Researchers have found three new drug-like compounds that target a protein responsible for chemotherapy resistance in cancers, offering hope for improved treatment options. The compounds have shown promise in re-sensitizing resistant cancer cells to chemotherapy, improving the odds of survival for prostate cancer patients.
Researchers have created a new method for controlling gene activation, allowing for precise regulation of gene expression in cells. The method employs CRISPR technology combined with chemical compounds to activate specific genes without altering the genome.
Researchers from various disciplines set eight research axes to improve nutrition science, including sustainability, data analysis, and human behavior. The initiative aims to bring together experts to tackle key challenges in the field.
A recent Mayo Clinic study found that the number of new thyroid cancer cases is doubling, driven by the detection of previously undiagnosed low-risk tumors. These silent cancers often require unnecessary treatments, leading to financial and physical hardship for patients.
The researchers used broad ion beams to create nanostructured arrays on a gallium arsenide wafer, resulting in well-defined structures reminiscent of sand dunes. The process involves heating the sample during ion bombardment and compensating for missing atom bonds by forming pairs of gallium atoms.
Scientists explore reviving extinct Mediterranean forests through minimal human disturbance and restoration of native vegetation. They also investigate the impact of ocean noise pollution on undersea animals and propose internationally binding commitments to monitor and limit noise.
Researchers from Queen Mary University of London found declining numbers of Bovine TB infections in Scotland and Wales, while England's approach is unlikely to succeed. More frequent testing led to effective control of the disease, with a significant decline in infections.
Tropical Storm Etau formed near Iwo To, Japan on September 7 and was approaching Japan by September 8. The storm made landfall near Kyoto, Japan late on September 8/early September 9 and is forecast to dissipate due to land interaction.
Researchers at Northwestern University have developed a solution to create stable carbon nanotube-based integrated circuits using newly designed encapsulation layers. These layers protect the sensitive devices from environmental degradation, enabling reliable operation for years or even decades.
Tropical storm Grace has weakened to a depression in the Eastern Atlantic Ocean after just three days of formation. NASA's GPM satellite found only scattered areas of light rain in the system.
Researchers develop a new theory that describes how a knot's topology determines its mechanical forces, providing guidelines for choosing certain knot configurations. The theory accurately predicts the force needed to close a knot, given its topology and strand properties.
A study of over 1 million Medicare recipients found that flu vaccines with a high match rate to the prevalent strain reduced pneumonia hospitalizations by 4.2% and deaths by 2.0%. The study estimated lives saved and prevented hospitalizations annually in long-stay nursing home residents.
Scientists have elucidated a molecular mechanism that contributes to the 'cocktail effect' of endocrine disruptors when combined. The study shows that certain compounds bind cooperatively to a receptor in the cell nucleus, inducing a toxic effect at lower concentrations than individual molecules.
Researchers have expanded their search radius for dark matter particles using the CRESST experiment, which can now detect particles with masses below 10 GeV/c^2, including those comparable to a proton. The new detectors are being equipped and will begin measuring in late 2015.
Ozone concentrations commonly near urban areas can strongly inhibit bees' attraction to flowers due to fast scent degradation. The loss of scent signals affects the successful pollination of most insect-pollinated plants.
Child trafficking survivors experience poor mental health, self-harm, and suicide attempts, with 56% screening positive for depression and 15.8% reporting suicidal thoughts in the past month.
A study published in the Journal of Public Economics found that Prize Linked Savings (PLS) products, which combine savings with the possibility of winning large cash prizes, are more effective at inducing savings than standard interest-bearing accounts. This is particularly true for lower-income and less-educated individuals who are al...
Tropical Storm Jimena is being pushed west by strong vertical wind shear, affecting cloud top temperatures and thunderstorms. Forecasters expect the storm to gradually weaken over the next five days.
Researchers found that nearly 50% of Asian Americans with diabetes remain undiagnosed, with the highest prevalence in Hispanic Americans at nearly 23%. The study highlights the need for increased education and testing efforts among this population.
Scientists have discovered a novel approach to study neural circuits that change behavior, using Caenorhabditis elegans worms. By flipping the sign of a synapse, researchers were able to completely reverse behavior, suggesting that neural wiring is remarkably stable and allows for changes in behavior.
A study in a malaria-endemic region found that daily iron supplementation during pregnancy did not increase the risk of malaria, but resulted in increased birth weight and improved fetal outcomes. The authors suggest that universal iron supplementation may outweigh potential risks in low- and middle-income countries.
