Articles tagged with Bacterial Pathogens
Researchers at Texas A&M AgriLife Research have discovered a natural cocktail of four bacteriophages that can prevent and treat Pierce's disease in wine grapes. The phage treatment offers an alternative to pesticides for disease control, with promising results in both greenhouse experiments and field testing.
A Michigan State University study found that septic tanks are contaminating freshwater sources with fecal bacteria, threatening water quality and human health. The research used a novel source-tracking method to analyze 64 river systems in Michigan and identified areas with high numbers of septic systems as hotspots for pollution.
Researchers from Arizona State University and other institutions discovered how bees immunize their offspring against specific diseases using the bee blood protein vitellogenin. This process enables bee babies to better fight diseases once they are born, opening doors for creating edible vaccines for insects.
A recent study by IU biologist Farrah Bashey-Visser found that microorganisms are constantly evolving due to competition with other microorganisms, leading to the development of antibiotic-resistant bacteria. This can catch humans off guard, requiring them to play catch-up in treatment efforts.
Researchers at Duke University have discovered the role of HipA in recurring urinary tract infections, finding that mutant versions of the protein can cause multidrug tolerance by putting bacterial cells into dormancy. The study provides a new method for combating drug-tolerant infections.
Researchers at Northeastern University discovered that a specific mutation in the hipA gene leads to persistent E. coli cells in patients with relapsing urinary tract infections, paving the way for customized treatment regimens.
Researchers at Washington State University have found that UVC light can effectively inactivate up to 99.9% of foodborne pathogens on apples and pears, but listeria was more resistant. The technology is simple to implement and inexpensive, making it a promising solution for organic fruit processors.
A research team at the University of California, Davis, has identified a tiny protein called RaxX that helps plants fight off bacterial infections. The discovery could lead to more disease-resistant crop varieties and new treatments for microbial infections in both plants and animals.
Researchers at Joint BioEnergy Institute have identified a bacterial protein called RaxX that activates rice plant's immune response to Xanthomonas oryzaepv.oryzae, the pathogen causing bacterial blight. This discovery has important implications for future grass-type biofuel feedstocks and the worldwide supply of rice.
A study published in Clinical Infectious Diseases found that 47% of grocery store-bought meat products contained Klebsiella bacteria, with many strains resistant to antibiotics. This increase poses a significant risk to human health, particularly for urinary and blood infections.
Researchers discovered a messenger molecule that encourages bacteria to colonize catheters in mice, forming biofilms. The study highlights the importance of understanding biofilm formation to develop more effective therapies for infections like those caused by Pseudomonas aeruginosa.
Scientists at TGen are developing an accurate diagnostic test for Lyme disease using targeted DNA sequencing, which can pinpoint the presence and severity of tick-borne Lyme disease. The new test aims to provide actionable information for physicians and improve treatment outcomes.
Researchers from the University of Surrey have made a breakthrough discovery that the bacteria causing Buruli ulcer disease triggers a blood clot, similar to deep vein thrombosis. This finding suggests that anticoagulant medicines may be effective in treating the disease, leading to faster healing and fewer side effects.
Researchers have discovered that iron regulatory proteins play a crucial role in fighting off infection by controlling iron levels. The study found that mice lacking these proteins died when infected with the Salmonella bacteria, highlighting their importance in immune defense.
Researchers discovered that phytohormones regulate microbial abundance, influencing the composition of root microbiomes. The study found that plants can select and benefit from specific strains of microbes, but also face pathogens that take nutrients and damage plants.
A new study from Vanderbilt University Medical Center found that viruses, not bacteria, are the most commonly detected respiratory pathogens in U.S. adults hospitalized with pneumonia. The study highlights the need for more sensitive rapid diagnostic tests to identify pneumonia pathogens and target appropriate treatments.
A team of scientists from NUS discovered that blue LEDs can effectively kill major foodborne pathogens, especially when combined with chilling temperatures and mildly acidic conditions. This technology has the potential to replace chemical treatments for preserving acidic foods.
NC State engineers have created an effective and environmentally benign method to combat bacteria using silver-ion infused lignin nanoparticles, which effectively kill E. coli and other harmful microorganisms without harming the environment.
Research found that bacteria shapes changed from sticks to spheres to evade the immune system, revealing a key gene responsible for this transformation. This discovery could lead to new tools for preventing and treating respiratory infections.
A team of researchers has identified the first known exopolysaccharide receptor gene in plants, allowing them to distinguish between beneficial and harmful bacteria. This discovery has significant implications for agricultural research and medical science.
