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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Plants vs. disease: 'Trench warfare at the molecular level'

Researchers have learned that Pseudomonas syringae attacks healthy tomato plants by attaching itself to the plant cell, inserting a microscopic tube and sending a pathogenic protein into the cell. The plant cell detects alien proteins and mounts a defense using a molecular surveillance system.

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Key DNA enzyme can tolerate more mutations than expected

A new study reveals that a commonly used DNA polymerase can withstand an unprecedented number of mutations without compromising its function. Researchers have identified 8,000 active mutant forms, which may have significant implications for understanding evolution, cancer research, and the development of new biotechnological applications.

Unique study reveals new details on how genes are transcribed

Researchers have observed RNAP molecules possessing intrinsic transcription rates and propensities to pause and stop. The study provides new insights into how genetic expression in cells may be regulated, suggesting a kinetic competition between transcription and pausing.

DNA: A sloppier copier

Scientists have discovered a highly error-prone DNA copying system in bacteria that causes genetic mutations under ultraviolet radiation. This 'sloppier copier' reveals how cells can intentionally introduce mistakes to survive and evolve.

Kestrel 3000 Pocket Weather Meter

Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.

Researchers suggest new mechanism to explain DNA charge transfer process

A research team suggests that electronic charge transfer in DNA occurs through temporary distortions in its structure, creating a 'polaron' that carries the charge. This process can help scientists understand DNA damage and repair mechanisms, leading to potential applications in diagnostic techniques and micromachines.

Antibiotics-resistant bacteria

Scientists at the Weizmann Institute discovered that bacterial DNA forms a crystalline organization when exposed to stress, providing effective protection against oxidative agents and starvation. This finding may lead to the development of more efficient methods to fight bacterial diseases.

Wistar Scientists Gain Information About Molecular Recognition

Researchers at The Wistar Institute have identified a new mechanism of molecular recognition in which proteins regulate DNA transcription through asymmetric binding. This discovery sheds light on how homodimeric transcription factors can recognize their target DNA and has potential implications for drug design.

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Secrets Of The S.O.S Repair Service

Researchers at the Weizmann Institute of Science have revealed the molecular repair mechanism known as S.O.S. repair, which fixes DNA damage and introduces random genetic material to create a beneficial mutation. This discovery provides new insights into diseases like cancer and bacterial resistance to antibiotics.

Saliva: Your Spitting Image

Scientists have discovered that saliva can be used as a source of DNA for genetic testing, with the potential to identify individuals at risk of certain diseases. This non-invasive method has significant implications for disease screening and diagnosis, particularly for children who may not be able to give blood.

Endoscope May Have Transmitted Tuberculosis

Researchers discovered identical DNA fingerprints in bacterial cultures from two TB patients who were bronchoscoped at the same hospital. The study emphasizes the importance of maintaining TB DNA fingerprint registries to identify unsuspected transmission modes.

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