Active young adults with Type 1 diabetes have muscle complications
A study has found structural and functional changes in muscles of young adults with Type 1 diabetes, leading to reduced metabolism and increased risk of disability.
Type 1 Diabetes
Articles tagged with Type 1 Diabetes
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Active young adults with Type 1 diabetes have muscle complications: Study
A new study from McMaster and York universities found structural and functional changes in the power generation parts of the cell, or mitochondria, of those with diabetes. These changes could result in reduced metabolism, greater difficulty controlling blood glucose and accelerated disability development.
Active young adults with Type 1 diabetes have muscle complications: Study
A new study found structural and functional changes in the muscles of young adults with Type 1 diabetes, leading to reduced metabolism and greater difficulty controlling blood glucose levels. The study suggests revising exercise guidelines for those with Type 1 diabetes to prevent muscle damage.
Antioxidant therapy may reduce cardiovascular risk of young women with type 1 diabetes
Researchers are investigating the impact of antioxidant vitamins C and E, alpha lipoic acid, resveratrol, and Sirt1 on blood vessel health in premenopausal women with type 1 diabetes. Early evidence suggests that treatment may restore protection against cardiovascular disease.
Study finds high rates of type 1 diabetes near food swamps
A study published in the Endocrine Society's Journal of the Endocrine Society finds higher rates of type 1 diabetes in areas with a high proportion of fast food restaurants and convenience stores. The research suggests that an adverse food environment may contribute to the development of type 1 diabetes, particularly among adults.
Continuous glucose monitors proven cost-effective, add to quality of life for diabetics
A study found that continuous glucose monitors (CGMs) improve blood glucose control, reduce hypoglycemia episodes, and increase quality of life for patients with type 1 diabetes. The use of CGMs is cost-effective over manual testing with strips, with savings of $3,796 per year.
Kids with regular health care less likely to have life-threatening diabetic ketoacidosis
Children with regular healthcare are less likely to develop life-threatening diabetic ketoacidosis, a complication of type 1 diabetes. Adolescents with a regular family physician or pediatrician have a significantly reduced risk of DKA, highlighting the importance of primary care for children.
Risk of type 1 diabetes climbs when one population of T cells falls
A study in mice suggests that protective immune cells forming outside the thymus may defend against autoimmune diabetes. Gut microbes affecting this cell population may also protect against disease.
Genes can help predict children's risk of type 1 diabetes
Researchers calculated genetic scores from over 30 genes in 3000 children with no family history of type 1 diabetes. The upper quartile of scores was associated with a greater than 10% risk for pre-symptomatic stage of multiple islet autoantibodies by age 6.
Islet transplantation improves QoL for people with hard-to-control type 1 diabetes
A Phase 3 clinical trial funded by the National Institute of Allergy and Infectious Diseases found consistent and dramatic improvements in quality of life among participants with type 1 diabetes who had frequent severe hypoglycemia. Islet recipients also reported better overall health status despite needing lifelong treatment.
Providing free supplies to low-income families improves type 1 diabetes
A new study suggests that providing free insulin and blood glucose test strips to low- and middle-income families in India significantly improves blood-sugar control. The study also found that patients' knowledge of diabetes improved, especially those with higher education and urban dwellings.
Wearable heart rate monitor could signal low blood sugar in type 1 diabetes
Researchers developed a wearable heart rate monitor that detected hypoglycemia using beat-to-beat variation in heart rate. The device showed promise for timely detection of impending hypoglycemia, but requires further refinement to increase accuracy and precision.
Insulin pump known to be effective in adolescents, adults also benefits children
A new study by The Endocrine Society shows that an insulin pump system can improve glycemic outcomes in children with type 1 diabetes starting from age 7. The MiniMed 670G system also demonstrates effectiveness in adults and adolescents, leading to significant improvements in time spent within target glucose ranges and reduced A1c levels.
Unique inflammation patterns emerging in patients with type 1 diabetes
Research analysis of blood mediators in type 1 diabetes and kidney disease patients reveals 10 elevated proteins, with TNF-alpha family and IL-6 significantly impacting 40% of patients. This study suggests personalized medicine approach to target specific inflammatory mediators for effective treatment.
Paradigm shift in the diagnosis of diabetes
A new classification of diabetes has been discovered, which can predict the risk of serious complications and provide tailored treatment suggestions. The study, published in The Lancet Diabetes & Endocrinology, reveals that type 2 diabetes consists of several subgroups, each with unique characteristics.
