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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Does evolution select for faster evolvers?

New research by Rice University scientists reveals that horizontal gene transfer (HGT) contributes to the speed of evolution, allowing life forms to adapt faster. The study proposes a mathematical model that accounts for HGT and its impact on the dynamics of evolution.

Stealth technology maintains fitness after sex

Researchers discovered a new type of DNA parasite that can increase the spread of antibiotic-resistant bacteria. The 'stealth' plasmid produces a protein that helps it survive and thrive in bacteria, making it harder to eradicate with antibiotics.

McBride shows DNA detective work with paper-eating bacteria that 'glide'

A recent study analyzes the genome of Cytophaga hutchinsonii, a bacterium that efficiently breaks down cellulose. The research suggests a possible connection between motility and cellulose digestion, which could lead to more efficient conversion of cellulose into ethanol for bioenergy production.

Study finds the air rich with bacteria

A recent study conducted by scientists from the Lawrence Berkeley National Laboratory found an innovative DNA test to catalog airborne microbes. The research revealed a diverse bacterial population in Texas cities, which could aid in bioterrorism surveillance and climate change tracking.

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Researchers report initial success in promising approach to prevent tooth decay

Researchers have created a new smart anti-microbial treatment called STAMP that can selectively target and kill cavity-causing bacteria without harming good bacteria. The treatment uses a specific pheromone to locate the bacteria and an anti-microbial bomb to eliminate it, offering a promising approach to preventing tooth decay.

Bacteria that use radiated water as food

Researchers found a self-sustaining community of bacteria that rely on radioactive uranium to convert water molecules into usable energy, living 2.8 kilometers below Earth's surface. The discovery expands Earth's biosphere and raises excitement about the potential for life on Mars.

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Caterpillars tell us how bacteria cause disease

Researchers have discovered a way to sort through large numbers of bacterial gene sequences by testing them in caterpillars, allowing pinpointing of virulence genes. The new technique, Rapid Virulence Annotation (RVA), is helping bridge the knowledge gap in post-genomic era.

UA researchers find smallest cellular genome

Scientists found that the bacterium Carsonella ruddii has the fewest genes of any cell, with only 182 protein-coding genes in its tiny genome. This discovery provides new insights into bacterial evolution and suggests that some genes may have been transferred to the insect's genome.

Scientists use an 'ice lolly' to find polar bacteria in their own backyard

Researchers have developed a technique to isolate bacteria that interact with ice, leading to the discovery of species with properties such as Ice Recrystallisation Inhibition (IRI) and temperature-modifying abilities. These findings hold potential for applications in industries like snow-making and waste-water purification.

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Study illuminates how the plague bacteria causes disease

Researchers found that Yersinia bacteria harbor a protein called YpkA, which mimics an enzyme and blocks the host cell's ability to change shape and move. This discovery sheds new light on the factors that make Yersinia a deadly disease-causing agent.

Protein clue to tailor-made antibiotics

Scientists at the University of York have discovered a critical element in the mode of action of DNase colicins, which kill cells by destroying their DNA. Understanding this mechanism could lead to the development of new, targeted antibiotics.

The Midas Bug -- the bacterial alchemy of gold

New research published in Science reveals that specific bacteria present on gold grains precipitate gold from solution, providing a biological mechanism for gold formation. The study identified the bacterium Ralstonia metallidurans as responsible for this process, which has significant implications for the mineral exploration industry.

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Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.

Irradiation preserves T cell responses in bacterial vaccine

Researchers developed a vaccine using irradiated Listeria monocytogenes bacteria, providing better protection against disease than traditional heat-killed vaccines. The irradiated vaccine retained the ability to activate the immune system through Toll-like receptors, promoting long-term immunity.

Molecular DNA switch found to be the same for all life

Researchers have identified a common molecular machinery for initiating DNA replication in all three domains of life: Archaea, Bacteria, and Eukarya. This finding suggests that DNA replication is an ancient event that evolved millions of years ago.

The structure of a virus infecting bacteria resembles a human virus

Researchers have discovered a bacteriophage with a structure similar to human rotavirus, providing new information on the formation of viral particles and genetic distinction. This finding sheds light on the evolutionary origins of viruses, which likely share common ancestors across species.