A UTHealth researcher has received a $1.9 million NIH grant to study Clostridium difficile infections, which cause diarrhea and inflammation of the colon. The goal is to prevent toxins from being released and make them inactive in the gut without killing good bacteria.
New antimicrobial material could be used as a topical antibacterial treatment and disinfectant, effectively killing biofilms and promoting healing in chronic wounds.
Clostridium difficile, the most common cause of hospital-acquired diarrhea, tightly controls its intracellular iron levels to avoid DNA damage. The pathogen has multiple systems for importing ferrous iron compounds, which are more critical in anaerobic conditions.
A newly discovered human protein called intelectin has the ability to selectively identify and distinguish between human cells and those of disease-causing microbes. This discovery could lead to the development of new antibiotics and strategies to combat infectious diseases.
Researchers found that a single small genetic change enabled Yersinia pestis to transition from causing gastrointestinal infections to respiratory diseases, including pneumonic plague. This discovery may have helped explain how the plague spread globally, leading to devastating pandemics like the Black Death.
Researchers found that human urine's unknown factors interfere with bacterial FimH protein's ability to adhere to cells and switch off pilus production assembly. This exposes a crucial weakness in pathogen's ability to infect, making potential non-antibiotic treatments more effective
Indigo-Clean, a light fixture using Continuous Environmental Disinfection technology, kills harmful bacteria linked to hospital acquired infections. The technology, developed by University of Strathclyde, is now commercially available in the US and Canada, offering hospitals a safer environment for patients.
A team at Harvard's Wyss Institute discovered that bacteriostatic antibiotics slow down oxygen consumption, reducing cellular respiration and making bacteria tolerant. This can explain why certain antibiotic therapies fail. The findings provide a new strategy for developing urgently needed therapeutics.
Researchers discovered that the protein structure of a key membrane protein differs from a previously postulated model, providing a basis for new treatments. The study reveals how the protein pore opens and closes in response to substrate binding, offering insights into the pathogen's attachment mechanism.
Researchers have identified a new potential culprit in colon cancer, Providencia, and found a single signature of colon cancer in the gut microbiome. This discovery could help doctors predict prognosis and identify bacterial changes that affect patient health.
Engineers have created a prototype for real-time listeria bacterial contamination detection, aiming to detect levels as low as one bacteria in a 25-gram sample. The device utilizes nanobrushes that select and capture specific bacteria, mimicking the mechanism used by the Hawaiian bobtail squid's cilia.
Peter Greenberg and colleague Bonnie Bassler's work on quorum sensing has far-reaching implications for medicine and agriculture. Hundreds of bacterial species use quorum sensing to control various things, and the researchers aim to develop novel medicines targeting this process.
A Wyss Institute team is developing genetically engineered bacteria that can sense, report, and combat harmful microbial invaders in the human gut. The team aims to create a probiotic pill form of the microbes that could reduce the length of gastrointestinal illness, returning individuals to their activities sooner.
The research team created a single-molecule, real-time sequencing method to detect and phase DNA methylation in bacteria. They found that individual bacterial populations have distinct subpopulations with different gene expression patterns, which may contribute to increasing antibiotic resistance.
A new screen has identified key environmental signals that modulate bacterial behavior in Salmonella typhimurium, a food-poisoning bacterium. These signals trigger survival tactics and alter biofilm formation.
Researchers found that growing bacteria in mammalian tissue culture media instead of standard bacteriologic media makes them more sensitive to azithromycin. The drug is also effective when paired with colistin or antimicrobial peptides produced by the human body during infection, reducing bacterial counts by up to 99% in mouse models.
A new University of Windsor-led study published in the New England Journal of Medicine found that a sexual assault resistance education program significantly reduced the likelihood of completed rape among first-year university women. The EAAA program, which consists of four three-hour sessions, helped women assess risk, overcome emotio...
A team of researchers from the University of Freiburg has discovered how the toxins of Clostridium difficile bacteria enter the interiors of cells. The surface protein LSR receptor is responsible for binding to the CDT toxin, allowing it to penetrate the cell membrane and exert its lethal effect.
A study by Northwestern University scientists found that a Vibrio vulnificus toxin can inhibit tumor cell growth by cutting the Ras protein, which is central to cell division and survival. The toxin's ability to cleave Ras, rather than modify it, represents a novel mechanism for inactivating this protein.
Researchers have developed a new microscope technique using holographic images and machine-learning software to identify bacterial species at the single bacterium level. The approach has shown high accuracy in distinguishing between pathogenic and non-pathogenic bacteria, promising to reduce treatment time and improve patient outcomes.
