Articles tagged with Bacterial Pathogens
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Researchers from the University of Surrey have made a breakthrough discovery that the bacteria causing Buruli ulcer disease triggers a blood clot, similar to deep vein thrombosis. This finding suggests that anticoagulant medicines may be effective in treating the disease, leading to faster healing and fewer side effects.
A team of scientists from NUS discovered that blue LEDs can effectively kill major foodborne pathogens, especially when combined with chilling temperatures and mildly acidic conditions. This technology has the potential to replace chemical treatments for preserving acidic foods.
A new study from Vanderbilt University Medical Center found that viruses, not bacteria, are the most commonly detected respiratory pathogens in U.S. adults hospitalized with pneumonia. The study highlights the need for more sensitive rapid diagnostic tests to identify pneumonia pathogens and target appropriate treatments.
NC State engineers have created an effective and environmentally benign method to combat bacteria using silver-ion infused lignin nanoparticles, which effectively kill E. coli and other harmful microorganisms without harming the environment.
Research found that bacteria shapes changed from sticks to spheres to evade the immune system, revealing a key gene responsible for this transformation. This discovery could lead to new tools for preventing and treating respiratory infections.
A team of researchers has identified the first known exopolysaccharide receptor gene in plants, allowing them to distinguish between beneficial and harmful bacteria. This discovery has significant implications for agricultural research and medical science.
A UTHealth researcher has received a $1.9 million NIH grant to study Clostridium difficile infections, which cause diarrhea and inflammation of the colon. The goal is to prevent toxins from being released and make them inactive in the gut without killing good bacteria.
New antimicrobial material could be used as a topical antibacterial treatment and disinfectant, effectively killing biofilms and promoting healing in chronic wounds.
Clostridium difficile, the most common cause of hospital-acquired diarrhea, tightly controls its intracellular iron levels to avoid DNA damage. The pathogen has multiple systems for importing ferrous iron compounds, which are more critical in anaerobic conditions.
A newly discovered human protein called intelectin has the ability to selectively identify and distinguish between human cells and those of disease-causing microbes. This discovery could lead to the development of new antibiotics and strategies to combat infectious diseases.
Researchers found that a single small genetic change enabled Yersinia pestis to transition from causing gastrointestinal infections to respiratory diseases, including pneumonic plague. This discovery may have helped explain how the plague spread globally, leading to devastating pandemics like the Black Death.
Researchers found that human urine's unknown factors interfere with bacterial FimH protein's ability to adhere to cells and switch off pilus production assembly. This exposes a crucial weakness in pathogen's ability to infect, making potential non-antibiotic treatments more effective
Indigo-Clean, a light fixture using Continuous Environmental Disinfection technology, kills harmful bacteria linked to hospital acquired infections. The technology, developed by University of Strathclyde, is now commercially available in the US and Canada, offering hospitals a safer environment for patients.
A team at Harvard's Wyss Institute discovered that bacteriostatic antibiotics slow down oxygen consumption, reducing cellular respiration and making bacteria tolerant. This can explain why certain antibiotic therapies fail. The findings provide a new strategy for developing urgently needed therapeutics.
Researchers discovered that the protein structure of a key membrane protein differs from a previously postulated model, providing a basis for new treatments. The study reveals how the protein pore opens and closes in response to substrate binding, offering insights into the pathogen's attachment mechanism.
Researchers have identified a new potential culprit in colon cancer, Providencia, and found a single signature of colon cancer in the gut microbiome. This discovery could help doctors predict prognosis and identify bacterial changes that affect patient health.
Engineers have created a prototype for real-time listeria bacterial contamination detection, aiming to detect levels as low as one bacteria in a 25-gram sample. The device utilizes nanobrushes that select and capture specific bacteria, mimicking the mechanism used by the Hawaiian bobtail squid's cilia.
Peter Greenberg and colleague Bonnie Bassler's work on quorum sensing has far-reaching implications for medicine and agriculture. Hundreds of bacterial species use quorum sensing to control various things, and the researchers aim to develop novel medicines targeting this process.
A Wyss Institute team is developing genetically engineered bacteria that can sense, report, and combat harmful microbial invaders in the human gut. The team aims to create a probiotic pill form of the microbes that could reduce the length of gastrointestinal illness, returning individuals to their activities sooner.
The research team created a single-molecule, real-time sequencing method to detect and phase DNA methylation in bacteria. They found that individual bacterial populations have distinct subpopulations with different gene expression patterns, which may contribute to increasing antibiotic resistance.
