Articles tagged with Bacterial Pathogens
Researchers have discovered a chestnut leaf extract that blocks Staphlococcus aureus virulence and pathogenesis without detectable resistance. The extract, rich in ursene and oleanene derivatives, shuts down the ability of the bacteria to create toxins by taking away its weapons.
Researchers at TSRI found that Staphylococcus aureus develops resistance to arylomycin by switching on a previously uncharacterized set of genes, bypassing the essential protein Type I signal peptidase. This discovery highlights the built-in redundancies that help bacteria survive in many environments.
The Wyss Institute has developed an improved blood-cleansing device that can treat sepsis by removing pathogens and toxins from the bloodstream. The new device uses a genetically engineered pathogen-capturing protein to bind all types of live and dead infectious microbes, including bacteria, fungi, viruses, and toxins.
Researchers have identified a protein called sigma54 that controls bacterial defenses, including the production of resistant outer coats and defensive structures. Understanding how sigma54 works could lead to the development of new compounds that can kill bacteria, providing a potential solution to antibiotic resistance.
Researchers from the University of Basel's Biozentrum have discovered a mechanism by which FIC proteins send bacteria into a state of dormancy, protecting them from antibiotics. This discovery sheds light on the evolutionary origins of pathogens and their tools, offering new avenues for understanding bacterial evolution.
Researchers have developed an easy-to-implement method to eliminate or reduce cross-contamination in commercial processing facilities that prepare leafy greens for the market. The new approach uses a photocatalyst to kill bacteria, particularly E. coli, which is responsible for many outbreaks.
Researchers have discovered how an emerging class of antibiotics targets bacterial membranes, showing promise in combating superbugs. The study reveals that these antimicrobial lipopeptides form micelles that stick to the bacterial membrane, selectively killing cells while sparing mammalian host cells.
Researchers identified the molecular mechanism behind H. pylori's adhesion protein using powerful x-rays, revealing a specific 'groove' that enables attachment to stomach sugars. This discovery could lead to the development of novel strategies to clear H. pylori from the stomach.
Researchers at U-M have identified a key link between stress signals and bacterial growth in the lungs, which may lead to better prevention and treatment of pneumonia. The study found that certain bacteria thrive in response to catecholamines, a type of distress signal produced by the body's immune cells.
When fruit flies get sick, their offspring become more diverse due to increased genetic variability. This adaptation may help the offspring survive future threats from the same pathogens. The findings demonstrate that parents can alter the genotypes of their offspring, a strategy that could be beneficial for survival.
Researchers analyzed 80 studies to identify best cleaning practices, but found a lack of evidence on most effective methods. Studies showed mixed results, with some agents and methods reducing hospital-acquired infections like C. difficile.
Researchers have discovered that cathelicidins, antimicrobial peptides produced by gut bacteria, play a crucial role in preventing the development of type 1 diabetes. By re-establishing a normal level of cathelicidin in diabetic mice, scientists were able to suppress autoimmune disease.
Researchers developed an animal model that replicates the imbalance of gut bacteria associated with malnutrition, a disease responsible for one-fifth of child deaths worldwide. The model will enable testing of treatments and understanding how malnutrition impacts cognitive development and growth.
Researchers discovered that Listeria monocytogenes can grow on refrigerated smoked salmon by utilizing different metabolic pathways than those used in laboratory media. This finding could lead to the development of inhibitors to control pathogen growth on foods and improve risk assessments.
Researchers at Texas A&M AgriLife Research have discovered a natural cocktail of four bacteriophages that can prevent and treat Pierce's disease in wine grapes. The phage treatment offers an alternative to pesticides for disease control, with promising results in both greenhouse experiments and field testing.
A Michigan State University study found that septic tanks are contaminating freshwater sources with fecal bacteria, threatening water quality and human health. The research used a novel source-tracking method to analyze 64 river systems in Michigan and identified areas with high numbers of septic systems as hotspots for pollution.
Researchers from Arizona State University and other institutions discovered how bees immunize their offspring against specific diseases using the bee blood protein vitellogenin. This process enables bee babies to better fight diseases once they are born, opening doors for creating edible vaccines for insects.
A recent study by IU biologist Farrah Bashey-Visser found that microorganisms are constantly evolving due to competition with other microorganisms, leading to the development of antibiotic-resistant bacteria. This can catch humans off guard, requiring them to play catch-up in treatment efforts.
Researchers at Northeastern University discovered that a specific mutation in the hipA gene leads to persistent E. coli cells in patients with relapsing urinary tract infections, paving the way for customized treatment regimens.
