Articles tagged with Type 1 Diabetes
Researchers at Northwestern University are developing novel biomaterials and imaging techniques to improve the survival and function of transplanted islet cells in patients with type 1 diabetes. The grant will fund efforts to create microenvironments favorable for islet survival and function via controlled delivery of biological factors.
Researchers at Joslin Diabetes Center have developed a new imaging technology using magnetic resonance imaging to detect early signs of type 1 diabetes. The technology tracks miniscule magnetic nanoparticles leaking from the blood vessels of the pancreas, allowing for non-invasive monitoring of the disease's progression.
Researchers at Baylor College of Medicine have discovered a new gene associated with an increased risk of developing type 1 diabetes. SUMO-4 plays a key role in regulating the immune system and has been found to prolong the inflammatory response when mutated, leading to cell death and destruction of insulin-producing cells.
The study found that increasing PPAR-gamma activity in dendritic cells can activate NKT cells specifically, which may slow down the process of type 1 diabetes. Researchers believe that modulating CD1d expression and NKT cell activation could provide insight into how to combat autoimmunity.
Researchers found a natural mutation of the SUMO-4 gene, which regulates immune system activity, to be a major contributor to type 1 diabetes. The mutation increases the immune system's reactivity to environmental triggers, leading to an autoimmune response that attacks the patient's own tissue.
Researchers studied insulitis lesions in genetically engineered mice and discovered that inducible co-stimulator (ICOS) plays a crucial role in keeping insulitis respectful. Blocking ICOS disrupts the balance between T effector and regulatory cells, leading to diabetes progression.
Researchers discover a new strategy to combat type 1 diabetes by blocking the interaction of RAE-1 with its immune receptor, NKG2D. The treatment has shown complete effectiveness in preventing diabetes development in mice and promises potential as an effective human treatment.
Researchers at Rockefeller University have discovered that dendritic cells can stimulate the growth of suppressor T cells, which turn off the immune response and rescue islet cells from destruction. This breakthrough could lead to a prevention of Type 1 diabetes in humans.
Researchers found that natural killer cells are associated with destructive insulitis and beta cell destruction, suggesting a potential new target for halting or slowing disease progression. The study's findings have implications for understanding the complex interactions between immune cells and the development of type 1 diabetes.
A new protein form, liCTLA-4, found to inhibit T cell responses and reduce activation. Increased expression of liCTLA-4 in resistant mice strains suggests its role in preventing T cell-mediated autoimmune diseases like type 1 diabetes.
UVa researchers have identified a gene, Stat-4, that plays a key role in the development of type 1 diabetes. Disrupting this gene may help prevent the disease, and a new anti-inflammatory compound, Lisofylline (LSF), has shown promise in inhibiting its activation.
A synthetic compound called ISO-1 appears to work by blocking inflammation and protecting mice from developing type 1 diabetes. The researchers believe it could be developed into an oral drug that provides long-lasting protection for young people.
Researchers have successfully treated individuals with Type 1 diabetes using a single infusion of islet cells, with recipients maintaining insulin independence for over one to three years. The new treatment approach uses optimized recipient immunosuppression and a novel anti-CD3 monoclonal antibody.
Researchers develop gene therapy to enhance islet cell function and survival after transplantation. The technique uses a growth factor DNA to induce cell division, improving insulin production and glucose control in rat models. However, standard immunosuppression drug therapy may be harmful, inducing insulin resistance and diabetes.
A new study by the Society for Women's Health Research has found that spleen cells can rapidly regrow adult islet cells without embryonic stem cells. This breakthrough discovery opens up a new approach to treating Type 1 diabetes, which develops when the immune system attacks insulin-producing islet cells.
A study found that prenatal exposure to a diabetic environment from mothers with type 1 diabetes is associated with increased occurrence of impaired glucose tolerance and a defective insulin secretory response in adult offspring. This effect was observed independently of genetic predisposition to type 2 diabetes.
Researchers discovered that lisofylline treatment reduced the incidence of Type 1 diabetes in mice by 67%, indicating its potential to protect insulin-producing cells. The study published in Pancreas journal suggests that lisofylline may slow down or prevent the disease in people at high-risk.
A new study suggests that type 1 diabetics can develop insulin resistance, increasing their risk of heart disease. Insulin resistance occurs when the body fails to use insulin properly, leading to high blood sugar levels and a greater risk of cardiovascular events.
