Articles tagged with Type 1 Diabetes
Research published in Diabetologia suggests Sweden may have 2-3 times more adolescents and young adults with type 1 diabetes than estimated. The study used a new method to estimate incidence rates among young people, finding a significant disparity between previous estimates.
A recent study found that DKA rates among US youth with type 1 diabetes remained unchanged over the last 8 years, affecting nearly a third of all youth with the condition. The study also showed disproportionate rates among younger children, non-White racial/ethnic groups, and those without private health insurance.
Researchers found that rotavirus infection activates specific immune cells, including dendritic cells and T cells, which can recognize and destroy insulin-producing islet cells. This 'bystander activation' contributes to the acceleration of autoimmune diabetes in a mouse model.
Researchers found that rotavirus infection accelerates type 1 diabetes development through a bystander effect, where the immune system attacks insulin-producing cells. The study suggests that treatments targeting this immune response could be beneficial for preventing type 1 diabetes in children at risk.
The University of Colorado will receive a $2.1 million grant to help adolescents with Type 1 diabetes manage their disease and improve health outcomes through the Flexible Lifestyle 3mpowering Change (FL3X) study. The study aims to teach teens how to manage insulin, blood sugar, and daily tasks, with positive outcomes from a pilot study.
A study of 44 middle-age adults with Type 1 diabetes found that those diagnosed at older ages had weaker brain connectivity compared to those diagnosed earlier. The researchers suggest that further study is needed to understand the impact of early diagnosis on brain function and development.
Researchers found that gut microbiota diversity and interaction networks vary significantly between children with and without autoantibodies, influencing the body's immune system. The study suggests that identifying parameters affecting negative microbiome characteristics can lead to new approaches in preventing autoimmune processes.
Researchers at Helmholtz Munich have found that GAD antibody affinity is a key indicator of LADA disease progression. The study used GAD vaccination to examine the impact on antibody affinity in 46 LADA patients, finding no influence from vaccination. Patients with high affinity had low insulin production and required insulin therapy s...
Researchers found that children with prediabetes and multiple islet autoantibodies had lower vitamin D levels, which increased during summer months. Vitamin D supplementation may be recommended at an early stage to prevent deficiency.
A new study found that individuals with a history of hypoglycemia are more likely to experience recurrent episodes when using an automatic insulin pump. The ASPIRE study suggests that the 'threshold suspend' feature may not be effective in preventing subsequent events.
Lund University researchers have created a method to visualize inflammatory processes in the pancreas during type 1 diabetes. This allows them to study the body's response to new treatment strategies and potentially develop a model for human immune system diseases.
Researchers found that skin cells from people with type 1 diabetes display elevated calcium levels when exposed to cytokines or fat, suggesting a link between environmental stimuli and genetic predisposition. This discovery may help identify susceptible individuals before disease onset.
A new study, funded by the NIH, will investigate whether reducing uric acid levels can slow down kidney function decline in people with type 1 diabetes. The research aims to find an additional safe and inexpensive way to prevent or delay kidney failure.
Researchers have discovered that a cancer drug can protect the insulin-producing cells in the pancreas and prevent the development of type 1 diabetes in mice. The medication works by reducing sterile inflammation and delaying cell destruction. This finding is a step towards developing a preventive treatment for type 1 diabetes.
Professor Len Harrison has been awarded the JDRF Australia Lifetime Research Achievement Award for his groundbreaking work on improving treatments for people with type 1 diabetes. His research aims to prevent or delay the onset of the disease, bringing hope for better therapies and treatments.
Research published in Diabetologia shows that pre-existing diabetes in pregnant women significantly increases the risk of fetal and infant death. The study found a four-and-a-half times higher risk of fetal death and an almost doubling of infant mortality compared to women without diabetes.
Researchers have identified adolescents with type 1 diabetes at risk of developing heart and kidney diseases through a simple urine test. The study found that normal variation in albumin levels can be an indicator of risk during adolescence.
New technology enabled scientists to prove that most people with type 1 diabetes have active beta cells producing insulin in response to food, contrary to previous thought. This finding has significant implications for understanding the biology of Type 1 diabetes and may lead to new therapies to preserve or replenish beta cells.
Joslin researchers found T cells, not B cells, contribute to beta cell proliferation in type 1 diabetes. Immune cells secrete inflammatory cytokines and chemokines that enhance beta cell growth.
The Joslin Diabetes Center will conduct a clinical trial to evaluate the benefits of allopurinol in reducing kidney function loss among people with type 1 diabetes. The five-year trial aims to determine if high serum uric acid levels are the cause of diabetic kidney disease.
