Articles tagged with Bacterial Pathogens
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A Danish research team has gained a new understanding of the diarrhea-causing bacteria, ETEC, and is exploring its potential for developing an entirely new class of vaccines. The research aims to create a vaccine that can activate the immune system to recognize the agent as foreign and destroy it.
Researchers at UT Southwestern Medical Center found that enterohemorrhagic E. coli (EHEC) uses Bacteroides thetaiotaomicron to worsen its own infection by stealing scarce resources from other gut bacteria. This discovery opens up new avenues for understanding how microbiota composition impacts infection outcomes.
Researchers at Brown University have developed a new strategy to combat antibiotic-resistant bacteria by using molecular decoys. By administering fragments of antimicrobial agents alongside the full compounds, the researchers were able to increase their effectiveness against efflux pumps that stand guard along bacterial cell membranes.
A team of scientists has created a synthetic surface that can control the adhesion of E. coli bacteria using light. By switching on and off specific wavelengths, researchers can reverseorientate carbohydrate structures to influence bacterial bonding.
Microbial succession in restrooms begins with gut and vaginal bacteria, followed by skin and outdoor microbes. Skin and outdoor taxa comprise most of the cultured communities, suggesting restrooms are not significantly unhealthy or healthy.
Researchers found that blocking angiogenesis can reduce bacterial numbers, limit their spread and increase survival rates in infected lab animals. The study suggests a potential new therapeutic approach targeting the body's response to tuberculosis rather than directly attacking the bacteria.
Scientists have discovered that animals, including ticks and mites, have stolen bacterial toxin genes to defend against microbial infections. The transfer of these genes has been found in various animal species, including the deer tick, which can transmit Lyme disease.
Researchers found that bacterial infections due to Staphylococcus aureus aggravate neurodermatitis by triggering the formation of myeloid-derived suppressor cells, which suppress both harmful and beneficial immune responses in the skin. This can lead to chronic inflammation, itching, and social stigmatization in patients.
Researchers used whole genome sequencing to track and control an Acinetobacter baumannii outbreak at Queen Elizabeth Hospital Birmingham, identifying transmission hotspots and implementing new decontamination protocols. The study demonstrates the effectiveness of real-time genome sequencing in controlling hospital outbreaks.
Research found that Pseudomonas aeruginosa uses a sense of touch to detect hosts, allowing it to initiate infection without relying on chemical signals. The bacteria's ability to infect is linked to the PilY1 protein, which can be targeted for treatment.
Scientists have identified three proteins - GapA, CrmA and Mgc2 - essential for the gliding mechanism of Mycoplasma gallisepticum. This discovery could lead to developing a vaccine by targeting non-motile, non-pathogenic bacteria.
A recent report reveals that Vibrio coralliilyticus is not only more widespread and deadly than previously believed but also infects various fish, shellfish, and oysters, including rainbow trout and larval brine shrimp. Researchers have developed a rapid diagnostic assay for this bacteria to assess problems in oyster and coral health.
The UCI team has created a new technology called Integrated Comprehensive Droplet Digital Detection (IC 3D) that can detect bacterial invaders in blood samples with unprecedented speed and accuracy. In as little as 90 minutes, IC 3D can identify bacteria at single-cell sensitivity without the need for cell culture.
The Carnegie Institution has received Phase II Grand Challenges Explorations funding to develop a transformative strategy for controlling rice blight, a major challenge to food security. The project aims to achieve broad, durable resistance to the disease and apply its findings to existing rice breeding initiatives.
Researchers mapped ETEC bacteria's genetic composition to reveal its spread and identify potential vaccine targets. The study suggests a single bacterium has divided worldwide, leading to the development of a globally beneficial vaccine.
Researchers found that salivary mucin MUC5B limits biofilm formation by keeping S. mutans suspended in the liquid medium, preventing cavities. Boosting native defenses may be a better way to fight dental caries than relying on exogenous materials.
Researchers from RIKEN found that a subtle change in the Lon enzyme allows bacteria to quickly adapt between low-oxygen gut environments and high-oxygen outside conditions. This discovery could lead to new therapeutic targets for enteric diseases.
A new UCSB study reveals that a fungal pathogen in amphibians disrupts the skin microbiome, leading to dramatic changes in bacterial communities. The research has significant implications for understanding infectious disease dynamics and developing responses to diseases causing amphibian extinction.
Researchers at ETH Zurich have discovered a new agent in fungi that kills bacteria, known as copsin, which has the same effect as traditional antibiotics but belongs to a different class of biochemical substances. The substance was found in the common inky cap mushroom Coprinopsis cinerea and is responsible for its antibiotic effect.
