Ten life scientists have been awarded EMBO Installation Grants to establish laboratories in Croatia, Czechia, Estonia, Greece, Poland and Portugal. The grants support research projects on various topics including protein quality control and myeloid cell heterogeneity.
EMBO has announced the selection of 27 young scientists to join its prestigious Young Investigator Programme, with projects spanning cell and computational biology, immunology, neuroscience, and more. The programme supports innovation and collaboration among new leaders in life sciences.
Review Commons is expanding its scope and scale with added funding, welcoming Biochemical Journal, Genes & Development, Genome Biology, and Immunology & Cell Biology as new affiliate journals. The platform now supports a diverse range of publishers and enables authors to reuse peer reviews for multiple journal submissions.
The new global investigators will receive financial support to build and expand their network and research portfolios over four years. They will also have access to training and networking activities.
Researchers found that iron supplementation can sustain muscle function, mass, and survival in mouse models of colon cancer. In humans, a small group experienced moderate strength improvement after iron injection, suggesting potential benefits for cachexia sufferers.
Researchers found that damaged telomeres increase the expression of ACE2, the human SARS-CoV-2 cell receptor, leading to increased viral susceptibility in the elderly. This DNA damage response is triggered by telomere shortening and dysfunction in aging cells.
A study published in Molecular Systems Biology reveals that tumour cells resistant to treatment exhibit 'metabolic and epigenetic memory' of the tumour state. This finding highlights the importance of glycolysis in sustaining cellular metabolism and provides a potential therapeutic target for preventing breast cancer recurrence.
Andrea Ablasser is awarded the EMBO Gold Medal 2021 for her groundbreaking research on how cells recognize double-stranded DNA as a danger signal. Her work may pave the way for therapeutic opportunities for inflammatory conditions and cancer treatment.
Researchers developed an in vitro human-derived tissue model to study SARS-CoV-2 infection and its progression to ARDS. The model revealed a cellular immune response to the virus, indicating potential for effective treatment with interferon lambda.
Researchers discovered biomarkers associated with COVID-19 immunopathology and multi-organ damage, enabling early identification of patients at risk of severe symptoms. The study's findings have potential for developing prognostic classification models to target treatments accordingly.
A German meat processing plant outbreak highlights the importance of maintaining high quality air flow to restrict SARS-CoV-2 transmission. The study found that a single worker transmitted the virus to over 60% of co-workers within an 8-meter distance.
Sarah-Maria Fendt and Markus Ralser receive the EMBO Gold Medal for their pioneering work in understanding metabolic changes during cancer proliferation and metastasis formation. Their discoveries have the potential to develop more effective cancer therapies.
Scientists have found that a small proportion of individuals possess high levels of antibodies targeting the normal PrP version of the prion protein. These antibodies may be beneficial in targeting pathological aggregates for degradation by phagocytic cells, potentially offering new tools for studying neurodegeneration. The discovery s...
EMBO has awarded nine researchers with Installation Grants to set up independent laboratories in the Czech Republic, Poland, Portugal, and Turkey. The grants support young group leaders in establishing their labs in countries that struggle to compete scientifically with well-funded research centers.
Review Commons, launched by ASAPbio and EMBO Press, enables high-quality pre-journal peer review of manuscripts from the life sciences. This platform empowers authors to make informed decisions on paper submission and expedites submission to affiliate journals without restarting reviews.
Researchers found that MALT1 levels correlate with patient survival in brain cancer, and blocking the gene with MALT1 inhibitors causes glioblastoma stem cells to undergo cellular suicide. This discovery points to the potential of further exploring MALT1 inhibitors as a treatment for glioblastoma.
Molecular Systems Biology has appointed systems biologist M. Madan Babu as its new Chief Editor, strengthening the journal's position in the field of systems biology. The appointment aims to encourage interdisciplinary research and bridge silos between fields.
Scientists analyzed the virus' course of action and discovered how it captures host ribosomes using a structured RNA sequence called IRES. This finding advances research into feeding bees RNA molecules that interfere with the virus's RNA, potentially offering a solution to Colony Collapse Disorder.
A research team has identified a novel caloric restriction mimetic, 3,4-dimethoxychalcone, which induces autophagy and promotes longevity. The substance may prove useful in treating age-related diseases such as cardiovascular disease and cancer.
Review Commons aims to accelerate and streamline the process of publishing by conducting high-quality peer review of manuscripts before journal submission. Peer reviewers evaluate technical rigor, suggest improvements, and comment on potential value to specific communities.
Researchers have identified six proteins associated with early-stage non-alcoholic fatty liver disease (NAFLD), a condition that can progress to end-stage liver cirrhosis. The discovery of protein PIGR as a candidate biomarker for liver damage tests offers a promising new diagnostic tool.
A study discovered that a microRNA cluster regulates synaptic strength and is involved in controlling social behavior in mammals. The researchers found that the absence of this microRNA cluster results in increased sociability in mice.
SourceData from EMBO is an open platform that makes research data directly searchable, while BioStudies aggregates the data files linked to a specific publication or project. This integrated workflow enables authors to make their published data openly accessible and easy to find.
A new study has identified a specific peptide that directly binds to the ion-channel CFTR, impairing its function and triggering cellular stress and inflammation. This interaction can be inhibited by a potentiator of CFTR, which may offer protection against gluten-induced intestinal symptoms.
Researchers found that mice lacking the Maged1 gene are unresponsive to cocaine and show diminished dopamine release, highlighting its role in addictive behavior. The study provides new insights into the molecular mechanisms underlying drug addiction.
Scientists have engineered red blood cell lines to express fewer antigens, making them less immunogenic for patients with rare blood types. This breakthrough could lead to the development of more universal blood sources for transfusion patients.
