Researchers discover STING's critical role in treating autoimmune diseases by evoking expression of enzyme IDO, which blocks immune attack on healthy body constituents. Mice with STING deficiency had no response to DNA nanoparticles, highlighting the protein's essential role in recognizing the molecule that senses DNA.
SourceMedical College of Georgia at Augusta University·JournalThe Journal of Immunology·DateSep 9, 2013
A phase II study tested thymoglobulin, an antithymocyte globulin treatment, in new-onset type 1 diabetic patients. While most younger patients showed decline in beta cell function, older patients experienced little change. The study did not meet its primary endpoint and may have identified biomarkers for safety and efficacy.
SourceBenaroya Research Institute at Virginia Mason·JournalThe Lancet Diabetes & Endocrinology·DateAug 27, 2013
A recent study found that glucagon, a hormone involved in regulating appetite, fails to induce feelings of fullness in obese individuals. However, it successfully suppresses hunger pangs in people with type 1 diabetes, according to researchers from The Endocrine Society.
SourceThe Endocrine Society·JournalThe Journal of Clinical Endocrinology & Metabolism·DateAug 20, 2013
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Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
A recent clinical trial found that patients with new-onset type 1 diabetes treated with teplizumab exhibit greater preservation of C-peptide, a biomarker of islet cell function. Further analysis identified a discrete subset of treatment responders who demonstrated especially robust responses.
SourceBenaroya Research Institute at Virginia Mason·JournalDiabetes·DateAug 15, 2013
Four research projects, including insulin gene therapy and a revolutionary sensor platform, will receive funding from the Minnesota Partnership for Biotechnology and Medical Genomics to develop new therapies for diabetes management and prevention. The selected researchers were awarded $2 million in total.
Researchers found that adding foods rich in amino and fatty acids, such as leucine and omega-3 fatty acids, may help youth with Type 1 diabetes produce some of their own insulin for up to two years after diagnosis. This approach could benefit the lives of these children by reducing the risk of diabetes complications.
SourceUniversity of North Carolina at Chapel Hill·JournalDiabetes Care·DateJul 16, 2013
Researchers found that introducing solid foods before 4 months increases Type 1 diabetes risk, while breast-feeding reduces it. The study suggests parents wait until after 4 months and introduce solid foods by 6 months or soon after with breastfeeding to lower the risk.
SourceUniversity of Colorado Anschutz Medical Campus·JournalJAMA Pediatrics·DateJul 9, 2013
A study published in JAMA Pediatrics found both early and late first exposure to solid food is associated with an increased risk of developing Type 1 diabetes. Early introduction to fruit and late introduction to rice/oat were linked to higher risk, while breastfeeding during wheat/barley introduction may decrease the risk.
SourceJAMA Network·JournalJAMA Pediatrics·DateJul 8, 2013
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A new study published in JAMA Pediatrics suggests that early childhood respiratory infections may be a potential risk factor for developing type 1 diabetes mellitus. The research found associations between respiratory infections during the first six months of life and later development of persistent islet autoimmunity.
SourceJAMA Network·JournalJAMA Pediatrics·DateJul 1, 2013
Researchers at UC Irvine are working on two groundbreaking projects to treat Type 1 diabetes: islet cell transplantation using ultrapure algae membranes and the development of an accurate insulin sensor for real-time blood sugar monitoring. These innovations aim to improve treatment options and potentially cure the disease.
A decade-long study reveals that nearly 70% of children with multiple islet autoantibodies developed T1D within 10 years, highlighting the importance of pre-diabetes research. The study also found that progression of the disease was faster for those who showed the presence of antibodies at younger than three years old.
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A study found that multiple islet autoantibodies predict a high rate of progression to type 1 diabetes, particularly among younger children and females. The researchers analyzed data from three cohort studies involving over 3,000 genetically at-risk children.
The TEDDY study has identified a unique perspective on which molecular and environmental factors contribute to type 1 diabetes. By parsing genetic mutations, scientists can better predict disease progression and identify potential protective factors.
SourceMedical College of Georgia at Augusta University·DateJun 12, 2013
Researchers are testing whether a drug called aldesleukin can reduce the number of insulin injections needed for type 1 diabetes patients. The trial aims to slow disease progression and give patients more control over their condition.
Researchers at the University of Missouri School of Medicine have discovered a potential cure for Type 1 diabetes by combining adult stem cells with a new drug. The discovery reveals that blood vessels are essential for insulin production and repairing them can help restore insulin-making cells.
SourceUniversity of Missouri School of Medicine·JournalDiabetes·DateMay 29, 2013
Researchers have identified an immune protein called CD52 that can suppress the immune response and prevent or reverse type 1 diabetes. This discovery has wider implications for treating autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.