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Technique speeds up detecting, treating wound bacteria

Researchers have developed a new technique to detect and identify wound bacteria, significantly reducing the time it takes for lab personnel to figure out what type of bacteria is present. This allows for more accurate treatment to begin sooner, which can help prevent antibiotic resistance.

DNA: Bacteria's survival ration

A recent study found that bacteria can utilize DNA as a critical food source, enabling them to outcompete other microbes and survive longer. The study identified eight genes necessary for this process, known as nutritional competence, which could have applications in medical research and the development of genetic antibiotics.

Proteus mirabilis will give up its genetic secrets at ASM meeting

Researchers have gained insights into the genetic mechanisms of Proteus mirabilis, a bacterium causing kidney stones and complicated urinary tract infections. The complete genome sequence, including 3,693 genes and 4.063 megabases of DNA, will help scientists identify potential targets for new vaccines.

Ready, set, mutate… and may the best microbe win

Rice University researchers capture natural selection in a flask using bacteria G. stearothermophilus. The study reveals that only six populations with specific mutations can outcompete others, pointing to the development of a system to predict antibiotic resistance.

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Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.

First link of oral bacteria and preterm birth found in human

Researchers discovered a link between oral bacteria and preterm birth, finding Bergeyella bacteria in the amniotic fluid of pregnant women. This pilot study suggests that oral bacteria may play a role in premature deliveries, which can lead to health challenges for babies and increased medical costs.

Mars meteorite similar to bacteria-etched earth rocks

A Mars meteorite containing tiny burrows has been discovered, sparking interest in the search for life beyond Earth. The discovery, published in Astrobiology journal, suggests that Martian rock formations may be similar to those created by bacteria on Earth.

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Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.

Science class experiment reveals vitamin B12 secret

Researchers led by Graham Walker discovered a mutant bacteria with a specific defect in the bluB gene involved in B12 synthesis. By analyzing mutations, they tracked molecular details of how bacteria provide nutrients to plants.

Flesh-eating bacteria escape body's safety net

Researchers at UCSD have found that disease-causing Strep bacteria release an enzyme that degrades neutrophil DNA nets, allowing them to escape the immune system and spread in body tissues. This discovery could lead to new treatments by inhibiting this enzyme, making it easier for the immune system to clear the pathogen.

Ticks, flukes, and genomics: Emerging pathogens revealed

Scientists have sequenced the complete genomes of three emerging pathogens causing ehrlichiosis, a disease affecting humans, dogs, cattle, sheep, and other animals. The study identified new genes allowing bacteria to evade immune systems and adapt to new niches.

When good DNA goes bad

A study at the University of Texas M. D. Anderson Cancer Center found that Z-DNA, a twisted shape of DNA, can cause genetic instability and breaks in human cells, particularly in those with Burkitt's lymphoma. The research opens up a new field of inquiry into the role of DNA shape in genomic instability and cancer.

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Unraveling the viral mechanism

Researchers have made a breakthrough in understanding how viruses infect cells using cryoelectron microscopy and computational methods. The study reveals the importance of proteins beyond the surface shell in binding to host cells, injecting DNA, and packaging it during virus formation.

Biologists build better software, beat path to viral knowledge

A team of biologists developed improved software to analyze virus structures, revealing new details about the Epsilon 15 virus that infects salmonella. The advancements enable scientists to observe previously invisible features, including non-symmetric components and a core with unknown function.

HIV prevention hope: Yogurt bugs that make antiviral drugs

Scientists have successfully engineered lactic acid bacteria to produce a viricide that disables HIV, paving the way for potential use as a microbicide. The genetically modified bacteria will be tested in monkeys this summer, with human trials planned for three years.

Polymer aids in blood clotting, pointing way to new treatment

Researchers have discovered that polyphosphate accelerates blood clotting and delays its breakdown, leading to longer-lasting clots. The Center for Hemostasis Research at the University of Illinois will continue to study this discovery to develop effective treatments for uncontrollable bleeding.

