Articles tagged with Type 1 Diabetes
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers screened 25,000 children in the Denver metro area and found that early detection can reduce incidence of diabetic ketoacidosis by 20%, leading to improved disease control and reduced healthcare costs. The study highlights the potential for screening to improve overall quality of life and reduce long-term health risks.
The Critical Path Institute (C-Path) has received a letter of support from the European Medicines Agency (EMA) to facilitate the development and validation of pancreatic islet autoantibodies as enrichment biomarkers for type 1 diabetes clinical trials. This collaboration aims to accelerate drug development in T1D by identifying patient...
Two case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in adults and infants during the pandemic. The technology showed improved outcomes with increased time-in-range, as patients received virtual management and dose adjustments.
Research from Joslin Diabetes Center found that autoantibodies against heart muscle proteins are associated with increased volume of the left ventricle, reduced pumping function, and higher risk of failure. The study suggests a novel process involving the heart linked to poor glycemic control in type 1 diabetes patients.
A recent study found that technology use by adults with type 1 diabetes is lower among African-American and Hispanic patients. The use of continuous glucose monitors (CGM) and continuous subcutaneous insulin infusion (CSII) devices was significantly lower in these groups, highlighting racial disparities in access to healthcare.
Researchers at St. Jude Children's Research Hospital created an 'atlas' of gene-regulatory mechanisms in immune cells that facilitate Type 1 diabetes. The study revealed a dual biological personality of T cells, enabling them to retain the ability to attack insulin-producing cells across successive generations.
A study analyzing 6 million days of real-world data shows the MiniMed 670G system can maintain target glucose range of 70-180 mg/dL over 71% of the time. The AutoMode feature improves glycemic control, reducing low and high blood sugar episodes.
Researchers at UW-Madison discovered that removing a specific gene from insulin-producing cells can prevent Type 1 diabetes in mice by allowing the cells to disguise themselves from immune cells. This genetic manipulation enabled the cells to evade an autoimmune response, leading to normal glucose levels and insulin production.
Research found that individuals with type 2 diabetes who participate in online support groups have worse health outcomes and higher levels of disease-related complications. In contrast, users with type 1 diabetes did not show a significant correlation between forum participation and health outcomes.
Research reveals that children diagnosed with type 1 diabetes under 7 years old have a different form of the condition compared to those diagnosed at 13 or above. The study proposes two distinct endotypes: T1DE1 and T1DE2, which could lead to new treatments and a potential cure for some people.
A large observational study of nearly 387,000 children found no association between rotavirus vaccination and the development of type 1 diabetes. Researchers noted limitations and potential confounding variables that may have affected results.
Researchers at Penn Medicine discovered that changes in DNA sequence can trigger chromatin misfolding in white blood cells, increasing the risk of developing Type 1 diabetes. The study found that these misfolded regions occur before the disease onset and may serve as a diagnostic tool.
Boston College biologist Emrah Altindis received a $300,000 grant from the G. Harold and Leila Y. Mathers Foundation to explore the role of gut microbes and viruses in triggering Type 1 diabetes. The research aims to understand molecular mimicry as a potential cause of the autoimmune disease.
The Juvenile Diabetes Research Foundation (JDRF) honored five researchers for their outstanding contributions to type 1 diabetes research, including breakthroughs in beta cell autoimmunity and immune therapies. The awards recognize significant progress toward curing T1D, with funded research totaling over $2.2 billion.
New research from the University of Colorado Anschutz Medical Campus suggests that changes in the environment may contribute to the rising incidence of type 1 diabetes. The study examined various environmental exposures and found that none of the associations were strong enough to explain the rapid increase alone.
Researchers identified growth differentiation factor 15 (GDF15) as a key player in delaying type 1 diabetes onset in diabetic mice. Treatment with GDF15 reduced development of diabetes by 53% in non-obese diabetic mice, providing a potential target for prevention and treatment.
A team of CHOP researchers has discovered a genetic signature that can help diagnose adult-onset 'type 1.5' diabetes, which shares characteristics with pediatric-onset type 1 diabetes. The finding could lead to more effective diagnostic methods and improve treatment outcomes for adults.
Researchers deciphered a mechanism impairing regulatory T cell differentiation and stability in type 1 diabetes. Inhibiting the miRNA142-3p molecule increased functional Tregs and reduced autoimmune activation.
Patients with type 1 diabetes and high lipoprotein(a) levels have a significantly higher risk of developing cardiovascular disease, including coronary artery disease and calcified aortic valve disease. High blood glucose levels are also associated with elevated lipoprotein(a) levels in this patient group.