SourceWalter and Eliza Hall Institute·JournalNature Immunology·DateMay 19, 2013
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SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers developed a biomaterial that successfully engrafted insulin-producing cells into diabetic mice, reversing symptoms in just 10 days. The material promotes blood vessel formation and allows cells to survive and function within the body.
SourceGeorgia Institute of Technology·JournalBiomaterials·DateMay 9, 2013
A new study links type 1 diabetes to an increased risk of heart disease through the production of the inflammatory protein calprotectin, which fuels the buildup of artery-clogging plaque.
SourceColumbia University Irving Medical Center·JournalCell Metabolism·DateMay 7, 2013
A major international TEDDY study found no evidence of a causal link between early viral infections and the rapid onset of Type 1 diabetes in young children. Despite analysis of over 8,000 children and blood samples, researchers discovered little association between viral infections and disease progression.
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A study by University of Montreal researchers found a negative correlation between household income and glycated hemoglobin levels in children with type 1 diabetes. The difference in glycated hemoglobin levels corresponds to a doubling of the risk of eye damage, highlighting the need for greater support for low-income families
SourceUniversity of Montreal·JournalThe Journal of Clinical Endocrinology & Metabolism·DateApr 4, 2013
A new study by Joslin researchers found that dietary fat can impact glucose levels and insulin dosing for people with type 1 diabetes. The study's findings have significant implications for managing the condition, highlighting the need to consider both carbohydrates and fats in insulin calculations.
SourceJoslin Diabetes Center·JournalDiabetes Care·DateMar 27, 2013
Youth with type 1 diabetes face increased risk of heart attacks, strokes, blindness, and kidney failure after transitioning to adult care without adequate support. The study found that nearly 80% of individuals had left pediatric care by age 21, highlighting the importance of effective transition planning.
SourceUniversity of Colorado Anschutz Medical Campus·JournalPEDIATRICS·DateMar 26, 2013
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Young people with Type 1 diabetes who transitioned from pediatric to adult care are 2.5 times more likely to have chronically high blood glucose levels, increasing the risk of heart attacks, strokes, and kidney failure. The estimated median age of patients when this transition occurred was 20.1 years.
SourceUniversity of California - Los Angeles Health Sciences·JournalPEDIATRICS·DateMar 25, 2013
A recent study published in Cell Metabolism reveals that a single mutation in the SIRT1 gene can cause type 1 diabetes in humans. The researchers identified a previously undocumented mutation that led to an amino acid substitution in the SIRT1 protein, resulting in high levels of blood sugar.
SourceCell Press·JournalCell Metabolism·DateMar 5, 2013
A study published in Cell Metabolism identified a single gene mutation in SIRT1 as a potential cause of type 1 diabetes. The research found that the mutated gene led to impaired beta cell function and increased susceptibility to diabetes.
The Benaroya Research Institute has established a T1D Exchange Biobank Operations Center with a $4.4 million grant from The Leona M. and Harry B. Helmsley Charitable Trust. This center will coordinate clinical study proposals and sample requests, facilitating research with thousands of participants.
SourceBenaroya Research Institute at Virginia Mason·DateFeb 14, 2013
Researchers found that white, non-Hispanic young adults with higher serum levels of vitamin D had about half the risk of developing Type 1 diabetes than those with lower levels. The study suggests that inadequate vitamin D intake may be an important risk factor for autoimmune diseases.
SourceHarvard T.H. Chan School of Public Health·JournalAmerican Journal of Epidemiology·DateFeb 4, 2013
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Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
Researchers found a significant decrease in carotid intima-media thickness one year after islet transplant, indicating slower atherosclerosis progression. Patients achieved insulin independence and showed improved glycemic control.
SourceUniversity of Illinois Chicago·JournalDiabetes Care·DateJan 28, 2013
The incidence of type 1 diabetes in Philadelphia children has increased by 29 percent over the past two decades, with black children ages 0-4 years at highest risk. The rapidly rising risk requires immediate attention due to often-delayed diagnosis and high mortality rates.
SourceUniversity of Pennsylvania School of Nursing·JournalDiabetes Care·DateJan 23, 2013
Researchers discovered that innate immune cells, particularly dendritic cells, trigger the activation of killer T-lymphocytes targeting pancreatic cells. The study sheds light on new ways to regulate the auto-immune reaction and offers potential therapeutic approaches for preventing Type 1 diabetes.
