Articles tagged with Bacterial Pathogens
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Scientists at Université de Genève found a novel regulatory mechanism in the HigBA toxin-antitoxin system that can selectively kill bacteria when they suffer from DNA damage. This discovery could lead to new treatments for bacterial infections by forcing bacteria to turn their weapons against themselves.
A new Penn study reveals that fish induce production of a specific antibody, IgT, in response to pathogen exposure on their gills. The researchers found that IgT coats the microbiota in the gills, helping control the community of friendly microbes.
Researchers have provided a molecular blueprint of Globomycin, an antibacterial candidate with promise in stemming the post-antibiotic tide. The blueprint may aid the design of better globomycin analogues and explore thousands of new antibiotic solutions to common infections.
The study reveals novel adaptations and traits in infectious species of Leptospira that help illuminate its evolutionary history and provide new preventive and treatment approaches. It identifies key pathogen-specific features, including the CRISPR-Cas genetic machinery, which are unique to pathogenic Leptospira.
A critical discovery about how bacteria feed on an unusual sugar molecule found in leafy green vegetables could hold the key to explaining how 'good' bacteria protect our gut and promote health. Leafy greens are essential for feeding good gut bacteria, limiting the ability of bad bacteria to colonise the gut.
Researchers found that certain bacteria, including Francisella tularensis and Salmonella enterica, can spread rapidly throughout the body by interacting with immune cells called macrophages. This process, known as trogocytosis, allows bacteria to evade detection and survive inside infected cells.
Researchers found that urban homes have more human bacteria, such as Streptococcaceae and Lactobacillaceae, while rural homes have higher proportions of environmental bacteria like soil species. This shift could contribute to immune disorders like asthma and obesity in the industrialized world.
The INNUENDO project aims to integrate whole genome sequencing into routine surveillance and outbreak investigations, addressing the need for accessible IT frameworks and expertise. The cross-sectorial framework will standardize process, simplify data analysis, and enhance public health microbiology capabilities.
Researchers at Princeton University discovered the mode of action of antibiotic tropodithietic acid (TDA), revealing its ability to kill cancer cells. TDA's unique mechanism involves disrupting cell membrane function, rendering it a potential anticancer agent.
Researchers identify RimK as a crucial regulator of bacterial movement, which is essential for initiating infections. Disabling this protein significantly reduces the ability of bacteria to infect plants and humans, offering a new target for anti-infective drugs.
Researchers have discovered a natural clay deposit that exhibits strong antibacterial activity against the ESKAPE group of bacterial pathogens, including MRSA and other antibiotic-resistant strains. The clay, named Kisameet clay, has been used for centuries by indigenous communities to treat various ailments.
Researchers found that antiperspirant and deodorant significantly influence the type and quantity of bacteria on human skin. The study revealed a drastic shift in microbial ecosystems when participants used these products.
Research provides new insights into Group A Streptococcus by demonstrating its toxin, Streptolysin S, targets a specific protein on red blood cells, leading to hemolysis. Chemical inhibition of this protein reduces the toxin's activity and alters the pathology of GAS in skin infections.
The BARDOT technology uses optical scattering techniques to create a unique 'fingerprint' pattern for each pathogen, eliminating the need for reagents. This innovation has shown great promise in identifying dangerous pathogens such as Listeria, Staphylococcus, Salmonella, Vibrio, and E. coli.
Researchers found that ancient medicinal clay exhibits potent antibacterial activity against ESKAPE strains of bacteria, including Enterococcus faecium and Staphylococcus aureus. The rare mineral clay may provide a new treatment option for serious infections caused by these resistant pathogens.
A recent study published in Journal of Molecular Medicine found that e-cigarette vapor boosts bacterial virulence and inflammation, suppressing the human immune system. The research also revealed that exposure to e-cigarette vapor increases the risk of bacterial infections and suppresses lung function.
Researchers found that the bacterium Yersinia pestis persisted in Europe, causing repeated devastating waves of plague epidemics. The discovery sheds light on the evolutionary history of the pathogen and its potential role in modern-day antibiotic resistance.
A team of biologists at UC San Diego has developed a new method to determine if bacteria are susceptible to antibiotics within a few hours. The approach allows doctors to rapidly identify the appropriate treatment for patients with life-threatening bacterial infections, potentially slowing the emergence of drug resistance.
A new machine-learning technique, denoising autoencoder, uncovers previously unknown gene-expression patterns in P. aeruginosa, a notorious pathogen resistant to standard antibiotic therapies. The system identified characteristic patterns in response to antibiotics and low oxygen conditions.
