through therapeutic interventions targeting miR200.
Researchers have discovered a potential new treatment for type 1 diabetes using the anti-inflammatory cytokine interleukin-35, which can reverse or cure the disease in mice models. The study also found that IL-35 concentrations are lower in T1D patients than healthy individuals.
Researchers found that type 1 diabetes patients have significantly lower levels of four proteins (IL8, IL-1Ra, MCP-1, and MIP-1β) that help protect against immune attack. These findings suggest a potential protein cocktail that could aid in disease diagnosis and management, as well as new therapeutic strategies.
The T1DAL study found that alefacept treatment preserved beta cell function in 30% of participants with new-onset type 1 diabetes. Alefacept also reduced insulin dose requirements and major hypoglycemic events compared to the placebo group.
People diagnosed with type 1 diabetes at older ages have weaker brain connections in midlife compared to those who were diagnosed earlier, according to a new study. The research found that individuals diagnosed later in childhood had the weakest brain connectivity as they aged.
A new laser sensor can continuously monitor blood glucose levels without penetrating the skin, offering a pain-free alternative to traditional methods. The technology has potential to improve the lives of millions by enabling constant monitoring and self-regulation.
A new study published in the Journal of Nutrition Education and Behavior found that healthier food options are more expensive than standard options. The researchers recruited families with children aged 1-6 years with type 1 diabetes and found that a healthier market basket cost 18% more than the standard basket.
Researchers have created an implantable device that continuously measures blood sugar levels and automatically releases insulin as needed, eliminating the need for constant monitoring and daily injections. The artificial pancreas maintained blood glucose within target range nearly 80% of the time in computer simulations.
Researchers found that pet care can significantly improve monitoring of Type 1 diabetes in adolescents, leading to lower blood glucose levels. The study's senior author instructs families to associate regular pet fish care with diabetes care, resulting in improved hemoglobin A1C levels.
A Montréal research team found that the dual-hormone artificial pancreas provides the most benefits by reducing time spent in nocturnal hypoglycaemia. The study also showed that no participant using the system experienced a nocturnal hypoglycaemia event requiring treatment.
Researchers have developed a novel approach using liposomes to prevent the onset of Type 1 Diabetes in mice, offering a promising candidate for human vaccination. The technique avoids damaging insulin-producing pancreatic cells and induces immunological tolerance, providing a potential solution for this incurable disease.
A five-year phase II clinical trial testing the ability of BCG to clinically improve type 1 diabetes in adults will be conducted at Massachusetts General Hospital. The trial aims to create a lasting therapeutic response and has received $19 million out of $25 million needed for the study.
Researchers gave disposable cameras to 40 adolescents with Type 1 diabetes to capture their experiences. The findings reveal key differences in boys and less-affluent young people, which could shape patient care and education. The study also highlights the impact of food on managing the disease.
Researchers developed a 3D printing technique to create scaffolds for insulin-producing cells, which showed full functionality and improved transplantation success rates. The bioplotting method enabled the creation of porous structures that facilitated glucose and insulin exchange, while protecting the cells from the immune system.
Researchers found that larger spheres, at least 1.5 millimeters in diameter, triggered lower immune response and developed less scar tissue on their surface. This breakthrough could lead to a viable cure for type 1 diabetes by eliminating the need for lifelong immunosuppressive drugs.
A study reveals that almost a quarter of our genes exhibit seasonal variation, impacting immune cells and blood composition. This seasonality may explain why certain conditions worsen in winter, with some genes more active in summer.
Research led by the University of Pittsburgh Graduate School of Public Health shows that people with type 1 diabetes experience accelerated brain aging, correlated with slower information processing and cognitive difficulties. The study suggests clinicians should screen middle-aged patients for cognitive complications to prevent potent...
The Helmsley Charitable Trust has launched a global type 1 diabetes prevention initiative, investing $8.7 million in international grants to support observational studies and clinical trials. The project aims to identify new pathways to prevent the disease through data analysis and intervention clinical trials.
A Swedish study found that maternal overweight and obesity increases the risk of type 1 diabetes in children when neither parent has diabetes. The study, published in Diabetologia, suggests that reducing maternal weight before and during pregnancy could lower the incidence of T1D.