SourceINSERM (Institut national de la santé et de la recherche médicale)·JournalNature Medicine·DateDec 19, 2012
Researchers have identified a genetic variant associated with an increased risk of autoimmune diseases like type 1 diabetes. In a mouse model study, turning off the PTPN22 gene reduced the risk of autoimmune diabetes and increased regulatory T cells.
SourceJoslin Diabetes Center·JournalDiabetes·DateNov 28, 2012
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Drs. Christophe Benoist and Diane Mathis were awarded the 2012 Naomi Berrie Award for their contributions to understanding type 1 diabetes. They elucidated key immunological mechanisms, including T-cell priming and central tolerance, which may lead to prevention or reversal of the disease through immunization.
SourceColumbia University Irving Medical Center·DateNov 19, 2012
A six-year study found a correlation between vitamin D3 serum levels and subsequent incidence of Type 1 diabetes, suggesting a preventive role for vitamin D3 in this disease. Researchers estimate that achieving an optimal serum level of 25(OH)D at 50 ng/ml can lower the risk of developing type 1 diabetes by half.
SourceUniversity of California - San Diego·JournalDiabetologia·DateNov 15, 2012
Scientists have identified stem cells in the adult pancreas that can be turned into insulin-producing cells, offering a potential cure for type 1 diabetes. This breakthrough discovery provides further evidence of the existence of stem cells beyond embryos and may lead to new treatments for the condition.
SourceWalter and Eliza Hall Institute·JournalPLOS ONE·DateNov 14, 2012
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Researchers from Benaroya Research Institute, Seattle Children's Research Institute, and University of Virginia are joining forces to study the genetic causes of Type 1 diabetes. The study aims to identify immunologic pathways involved in the disease, which can be targeted for diagnosis and therapy.
SourceBenaroya Research Institute at Virginia Mason·DateOct 18, 2012
Researchers at Thomas Jefferson University found that normalizing the population of protective T regulatory cells in the pancreatic lymph nodes can regenerate insulin-producing beta cells and normalize blood sugar levels in diabetic mice. The study suggests a new approach to confront local autoimmune reactions in type 1 diabetes.
SourceThomas Jefferson University·JournalCellular and Molecular Immunology·DateOct 9, 2012
A Scottish study found people with type 1 diabetes have a higher risk of heart attacks, strokes, and premature death compared to the general population. The researchers also discovered that women are more at risk than men, with higher rates of cardiovascular events and deaths from any cause.
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A new study suggests that oral insulin may prevent or delay the onset of type 1 diabetes among individuals with autoantibodies against insulin. The study found that participants who took oral insulin had a delayed development of type 1 diabetes compared to those who took placebo capsules. The delaying effect was attributed to the immun...
Researchers aim to develop a biologic cure for diabetes by addressing immunosuppression, poor islet viability, and implantation issues. The new funding will support the development of bioactive scaffolds and conformal coatings to protect implanted cells from the immune response.
A phase I clinical trial confirms that a generic vaccine can kill autoimmune cells targeting insulin-secreting cells, temporarily restoring insulin production in patients with type 1 diabetes. The treatment pathway has been validated in humans and shows early evidence of effectiveness.
SourceMassachusetts General Hospital·JournalPLOS ONE·DateAug 8, 2012
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Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
The American College of Physicians developed a free curriculum to train internal medicine residents in identifying and eliminating wasteful treatment options. The high-value, cost-conscious care curriculum focuses on patient cases requiring careful analysis of benefits, harms, costs, and evidence-based decision making.
SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·DateJul 9, 2012
Researchers found that continuous glucose monitoring devices and insulin pumps improve blood sugar levels and reduce time spent with high levels in patients with type 1 diabetes. These new technologies offer a more convenient alternative to traditional methods, but adherence is key to effectiveness.
SourceJohns Hopkins Medicine·JournalAnnals of Internal Medicine·DateJul 9, 2012
Researchers at UNC School of Medicine used injections of non-depleting antibodies to rapidly reverse the onset of Type I diabetes in mice. The treatment maintained disease remission indefinitely without harming the immune system, with some animals remaining free of diabetes after over 400 days.
SourceUniversity of North Carolina Health Care·JournalDiabetes·DateJul 5, 2012
A new study found that adding liraglutide to insulin therapy improves blood sugar control in obese adults with poorly controlled Type 1 diabetes. Patients also experienced significant weight loss and lower blood pressure.
Scientists at Joslin Diabetes Center have identified a new cause of cardiac damage after heart attacks in people with type 1 diabetes. A runaway autoimmune response triggered by alpha-myosin leads to chronic inflammation, cardiomyopathy, and heart failure. The study offers promising targets for future interventions to protect the heart.
