A new hybrid biomaterial delivers a chemotherapeutic agent and RNA interfering technology to silence drug resistance, resulting in substantial decrease in cancer cell viability. The material's ease of modification allows for swapping out components to suit specific cell lines and drugs.
A recent study found that 44% of nursing home residents with dementia were taking PIMs at admission, and many stopped or started these medications during their stay. The researchers suggest a person-centered approach to discontinuing PIMs, especially for frail older adults.
A study of older adults seen in emergency departments found that nearly half had visited an ED before their death, yet many did not receive mental health evaluation or treatment. The researchers concluded that improving responses to suicide risk detection and treatment for older adults are crucial to reducing deaths from suicide among ...
A study shows that Alaska's universal hepatitis B vaccination programme has wiped out hepatitis B infection and liver cancer cases in the state's young people. The program, introduced in the 1980s, led to a significant decrease in acute symptomatic HBV infection and liver cancer cases among Alaskan Native children, with no reported cas...
Research reveals that young women who start menstruating earlier may spend less time in education due to delayed emotional development. On average, starting menstruation one year later was associated with an additional 53 days spent in education.
Scientists developed a method to quantify past oxygen depletion in oceans using thallium isotope composition of ancient seafloor sediments. The analysis suggests up to half of the deep ocean was oxygen-depleted during Oceanic Anoxic Event 2, with modern trends showing similar rates of deoxygenation.
Researchers have improved the properties of an AMP from a spider, making it more effective against bacteria and cancer cells. The modified peptide was found to be 10 times better at killing most bacteria than the previous cyclic form, while also selectively targeting certain types of cancer cells.
Researchers identified a potential biomarker, glycolate, that could stay in urine up to 20 hours after GHB ingestion. This finding could lead to tests with greater detection windows and less sample manipulation required.
Researchers at Children's Hospital Los Angeles have successfully defined a rare pediatric malignant liver disease, HEMNOS, which showed positive treatment outcomes when treated like hepatoblastoma. The study found that all patients survived and achieved remission despite being considered high risk.
Researchers found that while partial line replacements can decrease lead levels in tap water, concentrations spike right after and remain elevated for months. Full service line replacement or flushing the replaced pipes is recommended to address potential contamination.
A 94-million-year-old climate change event showed severe oxygen depletion in ancient oceans, with a similar rate of decline observed in contemporary oceans. Researchers used Thallium isotope analysis to examine organic-rich sediment and found evidence of rapid oxygen loss before a major climate event.
Neurobiologists have reconstructed nerve cells and synapses in a larval brain, revealing new circuit connection patterns that will aid future research on brain function. The project represents a significant contribution to the creation of a complete wiring diagram of the Drosophila larvae's brain.
Individuals with eating disorders are more likely to be convicted of theft and other crimes, with 12% and 7% incidences reported. Researchers call for further investigation into the relationship between crime and eating disorder psychopathology.
A study of over 3000 asthma patients in Australia and New Zealand found that while more expensive medication was used in Australia, similar treatment outcomes were achieved despite better adherence to medication in the cheaper-medicine country. The findings suggest that policy differences play a significant role in asthma management.
Recent damming has drastically reduced the migration opportunities of fish species, leading to lost habitat and river connectivity issues. The lack of pre-1950 data on ecological harm may underestimate the effects of damming.
Researchers found intentional engraving on human bone from Gough's Cave, indicating a multi-stage cannibalistic ritual. The zig-zagging cuts hold symbolic connotations and represent an early example of cannibalistic funerary behavior.
A new study introduces a finger prick test for patients with rheumatoid arthritis and other autoimmune conditions taking adalimumab, enabling easy monitoring of drug levels without full blood draws. This method simplifies therapeutic drug monitoring, potentially benefiting patient care.
A Cleveland Clinic study found that price increases for nitroprusside and isoproterenol led to a significant decrease in their use between 2012 and 2015. The medications, used primarily in hospitals with no direct-to-consumer advertising, saw a 53% and 35% drop in patient treatment respectively.
Scientists explore gene therapy for injured peripheral nerves, aiming to improve functional recovery after microsurgical repair. The approach involves modifying a directional cue for nerve cells to promote fast regeneration and functional recovery.
Researchers at the University of Bergen have successfully transformed skin puncture cells from diabetes patients into insulin-producing cells. The goal is to transplant these cells under the skin, potentially replacing insulin shots and blood sugar measurements.