A new screen has identified key environmental signals that modulate bacterial behavior in Salmonella typhimurium, a food-poisoning bacterium. These signals trigger survival tactics and alter biofilm formation.
A new University of Windsor-led study published in the New England Journal of Medicine found that a sexual assault resistance education program significantly reduced the likelihood of completed rape among first-year university women. The EAAA program, which consists of four three-hour sessions, helped women assess risk, overcome emotio...
Researchers found that growing bacteria in mammalian tissue culture media instead of standard bacteriologic media makes them more sensitive to azithromycin. The drug is also effective when paired with colistin or antimicrobial peptides produced by the human body during infection, reducing bacterial counts by up to 99% in mouse models.
A team of researchers from the University of Freiburg has discovered how the toxins of Clostridium difficile bacteria enter the interiors of cells. The surface protein LSR receptor is responsible for binding to the CDT toxin, allowing it to penetrate the cell membrane and exert its lethal effect.
Researchers have developed a new microscope technique using holographic images and machine-learning software to identify bacterial species at the single bacterium level. The approach has shown high accuracy in distinguishing between pathogenic and non-pathogenic bacteria, promising to reduce treatment time and improve patient outcomes.
A study by Northwestern University scientists found that a Vibrio vulnificus toxin can inhibit tumor cell growth by cutting the Ras protein, which is central to cell division and survival. The toxin's ability to cleave Ras, rather than modify it, represents a novel mechanism for inactivating this protein.
A Twin study led by TGen researchers found that a person's environment is more important than their genes in determining nasal bacteria. Some common nasal bacteria may even protect against MRSA colonization, according to the study published in Science Advances.
Researchers introduce a two-pronged system to combat antibiotic resistance by eliminating genes that cause resistance and conferring protection against lethal phages. The system, based on bacterial viruses called phages, has the potential to turn the tide on untreatable infections.
A study reveals that Obg plays a crucial role in bacterial persistence, allowing certain cells to survive antibiotics. The researchers' findings suggest that targeting the novel persistence pathway could lead to more effective treatment strategies for bacterial infections.
Scientists from HIPS and HZI discover cyclohexylgriselimycin, a variant of griselimycin, effective against Mycobacterium tuberculosis with low risk of resistance development. The new agent targets DNA clamp, preventing bacterial proliferation and offering potential therapeutic approach to drug-resistant tuberculosis.
A study found that at least 60% of toothbrushes were contaminated with fecal coliforms, even after decontamination methods. The researchers advise better hygiene practices for students who share bathrooms to prevent the transmission of potentially pathogenic organisms.
Research found that 90% of bacteria on human skin are either dead or inactive, with different areas harboring varying proportions of metabolically active, inactive, and dead microbes. Activity levels decreased with age, suggesting a possible relationship between the microbiome and immune system function.
Researchers at NYU Langone found that contact lens wearers have a diverse set of microorganisms in the eyes that resemble those on their eyelid skin. This study suggests that improved eyelid and hand hygiene may help prevent eye infections
Researchers discovered that bladder cells can physically eject bacteria that invade the host cell, similar to vomiting. This finding may help treat recurring UTIs by eliminating bacterial reservoirs in the bladder cells. The study also identified a potential way to accelerate and amplify this expulsion mechanism using chemical targets.
Researchers at Georgia State University found that an existing anti-stroke drug, Vinpocetine, is effective in suppressing mucus overproduction and improving bacterial clearance in animal studies. The study could lead to a novel, non-antibiotic treatment for otitis media, potentially reducing hearing loss and enhancing host defense.
Researchers found phages in 49 out of 50 chicken samples that can transduce antimicrobial resistance genes to E. coli bacteria, highlighting the need for phage therapy and improved disinfection methods.
E. coli O104:H4 acquired genes through horizontal gene transfer, increasing virulence and antibiotic resistance. The bacterium's genome comprises prophage elements involved in Shiga toxin production.
Researchers at Tel Aviv University have developed a method to preserve milk using short pulsed electric fields, which can kill bacteria and extend shelf life. The technology is energy-efficient and does not require constant electricity supply, making it suitable for use in developing countries.
A study by University of Liverpool researchers reveals that pneumolysin released during Streptococcus pneumoniae infection causes cardiac injury and death. Liposome therapy has been shown to neutralize the toxin, mitigating damage to heart muscle cells.
A Virginia Tech team, led by Amy Pruden and Monica Ponder, is examining the impact of antibiotic use in agriculture on human health. They aim to identify ways to control the spread of antibiotic-resistant bacteria and genes in the food chain.
