Articles tagged with Type 1 Diabetes
The National Institutes of Health has awarded a grant to develop and evaluate an artificial pancreas for pregnant women with type 1 diabetes. The project aims to improve patient and fetal outcomes by adapting automated insulin delivery technology.
A study found a significant decrease in type 1 diabetes diagnoses in children aged 0-4 years after the introduction of the rotavirus vaccine in 2007. The researchers suggest that preventing rotavirus infection may also reduce the risk of type 1 diabetes.
A new study found that only a minority of US adults with type 1 diabetes achieve target hemoglobin A1c levels, indicating poor blood glucose management. The study revealed increasing HbA1c levels in young adults and teens over the past 5 years.
Researchers have developed a new risk score that takes into account genetic information to identify babies at high risk of type 1 diabetes. The score is nearly twice as efficient as existing methods and also effective at predicting type 1 diabetes in adults, helping with early diagnosis and treatment.
Patients with type 1 diabetes and poor blood sugar control face a higher risk of fragility fracture compared to those with good glycemic control. Good blood sugar control is an important goal for patients with diabetes, and research shows that it may help reduce the risk of fractures in type 1 diabetes patients.
Researchers found that trained alert dogs can detect hypoglycaemic episodes in 83% of cases, helping Type 1 patients regulate blood sugars non-invasively. The study provides the first large-scale evaluation of medical detection dogs in detecting hypoglycaemia.
The TEDDY study, following nearly 9,000 children over five years, aims to identify high-risk genes and environmental factors that contribute to type 1 diabetes. Early screening and intervention may be possible through analyzing autoantibodies in newborns and tracking changes in risk factors as children age.
Patients with type 1 diabetes exhibit altered brain connectivity patterns compared to healthy individuals, according to a new study published in PLOS ONE. The research, led by the University of Barcelona, employed fMRI techniques to investigate brain activity during working memory tasks.
A study published in JCI Insight found that a specific subset of immune B cells, CD19+IgM+, can delay the onset of type 1 diabetes in mice. This discovery opens up new possibilities for developing therapies targeting this disease subtype.
Research finds that socio-economic conditions in regions affect T1 diabetes treatment, with disadvantaged areas having higher blood glucose levels, lower use of pump therapy and CGMS, and better outcomes for severe hypoglycemia. Frequent use of pump therapy and CGMS could improve treatment outcomes in these regions.
A new study found a significant increase in type 1 diabetes cases across Europe, with rates rising by 3.4% per year. The study's findings have important implications for healthcare planning and delivery, highlighting the need for improved blood sugar control and increased support services.
An investigation by The BMJ found that tens of thousands of UK patients with type 1 diabetes are being denied access to flash glucose monitoring devices due to a postcode lottery. Despite NHS guidance, only 3-5% of patients have access to the devices, compared to 20-25% recommended by clinical commissioning groups.
Researchers at Baylor College of Medicine found three distinct phases in infant gut microbiome development from 3-46 months of age. Partial breastfeeding was associated with higher abundance of probiotic bacteria, while cessation accelerated maturation and change in microbial diversity.
A new $3.3 million grant will fund a high-resolution reference map of pancreatic cells to identify molecular changes leading to type 1 diabetes.
Scientists at Newcastle University have found that metformin can reduce the presence of microRNAs that contribute to heart disease in patients with Type 1 diabetes. By decreasing these microRNAs, metformin improves glucose levels and promotes blood vessel repair, opening up new treatment options for this vulnerable patient group.
A study highlights strategies to help teens with type 1 diabetes manage high cholesterol and blood pressure, including offering realistic guidance, encouraging regular exercise, and promoting healthy eating habits. The research emphasizes the importance of personalized approach and team effort in addressing these conditions.
A new study found that 21% of individuals with insulin-treated diabetes diagnosed after age 30 have severe insulin deficiency, characteristic of late-onset type 1 diabetes. These patients often experience delays in diagnosis and treatment due to misdiagnosis as type 2 diabetes.
The BCG vaccine, used to prevent tuberculosis, can reduce blood sugar levels in people with advanced type 1 diabetes by mimicking microbial exposures. The vaccine appears to reset abnormal metabolic functions, boosting the immune system to consume sugar and reduce blood glucose levels over time.
A new hybrid closed-loop insulin delivery system was compared to sensor-augmented pump therapy for blood sugar control in patients with poorly controlled type 1 diabetes. The study found that the hybrid closed-loop system achieved significantly better glucose control and reduced the risk of hypoglycaemia.
A high-gluten diet during pregnancy is associated with an increased risk of type 1 diabetes in children, according to a large observational study. The researchers found that the child's risk of developing type 1 diabetes increased proportionally with the mother's gluten intake during pregnancy.