Researchers found that palbociclib induces substantial changes in the proteasome, degrading proteins required for cell cycle progression and driving cells into senescence. The discovery suggests that proteasomal activity may be an additional mechanism by which palbociclib stalls proliferation.
A new blood test has been developed to detect early indicators of Alzheimer's disease, measuring the relative amounts of pathological and healthy amyloid-beta forms in the blood. The test was found to reliably detect signs of the disease on average eight years before diagnosis, with an overall diagnostic accuracy of 86%.
Seven researchers from Portugal, Czech Republic, Estonia, Poland, and Turkey will receive €50,000 grants to set up independent laboratories. The funding aims to improve European science competitiveness by supporting talented scientists in countries with limited research resources.
SourceData provides a suite of tools to generate, validate and use figure data, making it efficient to find and reuse published results. The platform links figures to other related figures across papers and journals, creating a searchable knowledge graph.
SourceData, an open platform from EMBO, has been recognized for its innovative approach to making published scientific data easily findable. The platform uses a machine-readable format to describe the data published in figures, allowing researchers to search directly for data on specific research questions.
Researchers have discovered that stabilizing TREM2, a protein involved in neurodegenerative diseases, could be a viable therapeutic strategy to combat Alzheimer's disease. The study found that a mutation in the TREM2 gene accelerates its cleavage, leading to reduced full-length protein on microglia cells.
Researchers at the University Medical Center Goettingen identified a molecular link between PTSD and Alzheimer's disease, specifically Formin 2. Formin 2 mutant mice show PTSD phenotypes at an early age and develop age-related memory decline.
Researchers found that tumor cells entering a reversible state of proliferation arrest when glutamine is depleted, rather than dying. c-MYC levels are down-regulated upon glutamine deprivation, suggesting it couples transcription to nucleotide availability.
Researchers have devised a strategy to specifically target cancer stem cells in some cancers and reduce their tumor-generating potential. Combining Nutlin-3 and Paclitaxel showed potentiated tumor response and prevented relapse in Numb-deficient tumors, suggesting the potential of these drugs as treatment options.
Researchers have characterized cerebral organoids, showing they recapitulate human brain developmental processes and involve forebrain organizing centers. These findings advance our understanding of normal organoid development and are essential for modeling human developmental diseases.
A study by Laurine Gilles and colleagues sheds light on the genetics behind haploid induction in maize, revealing the molecular identity of a key gene that promotes fertilization. The identification of 'Not Like Dad' is an important breakthrough to fully understand the process and translate this breeding tool to other crops.
A study published in The EMBO Journal found that cocaine-induced place preference in mice is independent of lasting NAc neuronal rewiring. Silent synapse formation and unsilencing during withdrawal are essential for many addictive behaviors but not for this specific behavior.
A new tissue culture system has revealed that microglia from aged brains are engulfing amyloid plaques on site, with young microglia secreting factors to rejuvenate older cells. The discovery highlights a potential strategy for removing amyloid plaques and improving cognition in Alzheimer's disease.
The EMBO Installation Grants program supports talented researchers in establishing independent research groups across Europe. The grants provide financial assistance, networking opportunities, and practical support to help scientists advance their research.
Researchers found that CHD1-depleted human prostate cancer cells are hypersensitive to DNA breaks and chemotherapeutic drugs, including PARP inhibitors. This suggests CHD1 as a potential biomarker for targeted prostate cancer therapy.
Researchers Richard Benton and Ben Lehner received the 2016 EMBO Gold Medal for their groundbreaking work on insect olfaction and developmental biology. They discovered novel genes in odorant receptors, shedding light on the evolution of scent perception, and revealed stochastic variances in gene expression driving phenotypic diversity.
EMBO has elected 58 outstanding scientists as new members, including Adam Antebi and George Fu Gao, in recognition of their groundbreaking research. The organization aims to support talented researchers at all stages of their careers and promote international collaboration.
A new biomarker of brain inflammation in early-stage Alzheimer's disease has been identified, indicating that microglia-mediated inflammation may demarcate the transition from preclinical to full dementia. The TREM2 protein fragment in cerebrospinal fluid levels closely mirror microglia activity during the course of the disease.
Fiona Watt receives the 2016 FEBS | EMBO Women in Science Award for uncovering mechanisms controlling mammalian epidermal stem cell renewal and differentiation. Her work also investigates the role of inflammation, physical forces, and epigenetics in skin stem cell behavior.
Researchers discovered a direct link between Wbp2 and progressive high-frequency hearing loss in mouse models and human clinical cases. The study found that Wbp2 expression loss leads to reduced hormone receptor expression and hearing impairment.
Andrea Ballabio and John Diffley receive the 2016 Louis-Jeantet Prize for Medicine for their pioneering work on lysosomal function and its significance in diseases such as neurodegenerative disorders, cancer, and obesity. Their research could lead to new therapeutic tools for treating human diseases.
Researchers have identified the KLF4 protein as a crucial regulator in the development of Cerebral Cavernous Malformation (CCM), a disease characterized by vascular lesions that can lead to cerebral hemorrhage. The study suggests that blocking the development and progression of CCM could prevent mortality due to brain hemorrhage.
EMBO has selected 23 young researchers as its latest cohort of Young Investigators, representing ten countries and covering various fields of research. The programme offers benefits such as funding, access to core facilities, and professional development opportunities to support their careers.
A study in mice reveals that specific brain areas control paternal versus infanticidal behavior. The activation patterns of these areas determine whether a male mouse will show caring or aggressive behavior towards newborn pups. This discovery could have implications for understanding societal problems such as child-directed aggression...