A study found that repeated schistosome exposure leads to a limited immune response due to the presence of IL-10-producing CD4+ T cells in the skin. These cells help prevent excessive inflammation and allow the parasite to survive by suppressing the immune system.
Researchers at the University of Georgia have found that Tokay geckos harbor bacteria resistant to multiple antibiotics, posing a risk to pet owners. The study highlights the importance of pathogen screening in the pet trade to prevent antibiotic-resistant bacteria from entering households.
A novel antibody, Ab926, has been discovered that can prevent E. coli from attaching to human cell surfaces and also dislodge bacteria already attached. This antibody works by binding to the side of the FimH pocket, rather than directly competing with free-floating mannose.
Researchers at the Institute of Food Research have visualized the structural changes Clostridium spores undergo during germination, which could help control pathogenic bacteria. The study provides new insights into the genetic controls of spore germination and reveals that spores have polarity that aligns structures correctly.
Researchers discovered that certain bacteria can block their own growth and that of resistant mutants, providing a potential new strategy to combat antibiotic resistance. This finding could lead to improved treatments for infections caused by resistant bacteria.
A landmark genomic study reveals a single clade of typhoid bacteria, H58, is driving global spread, displacing other strains and creating a previously underappreciated epidemic. The study highlights the urgent need for global surveillance and coordinated efforts to prevent and control antimicrobial-resistant typhoid.
The EU-funded MycoSynVac project combines gene engineering and biotechnology to design a novel veterinary vaccine chassis based on Mycoplasma pneumoniae. This chassis will be used to create specific vaccines against two highly detrimental pathogens, as well as for cell therapy and infectious lung disease treatment.
Researchers developed a novel approach using a molecular homing beacon that attracts pre-existing antibodies to attack pathogenic bacteria. The technology shows promise in targeting multidrug-resistant bacterial pathogens, and could potentially be applied to other infections, viruses, or cancer cells.
University of Adelaide researchers identified a common building block called PATR in virulence factors of many major harmful bacteria. The discovery could lead to the development of broad-spectrum bacterial virulence inhibitors, revolutionizing antibiotic treatments.
A new experimental drug increases HIF-1α levels in human bladder cells, making them resistant to UTI-causing bacteria. The treatment also protects mice against UPEC infection and reduces colonization rates.
Researchers have discovered an experimental drug that stabilizes the immune defense protein HIF-1alpha, increasing its levels in human bladder cells and mice. This leads to improved resistance against major UTI pathogen E. coli, highlighting a new approach to combating antibiotic-resistant infections.
Researchers developed biocompatible and biodegradable nanoparticles with effective antibacterial activity against E. coli, S. aureus, and B. subtilis. The NPs disrupt bacterial walls, induce reactive oxygen species, and cause cell invagination, making them a promising antimicrobial agent.
Researchers identify a time window when moderately resistant bacteria are sensitive to antibiotics, allowing for optimal treatment design. A new approach may help reintroduce antibiotics that were previously disregarded due to treatment failure concerns.
Researchers have identified a single, simple metric to guide antibiotic dosing that could bring first-line antibiotics back into the fight against drug-resistant pathogens. A computer simulation revealed that a regimen based on a pathogen's recovery time could eliminate an otherwise resistant strain of bacteria.
A study by University of Chicago scientists reveals how immune cells shape the gut microbiota to naturally limit infections. Intestinal immune cells, called type 3 innate lymphoid cells (ILC3s), play a crucial role in detecting harmful bacteria.
Researchers found that a concentrated maple syrup extract makes disease-causing bacteria more susceptible to antibiotics, leading to lower antibiotic usage. The extract also reduces biofilm formation of pathogenic bacteria, making it a potentially simple and effective approach for reducing antibiotic resistance.
Researchers analyzed data on 325 cancer patients hospitalized with pneumonia and found that severe illness and organ dysfunction are better predictors of outcome than multiresistant bacteria. The study suggests personalized treatment protocols can reduce mortality in these patients.
The NIH has awarded $11 million to develop diagnostic tools for hospital-associated pathogens, including those resistant to most antimicrobials. The goal is to provide rapid and efficient tests that can detect the presence of these bacteria in three hours or less.
Researchers have identified a new compound produced by freshwater bacteria that is effective against drug-resistant tuberculosis and other infections. The discovery provides a promising alternative to current treatments and could help combat the growing threat of antimicrobial resistance worldwide.
Researchers have made significant progress in understanding the complex relationship between bacteria and the deadly frog disease chytrid fungus. The study found that only a small proportion of bacteria inhibited all forms of the disease, highlighting the need for diverse probiotic treatments to combat its shifting targets.