A new study from the University of Iowa found that 8.5% of American adults have been diagnosed with type 2 diabetes, while 0.5% have type 1 diabetes. Type 2 diabetes is overwhelmingly more common, accounting for 91.2% of all diagnosed cases.
A study published in Frontiers in Immunology reveals that a specific immune checkpoint molecule, interleukin-10 (IL-10), is not functioning properly in mice with type 1 diabetes. This defect leads to an overactive immune response, attacking insulin-producing cells and causing the disease.
A new collagen-based treatment has shown promise for reversing Type 1 diabetes in both humans and dogs, offering a minimally invasive alternative to traditional therapies. The treatment involves injecting a solution containing pancreatic cells mixed with collagen, which can restore insulin independence for at least 90 days.
Research reveals women with type 1 diabetes diagnosed before age 10 experience significantly reduced life expectancy, with heart attacks occurring 90 times more frequently than in non-diabetic individuals.
People with younger-onset type 1 diabetes have a higher risk of cardiovascular complications and premature death. The study found that those diagnosed before the age of 10 had a 30-times greater risk of serious cardiovascular outcomes than those in the general population.
A single course of antibiotics early in childhood may increase the risk for Type 1 diabetes, according to a study published in eLife. The research found that four bacterial species groups were significantly more abundant in the guts of mice treated with the antibiotic, and likely involved in driving progression of the disease.
A large study found that children of mothers with type 1 diabetes have a significantly higher body mass index, waist circumference, and fasting blood glucose level. The researchers suggest that pediatricians should monitor these children for early warning signs of the condition.
Researchers found that proteins in saliva reflect high blood sugar levels in young patients with type 1 diabetes, allowing for early prediction of complications. A potential new preventive treatment has been identified using gene database searching.
A new clinical trial will assess the impact of high-dose omega-3 fatty acids and vitamin D supplementation on halting type 1 diabetes progression. The POSEIDON Study aims to reduce inflammation, increase insulin secretion, and promote a potential cure for this autoimmune disease.
A breakthrough discovery by RMIT University could enable early detection of Type 1 diabetes in newborns, potentially delaying or preventing the onset of the disease. The collaboration combines lab-on-a-chip technologies with biomarker detection to identify early loss of beta cells.
A human clinical trial revealed verapamil as a safe and effective therapy to reduce insulin requirements and hypoglycemic episodes in adult subjects with recent onset Type 1 diabetes. The study found that regular oral administration of verapamil enabled patients to produce higher levels of their own insulin.
A new study found that one in four working-age adults with type 1 diabetes experienced at least one gap of 30 days or more in their private health insurance, leading to a five-fold increase in emergency room visits and hospital stays. The gaps resulted in higher blood sugar levels and decreased satisfaction with life.
A study by Karolinska Institutet found a clear correlation between elevated blood glucose levels in mothers and the risk of heart defects in their babies. Pregnant women with type 1 diabetes are at a higher risk, especially those with high blood glucose levels during early pregnancy.
Women with well-controlled type 1 diabetes often give birth to babies that are large for their gestational age, despite excellent glycemic control throughout pregnancy. Continuous glucose monitoring revealed elevated fetal weight and abdominal circumference percentages.
A recent study has linked increased risk of autism spectrum disorder (ASD) in children born to mothers with the three main types of diabetes. The research, published in JAMA Network, suggests a higher risk for children exposed in utero to maternal preexisting type 1 diabetes and gestational diabetes diagnosed by 26 weeks.
Long-term follow-up of BCG vaccine trial participants shows significant clinical benefits, including near-normal blood sugar levels, which persist for up to five years. The study reveals a novel metabolic mechanism that increases cellular glucose consumption, leading to improved insulin sensitivity.
A study by McGill University Health Centre found that two-thirds of teenagers and young adults with type 1 diabetes experience stigma, which can lead to neglecting treatment and severe hypoglycemia. The study also highlights the need for social support and resiliency programs to help individuals manage their condition.
A study published in Diabetes Care found that the rapid decline in insulin production associated with Type 1 diabetes follows a two-phase pattern: an initial exponential fall and a subsequent stable phase. This discovery suggests that people with Type 1 diabetes may retain some working beta-cells for seven years after diagnosis.
A study by Joslin Diabetes Center researchers has found a correlation between long-term type 1 diabetes and mild cognitive decline, particularly in memory. The decline is also associated with an increased risk of cardiovascular disease.
Researchers have developed a new approach using synthetic hydrogel particles to educate the immune system to accept transplanted insulin-producing islets. The technique could allow for an 'off-the-shelf' therapy for type 1 diabetes without long-term immune suppression, potentially treating millions of people worldwide.