A clinical trial is underway to study the efficacy of umbilical cord-derived mesenchymal stem cells as a potential therapeutic for new onset type 1 diabetes. The trial, funded by the NIH, aims to determine if systemic administration of these cells can reduce disease progression and preserve insulin secretion.
Researchers found that adjusting CGM alarm settings can inform patients about high or low blood sugar events early, enabling timely treatments. The study suggests simpler adjustments to these thresholds could lead to better management of hypo- and hyperglycemia for people with type 1 diabetes.
A three-year clinical study found that reducing uric acid levels with the generic drug allopurinol did not slow diabetic kidney disease progression in type 1 diabetes patients. The study's conclusions provided a clear answer to an important scientific question, while suggesting further research may be needed.
A multi-center trial found that the artificial pancreas system improved users' blood glucose control throughout the day and overnight, reducing hyperglycemia and hypoglycemia events. The study showed significant benefits of the new system over existing treatments, with no severe hypoglycemia events occurring in either group.
A new artificial pancreas system improved blood glucose control throughout the day and overnight, reducing time in range for high and low glucose levels. The system also showed improvements in hemoglobin A1c and other measurements related to diabetes control compared to current technology.
A new artificial pancreas system improved participants' blood glucose control throughout the day and overnight, reducing the risk of low blood sugar levels. The system's advanced algorithms and safety features enabled users to achieve near-normal blood sugar levels every morning.
A new study suggests that rotavirus infection may trigger the development of type 1 diabetes. Researchers found a significant decrease in the incidence of type 1 diabetes in Australian children under four years old after the introduction of rotavirus vaccination.
A new calculator developed by the University of Exeter will help clinicians classify patients with type 1 or type 2 diabetes, reducing complications and misdiagnosis. The calculator combines blood test results with age and BMI to provide a personalized medicine approach.
A study published by researchers from the Turku Bioscience Centre found changes in circulating molecules in the blood that may be new markers of type 1 diabetes. This discovery could provide an early window for intervention and prevention of the disease.
Patients with type 1 diabetes who experience hospitalizations for ketoacidosis or hyperglycemic comas have an increased risk of subsequent suicidal attempts. The risk is strongly associated, with a threefold increased risk for those with multiple hyperglycemic coma hospitalizations.
A Norwegian study found that a child's gluten intake at 18 months is associated with a 46% increased risk of developing type 1 diabetes for each extra 10g of gluten consumed. The mother's gluten intake during pregnancy was not linked to the risk.
Researchers found that carbohydrate content and meal type are the most important factors affecting carb-counting accuracy. Larger meals tend to have more errors, while smaller meals have fewer mistakes.
A highly predictive genetic risk score is being developed by Paul Tran to identify children at significant risk of developing type 1 diabetes. The algorithm uses a feedforward neural network to analyze thousands of gene variants associated with the disease, aiming to predict with five times better accuracy than current systems.
A new study by the University of Turku and Tampere University found that chronic enteroviral infection can modify broadly pancreatic cellular functions, including alterations in protein expression and secretion. The study suggests that such infections may have adverse health effects, particularly on the development of type 1 diabetes.
Researchers have identified microRNA-204 as a biomarker for early beta cell death in Type 1 diabetes, which can identify disease onset in children and adults with recent-onset Type 1 diabetes. Serum miR-204 levels were found to be elevated in individuals with Type 1 diabetes and inversely correlated with remaining beta-cell function.
Researchers at Scripps Research Institute have discovered a potential biological marker for early detection of type 1 diabetes using single-cell analysis of immune cells. The discovery could lead to earlier intervention and prevention of the disease, which affects over 1.25 million Americans.
Researchers at MUSC have identified a specific lipoprotein phenotype associated with an increased risk of preeclampsia in pregnant women with type 1 diabetes. Monitoring these patients closely and taking proactive measures to keep their blood pressure down can help prevent the complication.
A new study published in BMJ found that blood glucose levels between 48-52mmol/mol do not provide additional protection against organ damage, whereas levels below 48 do not offer further reduced risk. Patients with low HbA1c values need to monitor for excessively low glucose levels and fluctuations.
A recent study published in Nature Communications found that children with high genetic risk of developing type 1 diabetes have distinct gut microbiomes compared to those with low risk. The research suggests a link between genetic predisposition and environmental factors, highlighting the importance of the gut flora in autoimmune disea...
A recent study at University of Eastern Finland discovered a novel T-cell subset, peripheral helper T cells, associated with the onset of type 1 diabetes. These cells were found to be more frequent in children who later developed the disease and those with autoantibodies indicating genetic risk.