Sick Kids researchers discovered that nervous system autoimmunity attacks insulin-producing cells in the earliest stages of Type 1 diabetes. By modifying the attack on nervous tissue, they prevented subsequent diabetes in animal models, suggesting a critical role for early neuronal autoimmunity.
The international Type 1 Diabetes Genetics Consortium will collect and analyze genetic data from 2,500 families worldwide to identify genes contributing to the disease. The consortium aims to clarify the complex interaction between genetics and environment in type 1 diabetes.
Researchers found that increased nighttime systolic blood pressure is predictive of microalbuminuria and kidney disease in type 1 diabetes patients. The study suggests that this early warning sign may help prevent unnecessary therapies.
Researchers found strong relationships between nephropathy and insulin resistance throughout follow-up, unlike other risk factors such as blood pressure and blood fats. Lifestyle changes like proper diet, exercise, and smoking cessation may help people with type 1 diabetes avoid kidney disease.
Newborn diabetes screening benefits patients, medicine, and society by preventing complications, identifying at-risk individuals, and advancing research. Early detection enables targeted interventions to improve disease management, reduce hospitalizations, and lower medical costs.
Researchers have discovered a gene, Ian5, that appears to affect the function of the thymus and is linked to the development of type 1 diabetes in rats. The identification of this gene may also contribute to human type 1 diabetes and help researchers understand the underlying mechanisms of the disease.
A study of 200 type 1 diabetic patients found a significantly higher mortality rate among African Americans, due largely to acute complications. The results suggest an inadequacy in care for African Americans with type 1 diabetes, potentially linked to issues such as access to care and education.
Recent clinical trials found that low-dose insulin injections do not delay or prevent type 1 diabetes in high-risk individuals, contrary to earlier animal studies and pilot trials. However, the trials revealed valuable insights into immune and metabolic markers for assessing diabetes risk and identifying potential prevention strategies.
A new clinical trial has shown that a short-term use of a new drug can safely arrest the progression of Type 1 diabetes by targeting disease-causing T-cells. Patients who took the drug continued to produce their own insulin and needed less supplemental hormone, leading to improved metabolic control and reduced complications.
The new center will explore various initiatives toward insulin independence without long-term immunosuppression. Researchers will investigate less toxic drugs and test donor islets protected by a sheath-like membrane to reduce immune response.
A phase II study found that DiaPep277 treatment maintained insulin production in patients with early type 1 diabetes. The treatment also reduced the need for insulin therapy and altered immune response patterns.
Researchers found that DiaPep277 modulates the immune system to prevent autoimmune diabetes progression. The study showed significant increases in C-peptide levels and reductions in insulin requirements among patients receiving DiaPep277.
A study of 12,055 women found that children with recommended vitamin D supplements had a reduced risk of developing type 1 diabetes. The researchers suggest that health workers ensure all infants receive adequate vitamin D to prevent the condition.
Researchers found significant susceptibility for thyroid autoimmune disorders and Type 1 diabetes mellitus associated with DQ2 alleles, primarily transmitted from fathers to affected daughters. Hormonal factors may also regulate this interaction, as observed in the transmission of disease to pre- and postpubertal individuals.
The establishment of these centers brings together unique research expertise to perfect islet cell isolation and availability techniques. The centers aim to improve cellular viability, function, and shipping procedures for patients with type 1 diabetes.
A USC study found that teenagers and young adults with type 1 diabetes have a higher risk of atherosclerosis, or plaque buildup in their arteries. The study suggests that physicians should monitor lipid levels in these patients, even at an early age, to prevent cardiovascular problems.
A common treatment for diabetic crisis in children may contribute to a rare but often-fatal complication known as cerebral edema. Two simple blood test measurements can help predict which patients are at greatest danger of developing the potentially deadly complication.
Recent advances in diabetes treatment have improved blood sugar control, allowing patients to dodge complications until late life. New drug therapies, including metformin and insulin analogs, have enhanced treatment possibilities.
Scientists have found a novel gene, JM2, that causes an inherited form of type 1 diabetes and autoimmunity in boys. The mutations affect the protein's function, leading to hyperactive immune cells that destroy islet cells, resulting in diabetes and allergies.
