A new study published by researchers at Eastern Virginia Medical School has identified a protein-based enzyme called 12-Lipoxygenase (12-LO) as a key player in the development of Type 1 diabetes. The enzyme produces specific lipids that cause inflammation and lead to beta cell death, highlighting a potential target for new therapies.
SourceEastern Virginia Medical School·JournalThe Journal of Clinical Endocrinology & Metabolism·DateFeb 4, 2010
Researchers at the Salk Institute for Biological Studies have made a breakthrough in understanding how stress hormones affect insulin-producing cells. The study found that the hormone CRF can increase the rate of cell growth and proliferation, which could potentially lead to new approaches for treating type 1 diabetes.
SourceJDRF·JournalProceedings of the National Academy of Sciences·DateFeb 3, 2010
Research finds that African-American patients with type 1 diabetes who consume more calories and sodium are more likely to develop vision-threatening retinopathy. Low caloric and sodium intakes may have a beneficial effect on the progression of diabetic retinopathy in this population.
SourceJAMA Network·JournalArchives of Ophthalmology·DateJan 11, 2010
Researchers found that injections of rituximab slowed beta cell destruction in patients with newly diagnosed type 1 diabetes, suggesting a potential treatment option. The study suggests targeting B cells may improve beta-cell function in early type 1 diabetes.
SourceUT Southwestern Medical Center·JournalNew England Journal of Medicine·DateDec 4, 2009
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SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A study found that insulin resistance in adolescents with type 1 diabetes affects heart and vessel function, as well as exercise capacity. The research suggests that addressing insulin resistance early on may help decrease cardiovascular morbidity and mortality in this population.
SourceThe Endocrine Society·JournalThe Journal of Clinical Endocrinology & Metabolism·DateDec 1, 2009
A Swedish study found that pregnant women who eat vegetables daily have a lower risk of their child developing type 1 diabetes. The study analyzed data from almost 6,000 five-year-olds and found that those whose mothers rarely ate vegetables had a higher risk.
SourceUniversity of Gothenburg·JournalPediatric Diabetes·DateOct 27, 2009
A new gene data tool has achieved greater accuracy than conventional methods in assessing individual risk for type 1 diabetes. By analyzing a large set of gene markers, the tool identifies a large ensemble of genes that interact together to predict disease risk.
SourceChildren's Hospital of Philadelphia·JournalPLOS Genetics·DateOct 8, 2009
Researchers discovered that T cells recognize a specific marker on insulin-producing cells to gain access to the islets, triggering inflammation and destruction. The findings suggest new approaches to halt or prevent type I diabetes by blocking T cell entry into the islets.
SourceSt. Jude Children's Research Hospital·JournalImmunity·DateOct 8, 2009
Research highlights improved vision in type 1 diabetes patients, a link between macular degeneration and coronary heart disease, and the impact of vision on well-being across the lifespan. Effective treatments and better management of blood glucose levels contribute to the positive trend.
SourceAmerican Academy of Ophthalmology·JournalOphthalmology·DateOct 1, 2009
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Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
A recent study found inhaled insulin to be inferior to traditional insulin injections in maintaining optimal blood glucose levels. Despite this setback, researchers continue to explore alternative routes of insulin delivery, including MannKind Corporation's Technosphere Insulin.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalDiabetes Technology & Therapeutics·DateSep 23, 2009
The study found that regular CGM use is the primary factor in achieving better diabetes control, regardless of age. People using CGM devices six days per week or more showed similar levels of improvement in diabetes control across all age groups, from children to adults.
Scientists at Eastern Virginia Medical School have identified a vital step in the development of Type 1 diabetes and hope to develop a novel therapeutic approach by blocking an enzyme called 12-LO. Preliminary results are promising, and further research is underway.
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Scientists have discovered a potential clue to type 1 diabetes causes, finding that nearly half of patients have an abnormal immune response to wheat proteins. The over-reaction is linked to genes associated with the disease and may contribute to other immune problems.
Scientists at Stanford University have identified a gene variant that may play a role in the development of type 1 diabetes. The study found that cells in the pancreatic lymph nodes produce two forms of the Deaf1 gene, one functional and one nonfunctional. Increased levels of the nonfunctional variant were found in people with type 1 d...
SourceNIH/National Institute of Allergy and Infectious Diseases·JournalNature Immunology·DateAug 10, 2009
Scientists have discovered a way to regenerate insulin-producing beta cells from non-insulin-producing alpha cells, offering new hope for treating type 1 diabetes. The research found that modifying the expression of a specific gene in alpha cells can drive their conversion into functional beta cells.