A Twin study led by TGen researchers found that a person's environment is more important than their genes in determining nasal bacteria. Some common nasal bacteria may even protect against MRSA colonization, according to the study published in Science Advances.
Scientists from HIPS and HZI discover cyclohexylgriselimycin, a variant of griselimycin, effective against Mycobacterium tuberculosis with low risk of resistance development. The new agent targets DNA clamp, preventing bacterial proliferation and offering potential therapeutic approach to drug-resistant tuberculosis.
Researchers introduce a two-pronged system to combat antibiotic resistance by eliminating genes that cause resistance and conferring protection against lethal phages. The system, based on bacterial viruses called phages, has the potential to turn the tide on untreatable infections.
A study reveals that Obg plays a crucial role in bacterial persistence, allowing certain cells to survive antibiotics. The researchers' findings suggest that targeting the novel persistence pathway could lead to more effective treatment strategies for bacterial infections.
Research found that 90% of bacteria on human skin are either dead or inactive, with different areas harboring varying proportions of metabolically active, inactive, and dead microbes. Activity levels decreased with age, suggesting a possible relationship between the microbiome and immune system function.
A study found that at least 60% of toothbrushes were contaminated with fecal coliforms, even after decontamination methods. The researchers advise better hygiene practices for students who share bathrooms to prevent the transmission of potentially pathogenic organisms.
Researchers at NYU Langone found that contact lens wearers have a diverse set of microorganisms in the eyes that resemble those on their eyelid skin. This study suggests that improved eyelid and hand hygiene may help prevent eye infections
Researchers discovered that bladder cells can physically eject bacteria that invade the host cell, similar to vomiting. This finding may help treat recurring UTIs by eliminating bacterial reservoirs in the bladder cells. The study also identified a potential way to accelerate and amplify this expulsion mechanism using chemical targets.
Researchers found phages in 49 out of 50 chicken samples that can transduce antimicrobial resistance genes to E. coli bacteria, highlighting the need for phage therapy and improved disinfection methods.
Researchers at Georgia State University found that an existing anti-stroke drug, Vinpocetine, is effective in suppressing mucus overproduction and improving bacterial clearance in animal studies. The study could lead to a novel, non-antibiotic treatment for otitis media, potentially reducing hearing loss and enhancing host defense.
E. coli O104:H4 acquired genes through horizontal gene transfer, increasing virulence and antibiotic resistance. The bacterium's genome comprises prophage elements involved in Shiga toxin production.
Researchers at Tel Aviv University have developed a method to preserve milk using short pulsed electric fields, which can kill bacteria and extend shelf life. The technology is energy-efficient and does not require constant electricity supply, making it suitable for use in developing countries.
A study by University of Liverpool researchers reveals that pneumolysin released during Streptococcus pneumoniae infection causes cardiac injury and death. Liposome therapy has been shown to neutralize the toxin, mitigating damage to heart muscle cells.
A Virginia Tech team, led by Amy Pruden and Monica Ponder, is examining the impact of antibiotic use in agriculture on human health. They aim to identify ways to control the spread of antibiotic-resistant bacteria and genes in the food chain.
A study found that repeated schistosome exposure leads to a limited immune response due to the presence of IL-10-producing CD4+ T cells in the skin. These cells help prevent excessive inflammation and allow the parasite to survive by suppressing the immune system.
Researchers at the University of Georgia have found that Tokay geckos harbor bacteria resistant to multiple antibiotics, posing a risk to pet owners. The study highlights the importance of pathogen screening in the pet trade to prevent antibiotic-resistant bacteria from entering households.
A novel antibody, Ab926, has been discovered that can prevent E. coli from attaching to human cell surfaces and also dislodge bacteria already attached. This antibody works by binding to the side of the FimH pocket, rather than directly competing with free-floating mannose.
Researchers at the Institute of Food Research have visualized the structural changes Clostridium spores undergo during germination, which could help control pathogenic bacteria. The study provides new insights into the genetic controls of spore germination and reveals that spores have polarity that aligns structures correctly.
Researchers discovered that certain bacteria can block their own growth and that of resistant mutants, providing a potential new strategy to combat antibiotic resistance. This finding could lead to improved treatments for infections caused by resistant bacteria.
A landmark genomic study reveals a single clade of typhoid bacteria, H58, is driving global spread, displacing other strains and creating a previously underappreciated epidemic. The study highlights the urgent need for global surveillance and coordinated efforts to prevent and control antimicrobial-resistant typhoid.