The grant will explore various dosing regimens of daptomycin, a lipopeptide antibiotic, to treat vancomycin-resistant Enterococcus faecium (VREfm) bacteria. The research aims to prevent resistance development and improve treatment outcomes for patients with life-threatening infections.
Researchers at Washington University in St. Louis have identified a virulence factor secreted by the bacterium Acinetobacter baumannii, which is resistant to traditional antibiotics. The discovery could lead to the development of new antivirulence antibiotics that can suppress pathogen growth without eliminating susceptible bacteria.
Scientists uncover the structural and functional properties of the BabA protein, which adapts to different ABO blood group sugars in humans. The discovery provides perspectives on developing drugs that disrupt bacterial attachment and eradicating Helicobacter pylori infections.
A UBC study found that rats can absorb disease agents from their environment and spread them, posing a significant health threat to both poultry and humans. The researchers discovered avian pathogenic E. coli in the feces of farm rats, with over one quarter carrying multidrug-resistant strains.
Researchers found that bacterial growth and biofilm formation depend on fluid flow and space shape. Fluid flow can interfere with quorum sensing, affecting disease-causing bacteria behavior.
Researchers found that short-term exposure to different outside host resource types and concentrations affects Serratia marcescens' virulence in Galleria mellonella-moth. This suggests that even genetically similar bacteria can differ in their virulence depending on the source of nutrients.
A Georgia State University researcher is investigating how the adaptive immune system can control intestinal bacteria to prevent inflammation in the gut. The project aims to identify a way to activate the mucosal immune system to reduce levels of bacteria with high potential to promote inflammation.
Researchers found that if groups of targeted cells are large enough, the bacterial superweapon T6S can be thwarted. This allows protected interior cells to multiply quickly and replenish the group's numbers, making it impossible for the bacteria to take over. The study provides insight into how cells withstand powerful aggressors.
The NIH has awarded funding for 24 research projects developing non-traditional antibacterials, including therapeutic bacteria and phage therapy, to combat increasing antibiotic resistance. The grants aim to provide new treatment options for deadly infections.
Researchers at Arizona State University have identified the natural environment of formation for toxic clay antibacterial properties. The discovery reveals how chemically reduced iron tricks bacterial cells into opening their walls, followed by aluminum, which propels the cell wall open and poisons the cell.
The study of the Iceman's gut microbes reveals a surprising connection to Asian strains and modern European strains, suggesting that recent human migrations influenced European genetic makeup. The findings also indicate that the Iceman may have been ill before his murder, with high levels of virulence factors in his gut microbiome.
A harmless bacterium found in the nose can inhibit a major cause of pneumonia, meningitis, and other infections. The study provides evidence that Corynebacterium accolens releases antibacterial free fatty acids from human nostrils and skin surface triacylglycerols.
Scientists are exploring the potential of bacteriophages, which target specific bacteria, to prevent and treat intestinal illnesses like Salmonella, Campylobacter, and E. coli in children. The research aims to develop a new approach for treating food poisoning in developing countries.
Researchers at Georgia State University have discovered a critical role for CYLD in controlling the body's inflammatory response to pathogens. This finding could lead to the development of novel anti-inflammatory agents, as traditional treatments like steroids can cause serious side effects.
Researchers have discovered that Bacillus cereus can form small colony variants in response to aminoglycoside antibiotics, making it resistant to these therapies. This alternative lifestyle allows the bacteria to survive harsh conditions and evade traditional diagnostic methods.
Researchers at UGA found that harmful bacteria like salmonella can survive in dry foods for six months or longer, including cookie and cracker sandwiches. The study highlights the need to test all ingredients used in these foods to prevent contamination and outbreaks.
Researchers have discovered a novel receptor in Vibrio fischeri that senses fatty acids, allowing the bacterium to migrate towards these compounds. This finding sheds light on the symbiotic relationship between the Hawaiian bobtail squid and its luminescent bacteria.
Researchers identified a key protein involved in bacterial sugar coating and found a compound that blocks its action, offering hope for new antibiotics. The study's findings may lead to the development of more effective anti-microbials.
A collaboration between computer scientists and geneticists at Stanford University has produced a novel technique for mapping the diversity of bacteria living in the human gut. The new approach revealed a far more diverse community than the researchers had anticipated, with many different strains of the same species identified.
Researchers at Griffith University have made a groundbreaking discovery about how bacteria interact with human cells, revealing high-affinity biomolecular interactions between glycans that were previously thought to be weak or non-existent. This finding opens up new avenues for developing vaccines and drugs to block infections.
Scientists have developed a human-gut-on-a-chip model that allows them to analyze the interactions between normal gut microbes and pathogenic bacteria, providing new insights into inflammatory bowel diseases. The technology has revealed four small proteins that stimulate inflammation, opening up a potential therapeutic pathway for trea...