A study found a significant increase in diabetic ketoacidosis rates among Colorado youth with type 1 diabetes, from 39% in 1998 to 46% in 2012. The incidence of this life-threatening complication rose sharply after 2007, coinciding with an increase in child poverty prevalence.
Researchers have successfully completed the first step in developing an insulin vaccine to prevent type 1 diabetes. The Pre-POINT study showed a positive immune response in children at high risk for the disease, with no adverse reactions observed.
A study in Colorado found a 55% increase in diabetic ketoacidosis among youth with type 1 diabetes between 1998 and 2012. Younger age, African American race, and private insurance were associated with higher risk of DKA, while family history and public insurance were protective factors.
A pilot study found that daily oral insulin administration induced an immune response without hypoglycemia, supporting the need for a phase 3 trial to prevent islet autoimmunity and diabetes. The study enrolled genetically at-risk children and showed varying responses to different doses of oral insulin.
Researchers found that children given daily doses of oral insulin developed a protective immune response to the disease, which could lead to the development of a vaccine against type 1 diabetes. The study showed increased immunity with higher doses of oral insulin, suggesting a potential treatment strategy.
A study analyzing Welsh data reveals that children with type 1 diabetes are at a significantly higher risk of hospital admission compared to their non-diabetic peers. The research found that younger children and those from lower socioeconomic backgrounds are most at risk, highlighting the need for improved support and care.
Research published in BMJ Open found that children with type 1 diabetes are almost five times more likely to be hospitalized compared to their peers. The study, which analyzed data from over 1577 Welsh children, also revealed that pre-schoolers and those from disadvantaged backgrounds are most at risk of hospital admission.
Researchers at National Jewish Health found a response in human cells consistent with vaccination response in mice, using a mutated insulin fragment. The finding suggests an immune response in humans could lead to a vaccine and treatment for diabetes.
Scientists at Scripps Research Institute have developed a synthetic compound that prevents type 1 diabetes in animal models by suppressing immune cells. The study suggests Th17 cells play a key role in the disease and that using ROR-specific compounds may be an effective preventative therapy.
Engineers at Oregon State University have developed an improved type of glucose sensor for patients with Type 1diabetes, utilizing electrohydrodynamic jet printing. The new system is more precise, less intrusive, and cost-effective, with the potential to improve diabetes management and treatment.
A research group including a UF expert has located and narrowed down genes that play a role in Type 1 diabetes. The findings will help predict who might develop the disease and how to prevent it, leading to more effective treatments.
The Endocrine Society has selected 22 winners of the Helmsley Charitable Trust Abstract Awards in Type 1 Diabetes, recognizing outstanding work in clinical care and underlying mechanisms. The award winners will present their research at ENDO 2015 and received travel grants to attend.
A new study confirms earlier findings that African-American children have significantly higher HbA1c levels than their white counterparts despite similar average blood glucose levels. The study calls for prioritizing efforts to identify and address the sources of ongoing disparities in young patients with type 1 diabetes.
Researchers have developed a novel imaging technique using ferumoxytol and MRI to visualize pancreatic inflammation in patients with newly diagnosed type 1 diabetes. The study found clear evidence of ongoing inflammation in the pancreas, which could help predict disease progression and identify potential therapeutic targets.
Researchers are developing an artificial pancreas (AP) to manage pediatric diabetes, aiming to alleviate parents' stress and anxiety. The device will be tailored to consider children's unpredictable eating habits and physical activity, and its safety, efficacy, reliability, and ease of use will be prioritized.
Researchers have developed a long-lasting, glucose-responsive insulin derivative called Ins-PBA-F, which self-activates when blood sugar levels rise. Tests on mouse models show that one injection works for up to 14 hours, automatically lowering blood sugar levels.
A longitudinal study found that infants who developed type 1 diabetes had a significant drop in microbial diversity prior to disease onset, including a decrease in health-promoting bacteria and an increase in potentially harmful ones. The study also revealed stable biological functions served by the microbiome across individuals.
A large meta-analysis involving over 200,000 people with type 1 diabetes found that women face a 40% increased excess risk of death from all causes and have more than twice the risk of dying from heart disease compared to men. Women with type 1 diabetes also face a greater excess risk of strokes and kidney disease.