A team of Type 1 diabetic athletes, including University of North Carolina M.D.-Ph.D. candidate Jeremy Ackerman, will climb Cerro Aconcagua in Argentina to raise awareness about diabetes and conduct scientific research on the effects of altitude on diabetics.
The DIRECT programme aims to establish whether candesartan cilexetil can prevent and treat diabetic retinopathy. The trial will investigate the effect of RAS blockade on diabetic patients with and without retinopathy.
Researchers found a strong association between high calcium scores and heart disease in people with Type 1 diabetes. The study suggests that a non-invasive heart scan may identify patients at high risk for heart disease earlier, allowing for potential interventions to lower their risk.
The National Institutes of Health (NIH) is launching a new clinical trial to test a promising transplant therapy for type 1 diabetes. The Edmonton protocol involves transplanting insulin-producing pancreas cells and aims to induce immune tolerance, allowing people with the condition to stop relying on insulin injections.
Researchers found that Avandia improves beta cell function, as measured by proinsulin to insulin ratio, indicating potential benefits for long-term glycemic control and disease progression. The study's results support the use of Avandia in type 2 diabetes treatment and suggest its potential to delay disease progression.
The JDF Center aims to develop new gene therapy techniques to increase islet cell supply for transplantation and protect transplanted cells from immune system attack. The center will focus on making islet cell transplants viable for young patients with Type 1 Diabetes.
A study found that young women with diseases requiring strict diets may experience unhealthy eating attitudes and behaviors, which can increase the risk of vascular complications and brain damage. The research highlights the need for clinicians to monitor signs of disordered eating in patients with chronic diseases.
Researchers found that diabetics under specialist care had significantly lower blood glucose levels and higher participation in self-care practices. The effect was particularly notable among patients with lower education levels.
Researchers have developed a new and painless way to measure glucose levels in diabetics using low-frequency ultrasound. The method, described in a recent study, involves making the skin permeable with ultrasound waves, allowing glucose to cross the skin and be measured continuously for up to 12 hours.
Researchers developed a reliable blood test to diagnose diabetes in children at an early stage, allowing for prediction of the condition with a reliability of 50%. The test measures concentration of islet antibodies in a child's blood and combines it with DNA testing for hereditary susceptibility.
A University of Pittsburgh study has found that depressive symptoms are a significant risk factor for coronary heart disease among people with Type 1 diabetes. The study's results also suggest that blood sugar levels do not strongly predict the likelihood of this complication.
The UofA research team is working to prevent rejection of transplanted islet cells, allowing diabetics to become insulin-free. Researchers are also developing procedures for transplanting islet cells before physical complications set in.
Researchers found slight memory impairment in children on intensive diabetes therapy, with a three-fold higher rate of severe hypoglycemic incidents compared to conventional therapy. The study suggests potential long-term cognitive consequences related to repeated hypoglycemic episodes.
A recent study found that nearly half of people with type 2 diabetes stop taking their oral anti-diabetic drugs (OADs), leading to a higher risk of complications such as blindness, amputation, and cardiovascular problems. The study revealed that individuals who discontinued treatment were almost three times more likely to die than thos...
A pan-European study found that type 2 diabetes in Europe is a significant healthcare burden, with total costs exceeding €29 billion and average individual costs more than double those of the general population. Preventing long-term complications through urgent action is crucial to reducing these costs.
Research highlights potential causes of autoimmune diseases, including prenatal exposure to environmental chemicals and certain dietary factors. Studies also explore links between ultraviolet radiation, stress, and exposure to heavy metals.
Studies suggest that involving individuals with diabetes in their care can improve quality of life and reduce complications. The results highlight the importance of patient education and empowering patients to make informed treatment choices.
Researchers found that resistant mice have higher levels of antioxidant enzymes, which help protect against pancreatic beta-cell destruction. The study suggests a single gene may be responsible for the genetic resistance, and identifying it could lead to therapies to boost natural defenses against diabetes.
Researchers at the University of Pittsburgh found that HbA1 levels predict mortality from coronary artery disease in women with Type 1 diabetes. However, this association was not seen in men with the same condition. The study analyzed data from over 600 subjects and suggests a gender-specific link between hyperglycemia and CAD risk.
Harvard and UF researchers identified a component of the human immune system that appears to prevent type 1 diabetes in a group of people at high risk. The protein interleukin-4 (IL-4) is produced in large amounts in these individuals and may suppress the arm of the immune system involved in the destruction of insulin-producing cells.