A study published in the Archives of Internal Medicine found that intensive glucose control halves the rate of eye and kidney damage in people with longstanding type 1 diabetes. The study also showed lower rates of cardiovascular disease events and improved vision loss rates compared to conventional control.
SourceNIH/National Institute of Diabetes and Digestive and Kidney Diseases·JournalArchives of Internal Medicine·DateJul 27, 2009
Researchers analyzed data from studies on type 1 diabetes to find that intensive treatment can significantly reduce the risk of complications. The study showed improved outcomes in patients treated with more intensive therapy.
SourceJAMA Network·JournalArchives of Internal Medicine·DateJul 27, 2009
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A treatment that significantly slows the progression of eye injury in people with type 1 diabetes has been found. The treatment uses an antihypertensive medication commonly prescribed to treat high blood pressure, and was shown to slow diabetic eye damage in over 65% of participants.
SourceUniversity of Minnesota·JournalNew England Journal of Medicine·DateJul 1, 2009
A recent major study has found that children and young people with type 1 diabetes are more likely to be overweight or obese than those without diabetes. The research, which compared data from over 11,000 children and youths, also highlights significant differences in weight problems among different racial and ethnic groups.
Researchers found that a combination of insulin and vitamin C stopped blood vessel damage caused by Type 1 diabetes in patients with poor glucose control. The therapy's effectiveness was proven in humans for the first time, offering hope for diabetic patients to avoid complications.
SourceUniversity of Oklahoma·JournalThe Journal of Clinical Endocrinology & Metabolism·DateJun 8, 2009
A study found that continuous glucose monitoring (CGM) devices enable people with excellent blood sugar control to continue managing their diabetes while reducing the frequency of low blood sugar events. CGM devices helped participants spend more time in the target blood sugar range and reduced biochemical hypoglycemia.
According to a new study, type 1 diabetes cases in children under five years are expected to double by 2020 if current trends continue. The researchers found an overall increase of 3.9% per year, with the highest rates seen in children under 5 and those between 10-14 years old.
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Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers have identified the protein ILK as promoting growth of aggressive rhabdomyosarcoma cells and suppressing ERMS cell growth. A therapy targeting ILK may provide a tailored approach for treating the lethal form of RMS, ARMS.
SourceJCI Journals·JournalJournal of Clinical Investigation·DateMay 26, 2009
A study published in The Journal of Pediatrics found that telemedicine improves diabetes care for school children with better blood sugar control and reduced hospital visits. School nurses who used the program reported improved patient outcomes, including increased patient satisfaction and completed tasks related to their diabetes care.
SourceElsevier Health Sciences·JournalThe Journal of Pediatrics·DateMay 21, 2009
A study of nearly 6,900 patients found that simultaneous pancreas-kidney (SPK) transplantation resulted in a 89% long-term survival rate compared to 80% for kidney-only transplants and 65% for deceased donor transplants. SPK recipients were also more likely to die during the first year after transplantation.
SourceAmerican Society of Nephrology·JournalClinical Journal of the American Society of Nephrology·DateApr 30, 2009
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Researchers found that blocking a hormone called BAFF can prevent the development of Type 1 diabetes in mice. By depleting B cells, regulators of the immune system rise, allowing T regulatory cells to function properly and making killer T cells tolerant of insulin-producing cells.
A study found that stem cell transplantation significantly increased C-peptide levels and improved glycemic control in patients with type 1 diabetes, leading to prolonged insulin independence. The treatment has the potential to reverse type 1 DM in humans, but further studies are needed to confirm its role.
A new study found that over 60% of pancreases from children with type 1 diabetes showed evidence of enteroviral infection, suggesting a potential link between viruses and the disease. The research suggests that enteroviral infection may trigger an immune response that destroys beta cells in the pancreas.
SourceThe Peninsula College of Medicine and Dentistry·JournalDiabetologia·DateMar 5, 2009
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Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Scientists from the University of Cambridge discovered four rare genetic mutations that reduce the risk of developing type 1 diabetes, a link between T1D and enterovirus infections established. The IFIH1 gene variants were found to protect against T1D by reducing immune activation caused by enterovirus infections.
SourceUniversity of Cambridge·JournalScience·DateMar 5, 2009
The SEARCH for diabetes in youth study found alarmingly high rates of diabetes among every racial and ethnic group. Type 1 diabetes is more common than previously reported in Hispanic and African-American youth, while type 2 diabetes is more prevalent in Asian/Pacific Islanders.