SourceJoslin Diabetes Center·JournalScience Translational Medicine·DateJun 13, 2012
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A study by Joslin Diabetes Center found that a significant number of people with long-term type 1 diabetes developed little to no diabetic eye disease over time. The researchers hope to identify the factors behind this protection, which could lead to new treatments or prevention strategies.
The Hypoglycemia-Hyperglycemia Minimizer (HHM) System successfully detects blood glucose highs and lows, automatically adjusting insulin delivery to safely manage type 1 diabetes. The study's findings lay the groundwork for further clinical trials and a potential game-changer for millions living with the condition.
Scientists at the Toronto General Hospital Research Institute showed that an experimental bariatric surgery can lower blood sugar levels in non-obese rats with type 1 diabetes. The study demonstrated that duodenal-jejunal bypass surgery activates novel nutrient-sensing signals in the jejunum, rapidly lowering blood sugar levels.
SourceUniversity Health Network·JournalNature Medicine·DateMay 20, 2012
A clinical study demonstrates the effectiveness of an automated insulin dosage titration system in improving blood glucose control and reducing hypoglycemic events. The system, developed by Hygieia, Inc., automatically updates insulin dosage for patients with type 2 or type 1 diabetes, leading to improved glycemic targets.
SourceKureczka/Martin Associates·JournalDiabetes Technology & Therapeutics·DateMay 9, 2012
Researchers have identified significant differences in how diabetes affects Asian populations, including unique markers for type 1 diabetes diagnosis. The study highlights the need for culturally sensitive care, tailored treatment guidelines, and expanded education programs.
SourceJoslin Diabetes Center·JournalDiabetes Care·DateMay 8, 2012
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CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
The iDEAL study is a Phase II clinical trial evaluating the safety and efficacy of iCo-007 in treating diabetic macular edema. The trial aims to improve visual acuity in patients with DME, a leading cause of blindness in working Americans.
Scientists discover that cellular stress takes place in pancreatic beta cells before T1D onset, potentially igniting autoimmune attack. ER stress response may contribute to beta cell dysfunction and death, shedding light on disease progression and potential therapeutic targets.
Researchers have developed a personalized immune mouse that can recreate an individual's immune system, allowing for unprecedented analysis of abnormalities contributing to type 1 diabetes and other autoimmune diseases. This model has the potential to develop individualized immunotherapies against cancer and infection.
SourceColumbia University Irving Medical Center·JournalScience Translational Medicine·DateMar 14, 2012
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
A new JDRF-funded study identifies genes expressed in beta cells, suggesting a role in their own destruction leading to T1D. The research may help explain why the immune system specifically attacks beta cells, opening up new avenues for understanding and treating the disease.
A study from Massachusetts General Hospital found that C-peptide production persists for decades after Type 1 diabetes onset, and beta cell functioning remains intact at low levels. The novel ultrasensitive assay detected C-peptide in 34 of 54 blood samples, suggesting a longer window for therapeutic intervention.
SourceMassachusetts General Hospital·JournalDiabetes Care·DateFeb 21, 2012
Scientists studied children with newly diagnosed type 1 diabetes to understand its initial stages. They found variability in T-regulatory cell activity and increased immune-boosting cells, which may help develop new treatments.
SourceUniversity of Rochester Medical Center·JournalDiabetes·DateFeb 16, 2012
A study found that automatic suspension of insulin delivery via insulin pumps reduces the severity and duration of hypoglycemia in individuals with type 1 diabetes. The 'low glucose suspend' feature significantly decreases hypoglycemic episodes, reducing the risk of rebound hyperglycemia.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalDiabetes Technology & Therapeutics·DateFeb 9, 2012
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A recent study suggests that seasonal variations in the immune system may impact the effectiveness of a vaccine targeting type 1 diabetes. The vaccine, which uses the GAD65 antigen, showed promise in earlier trials but failed to demonstrate significant effects in its latest phase 3 trial. The study's authors propose that factors such a...
SourceLinköping University·JournalNew England Journal of Medicine·DateFeb 1, 2012
Scientists at Joslin Diabetes Center identified two novel markers that can predict renal failure in patients with Type 1 and Type 2 diabetes, ten years in advance. High concentrations of TNFR1 and TNFR2 accurately predict the risk of renal function loss.
SourceJoslin Diabetes Center·JournalJournal of the American Society of Nephrology·DateJan 19, 2012
Researchers at Cardiff University have discovered a link between killer T-cells and the development of Type 1 diabetes. The study found that killer T-cells can attack and destroy insulin-producing cells in the pancreas, leading to a lack of insulin and high blood sugar.
SourceCardiff University·JournalNature Immunology·DateJan 15, 2012