Researchers discovered that circVAPA modulates the miR-377-3p and miR-494-3p/IGF1R/AKT axis to promote SCLC progression. CircVAPA depletion enhances the inhibitory effects of an IGF1R kinase inhibitor, providing a potential therapeutic strategy.
Researchers investigated quantum fluid dynamics at extremely low temperatures, revealing vortices undergo 'superdiffusion' before transitioning to normal diffusion. The study's findings provide a new way to understand complex quantum turbulence and its underlying laws.
The TCT MedTech Innovation Forum brings together clinicians, entrepreneurs, investors, payors, and regulators to identify clinical challenges and opportunities for innovation in cardiovascular care. The forum aims to shape the future of patient care through informed discussion and real-world insight.
Researchers at UChicago have created a 'quantum flute' that can coerce particles of light to interact with each other in a way never seen before. This breakthrough has the potential to simplify complex quantum computations and enable new forms of error correction in quantum computers.
Researchers discovered that hippocampal place cells represent direction and distance to a goal in addition to current location. A vector field provides signal towards the goal, aiding flexible navigation.
A new gene therapy for sickle cell disease was tested in mice but proved ineffective due to the complex genetic make-up of the Berkeley mice. The study suggests that researchers should carefully consider the genetics of the mice used to test human diseases.
The American Broncho-Esophagological Association has established new standards for swallowing fluoroscopy, providing a comprehensive guide for clinicians to improve patient care. The guidelines cover areas such as patient selection, fluoroscopic study choice, radiation safety, and training requirements.
A study found that one in three children with asthma are readmitted to hospital, with most presentations being preventable. Gaps in care and lack of follow-up appointments contribute to high readmission rates. Interactive digital symptom monitoring and community-based education programs can help reduce readmissions.
A new study finds that climate variables like temperature, rainfall, and ocean warming predict mosquito population growth in Sri Lanka for the next one to six months. The research can inform programs to limit dengue transmission, a major public health problem in the country.
Researchers have designed a new vaccine candidate using bacterial vesicles coated on gold nanoparticles to deliver antigens and stimulate an immune response against tuberculosis. The use of outer membrane vesicles has shown promise in inducing a better immune response compared to traditional subunit vaccines.
Astrocytes in the thalamus play a key role in susceptibility to seizures after brain injuries. Targeting a specific protein, GAT3, in these cells may prevent long-term damage.
The relaunched National Clinical Impact Awards (NCIAs) are seen as a missed opportunity to create a more inclusive and team-based recognition system. Critics argue that the scheme still focuses on individual achievements, potentially perpetuating existing inequalities in the NHS workforce.
Using nearly two decades of research and ultrabright X-ray beams, scientists have created a detailed structural map of the nuclear pore complex (NPC), a key regulator of cellular operations. The results provide significant implications for understanding disease mechanisms and developing new treatments.
Researchers at Duke University have developed a new design for plasmonic metasurfaces that greatly expands their frequency range while also making them more robust against the elements. The new fabrication process allows for the use of a wide variety of shapes, opening up new possibilities for applications such as super cameras.
A new theory suggests that lack of perceived safety in marginalized communities can have a direct impact on physical and mental health. This concept challenges decades-old thinking that minority stress is the primary cause of health disparities in the LGBTQ community.
A multicenter study found that radiologists can accurately diagnose rickets and classic metaphyseal lesions (CMLs) with high interobserver agreement and diagnostic performance. The study highlighted the importance of considering age factors in diagnosis, as CMLs mostly occur in children younger than 6 months.
Researchers at MIT and Weizmann Institute of Science visualize electron vortices in ultraclean tungsten ditelluride, confirming theoretical predictions. The observation could lead to more efficient next-generation electronics by reducing energy dissipation.
Researchers from Tianjin Medical University General Hospital review sarcopenic obesity's impact on liver disease, including nonalcoholic fatty liver disease and cirrhosis. The study aims to clarify the pathogenesis of sarcopenic obesity and identify potential therapeutic avenues.
Fossil frogs died during mating due to drowning as they were submerged by one or more males. The study suggests that the mating behaviours of modern frogs are ancient and have been in place for at least 45 million years.
Scientists at Brown University used functional MRI to reveal a brain pathway that processes light-intensity signals, which can modulate the prefrontal cortex and affect mood. The study found that light suppresses activity in the prefrontal cortex in proportion to its intensity.