A report by three neurosurgeons highlights industry's growing role in funding neurosurgery research, while also addressing ethical concerns and disparities. The authors advocate for careful oversight and disclosure to maintain high ethical standards.
Researchers at the University of Missouri found that women with increased cadmium levels have a higher risk of endometrial cancer, with rates increasing by 22% in individuals with elevated levels. The study recommends limiting cadmium intake through diet and lifestyle changes to reduce associated cancer risks.
A study found that drought recovery depends on post-drought weather conditions and location. In general, most areas recover in under six months, while high-latitude regions need up to two years. Climate models predict more frequent droughts, which could lead to a double whammy effect if ecosystems are hit before they recover.
Research at RIT develops new precision quantum sensing solutions using levitated optomechanics, capturing data with improved accuracy. The study aims to create smaller and lighter sensors for various applications, including detecting gravitational waves and perfecting quantum computing.
A new analysis published in Science Advances found that the probability of moderate earthquakes in Oklahoma is two times higher than initially predicted, contradicting earlier predictions of reduced seismic activity. Moderate earthquakes continue to pose a significant hazard in central and western Oklahoma.
Researchers at UTA are developing iWork, a robot-based system that assesses workers' physical, cognitive, and collaborative skills. The system uses advanced computational methods to identify human ability, intent, and potential, providing personalized training solutions for millions of people seeking retraining for manufacturing jobs.
Researchers found distinct protein structures and varying chitin ratios in cicada wings compared to locust wings. This difference may contribute to cicadas' relatively heavy wings, limiting their flight distances.
Researchers found that maternal inflammation can lead to changes in the fetal brain, particularly in the amygdala, which plays a crucial role in emotional processing. This association has been linked to impaired impulse control and an increased risk of psychiatric disorders.
Two researchers, Suneel Apte and Jeffrey Holmes, have been awarded grants to study the extracellular matrix, a key component in heart health and disease. Their research aims to uncover novel disease markers and targets for developing drugs to treat cardiovascular disease.
The American Geriatrics Society calls for bipartisan collaboration to improve the nation's healthcare system, focusing on expanded in-home care options and adequate resources for caregivers. Experts also emphasize the need for geriatricians' training and research on healthy aging and age-related health problems.
A new study suggests that human settlement of Jamaica may have led to the extinction of the Xenothrix mcgregori monkey species. The research uses radiocarbon dating to estimate that the monkey died between 505 and 573 A.D., overlapping with non-European human arrival on the island.
Researchers found that the moon's magnetic field declined by about 90 percent over 3.56 billion years ago, with a 1-2.5 billion year time frame for its existence. This discovery has implications for habitability on other moons and planets, as well as the potential for life to respond to unstable environments.
The researchers created prototypes of conductive glass with metal ions that spread out over the surface, blocking light in response to electrical current. This technology has the potential to transform homes, businesses, cars, and more by reducing energy consumption and costs.
A study found that apathy is present in half of nursing home patients and linked with an increased risk of dying over a 4-month period. Screening and treatment strategies for apathy are necessary to improve quality of life and advanced care planning.
Researchers at Poker Flat Research Range in Alaska used high-speed cameras to capture the rare phenomenon of an aurora flickering. The team discovered that faster flickerings occur at speeds of 1/60-1/50 and 1/80 seconds, revealing a complex exchange of energy between plasma waves and particles.
A study published in JAMA Surgery found that women with a history of C-section delivery had a higher risk of reoperation and surgical complications after undergoing a hysterectomy. Women with two or more C-section deliveries were also more likely to receive blood transfusions.
Increases in bone marrow fat are associated with a decline in bone density after gastric bypass surgery, while improvements in blood sugar control are linked to reduced marrow fat levels. The study suggests that weight loss and blood sugar metabolism may influence bone health through changes in bone marrow fat.
Greater intraindividual reaction time variability was found to predict shorter survival times in older adults, independent of cognitive decline. The study used computerized reaction time tests to measure participants' responses and found that increased variability was associated with a higher risk of mortality.
A new study found that motivating high school classroom environments can positively influence students' STEM interests, with 65% of students showing STEM career intentions in classrooms with perceived high levels of peer interest. Peer interest was also linked to improved or maintained grades in science and math courses.