Research published at EASD annual meeting shows having children lowers mortality in people with type 1 diabetes, particularly for women. Mortality rates are significantly higher among women with diabetes compared to controls, but having offspring reduces this disparity.
A UK study found improved life expectancy for people with type 1 diabetes, particularly among younger individuals. The research suggests that this improvement should be reflected in life insurance policies, but gaps in life expectancy remain between the T1DM population and general populations.
A study of 1038 patients with type 1 diabetes reveals that social deprivation and poor blood sugar control are independent risk factors for mortality. Those with higher HbA1c levels and lower socioeconomic status were more likely to die from complications related to the disease.
The study found that sensor-augmented pump therapy significantly reduced the rate of severe and moderate hypoglycemia among patients with type 1 diabetes, particularly those with impaired awareness. The technology demonstrated potential to reduce the duration and frequency of significant hypoglycemia.
A large European study suggests men with type 1 diabetes have better blood sugar control than women, especially in older age groups. Women tend to have higher HbA1c levels due to lower hemoglobin levels, which could explain the difference.
Researchers found that alefacept preserved the body's ability to produce its own insulin, with fewer episodes of hypoglycemia, while selectively targeting disease-causing T cells. The study suggests a potential new strategy for treating type 1 diabetes by restoring balance between immune cells.
A phase II study found that alefacept treatment significantly reduced insulin use and hypoglycemic events in newly diagnosed type 1 diabetics. The therapy targeted memory T-cells, preserving regulatory T-cells.
The new procedure, known as the CIT07 protocol, resulted in significantly improved islet cell function and enabled patients to discontinue daily insulin injections. The approach reduced inflammation and allowed for more efficient use of fewer islet cells.
Researchers discover STING's critical role in treating autoimmune diseases by evoking expression of enzyme IDO, which blocks immune attack on healthy body constituents. Mice with STING deficiency had no response to DNA nanoparticles, highlighting the protein's essential role in recognizing the molecule that senses DNA.
A phase II study tested thymoglobulin, an antithymocyte globulin treatment, in new-onset type 1 diabetic patients. While most younger patients showed decline in beta cell function, older patients experienced little change. The study did not meet its primary endpoint and may have identified biomarkers for safety and efficacy.
A recent study found that glucagon, a hormone involved in regulating appetite, fails to induce feelings of fullness in obese individuals. However, it successfully suppresses hunger pangs in people with type 1 diabetes, according to researchers from The Endocrine Society.
A recent clinical trial found that patients with new-onset type 1 diabetes treated with teplizumab exhibit greater preservation of C-peptide, a biomarker of islet cell function. Further analysis identified a discrete subset of treatment responders who demonstrated especially robust responses.
Four research projects, including insulin gene therapy and a revolutionary sensor platform, will receive funding from the Minnesota Partnership for Biotechnology and Medical Genomics to develop new therapies for diabetes management and prevention. The selected researchers were awarded $2 million in total.
Researchers found that adding foods rich in amino and fatty acids, such as leucine and omega-3 fatty acids, may help youth with Type 1 diabetes produce some of their own insulin for up to two years after diagnosis. This approach could benefit the lives of these children by reducing the risk of diabetes complications.
Researchers found that introducing solid foods before 4 months increases Type 1 diabetes risk, while breast-feeding reduces it. The study suggests parents wait until after 4 months and introduce solid foods by 6 months or soon after with breastfeeding to lower the risk.
A study published in JAMA Pediatrics found both early and late first exposure to solid food is associated with an increased risk of developing Type 1 diabetes. Early introduction to fruit and late introduction to rice/oat were linked to higher risk, while breastfeeding during wheat/barley introduction may decrease the risk.
A new study published in JAMA Pediatrics suggests that early childhood respiratory infections may be a potential risk factor for developing type 1 diabetes mellitus. The research found associations between respiratory infections during the first six months of life and later development of persistent islet autoimmunity.
Researchers at UC Irvine are working on two groundbreaking projects to treat Type 1 diabetes: islet cell transplantation using ultrapure algae membranes and the development of an accurate insulin sensor for real-time blood sugar monitoring. These innovations aim to improve treatment options and potentially cure the disease.
A decade-long study reveals that nearly 70% of children with multiple islet autoantibodies developed T1D within 10 years, highlighting the importance of pre-diabetes research. The study also found that progression of the disease was faster for those who showed the presence of antibodies at younger than three years old.