A team of WVU researchers has developed a biodegradable composite material using cotton fibers from recycled mattresses, with the goal of replacing single-use plastics. The new material will be created through 3D printing and can be used to produce various consumer products, such as beverage straws and disposable packaging.
A recent study by UNC-Chapel Hill biologists reveals the crucial link between benthic cyanobacterial mats and coral Black Band Disease, a pressing conservation concern. The researchers suggest mitigating strategies to reduce its spread and highlight the importance of monitoring reef cover of cyanobacterial mats for effective management.
Research led by the University of Otago found a strong association between skin infection and rheumatic fever, highlighting the importance of treating skin infections in young children to prevent rheumatic fever. The studies also revealed barriers to accessing primary health care and a family history of rheumatic fever as risk factors.
Researchers have discovered a selfish genetic element, known as Segregation Distorter (SD), that skews genetic inheritance. SD has caused dramatic changes in chromosome organization and genetic diversity, leading to the accumulation of deleterious mutations.
Research from Penn State and Michigan State found paternal depression symptoms associated with adolescent depression and behavior problems, even among non-genetically related families. Parent-child conflict was a key factor contributing to these effects.
Researchers highlight need for stronger integration of international negotiations to protect the ocean. They emphasize the importance of the ecosystem approach and regional environmental management plans in achieving a more cohesive global governance solution.
A study by University of Illinois researchers reveals that a vaccine and virus can infect the same cells in living animals, sharing molecular tools to spread. The findings should inform vaccine design to eliminate potential attributes that help viruses spread.
A team of researchers has developed a process that can recycle carbon dioxide into fuels and useful chemicals using only solar energy. The new technology uses semiconductor nanowires to split carbon dioxide molecules, producing syngas, a precursor for various fuels and chemicals.
Outpatient antibiotic management of selected patients with appendicitis is safe, allowing many to avoid surgery and hospitalization. This treatment approach is associated with fewer serious adverse effects compared to hospitalization.
Researchers at Medical University of Vienna discovered that inhibiting the S100A9 systemically can reduce psoriasis severity, paving the way for a paradigm shift in treatment. The study also highlights the importance of modulating neutrophil infiltration and its impact on skin and joint disease.
A modeling study estimates COVID-19 vaccination prevented significant number of infections, hospitalizations and deaths among vaccinated US adults from December 2020 to September 2021. The study found 27 million SARS-CoV-2 infections, 1.6 million hospitalizations, and 235,000 deaths were averted through vaccination.
A new study finds that climate warming could deepen environmental injustice in urban areas, with extreme heat events leading to increased labor losses and economic burdens. Plausible adaptation strategies like green roofs and cool walls can help mitigate these impacts and reduce income inequality.
Researchers at NIST found that gecko setae are coated in an ultra-thin layer of lipids, which repel water and help maintain grip on wet surfaces. This discovery could lead to the development of biomimetic products, such as gecko boots or gloves for improved traction.
A study found that Omicron's neutralization capacity outperforms its predecessors, even in vaccinated individuals. Antibody levels against ancestral SARS-CoV-2 are roughly 10 times higher in vaccinated people than those with natural immunity.
Researchers analyzed the Hunga Tonga-Hunga Ha'apai volcano's eruption to understand its effects on atmospheric waves. The blast provided an unprecedented view of atmospheric waves, allowing scientists to better predict the weather and climate.
Researchers developed a novel convolutional neural network for facial expression recognition, outperforming conventional models while being computationally less expensive. The new model achieved an accuracy of 72.4% using only 58,000 parameters.
A new UCLA study found that transgender patients who underwent gender-affirming facial feminization surgery reported higher scores in seven measures of psychosocial health, including anxiety, depression, and positive affect. The study suggests that facial feminization surgery is an important procedure for treating gender dysphoria.
Research found that hunger is strongly associated with feelings of anger, irritability, and lower levels of pleasure. The study tracked participants' emotions and hunger levels over 21 days, finding a significant link between hunger and negative emotional states.
Experimental study finds large DNA insertions caused by retrotransposition can increase cancer risk in human cells edited with CRISPR/Cas9. In contrast, base editing and prime editing show much lower rates of retrotransposition.
The review highlights the importance of intrinsically flexible electrode materials, organic semiconductors, dielectric materials, and electroluminescent devices for intrinsically flexible displays. Current strategies focus on designing polymer chains, controlling molecular weight, and blending with elastomer polymers.