The Lancet Diabetes & Endocrinology: Researchers propose five distinct types of adult-onset diabetes
Researchers identified five distinct subtypes of type 2 diabetes and one autoimmune type, each with unique characteristics and associated complications. These findings may enable tailored treatment approaches for patients with diabetes, moving towards precision medicine.
Unique pancreatic stem cells have potential to regenerate beta cells, respond to glucose
Scientists have identified progenitor cells within the human pancreas that can be stimulated to develop into glucose-responsive beta cells. These findings open the door to developing regenerative cell therapies for those living with type 1 diabetes.
Researchers find existing drug effective at preventing onset of type 1 diabetes
Researchers discovered that a common blood pressure medication, methyldopa, can prevent the onset of type 1 diabetes in up to 60% of those at risk by blocking a specific molecule. The study used a supercomputer and found that methyldopa not only blocks the DQ8 molecule but also doesn't harm other immune cells.
Genetic discovery may help better identify children at risk for type 1 diabetes
Researchers identified six novel chromosomal regions associated with type 1 diabetes, enabling the discovery of more genes that cause the disease. The study also found different genetic markers for early detection of autoantibodies in patients at risk.
New study reveals adverse impact of both type 2 and type 1 diabetes on pregnancy outcomes
A new study found that both type 2 and type 1 diabetes are associated with complications during pregnancy, including stillbirths, emergency Caesarean sections, and infant mortality. The research also found a significant increase in high birth weight and preterm delivery among babies born to mothers with diabetes.
Autoimmune reaction successfully halted in early stage islet autoimmunity
Researchers at Helmholtz Munich successfully halted an autoimmune reaction in the early stages of islet autoimmunity, a key step in developing potential treatments for type 1 diabetes. The study reveals that inhibiting the miRNA181a/NFAT5 axis can increase Treg formation and reduce immune activation.
Diabetes increases over time in children but adults account for most new cases in China
A recent study found a rapid increase in type 1 diabetes cases among children in China over the past two decades. The majority of new cases are diagnosed in adults, highlighting the need for more resources to improve care for adult-onset type 1 diabetes.
Spider's web inspires removable implant that may control type 1 diabetes
A new removable implant has been developed to control type 1 diabetes, with hundreds of thousands of islet cells protected by a thin hydrogel coating and attached to a polymer thread. This therapy could replace daily insulin injections and offer a more effective management solution for the disease.
Is it possible to prevent type 1 diabetes by avoiding cow's milk?
A large-scale international randomized trial showed that weaning to an extensively hydrolyzed casein formula during infancy did not reduce the incidence of type 1 diabetes. The study, TRIGR Study, followed infants for at least 10 years and found no evidence to revise current dietary recommendations.
Modifying baby formula doesn't prevent type 1 diabetes in children
A large-scale international trial found that modifying baby formula to reduce cow's milk proteins didn't decrease the risk of type 1 diabetes. The study followed 2,159 infants with a family member affected by type 1 diabetes and genetic risk for years to determine which developed diabetes.
New clinical trial accepting patients, hopes to ease type 1 diabetes management
A new nationwide clinical trial aims to make managing type 1 diabetes easier for patients using the world's first hybrid closed-loop system automated insulin delivery device. The trial, funded by Medtronic, will monitor blood glucose levels and adjust insulin doses continuously to help patients maintain stable blood sugar levels.
Tiny bilirubin-filled capsules could improve survival of transplanted pancreatic cells
Researchers have developed tiny bilirubin-filled capsules that can improve the survival rates of transplanted pancreatic islet cells. This breakthrough has implications for treating Type 1 diabetes in both canine and human patients, with a potential treatment program for dogs that could lead to improved treatments for humans.
Immunotherapy, gene editing advances extend to Type 1 Diabetes
Researchers at Seattle Children's are exploring therapies that reprogram T cells to calm down an overactive immune response, which may hold promise for curing type 1 diabetes. The goal is to develop a treatment that could protect new patients from the life-long requirement for insulin therapy.
Type 1 diabetes as common in adults as children, but many adults misdiagnosed
Research published in the Lancet Diabetes & Endocrinology found that over 40% of type 1 diabetes cases occur after age 30, and many adults are initially misdiagnosed with type 2. Type 1 diabetes requires insulin treatment to control blood sugar levels, while type 2 can often be managed with diet and medication.
Continuous glucose monitors warn of low blood sugar threat
A study published in the Journal of Clinical Endocrinology & Metabolism found that continuous glucose monitors can protect against hypoglycemia episodes, even when the body's defense mechanisms are impaired. The devices raised awareness of low blood sugar threats and reduced severe episodes.