Researchers will use human pluripotent stem cells, CRISPR and human organoids to dissect beta cell defects and create a human cell model of type 1 diabetes. The goal is to identify the cellular actions leading to disease onset and potentially rescue surviving beta cells.
Researchers discovered a blood signature predicting type 1 diabetes before its onset, enabling early identification of high-risk children. The study, led by the University of Turku, could lead to disease prevention.
Researchers found that montelukast can disrupt inflammatory signaling in diabetic retinopathy, reducing small blood vessel and nerve damage. The study offers an early approach to treat type 1 diabetes and suggests a potential new treatment for the disease.
A global study of 12 million people found diabetes increases the risk of heart failure, with a significant increase for women. Women with type 1 diabetes have a 47% greater excess risk of heart failure compared to men, highlighting the need for sex-specific research.
A global study of 12 million people found that diabetes significantly increases the risk of heart failure, with women at greater risk than men. Type 1 and type 2 diabetes both pose a stronger risk for women, highlighting the need for sex-specific research into diabetes and its impact on heart health.
Patients with Type 1 diabetes who are obese often face denied pancreas transplantation due to high infection risks. However, robotic pancreas transplantation has shown promising results, reducing blood loss and surgical complications while improving patient outcomes.
Researchers analyzed samples from over 1,000 type 1 diabetes patients for 50 years or longer and found a protective protein called RBP3. Injecting RBP3 into rodents blocked diabetic retinopathy without severe side effects.
A study from Joslin Diabetes Center found that a minority of patients treated for decades with type 1 diabetes may have monogenic diabetes, which can be treated with oral drugs. The research suggests screening for genetic mutations in young people diagnosed with type 1 diabetes to identify potential treatment options.
Researchers from the University of Barcelona and IDIBAPS identified a molecular target, PTP1B phosphatase, that promotes the creation of new blood vessels in transplanted pancreatic islets. This study aims to improve the revascularization process, increasing the viability of cells and restoring regular sugar levels and glucose tolerance.
A new study shows that children who received all doses of the rotavirus vaccine had a 33% lower risk of getting diagnosed with type 1 diabetes. The study, published in Scientific Reports, used nationwide health insurance data and found that the vaccine was associated with a 94% lower rate of hospitalization for rotavirus infection.
Researchers found substantial T cell infiltration and few surviving beta cells in a patient's pancreas after IC therapy, contradicting previous reports of elevated PD-L1 expression
Researchers found that children with type 1 diabetes had slower growth in brain areas associated with mild cognitive deficits compared to children without T1D. The study suggests that glycemic exposure may adversely impact the developing brain in children with early-onset T1D.
A clinical trial found that teplizumab, an immunotherapy drug, can delay the onset of type 1 diabetes in people at high risk. The study, published in the New England Journal of Medicine, showed a median delay of two years in children and adults.
Researchers found that an immunotherapy treatment, teplizumab, effectively delayed the progression to clinical type 1 diabetes in high-risk individuals. Participants who received teplizumab took longer to develop clinical disease, with a median time of 48 months compared to just over 24 months for those in the control group.
Researchers found near-normal glycemic profiles in five long-term islet transplant recipients, with improved time-in-range metrics and reduced glucose variability. The study demonstrates the potential of islet transplantation as a successful long-term cell therapy for select patients with type 1 diabetes.
A 10-week pilot study integrated health coaching and incentives into standard treatment for pediatric patients with type 1 diabetes, lowering A1c levels by an average of .5%. Health coaches received greater empathy and engagement, while families benefited from personalized feedback and support.
A newly discovered immune cell, the 'X cell', has been found to be a major driver of the autoimmune response believed to cause type 1 diabetes. The X cell can act as both a B cell and a T cell, amplifying the autoimmune response.
Children with type 1 diabetes experience a 20% reduction in medication adherence during school holidays, weekends, and public holidays. This can have serious consequences for their health, increasing demand on healthcare systems and potentially leading to hospitalization and mortality.
Researchers identified a critical role for hypoxia-inducible factor 1-alpha (HIF-1A) in increasing the risk of type 1 diabetes after viral infections. The study suggests that exposure to coxsackievirus and other environmental triggers can lead to β-cell death and increased incidence of type 1 diabetes.
Researchers have identified protective factors that play a strong role in preventing diabetic kidney disease. The study found that certain enzymes, including PKM2, are present in people with good kidney function and may be used as biomarkers and targets for personalized clinical intervention.
Immunologists from The University of Texas at Austin captured a first-ever video of T-cells undergoing assassin-training in the body's safety test. The new imaging technique holds promise for improving human health by better understanding T-cell development and function in autoimmune disorders like Type 1 diabetes.