SourceAtrium Health Wake Forest Baptist·JournalDiabetes Care·DateFeb 27, 2009
The Environmental Determinants of Diabetes in the Young (TEDDY) study is expanding to enroll 200 newborns from Georgia and Florida with high-risk genes for type 1 diabetes. Researchers will monitor participants for 15 years, collecting data on genetic and environmental factors that contribute to the disease.
SourceMedical College of Georgia at Augusta University·DateFeb 25, 2009
JDRF-funded researchers have identified compounds that can stimulate insulin-producing cells in the pancreas, paving the way for potential regenerative medicines for type 1 diabetes. The study found two compounds that promote beta cell replication via different biological pathways.
SourceJDRF·JournalProceedings of the National Academy of Sciences·DateFeb 25, 2009
Dr. Wenbo Zhi, a postdoctoral fellow at the Medical College of Georgia, has received a two-year fellowship to study biomarkers associated with type 1 diabetes. He aims to identify protein biomarkers that can improve diagnosis and treatment using proteomic techniques.
SourceMedical College of Georgia at Augusta University·DateFeb 10, 2009
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Researchers aim to teach the immune system to ignore insulin-producing cells by boosting IDO levels. By enhancing this natural mechanism, they hope to slow or prevent disease progression in high-risk children. A new treatment approach could provide a breakthrough in preventing type 1 diabetes.
SourceMedical College of Georgia at Augusta University·JournalThe Journal of Immunology·DateFeb 4, 2009
Researchers describe a potential new therapeutic approach for diabetic retinopathy using ASP-440, a protease plasma kallikrein inhibitor. The study showed significant reductions in retinal vascular permeability and blood pressure in rodents, suggesting promising results for treating the condition.
JDRF-funded researchers at the University of Pittsburgh School of Medicine discovered a protein called cdk6 that regulates human beta cell replication. This finding provides proof-of-principle for stimulating human beta cell production and function.
A new study published in Value in Health estimates that Americans with diabetes had nearly 22% of hospital charges in 2005, totaling $171 billion. The study also found that individuals with type 1 diabetes were more likely to be hospitalized than those with type 2 diabetes.
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Researchers at Albert Einstein College of Medicine developed a technique to make foreign pancreatic cells invisible to the immune system, dramatically protecting them from rejection. The new method could pave the way for routine use of cell transplants as a therapy for type 1 diabetes in humans.
SourceAlbert Einstein College of Medicine·JournalGene Therapy·DateDec 31, 2008
A study from the Norwegian Institute of Public Health found no significant link between human parechovirus infections and typical symptoms in infants. However, researchers noticed an increase in parechovirus infection between 6-18 months, which could be due to factors such as maternal antibody loss or nursery exposure.
SourceNorwegian Institute of Public Health·JournalJournal of Medical Virology·DateDec 18, 2008
A study by researchers at Joslin Diabetes Center found that nearly three-quarters of youths with type 1 diabetes have insufficient levels of vitamin D, which may lead to bone fragility and increased fracture risk. The study recommends vitamin D supplementation to children with diabetes, especially those with inadequate sun exposure and...
SourceJoslin Diabetes Center·JournalThe Journal of Pediatrics·DateDec 15, 2008
Type 1 diabetes and celiac disease share common genetic mechanisms, including autoimmunity-related tissue damage and intolerance to dietary antigens, the study found. Researchers identified seven chromosome regions shared between the two diseases, suggesting a potential link in environmental triggers as well.
SourceUniversity of Cambridge·JournalNew England Journal of Medicine·DateDec 10, 2008
A recent study published in Diabetes Care highlights the significant barriers faced by type 1 diabetics when it comes to engaging in physical activity. The researchers found that those with a greater fear of hypoglycemia were also more likely to have poorer diabetes control, emphasizing the need for targeted education and support.
SourceUniversity of Montreal·JournalDiabetes Care·DateNov 26, 2008
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Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers at UCSF used kinase inhibitors to block and reverse type 1 diabetes in mice, showing potential for new therapeutic approach. The study found that 80% of mice with established diabetes reversed symptoms after two months of treatment.
SourceJDRF·JournalProceedings of the National Academy of Sciences·DateNov 18, 2008
Researchers found that cancer drugs imatinib and sunitinib can put type 1 diabetes into remission in 80% of test mice. The benefits of the drugs' rapid action are attributed to their ability to block platelet-derived growth factor receptor, a tyrosine kinase not known to be implicated in diabetes.
SourceUniversity of California - San Francisco·JournalProceedings of the National Academy of Sciences·DateNov 17, 2008
A population-based study of Type 1 diabetes patients found that better glycemic control reduces diabetic retinopathy progression. Additionally, a cohort study on age-related macular degeneration (AMD) discovered an association between poor night vision and increased risk of AMD progression.