A study found that multiple islet autoantibodies predict a high rate of progression to type 1 diabetes, particularly among younger children and females. The researchers analyzed data from three cohort studies involving over 3,000 genetically at-risk children.
The TEDDY study has identified a unique perspective on which molecular and environmental factors contribute to type 1 diabetes. By parsing genetic mutations, scientists can better predict disease progression and identify potential protective factors.
Researchers are testing whether a drug called aldesleukin can reduce the number of insulin injections needed for type 1 diabetes patients. The trial aims to slow disease progression and give patients more control over their condition.
Researchers at the University of Missouri School of Medicine have discovered a potential cure for Type 1 diabetes by combining adult stem cells with a new drug. The discovery reveals that blood vessels are essential for insulin production and repairing them can help restore insulin-making cells.
Researchers have identified an immune protein called CD52 that can suppress the immune response and prevent or reverse type 1 diabetes. This discovery has wider implications for treating autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.
Researchers developed a biomaterial that successfully engrafted insulin-producing cells into diabetic mice, reversing symptoms in just 10 days. The material promotes blood vessel formation and allows cells to survive and function within the body.
A new study links type 1 diabetes to an increased risk of heart disease through the production of the inflammatory protein calprotectin, which fuels the buildup of artery-clogging plaque.
A major international TEDDY study found no evidence of a causal link between early viral infections and the rapid onset of Type 1 diabetes in young children. Despite analysis of over 8,000 children and blood samples, researchers discovered little association between viral infections and disease progression.
A study by University of Montreal researchers found a negative correlation between household income and glycated hemoglobin levels in children with type 1 diabetes. The difference in glycated hemoglobin levels corresponds to a doubling of the risk of eye damage, highlighting the need for greater support for low-income families
A new study by Joslin researchers found that dietary fat can impact glucose levels and insulin dosing for people with type 1 diabetes. The study's findings have significant implications for managing the condition, highlighting the need to consider both carbohydrates and fats in insulin calculations.
Youth with type 1 diabetes face increased risk of heart attacks, strokes, blindness, and kidney failure after transitioning to adult care without adequate support. The study found that nearly 80% of individuals had left pediatric care by age 21, highlighting the importance of effective transition planning.
Young people with Type 1 diabetes who transitioned from pediatric to adult care are 2.5 times more likely to have chronically high blood glucose levels, increasing the risk of heart attacks, strokes, and kidney failure. The estimated median age of patients when this transition occurred was 20.1 years.
A recent study published in Cell Metabolism reveals that a single mutation in the SIRT1 gene can cause type 1 diabetes in humans. The researchers identified a previously undocumented mutation that led to an amino acid substitution in the SIRT1 protein, resulting in high levels of blood sugar.
A study published in Cell Metabolism identified a single gene mutation in SIRT1 as a potential cause of type 1 diabetes. The research found that the mutated gene led to impaired beta cell function and increased susceptibility to diabetes.
The Benaroya Research Institute has established a T1D Exchange Biobank Operations Center with a $4.4 million grant from The Leona M. and Harry B. Helmsley Charitable Trust. This center will coordinate clinical study proposals and sample requests, facilitating research with thousands of participants.
Researchers found that white, non-Hispanic young adults with higher serum levels of vitamin D had about half the risk of developing Type 1 diabetes than those with lower levels. The study suggests that inadequate vitamin D intake may be an important risk factor for autoimmune diseases.
Researchers found a significant decrease in carotid intima-media thickness one year after islet transplant, indicating slower atherosclerosis progression. Patients achieved insulin independence and showed improved glycemic control.
The incidence of type 1 diabetes in Philadelphia children has increased by 29 percent over the past two decades, with black children ages 0-4 years at highest risk. The rapidly rising risk requires immediate attention due to often-delayed diagnosis and high mortality rates.
Researchers discovered that innate immune cells, particularly dendritic cells, trigger the activation of killer T-lymphocytes targeting pancreatic cells. The study sheds light on new ways to regulate the auto-immune reaction and offers potential therapeutic approaches for preventing Type 1 diabetes.
Researchers have identified a genetic variant associated with an increased risk of autoimmune diseases like type 1 diabetes. In a mouse model study, turning off the PTPN22 gene reduced the risk of autoimmune diabetes and increased regulatory T cells.
Drs. Christophe Benoist and Diane Mathis were awarded the 2012 Naomi Berrie Award for their contributions to understanding type 1 diabetes. They elucidated key immunological mechanisms, including T-cell priming and central tolerance, which may lead to prevention or reversal of the disease through immunization.