Researchers have found that bats carry the bacterial species Bartonella mayotimonensis, which causes deadly human infections in the USA. Bats are ideal reservoirs for pathogenic viruses and play a vital role in natural ecosystems.
A study found that a gut bacterium, Csp_P, can reduce infection of mosquitoes by malaria parasites and dengue virus. The bacterium directly inhibits these pathogens in test tubes and shortens the life span of mosquitoes that transmit both diseases.
Researchers have developed a system to detect and monitor dangerous Gram-negative bacteria in real-time using PET scans. The approach uses a chemical tracer that selectively tags specific types of bacteria, providing rapid feedback on how they respond to antibiotics.
Researchers found that antibiotics can exacerbate Salmonella infection in mice, turning non-superspreaders into superspreaders. The study highlights concerns about the routine use of sub-therapeutic doses of antibiotics in livestock.
Antibiotic-resistant staph bacteria can exchange nutrients with each other and even with normal microbes to increase virulence during an infection. This challenges existing dogma on infectious diseases and may inform new treatment strategies.
Scientists identify tannic acid as a potential treatment for bacterial lung infections in cystic fibrosis patients, counteracting the harmful effects of the Staphylococcus aureus enzyme SMaseC. The discovery suggests that tannic acid may improve therapeutic outcomes for CF patients.
Researchers at The University of Nottingham have shed new light on the interaction between two proteins, laminin receptor (LAMR1) and galectin-3, and the human pathogen Neisseria meningitidis. This study provides critical components that cause the formation of pairs of molecules targeted by the bacterium.
A new study reviewing nearly 70 antimicrobial resistance studies suggests that aggressive treatment may not always be the best way to prevent resistant pathogens. The review found that varying drug dosages and treatment durations may affect resistance emergence, and moderate treatment could be a more effective strategy for some diseases.
Researchers found that MRSA biofilms form in joint fluid, making infections resistant to antibiotics. Pre-treatment with an enzyme can inhibit biofilm formation and increase bacterial susceptibility to antibiotics.
A new genetic test developed by scientists can detect canine fecal contamination in water, providing insights into the scale of the problem. The test identified 11 genetic markers common to most dog samples but absent from human ones, revealing the significant role dogs play in contaminating US waterways.
Sick mice produce specialized sugars to feed their gut microbiota and resist infection. Healthy recovery requires both L-fucose production and intact gut microbiota. The study suggests a potential role for L-fucose in preventing or tolerating Crohn's disease.
Researchers discover six unique states of pneumococcus bacteria, which can help develop tailored vaccines. The study found that each state has distinct DNA methylation patterns and alters gene expression, virulence, and disease severity.
Researchers found that plant seeds can be pre-colonized with beneficial bacteria, providing enhanced microbial protection. This discovery has significant implications for creating food-safe antimicrobials and understanding the importance of early colonization in establishing a healthy microbiome.
Researchers found that critically ill ICU patients lose almost all of their gut microbes and those left are mostly pathogenic, leading to life-threatening sepsis. The study suggests that minimizing antibiotic use and stabilizing remaining microbes could improve patient outcomes.
A research team from George Washington University has developed a new method for diagnosing pneumonia that uses DNA sequencing to identify bacterial pathogens. This approach could lead to more targeted and effective treatment, reducing healthcare costs and improving patient outcomes.
Researchers discovered that Streptococcus pneumoniae, the cause of most cases of bacterial pneumonia, can invade the heart and cause death of heart muscle cells. The study found that the pneumolysin toxin is responsible for this damage, and that an experimental vaccine formulation protected mice against cardiac invasion and heart damage.
Researchers at Duke Medicine and Duke-NUS Graduate Medical School Singapore detail how Yersinia pestis bacteria hitchhike on immune cells in lymph nodes to spread the bubonic plague. New therapies that block host immune function show promise in preventing infection and improving survival.
Researchers at the University of Cambridge used a new technique to study the immune response to live Salmonella vaccines, finding they enhance the ability to prevent bacterial replication and spread. This is crucial for preventing conditions like bacteraemia, a major killer in Africa.
Pathogens specifically target highly networked proteins with multiple functions to weaken their host. The plant model Arabidopsis thaliana shows that different pathogens attack the same proteins, suggesting a convergent targeting strategy.
Research reveals that 57 Panamanian tree species have distinct bacterial communities on their leaves, with some bacteria linked to nitrogen fixing and methane consumption. The study provides a comparable understanding of the host attributes that explain patterns of microbial diversity in the plant microbiome.