Researchers at Duke University have discovered the role of HipA in recurring urinary tract infections, finding that mutant versions of the protein can cause multidrug tolerance by putting bacterial cells into dormancy. The study provides a new method for combating drug-tolerant infections.
Researchers at Washington State University have found that UVC light can effectively inactivate up to 99.9% of foodborne pathogens on apples and pears, but listeria was more resistant. The technology is simple to implement and inexpensive, making it a promising solution for organic fruit processors.
Researchers at Joint BioEnergy Institute have identified a bacterial protein called RaxX that activates rice plant's immune response to Xanthomonas oryzaepv.oryzae, the pathogen causing bacterial blight. This discovery has important implications for future grass-type biofuel feedstocks and the worldwide supply of rice.
A research team at the University of California, Davis, has identified a tiny protein called RaxX that helps plants fight off bacterial infections. The discovery could lead to more disease-resistant crop varieties and new treatments for microbial infections in both plants and animals.
A study published in Clinical Infectious Diseases found that 47% of grocery store-bought meat products contained Klebsiella bacteria, with many strains resistant to antibiotics. This increase poses a significant risk to human health, particularly for urinary and blood infections.
Scientists at TGen are developing an accurate diagnostic test for Lyme disease using targeted DNA sequencing, which can pinpoint the presence and severity of tick-borne Lyme disease. The new test aims to provide actionable information for physicians and improve treatment outcomes.
Researchers discovered a messenger molecule that encourages bacteria to colonize catheters in mice, forming biofilms. The study highlights the importance of understanding biofilm formation to develop more effective therapies for infections like those caused by Pseudomonas aeruginosa.
Researchers have discovered that iron regulatory proteins play a crucial role in fighting off infection by controlling iron levels. The study found that mice lacking these proteins died when infected with the Salmonella bacteria, highlighting their importance in immune defense.
Researchers discovered that phytohormones regulate microbial abundance, influencing the composition of root microbiomes. The study found that plants can select and benefit from specific strains of microbes, but also face pathogens that take nutrients and damage plants.
Researchers from the University of Surrey have made a breakthrough discovery that the bacteria causing Buruli ulcer disease triggers a blood clot, similar to deep vein thrombosis. This finding suggests that anticoagulant medicines may be effective in treating the disease, leading to faster healing and fewer side effects.
A team of scientists from NUS discovered that blue LEDs can effectively kill major foodborne pathogens, especially when combined with chilling temperatures and mildly acidic conditions. This technology has the potential to replace chemical treatments for preserving acidic foods.
A new study from Vanderbilt University Medical Center found that viruses, not bacteria, are the most commonly detected respiratory pathogens in U.S. adults hospitalized with pneumonia. The study highlights the need for more sensitive rapid diagnostic tests to identify pneumonia pathogens and target appropriate treatments.
NC State engineers have created an effective and environmentally benign method to combat bacteria using silver-ion infused lignin nanoparticles, which effectively kill E. coli and other harmful microorganisms without harming the environment.
Research found that bacteria shapes changed from sticks to spheres to evade the immune system, revealing a key gene responsible for this transformation. This discovery could lead to new tools for preventing and treating respiratory infections.
A team of researchers has identified the first known exopolysaccharide receptor gene in plants, allowing them to distinguish between beneficial and harmful bacteria. This discovery has significant implications for agricultural research and medical science.
A UTHealth researcher has received a $1.9 million NIH grant to study Clostridium difficile infections, which cause diarrhea and inflammation of the colon. The goal is to prevent toxins from being released and make them inactive in the gut without killing good bacteria.
New antimicrobial material could be used as a topical antibacterial treatment and disinfectant, effectively killing biofilms and promoting healing in chronic wounds.
Clostridium difficile, the most common cause of hospital-acquired diarrhea, tightly controls its intracellular iron levels to avoid DNA damage. The pathogen has multiple systems for importing ferrous iron compounds, which are more critical in anaerobic conditions.
A newly discovered human protein called intelectin has the ability to selectively identify and distinguish between human cells and those of disease-causing microbes. This discovery could lead to the development of new antibiotics and strategies to combat infectious diseases.
Researchers found that a single small genetic change enabled Yersinia pestis to transition from causing gastrointestinal infections to respiratory diseases, including pneumonic plague. This discovery may have helped explain how the plague spread globally, leading to devastating pandemics like the Black Death.
Researchers found that human urine's unknown factors interfere with bacterial FimH protein's ability to adhere to cells and switch off pilus production assembly. This exposes a crucial weakness in pathogen's ability to infect, making potential non-antibiotic treatments more effective
Indigo-Clean, a light fixture using Continuous Environmental Disinfection technology, kills harmful bacteria linked to hospital acquired infections. The technology, developed by University of Strathclyde, is now commercially available in the US and Canada, offering hospitals a safer environment for patients.