Researchers have developed ImmuNet, an online tool that uses public experiments and machine learning algorithms to predict new immune pathway interactions and disease-associated genes. The tool accelerates the understanding of immunological mechanisms and diseases, ultimately leading to improved treatment options.
A new model for preventing and treating obesity in the United States has been proposed, integrating healthcare with community resources. The model centers on individual patients and family engagement, restructuring clinical services to address stigmatization and promoting behavioral changes.
Typhoon Kilo maintained its clear eye with NASA's Terra satellite imagery on September 7. The storm's maximum sustained winds near 65 knots (74.8 mph/120.4 kph) are expected to strengthen to 75 knots before weakening, affecting Japan and Russia.
Researchers at UCSF are studying a molecular pathway that underlies many cancers, with the goal of improving diagnosis and treatment. The grant will integrate data from preclinical studies and precision medicine technologies to generate high-resolution molecular information on NF1-associated tumors.
Ghana's Upper Guinea rain forests have seen a decline of over 50% in understory bird species due to increased illegal logging, which has more than doubled between 1995 and 2010
Researchers have created artificial plants that can produce methane and butanol using semiconducting nanowires and bacteria. This technology has the potential to replace fossil fuels with a sustainable and efficient alternative.
Researchers found that bloggers who accepted compensation tend to feel more empowered in their relationships with companies, rather than feeling indebted. However, the guidelines have not changed how bloggers acknowledge compensation, and many simply don't report accepting free products.
Researchers have identified a histone deacetylase inhibitor that reverses MECP2 alterations in mutant neurons, offering hope for treating the devastating neurological disorder. The breakthrough uses stem cell-derived 'mini-brains' to screen potential drug libraries, providing an efficient method for finding effective treatments.
A study by Umeå University researchers found that population growth is responsible for 86% of the increase in dengue incidence in Singapore, with climate change and urban heat islands contributing to the remaining 14%. The findings have significant implications for predicting future trends in dengue epidemics.
A study published in Environmental Research Letters found that peak-time emissions from diesel trains at London's Paddington Station exceeded European air quality recommendations and were higher than nearby roadsides on most days. The station's semi-enclosed design contributed to elevated concentrations of particulate matter, nitrogen ...
A new study found that psychoticism and immature defense mechanisms are risk factors for homophobia, while depression and neurotic defense mechanisms lower the risk. The study included 560 Italian university students and aims to address the long-standing debate about whether homosexuality is a disease.
Scientists at Sichuan University develop an alloy combining diamond and cubic boron nitride, exhibiting superior hardness and wear resistance when cutting through steel and granite. The novel process enables mass production of the alloy, which could revolutionize various industrial materials processing.
Scientists have discovered a new parasitoid wasp species that can kill up to 25% of the Asian fly larvae, a widely spread invasive pest corrupting large parts of the pigeon pea crops. This natural enemy has the potential to be a biocontrol agent, offering a promising solution for the Dominican Republic's economic losses estimated at 76%.
Researchers have identified a naturally occurring blood protein called lumican as a key player in the development of excessive scar tissue in fibrotic diseases. The study suggests that lumican triggers a vicious cycle when stimulated by tumor necrosis factor alpha, leading to increased production of scar tissue.
A national US sample of 16-26 year olds showed that 38% of e-cigarette users started smoking traditional cigarettes within a year, compared to 10% of non-e-cigarette users. E-cigarettes deliver nicotine slowly, allowing users to become tolerant and advance to cigarette smoking.
A $13.18 million NIH grant will enable Dr. Krauss and his colleagues to identify genetic determinants of statin efficacy and risk for adverse effects. The research program utilizes a multi-disciplinary approach incorporating genomic, transcriptomic, and metabolomic tools.
Research suggests that children who focus on their possible future selves and have strategies to attain these possibilities perform better academically and emotionally. In contrast, children who dwell on difficulties without planning for the future experience a negative impact on their optimism and fatalism.
The International Association for the Study of Lung Cancer has released new data for the TNM classification of lung cancer, which will inform the Eighth Edition of the staging manual. The new database includes 94,708 patients diagnosed worldwide from 1999-2010 and analyzes tumor size, lymph node involvement, and metastatic status.
New analysis reveals that excessive bubble formation limits heat transfer, leading to overheating and equipment damage. The study identifies optimal surface texturing to improve boiler efficiency and plant safety.