Can an insulin pill delay or prevent type 1 diabetes?
A daily insulin pill did not slow down or prevent type 1 diabetes development among individuals with a higher risk of developing the disease. The trial involved 560 participants who received either oral insulin or a placebo, and found that time to diagnosis was not significantly different between groups.
Enterovirus vaccine prevents virus-induced diabetes in a T1D experimental model
Scientists developed an enterovirus vaccine that protects against virus-induced diabetes in a mouse model for Type 1 diabetes. The study suggests the potential role of enteroviruses in human Type 1 diabetes and offers a new preventative treatment option.
Can a common ingredient in laundry detergent help advance diabetes research?
Researchers from Wake Forest Institute for Regenerative Medicine discovered that sodium percarbonate and calcium peroxide improved insulin-producing cell function and viability in lab-built bioartificial pancreas. Oxygen-generating materials could potentially supplement cells' high oxygen needs, aiding in diabetes treatment.
Cell-based therapy for type 1 diabetes?
Researchers at Boston Children's Hospital have successfully reversed type 1 diabetes in a mouse model by infusing pre-treated blood stem cells. The treated cells curbed the autoimmune reaction and reversed hyperglycemia in diabetic mice, with almost all mice cured of diabetes in the short term and one third maintaining normal blood sug...
Study refutes using anti-malaria drug to treat diabetes
A recent study from UC Davis researchers refutes the use of an anti-malaria drug to create new insulin-producing cells for Type 1 diabetes treatment. The findings highlight the crucial need for reproducibility in scientific research, contradicting a previous report that sparked excitement in the field.
Enough vitamin D when young associated with lower risk of diabetes-related autoimmunity
A study found that adequate vitamin D levels during infancy and childhood are associated with a reduced risk of islet autoimmunity, a precursor to type 1 diabetes. Vitamin D status varies by latitude, and higher childhood levels are significantly linked to decreased risk of IA.
Patients at risk over failure to recognize important diabetes subtype
A new study reveals that up to 97.3% of people with pancreatic disease are misdiagnosed with Type 2 diabetes, instead of the correct condition, Type 3c diabetes. This can lead to delayed treatment and devastating long-term effects for patients.
Insulin pumps associated with lower risk of serious complications among young patients with type 1 diabetes
A study published in JAMA found that insulin pump therapy among young patients with type 1 diabetes was associated with lower rates of severe hypoglycemia and diabetic ketoacidosis compared to traditional injections. This innovative treatment approach offers improved clinical outcomes for this vulnerable population.
The risk of type 1 diabetes not increased by swine flu vaccine Pandemrix
A new study of children from Sweden and Finland found that the swine flu vaccine Pandemrix did not increase the risk of developing autoantibodies against insulin-producing beta cells or type 1 diabetes. In fact, vaccinated children in Finland showed a reduced risk of developing autoantibodies and type 1 diabetes.
The Lancet: 24-hour glucose monitoring during pregnancy improves birth outcomes for women with type 1 diabetes and their babies
A new trial found that continuous glucose monitoring during pregnancy reduces the number of babies born larger than average, need for intensive care, and pre-eclampsia rates. Birth outcomes improved significantly for mothers using the device compared to traditional finger-prick tests.
Study shows new biomarker could predict which pregnant women with type 1 diabetes could develop pre-eclampsia
A new biomarker, LRG1, can predict the occurrence of pre-eclampsia in pregnant women with type 1 diabetes, increasing their risk by 4 times. The study found that LRG1 levels were significantly higher in women who developed PE compared to those who did not.
Drug for type 2 diabetes provides significant benefits to type 1 diabetic patients
A global study of over 800 patients with Type 1 diabetes found that dapagliflozin, a Type 2 diabetes medicine, significantly improved blood sugar levels. The results demonstrate the drug's efficacy as an adjunct therapy to insulin, reducing A1C levels by more than 0.5% without severe hypoglycemia.
Pregnancy outcomes remain poor in mothers with childhood-onset T1D, despite significant advances in obstetric and diabetic care
Research shows that pregnancy outcomes remain poor for women with type 1 diabetes, especially those diagnosed at a young age. The study found higher rates of pre-eclampsia, stillbirth, and low birth weight among mothers with childhood-onset T1D.
H1N1 swine flu may play a role in triggering type 1 diabetes
A nationwide Norwegian study found that H1N1 infected individuals, especially children under 15, were twice as likely to develop type 1 diabetes than the general population. Infection with H1N1 influenza virus was linked to a doubled risk of T1D in Norwegians aged 30 or younger.