Researchers found that naturally occurring climate variations, specifically El Niño and the North Atlantic Oscillation, drive sea level rise hot spots along the U.S. East Coast. These hot spots can amplify coastal flooding severity and are difficult to predict.
New research finds that temperature rises and increasing physical activity levels, not weather conditions, drive online searches for knee and hip pain. Temperatures peaked at 73 and 83 degrees Fahrenheit respectively.
A study found that a next-generation probiotic, Lactobacillus reuteri, produces an antibacterial compound that selectively kills C. difficile. This could lead to a preventative strategy for reducing the risk of C. difficile infections in patients taking antibiotics.
Researchers in India used numerical computations to investigate the role of chaotic magnetic field lines in generating intense electric current sheets, which are potential sites for extreme heating of the sun's corona. The simulations found a direct proportionality between the intensity of the current sheet and chaoticity.
A recent study demonstrates the safety of immunotherapy in treating type 1 diabetes. The treatment showed metabolic effects without accelerating β-cell destruction, suggesting a viable option for patients.
Scientists from Queen Mary University of London created an AI that uses internet searches to source and process associated words and images for a novel mind reading card trick. The computer assists in designing the trick by uncovering suggestions and acting as an aid to prompt further creativity.
Researchers use ancient pottery to study Iroquoian social networks and find that the Jefferson County Iroquoians played a key role as brokers between Haudenosaunee and Wendat groups. This discovery sheds new light on the importance of this lesser-known population in upstate New York.
Researchers studying fruit flies have found that a neurotransmitter called dopamine regulates social space, with too little or too much release causing male and female fruit flies to adjust their distance. The discovery may lead to new insights into disorders where personal space is an issue.
Researchers at Arizona State University have developed a plant-based Zika vaccine that is more potent, safer and cheaper to produce than existing alternatives. The vaccine targets the DIII domain of the Zika virus and has been shown to induce 100% protection against multiple Zika virus strains in mice.
A new study reveals the US Office of Nuclear Energy's budget history, showing a lack of effective allocation of resources and failure to support innovative research. The researchers recommend a new approach with stricter programmatic discipline and transparent evaluation processes to identify promising reactor concepts.
Researchers create high-resolution maps of the McMurdo Dry Valleys, showing rapid erosion and glacier thinning due to climate change. The study provides insights into the region's vulnerability to future warming and its potential impact on global sea levels.
A new study suggests that drought recovery times will increase due to climate change, potentially leading to widespread tree deaths and ecosystem disruption. The factors contributing to this increase include temperature extremes, precipitation, and carbon dioxide concentrations.
A University of Liverpool study found that ants are responsible for moving more than half of food resources from the rainforest floor. This role is crucial for nutrient redistribution and decomposition, maintaining a diverse and healthy soil environment.
A new study found that sharing personalized melanoma genomic risk information with relatives and friends can lead to increased discussions about skin cancer prevention. The study suggests that this process could encourage healthy behavior change within families.
The telescope is cooled to minus 387 Fahrenheit as scientists and engineers monitor its performance with temperature sensors and cameras. Once complete, the telescope will be integrated with the spacecraft and sunshield at Northrop Grumman, California, before undergoing final tests called 'observatory-level testing,'
The Hastings Center recommends adopting reimbursement policies and guidelines to support clinicians in providing informed consent for prenatal genetic testing. The authors also suggest funding education and counseling approaches to help patients make decisions about testing.
A new study by Florida State University researcher David Houle found that small mutations in fruit flies can predict up to 40 million years of evolution for this common household pest. The research suggests a tight relationship between mutation effects and evolutionary changes.
Scientists have established minimum metadata requirements for single-cell genomics and metagenome-assembled genomes, enabling researchers to compare analyses and assess genome quality. The proposed categories include Low-Quality Drafts, Medium-Quality Drafts, High-Quality Drafts, and Finished Quality.
A new study reveals that managerial support can help workaholics avoid attending work when sick and address work-family conflict. By recognizing the harm of presenteeism, managers can train themselves to develop protective factors against this phenomenon.
Researchers have discovered evidence of modern human presence in West Sumatra, dating back to 73,000 years ago, suggesting a possible early migration to Australia. The findings, published in Nature, shed new light on the origins of humans in Southeast Asia and challenge the current timeline.
A study in mice reveals how natural killer cells can cause a fetus to fail to grow or lead to miscarriages. Researchers identified potential treatments, including IVIG and targeted therapies, to prevent FNAIT-related miscarriages.