A new study from Kansas State University reveals that gut bacteria play a pivotal role in the communication system of German cockroaches, facilitating aggregation and reproductive maturation. The research identified specific fecal volatile carboxylic acids that reflect the microorganism contents of a cockroach's gut.
A new method developed by UC San Diego biologists can quickly identify and characterize compounds capable of controlling antibiotic-resistant bacteria in natural product extracts. This breakthrough could shave years off screening efforts and lead to the discovery of new antibiotics, addressing a growing global crisis.
Scientists at the Max Planck Institute found that cooperating bacteria form cell clusters to exclude non-cooperating bacteria from their community. This mechanism stabilizes long-term partnerships without requiring complex recognition of potential partners.
Research reveals how Bdellovibrio bacteriovorus uses an ankyrin-type protein called Bd3460 as a shield to protect itself against its own enzymes. The study found that the protein binds to the tip of the enzyme weapons, nullifying their action until they are safely secreted out of the Bdellovibrio and into the prey bacteria.
Researchers discovered a 'self-protection' protein in predatory bacteria that binds to enzymes, temporarily deactivating them. This mechanism helps Bdellovibrio bacteriovorus protect itself from its own attack while killing other bacteria.
Researchers found that an impaired immune system alters the composition of gut bacteria and affects its evolutionary pace. The study suggests personalized therapies based on individual gut bacteria composition may be more effective than generalist treatments for inflammatory bowel disease.
Researchers at Georgia State University developed novel antimicrobials targeting SecA, a key disease-causing component of bacteria. The study found that these inhibitors can overcome drug resistance and reduce toxin secretion, offering a promising alternative to existing antibiotics for treating MRSA infections.
Researchers have discovered a new strain of Candidatus Neoehrlichia in an Austrian red fox, sparking concerns about potential zoonotic transmission. The bacterium is genetically intermediate between two previously recognized forms and has been linked to flu-like symptoms in humans and pets.
Worcester Polytechnic Institute researchers are using a $1.3 million NIH award to model the use of copper in bacteria to gain advantages in the arms race between bacterial infections and antibiotic drugs.
Researchers at MassGeneral Hospital for Children and MIT will develop pathogen-specific bacteriophages to disarm Shigella flexneri, a cause of millions of infections worldwide. The project aims to create an innovative therapy to protect beneficial bacteria affected by antibiotic treatment.
Researchers at the University of Florida have developed genetically modified citrus trees that exhibit enhanced resistance to greening, reducing disease severity and even remaining disease-free after 36 months. The study, published in PLOS ONE, used a gene isolated from Arabidopsis to create the new trees.
Researchers at U of T discovered genetic mutations in Candida albicans that allow it to defend itself against neighboring bacteria. The fungus has evolved to ignore bacterial signals, potentially becoming a more significant threat to patients with weakened immune systems.
Researchers at UT Southwestern Medical Center have identified a pathogen-sensing molecule called Absent in Melanoma 2 (AIM2) that plays a vital role in maintaining gastrointestinal health. AIM2 detects DNA of harmful microorganisms and regulates inflammation in the gut, which could lead to targeted therapies for inflammatory bowel dise...
A new study reveals helpful bacteria living inside the Asian citrus psyllid affect its ability to spread the citrus greening disease pathogen. The infection alters the insect's metabolism and triggers an immune response, potentially increasing the pathogen's transmission.
A recent study published in Microbiome found that controlling the levels of specific gut bacteria, such as Escherichia, may help prevent severe diarrhea. The research, led by Michigan State University, discovered that patients with certain microbial community profiles had more severe disease.
Researchers discovered that knives and graters can transfer pathogens to produce items, highlighting the importance of proper hygiene. The study found that contamination occurred when utensils were not cleaned between uses, putting consumers at risk of foodborne illnesses.
A mathematical model reveals that competition between beneficial bacteria helps maintain the stability necessary for a healthy gut. By suppressing overabundant bacteria and keeping different species apart, hosts can intervene to maintain this natural balance.
The University of Leicester has been awarded £1.5 million to advance knowledge in three key areas that impact on health. Three groups have won awards led by Professor David Lambert, Professor Marco Rinaldo Oggioni, and Dr Shaun Cowley, investigating sepsis, infection spread, and cancer mechanisms.
Research found that composting is most reliable to kill bacteria with resistance genes in cow manure. Composting speeds up decomposition and reduces volume of manure. Manure management practices like composting and stockpiling can make it difficult for resistant bacteria to travel from farm to environment.
Researchers have determined the structure of a key enzyme in Mycobacterium tuberculosis, which could lead to new drugs for the disease. The discovery provides a potential starting point for developing treatments that target this enzyme.