New oral diabetes drug shows promise in phase 3 trial for patients with type 1 diabetes
A University of Colorado Anschutz Medical Campus study finds sotagliflozin helps control glucose and reduces the need for insulin in patients with type 1 diabetes. Patients experienced a lower rate of confirmed severe hypoglycemia than observed in patients on placebo and also had weight loss.
Study advances efforts to screen all children for Type 1 diabetes
Researchers developed a novel antibody detection technology that increases the sensitivity of Type 1 Diabetes tests, enabling screening for more autoimmune antibodies implicated in the disease. The technology holds promise for making populationwide screening practical and catching the disease earlier.
Variation in genetic risk explains which people develop type 1 diabetes in later life
A new study suggests that specific genetic variants increase the risk of developing type 1 diabetes in later life, including after the age of 30. The research found that individuals with certain HLA genotypes have a higher likelihood of developing late-onset T1D and being diagnosed at an older age.
Immune cells help fat deal with environmental challenges
Regulatory T-cells in adipose tissue increase in response to environmental stimuli, promoting heat production and fatty acid breakdown. This discovery highlights the complex interactions between immune cells and environment in maintaining metabolic balance.
New treatment on the horizon for type 1 diabetes sufferers
Researchers at Westmead Institute for Medical Research have discovered a new approach to treating type 1 diabetes, using pancreatic islet transplants delivered into the quadriceps muscle. This method presents fewer risks than current clinical practice of transplanting islets into the liver via the portal vein.
Protecting the guardians
Research in mice shows that gut bacteria play a crucial role in modulating the effects of a powerful protective gene against type 1 diabetes. The findings highlight the importance of early environmental exposures to a variety of germs in proper immune system development.
Coronary artery bypass surgery effective in patients with type 1 diabetes
A new study from Karolinska Institutet found that CABG reduces the risk of fatal heart disease and myocardial infarction in patients with type 1 diabetes by 45% and 47% respectively, compared to PCI.
Pioneering immunotherapy shows promise in type 1 diabetes
A clinical trial has observed noticeable changes in the behavior of immune systems of type 1 diabetes patients treated with peptides. The treatment has a noticeable effect on the immune system and suggests a potential way to protect remaining beta cells.
Immunotherapy shown to be safe for diabetes
A recent study demonstrates the safety of immunotherapy in treating type 1 diabetes. The treatment showed metabolic effects without accelerating β-cell destruction, suggesting a viable option for patients.
Towards a safe and scalable cell therapy for type 1 diabetes by simplifying beta cell differentiation
Scientists have identified a molecular handle to purify cells destined to become insulin-producing cells, enabling a streamlined and cost-efficient process for generating glucose-responsive beta cells. The discovery aims to address safety and end product consistency challenges in cell therapy for type 1 diabetes.
Medalist study underlines importance of glucose control in adults with Type 1 diabetes
A new study of adults with Type 1 diabetes for at least 50 years found that better glucose control is associated with a lower risk of cardiovascular disease. The research also discovered that exercise plays a significant role in lowering mortality rates from all causes in this population.
Type 1 diabetes risk linked to intestinal viruses
A new study suggests that certain viruses in the intestines may affect a person's chance of developing Type 1 diabetes. Children with less diverse gut viral communities are more likely to generate self-destructive antibodies, while those carrying a specific circovirus group are less likely to develop the disease.
Diabetes patients still produce insulin
A recent study published in Diabetes Care found that almost half of patients with type 1 diabetes for over ten years still produce some insulin. Higher levels of interleukin-35 were detected in these patients, suggesting a link between this protein and the regeneration of remaining insulin-producing cells.
Infections in early life associated with increased risk for celiac disease
Recurring gastrointestinal infections in early childhood significantly increase the risk of developing gluten intolerance, according to a new study. The research found a strong association between early respiratory tract infections and an elevated risk of celiac disease.
Mass. General study finds potential mechanism for BCG vaccine reversal of type 1 diabetes
A new study presents data from an FDA-approved clinical trial testing the generic vaccine BCG to reverse advanced type 1 diabetes. The findings suggest that BCG may induce a permanent increase in expression of genes that restore beneficial regulatory T cells (Tregs) preventing autoimmune attacks on the body's own tissue.
Scientists create unique disease 'catalog' linked to immune system gene variations
A comprehensive catalog of diseases associated with human leukocyte antigen (HLA) gene variations has been generated by researchers at Vanderbilt University Medical Center. The catalog identifies individuals at risk for certain autoimmune diseases and potential new associations with multiple sclerosis and cervical cancer.