A team at Harvard's Wyss Institute discovered that bacteriostatic antibiotics slow down oxygen consumption, reducing cellular respiration and making bacteria tolerant. This can explain why certain antibiotic therapies fail. The findings provide a new strategy for developing urgently needed therapeutics.
Researchers discovered that the protein structure of a key membrane protein differs from a previously postulated model, providing a basis for new treatments. The study reveals how the protein pore opens and closes in response to substrate binding, offering insights into the pathogen's attachment mechanism.
Researchers have identified a new potential culprit in colon cancer, Providencia, and found a single signature of colon cancer in the gut microbiome. This discovery could help doctors predict prognosis and identify bacterial changes that affect patient health.
Engineers have created a prototype for real-time listeria bacterial contamination detection, aiming to detect levels as low as one bacteria in a 25-gram sample. The device utilizes nanobrushes that select and capture specific bacteria, mimicking the mechanism used by the Hawaiian bobtail squid's cilia.
Peter Greenberg and colleague Bonnie Bassler's work on quorum sensing has far-reaching implications for medicine and agriculture. Hundreds of bacterial species use quorum sensing to control various things, and the researchers aim to develop novel medicines targeting this process.
A Wyss Institute team is developing genetically engineered bacteria that can sense, report, and combat harmful microbial invaders in the human gut. The team aims to create a probiotic pill form of the microbes that could reduce the length of gastrointestinal illness, returning individuals to their activities sooner.
The research team created a single-molecule, real-time sequencing method to detect and phase DNA methylation in bacteria. They found that individual bacterial populations have distinct subpopulations with different gene expression patterns, which may contribute to increasing antibiotic resistance.
A new screen has identified key environmental signals that modulate bacterial behavior in Salmonella typhimurium, a food-poisoning bacterium. These signals trigger survival tactics and alter biofilm formation.
A new University of Windsor-led study published in the New England Journal of Medicine found that a sexual assault resistance education program significantly reduced the likelihood of completed rape among first-year university women. The EAAA program, which consists of four three-hour sessions, helped women assess risk, overcome emotio...
Researchers found that growing bacteria in mammalian tissue culture media instead of standard bacteriologic media makes them more sensitive to azithromycin. The drug is also effective when paired with colistin or antimicrobial peptides produced by the human body during infection, reducing bacterial counts by up to 99% in mouse models.
A team of researchers from the University of Freiburg has discovered how the toxins of Clostridium difficile bacteria enter the interiors of cells. The surface protein LSR receptor is responsible for binding to the CDT toxin, allowing it to penetrate the cell membrane and exert its lethal effect.
Researchers have developed a new microscope technique using holographic images and machine-learning software to identify bacterial species at the single bacterium level. The approach has shown high accuracy in distinguishing between pathogenic and non-pathogenic bacteria, promising to reduce treatment time and improve patient outcomes.
A study by Northwestern University scientists found that a Vibrio vulnificus toxin can inhibit tumor cell growth by cutting the Ras protein, which is central to cell division and survival. The toxin's ability to cleave Ras, rather than modify it, represents a novel mechanism for inactivating this protein.
A Twin study led by TGen researchers found that a person's environment is more important than their genes in determining nasal bacteria. Some common nasal bacteria may even protect against MRSA colonization, according to the study published in Science Advances.
Researchers introduce a two-pronged system to combat antibiotic resistance by eliminating genes that cause resistance and conferring protection against lethal phages. The system, based on bacterial viruses called phages, has the potential to turn the tide on untreatable infections.
A study reveals that Obg plays a crucial role in bacterial persistence, allowing certain cells to survive antibiotics. The researchers' findings suggest that targeting the novel persistence pathway could lead to more effective treatment strategies for bacterial infections.
Scientists from HIPS and HZI discover cyclohexylgriselimycin, a variant of griselimycin, effective against Mycobacterium tuberculosis with low risk of resistance development. The new agent targets DNA clamp, preventing bacterial proliferation and offering potential therapeutic approach to drug-resistant tuberculosis.
A study found that at least 60% of toothbrushes were contaminated with fecal coliforms, even after decontamination methods. The researchers advise better hygiene practices for students who share bathrooms to prevent the transmission of potentially pathogenic organisms.
Research found that 90% of bacteria on human skin are either dead or inactive, with different areas harboring varying proportions of metabolically active, inactive, and dead microbes. Activity levels decreased with age, suggesting a possible relationship between the microbiome and immune system function.