A new NIH-funded study launched at UH Seidman Cancer Center aims to investigate the effects of physical activity on functional status, body composition, and biomarkers associated with breast cancer prognosis in older breast cancer survivors. The five-year clinical trial will focus on African American and low socioeconomic status women.
A team of researchers developed a system to study how materials respond to mechanical stress, enabling nondestructive characterization of structural materials. The tool could lead to aerospace components that are lighter and more tolerant to damage.
The study reveals that drugs behave as predicted in the computer-generated model of P-gp, allowing researchers to understand how they bind and inhibit the protein. This breakthrough enables scientists to predict better what will make an inhibitor work, potentially leading to new cancer treatments.
Survival rates for extremely preterm infants have increased significantly over the past 20 years, with improvements in maternal/neonatal care leading to reduced complications and mortality. The study found that survival without major complications increased approximately 2 percent per year for infants at 25 to 28 weeks' gestation.
A CTCA study found that the lung microbiome diversity in patients with lung cancer was characterized by a significant presence of Streptococcaceae family bacteria. This discovery may lead to new pharmacological cancer prevention strategies and improved treatment outcomes for lung cancer patients.
A new UC Davis study found that molecular tests, commonly used in US hospitals, often misdiagnose patients with C. difficile infection, leading to over-treatment and potential harm. The study suggests that traditional toxin tests are more effective in predicting clinical disease and outcomes.
Studying kangaroo cartilage reveals how shoulder and knee joints behave differently, leading to improved treatments and better implants. The researchers identified the collagen network as a key factor in absorbing forces without damaging.
Resin acids have been found to be effective in treating epilepsy by opening potassium channels and reducing nerve activity. The substances, which are fat-soluble and electrically charged, were synthesized from a natural molecule and tested on frog eggs and mice before patent applications were submitted.
Scientists have found that the cGAS sensor can detect single-stranded DNA, including guanosines, which triggers a strong immune response. The HI virus has evolved to eliminate guanosines from its genetic material, partially avoiding detection by the cell.
Researchers at the University of Michigan have developed solar cells that can track the sun using a kirigami-inspired design. The array of small solar cells tilts within a larger panel, keeping their surfaces more perpendicular to the sun's rays and raising the effective area soaking up sunlight.
A high body mass index (BMI) is linked to a lower risk of rheumatoid arthritis (RA) in men, but not women, according to a Swedish study. The association was strongest in men with increased abdominal obesity or visceral fat.
The Parsemus Foundation has awarded the second round of the Timmy Prize to three winners who contributed substantial information on the use of Calchlorin nonsurgical sterilant. The data sharing prize aims to increase understanding of the method's effectiveness and refine its methodology.
A new Duke University study reveals that adolescents aged 10 to 16 can be more analytical in their economic choices than slightly older young adults. Researchers found that teens carefully weigh decisions, using cost-benefit analysis skills, while young adults rely on simple rules.
A rarely collected parasitic woodwasp species has been found in the Ozark Mountains, expanding its known range hundreds of miles west. This discovery was made possible by photos posted on Flickr and BugGuide, which helped identify new specimens from the US National Entomology Collection.
A study published in JAMA Pediatrics found that survivors of child trafficking experienced physical and/or sexual violence, depression, anxiety, and PTSD. Mental health symptoms were associated with self-harm and suicide ideation among the 387 children and adolescents surveyed.
Studies in the September Health Affairs issue reveal declining global mortality rates for heart disease, stroke, and certain cancers, but increasing trends in diabetes, liver cancer, respiratory disease, and lung cancer deaths, particularly among women and in low- and middle-income countries.
A recent study published in JAMA Neurology found that continued smoking after an MS diagnosis is associated with accelerated disease progression. The study analyzed data from over 1,000 patients and found that those who continued to smoke converted to secondary progressive multiple sclerosis (SPMS) faster than those who quit.
Researchers found that dormice start hibernation early when beech trees produce few beechnuts, allowing them to survive during mild weather periods. This behavior changes the view on hibernation as a strategy to decrease energy expenditure.
A simplified 'Test and Treat' intervention was associated with increased engagement in HIV/AIDS care and a 62% reduction in mortality among participants. The program improved diagnosis, linkage to care, and treatment outcomes, with a significant increase in pre-ART CD4 testing and ART initiation.
Researchers found that preverbal infants can learn basic rules through audio-visual pairs only when stimuli match each other's nature. The study suggests that unified sensory input is crucial for effective learning in infancy.