The study reveals uterus transplant outcomes are safe for the recipient, living donor, and child, making it a potential solution for women struggling with uterine-factor infertility. Uterus transplants may be a viable option for these individuals, offering a chance to conceive and carry a pregnancy.
Scientists have found a new phenomenon where an atomic switch has to be switched back and forth four times to return to its original state. The spin of gadolinium atoms performs one full rotation during this process. This discovery opens up possibilities for material physics and could potentially be used to store information.
A team of UCI biologists finds that interleaving old information with new knowledge helps artificial neural networks retain long-term knowledge without catastrophic forgetting. This discovery holds potential for tackling cognitive issues and improving algorithm efficiency in various applications.
A new study published in the Journal of Obstetrics and Gynecology found that having sex less often during menopause is not associated with an increased risk of developing sexual pain. Women who maintain or increase their sexual frequency do not appear to be at higher risk for developing sexual pain, according to the study.
Researchers from the Max Planck Institute for Chemical Ecology elucidate the complete biosynthetic pathway of strychnine, a highly toxic alkaloid used as rat poison. The study reveals that the conversion of prestrychnine to strychnine occurs spontaneously, without an enzyme.
A study found that patients and their caregivers agreed on the severity of physical symptoms like pain and functionality, but disagreed on psychological symptoms like depression and anxiety. The researchers also noted that caregivers who were under stress overreported their patient's symptoms.
A study reveals how consumer DNA testing is changing the way people seek information about genetic relatives in donor conception, including ethnic estimates and tracing half-siblings. The widespread availability of commercial DNA databanks is transforming the landscape of donor conception.
The CCNY team, led by Ronald Koder, has developed a novel protein-based detector for the deadly nerve agent VX. The detector can detect VX in real-time without false positives from insecticides.
Using concentrated sunlight, a team of researchers from Sandia National Laboratories successfully roasted green chile, achieving comparable results to traditional propane roasting. The study found that solar power reduces greenhouse gas emissions by 2.68 pounds per 22 pounds of green chile roasted.
A new study by the University of Exeter found that people's perceptions of crime prevalence can significantly impact their legal judgments, with women and men holding different views on the frequency of certain crimes. The research emphasizes the importance of addressing these biases to ensure more informed verdicts.
Researchers uncover brain area responsible for driving action and suppressing drive in a novel task designed to study active action suppression. The team identified the dorsomedial striatum as the key region promoting action, while the indirect pathway suppresses it, leading to an 'impulsivity switch'.
A new imaging technique allows scientists to study mRNA molecules in the brains of living mice, revealing insights into how memories are formed and stored. The research could provide new information about diseases like Alzheimer's and help understand the process of memory generation and retrieval.
Researchers investigate regulatory frameworks governing preimplantation genetic testing in Japan, the UK, and Western Australia. The study highlights the need for a multidisciplinary approach to evaluate disease severity and make informed decisions about treatment.
The study reveals how the EGF receptor changes its shape when binding to its target, triggering cell growth and proliferation. The findings could lead to the design of new cancer drugs that evade resistance, says MIT chemist Gabriela Schlau-Cohen.
Researchers assessed total medical and out-of-pocket costs for genital gender-affirming surgery, finding that costs differed between procedures conducted in- and outside the patient's state of residence. The study aimed to provide a more comprehensive understanding of the financial burden of this type of surgery.
This study identified QNE1 as a key flowering regulator in soybeans, controlling the length of the vegetative period. The researchers found that QNE1 and another gene E4 regulate flowering time through different mechanisms, enriching knowledge of flowering gene networks.
A new study found that opioids like morphine can cause gastric inflammation due to increased acid secretion and delayed gastric emptying. Treatment with naloxone or proton pump inhibitors like omeprazole may provide gastroprotection, improving pain management and reducing side effects.
A cross-sectional study of 885 surgical residents revealed that trainees perceived as white received similar autonomy, while those perceived as African American, Black, Hispanic, or Latinx experienced disparities. Autonomy differences were negligible by the end of residency.
The study recommends a multi-layered approach to mitigate the impact of gas and oil production operations on communities and the environment. Reducing new drilling and properly discontinuing active and inactive oil and gas wells is considered most effective in eliminating environmental stressors.
Researchers developed a lidar-based system for smart cars to recognize objects more accurately than cameras. The system uses a grid map to divide the field of view into regions containing individual objects.