A recent study published in Proceedings of the National Academy of Sciences reveals a vast array of bacteria living on tropical tree leaves, including over 400 species found on a single tree. The discovery has significant implications for understanding forest health, disease resistance, and the impact of climate change.
Researchers at VIB/VUB have created a detailed three-dimensional image of the pores through which curli building blocks cross the bacterial cell wall, shedding light on biofilm formation. This breakthrough could lead to the development of small molecules that inhibit unwanted biofilm growth and pave the way for new applications in fiel...
Research in mice demonstrates that commensal bacteria enhance the immune system's ability to kill Klebsiella pneumoniae by boosting alveolar macrophage production of reactive oxygen molecules. The study suggests that signals from these beneficial bacteria play an active role in regulating immune function, even in the absence of infection.
Researchers have discovered Ixodes scapularis ticks in North Dakota, which vector Lyme disease, and are concerned about the potential spread of other tick-borne diseases. The ticks were found in six counties with established populations, raising concerns for public health.
Researchers identified lactic acid bacteria in honey that effectively counteracted severe human wound pathogens and persistent horse wounds. The bacteria produce a broad spectrum of antimicrobial compounds as needed, depending on the threat.
Researchers have developed a molecule that can silence the NDM-1 resistance gene in bacteria, restoring susceptibility to carbapenem antibiotics. This approach could be a viable strategy for treating resistant infections.
Scientists at Case Western Reserve University have found that a leaky gut is the underlying cause of non-AIDS complications in HIV-positive patients. The study, published in PLOS Pathogens, reveals that bacterial products seep out of the colon and trigger inflammation throughout the body.
Researchers at Kansas State University have discovered a family of proteins in Staphylococcus aureus that prevent neutrophils from functioning, leading to potential new treatments for staph infections and inflammatory diseases such as emphysema. The study sheds light on how the bacteria evade the immune system.
Scientists have found that Pseudomonas aeruginosa colonizes the nasopharynx before migrating to the lungs, leading to chronic infections. This new understanding provides an opportunity for developing treatments at the initial site of infection.
Recent research reveals that breast milk microbiomes are maintained by niche differentiation and dominant species, contradicting the traditional neutral theory. This finding has significant clinical implications for understanding mastitis and other diseases associated with breast milk.
Scientists discovered that Listeria uses RNA molecules to fine-tune protein production, allowing it to evade the immune system and resist antibiotics. By understanding this mechanism, researchers can develop targeted treatments to combat the life-threatening bacteria.
Researchers found that contaminated blood cultures can serve as diagnostic predictors for more targeted antibiotics. The study showed that highly resistant skin germs could indicate high mortality rates for the actual disease-causing bacteria.
Researchers have identified a unique class of materials, known as ionic liquids, that can neutralize biofilm-forming pathogens and deliver drugs through the skin. These materials are effective at disrupting biofilms and have minimal cytotoxicity effects on human cell lines.
A new study in mice finds that common gut bacteria protect against food allergies by inducing immune responses that prevent allergen exposure. Reintroducing Clostridia bacteria reverses sensitization to peanut allergens, indicating a unique protective role.
Scientists have identified Mycobacterium pinnipedii in Peru skeletons dating back at least 1000 years, revealing seals as a source of pre-Columbian tuberculosis. This finding sheds new light on the history of the disease in the Americas and has implications for future vaccine development.
A new study finds that ticks carrying Lyme disease are active throughout the year in Northwest California, posing a constant threat. The researchers' findings suggest that residents should take precautions year-round and know the symptoms of the disease.
Scientists have identified key regions of the Cwp84 enzyme that could be targeted by drugs to prevent Clostridium difficile colonization and toxin production. The research may lead to the development of a new type of anti-colonization inhibitor to treat C. difficile infection.
Researchers found that hoopoes' eggs change from bluish-grey to greenish-brown when exposed to preen gland secretion, which contains antimicrobial properties. This color change may serve as a signal about the mother bird's breeding quality.
Long antibiotic treatments are ineffective against slowly growing bacteria that persist in tissues, leading to ongoing disease. Slowly growing pathogens dominate treatment, posing a risk for relapse despite effective initial therapy.
Researchers found that the HIV virus's outer envelope is mistaken for bacterial antigens by the immune system, leading to ineffective antibodies. The study suggests a new hypothesis for how HIV vaccine development could be improved by targeting the gut flora.
Researchers discovered that a type of bacteria called Asaia blocks invasion of Wolbachia into mosquitoes' germlines, stopping the insects from transmitting Wolbachia to their offspring. This finding provides a potential answer to why some insect species are infected with Wolbachia while others are not.