A survey of patients with type 1 diabetes on a very-low-carbohydrate diet found exceptional blood-sugar control with few complications, including lower rates of hypoglycemia and diabetic ketoacidosis. The researchers call for controlled clinical trials to test the diet's safety and efficacy.
A new study found structural and functional changes in the muscles of young adults with Type 1 diabetes, leading to reduced metabolism and greater difficulty controlling blood glucose levels. The study suggests revising exercise guidelines for those with Type 1 diabetes to prevent muscle damage.
A review of 41 trials involving over 1000 people with type 1 diabetes found that artificial pancreas systems provided almost two and a half extra hours of normal blood glucose levels per day. The treatment also reduced time spent in both hyperglycaemia and hypoglycaemia compared to other types of insulin-based therapy.
A study has found structural and functional changes in muscles of young adults with Type 1 diabetes, leading to reduced metabolism and increased risk of disability.
A new study from McMaster and York universities found structural and functional changes in the power generation parts of the cell, or mitochondria, of those with diabetes. These changes could result in reduced metabolism, greater difficulty controlling blood glucose and accelerated disability development.
A study published in the Endocrine Society's Journal of the Endocrine Society finds higher rates of type 1 diabetes in areas with a high proportion of fast food restaurants and convenience stores. The research suggests that an adverse food environment may contribute to the development of type 1 diabetes, particularly among adults.
Researchers are investigating the impact of antioxidant vitamins C and E, alpha lipoic acid, resveratrol, and Sirt1 on blood vessel health in premenopausal women with type 1 diabetes. Early evidence suggests that treatment may restore protection against cardiovascular disease.
A study found that continuous glucose monitors (CGMs) improve blood glucose control, reduce hypoglycemia episodes, and increase quality of life for patients with type 1 diabetes. The use of CGMs is cost-effective over manual testing with strips, with savings of $3,796 per year.
Children with regular healthcare are less likely to develop life-threatening diabetic ketoacidosis, a complication of type 1 diabetes. Adolescents with a regular family physician or pediatrician have a significantly reduced risk of DKA, highlighting the importance of primary care for children.
A study in mice suggests that protective immune cells forming outside the thymus may defend against autoimmune diabetes. Gut microbes affecting this cell population may also protect against disease.
Researchers calculated genetic scores from over 30 genes in 3000 children with no family history of type 1 diabetes. The upper quartile of scores was associated with a greater than 10% risk for pre-symptomatic stage of multiple islet autoantibodies by age 6.
A Phase 3 clinical trial funded by the National Institute of Allergy and Infectious Diseases found consistent and dramatic improvements in quality of life among participants with type 1 diabetes who had frequent severe hypoglycemia. Islet recipients also reported better overall health status despite needing lifelong treatment.
A new study suggests that providing free insulin and blood glucose test strips to low- and middle-income families in India significantly improves blood-sugar control. The study also found that patients' knowledge of diabetes improved, especially those with higher education and urban dwellings.
Researchers developed a wearable heart rate monitor that detected hypoglycemia using beat-to-beat variation in heart rate. The device showed promise for timely detection of impending hypoglycemia, but requires further refinement to increase accuracy and precision.
A new study by The Endocrine Society shows that an insulin pump system can improve glycemic outcomes in children with type 1 diabetes starting from age 7. The MiniMed 670G system also demonstrates effectiveness in adults and adolescents, leading to significant improvements in time spent within target glucose ranges and reduced A1c levels.
Research analysis of blood mediators in type 1 diabetes and kidney disease patients reveals 10 elevated proteins, with TNF-alpha family and IL-6 significantly impacting 40% of patients. This study suggests personalized medicine approach to target specific inflammatory mediators for effective treatment.
A new classification of diabetes has been discovered, which can predict the risk of serious complications and provide tailored treatment suggestions. The study, published in The Lancet Diabetes & Endocrinology, reveals that type 2 diabetes consists of several subgroups, each with unique characteristics.
Researchers identified five distinct subtypes of type 2 diabetes and one autoimmune type, each with unique characteristics and associated complications. These findings may enable tailored treatment approaches for patients with diabetes, moving towards precision medicine.
Scientists have identified progenitor cells within the human pancreas that can be stimulated to develop into glucose-responsive beta cells. These findings open the door to developing regenerative cell therapies for those living with type 1 diabetes.
Researchers discovered that a common blood pressure medication, methyldopa, can prevent the onset of type 1 diabetes in up to 60% of those at risk by blocking a specific molecule. The study used a supercomputer and found that methyldopa not only blocks the DQ8 molecule but also doesn't harm other immune cells.