SourceAmerican Academy of Ophthalmology·JournalOphthalmology·DateNov 3, 2008
A DNA vaccine, BHT-3021, is being developed to reverse the immune response causing type 1 diabetes. The vaccine has shown safety and preliminary data indicate it may preserve beta cells and induce immune tolerance.
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Researchers found that green tea's EGCG reduced salivary gland damage and delayed insulin-dependent type 1 diabetes in a laboratory mouse. The study also showed that EGCG suppressed abnormal gene expression and lowered serum autoantibodies, reducing Sjogren's syndrome-like symptoms.
SourceMedical College of Georgia at Augusta University·JournalLife Sciences·DateOct 23, 2008
SmartCells' SmartInsulin is a once-a-day, glucose-regulated insulin that maintains continuous blood glucose control while reducing hypoglycemia risk. JDRF's $1M funding supports preclinical safety and efficacy testing for this treatment, aiming to improve patient safety and quality of life.
Dr. Xingxing Zang receives Type 1 Diabetes Pathfinder Award for his innovative research on B7x protein, which may prevent T lymphocytes from destroying pancreatic cells. The award supports his five-year study to explore the role of B7x in diabetes prevention and treatment.
Researchers have identified two novel gene locations associated with an increased risk of developing type 1 diabetes. The study, published in Diabetes, provides a promising lead for the development of more accurate diagnostic tests and potential preventive therapies.
SourceChildren's Hospital of Philadelphia·JournalDiabetes·DateOct 14, 2008
Researchers at Beth Israel Deaconess Medical Center discovered that the AAT protein can restore normal blood glucose levels in a mouse model of Type 1 diabetes. The study suggests that inflammation plays a key role in the disease and provides evidence for using the protein as an alternative treatment option.
SourceBeth Israel Deaconess Medical Center·JournalProceedings of the National Academy of Sciences·DateOct 13, 2008
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A JDRF-funded study suggests that exposure to certain bacteria may provide protection against developing type 1 diabetes. Researchers found that mice exposed to these harmless microbes had a lower risk of autoimmune disorders. The findings lend support to the 'hygiene hypothesis' and may lead to new therapeutic approaches for prevention.
The DIRECT studies found that candesartan can reduce the incidence of retinopathy in type 1 diabetes and increase its regression in type 2 diabetes. The treatment also showed a significant reduction in risk of progression by three or more steps on the EDTRS scale.
Researchers at Yale University and the University of Chicago showed that mice exposed to common stomach bacteria were protected against Type I diabetes. The findings support the so-called
A study by Stanford University scientists reveals that type 1 diabetes may not be caused by bad genes but by how normal genes and gene variants are expressed. Researchers found differences in gene expression between two groups of mice, suggesting a role for environmental stimuli in triggering the disease.
SourceNIH/National Institute of Allergy and Infectious Diseases·JournalClinical Immunology·DateSep 19, 2008
A multicenter clinical trial funded by the Juvenile Diabetes Research Foundation found that continuous glucose monitoring significantly improved blood sugar control in patients with type 1 diabetes. HbA1c levels decreased by an average of 0.53% in patients aged 25 and older, while improvements were not observed in younger age groups.
SourceJDRF·JournalNew England Journal of Medicine·DateSep 8, 2008
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Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers found that leptin can lower blood glucose levels and maintain them in a normal range for extended periods. The study shows promise for treating type 1 diabetes without insulin injections.
SourceUT Southwestern Medical Center·JournalProceedings of the National Academy of Sciences·DateAug 25, 2008
Researchers at MGH confirmed a potential new therapy for type 1 diabetes by selectively killing autoimmune cells in human patients. The treatment, which blocks a metabolic pathway regulating the immune system, eliminates immune cells that react against a patient's own tissues.
SourceMassachusetts General Hospital·JournalProceedings of the National Academy of Sciences·DateAug 25, 2008
The JDRF Scholar Award is granted to individual scientists who exhibit a unique creative vision and approach to research. Dr. Jeffrey Bluestone and Dr. Mark Cooper are the recipients of this prestigious award, which provides them with $250,000 annually for up to five years to conduct specialized research.
The University of South Florida has been awarded a seven-year, $128 million NIH grant to coordinate worldwide studies on the prevention and treatment of juvenile diabetes. The TrialNet project will screen over 150,000 children and adults to investigate new therapies for early signs of diabetes.
SourceUniversity of South Florida (USF Health)·DateJul 31, 2008
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Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.