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Researchers uncover E. coli's defense mechanism

Scientists discovered a bacterial defense mechanism that reduces nitric oxide levels in response to the toxin, allowing bacteria to fend off the body's defenses. The NorR protein plays a crucial role in this process, and researchers hope to develop new antibiotics by disrupting this mechanism.

Antibiotic resistance markers in GM plants not a risk to human health

A review by Stephen Gillespie and Philippe Gay finds no evidence of antibiotic resistance from GM crops being transferred to bacteria, which would be dwarfed by the impact of human antibiotics use. The authors conclude that while it's possible for transfer to occur, its contribution to antibiotic resistance is low.

Clearing jams in copy machinery

Two DNA polymerases, Pol III and Pol IV, coordinate their action to cross obstacles in the replication process. Pol III copies DNA while proofreading for errors, but can stall if it encounters a problem, allowing Pol IV to take over.

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Aranet4 Home CO2 Monitor

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Combating antibiotic resistance

Researchers propose that antibiotic-mediated DNA damage triggers a bacterial repair mechanism, increasing the likelihood of mutations leading to antibiotic resistance. Blocking this pathway could provide a promising strategy for controlling the spread of superbugs.

PNAS highlights for the week of April 25-29

Differences in UV perception allow songbirds to signal with private communication, while chestnut trees go silent during winter due to circadian clock gene regulation. A fungus has an energy-generating mechanism similar to bacteria, enabling it to harness light for proton pumping

Whale bones and farm soil: Sequencing biodiversity

Researchers analyzed whale skeletons and farm soil using metagenomics, discovering specialized bacteria that thrive in these environments. The study provides a new understanding of the diversity of microbial life on earth, with potential applications in fields such as agriculture and medicine.

Anammox bacteria produce nitrogen gas in oceans' snackbar

Researchers discovered anammox bacteria in Atlantic Ocean, removing ammonium and releasing nitrogen gas, contradicting decades-long theory. The new findings have significant implications for the global nitrogen cycle, models of climate predictions, and marine ecosystems.

Apple MacBook Pro 14-inch (M4 Pro)

Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.

Chemical engineer Kao explores antibiotic synthesis with DNA chips

Kao's research uses DNA microarrays to measure gene expression and identify a mutation that increases the production of erythromycin by five days. By recreating this mutation, she aims to develop new antibiotic-producing bacteria, revolutionizing the field of antibiotic synthesis.

Miniaturized lab permits saliva screening on the go

Researchers have developed a miniaturized lab that can detect HIV and bacteria in saliva using a portable oral swab kit. The device analyzes samples quickly and accurately, making it useful for rapid response situations such as bioterrorism incidents or emergency room emergencies.

Time to rewrite the species rulebook, MSU scientists say

Researchers at Michigan State University have found significant differences in genetic libraries among bacteria strains previously thought to be similar. The study suggests that current definitions may need revision as many bacteria share as few as 65% of their genes, highlighting the importance of ecological distinctiveness.

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GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.

Differences in gene usage dramatically change bacteria's 'lifestyles'

Scientists found significant differences in Salmonella and E. coli's use of a gene linked to processes that govern antibiotic resistance, altering their ability to survive in different environments. The study suggests that understanding such changes will help develop new treatments for disease-causing microorganisms.

Random gene activation helps ulcer bug escape immune system

Researchers discovered a new mechanism by which Helicobacter pylori bacteria can stick to stomach cells, allowing them to survive a strong immune response. By recombining DNA from two related genes, the bacteria can create a functional BabA gene, enabling it to bind tightly to Lewis B receptors.

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New quick test for drug-resistant strains of gonorrhea

A new quick test has been developed to detect drug-resistant strains of gonorrhea by identifying genes linked to resistance in urine samples or leftover products from other diagnostic techniques. The test uses probe technology to simplify analysis of samples that cannot be used for culturing organisms.

Bug's-eye-view of urinary tract reveals E.coli infection genes

Scientists have identified 313 up-regulated and 207 down-regulated E.coli genes in mouse urine, revealing new insights into bacterial growth and virulence factors. The study provides valuable information on growing conditions and could lead to more effective treatments for urinary tract infections.