Articles tagged with Bacterial Pathogens
Scientists have identified Mycobacterium pinnipedii in Peru skeletons dating back at least 1000 years, revealing seals as a source of pre-Columbian tuberculosis. This finding sheds new light on the history of the disease in the Americas and has implications for future vaccine development.
Scientists have identified key regions of the Cwp84 enzyme that could be targeted by drugs to prevent Clostridium difficile colonization and toxin production. The research may lead to the development of a new type of anti-colonization inhibitor to treat C. difficile infection.
Long antibiotic treatments are ineffective against slowly growing bacteria that persist in tissues, leading to ongoing disease. Slowly growing pathogens dominate treatment, posing a risk for relapse despite effective initial therapy.
Researchers found that hoopoes' eggs change from bluish-grey to greenish-brown when exposed to preen gland secretion, which contains antimicrobial properties. This color change may serve as a signal about the mother bird's breeding quality.
Researchers found that the HIV virus's outer envelope is mistaken for bacterial antigens by the immune system, leading to ineffective antibodies. The study suggests a new hypothesis for how HIV vaccine development could be improved by targeting the gut flora.
Researchers discovered that a specific type of IgG2 antibody protects Pseudomonas aeruginosa by binding to extra-long sugars on the bacterial surface. This protection can lead to reduced antibacterial capacity and worsened disease outcomes in immunized individuals.
Researchers discovered that a type of bacteria called Asaia blocks invasion of Wolbachia into mosquitoes' germlines, stopping the insects from transmitting Wolbachia to their offspring. This finding provides a potential answer to why some insect species are infected with Wolbachia while others are not.
Research reveals Salmonella Typhi uses Vi capsular polysaccharide to evade neutrophil recognition, allowing it to disseminate throughout the body. The 'cloaking device' makes S. Typhi practically invisible to neutrophils.
A team of scientists has found that genetic changes in a bacterial pathogen may be caused by chance environmental events rather than genetic mutations. The study, published in PNAS, analyzed 149 genomes of Salmonella enterica serovar Paratyphi A and found that the pathogen had not changed dramatically over its 450-year history.
A team of scientists at Duke University has discovered a molecule that exploits the body's natural response to fungi and bacteria, using copper to kill microbial pathogens. The findings show promise for developing broad-spectrum antimicrobial agents with minimal harm to healthy cells.
Researchers at Virginia Commonwealth University School of Medicine have identified three surface proteins on the Anaplasma phagocytophilum bacterium that cause tick-transmitted disease. Targeting these proteins could lead to effective prevention and treatment, enabling the development of a vaccine.
A study found that HIV infection alters the relationship between semen bacteria and immune factors, affecting viral load. Semen bacterial diversity was reduced in infected men, but restored after treatment.
Researchers have discovered how viruses called bacteriophages can be engineered to target and destroy a range of bacteria, including antibiotic-resistant C. diff, which causes fatal infections in hospitals. The study provides hope for developing an alternative to antibiotics.
A new paper by UCSB researchers scrutinizes Naegleria fowleri, a heat-loving amoeba causing rare but fatal infections. The study highlights the distinction between sapronotic diseases and conventional infectious diseases.
The Leishmania parasite protects flies from bacterial disease, increasing their lifespan and survival rate. This finding highlights the potential unintended consequences of using bacterial controls to control leishmaniasis.
Researchers discovered a small molecule produced by benign bacteria influences the behavior of Staphylococcus aureus, causing it to form biofilms. This finding could lead to new ways to manage bacterial communities and prevent infections.
Researchers at the University of Delaware have identified a protein called HSP70 that helps stabilize NOD2, a key protein involved in Crohn's disease. This finding provides a possible pathway for developing an effective therapy for the inflammatory bowel disease.
Researchers at Washington State University found that cinnamon oil is effective in killing several strains of E. coli, including non-O157 STEC, which causes approximately 110,000 cases of illness annually. The oil can be incorporated into films and coatings for packaging meat and produce to eliminate microorganisms.
Researchers found a significant presence of Treponema denticola, an opportunistic pathogen, in Oetzi's DNA mixture, supporting computer tomography-based diagnosis of periodontitis. The analysis also revealed Clostridia-like bacteria in a dormant state, which could impact future conservation efforts.
A study from Brigham and Women's Hospital found that infection can significantly alter the gut microbiota, leading to new microbial signatures that may help detect early stages of inflammation. These findings could aid in better treatment and prevention of gastrointestinal infections and inflammation.
Scientists have discovered that gut immunity actively maintains healthy bacterial communities through precise regulation of immunoglobulin A production by regulatory T cells. This complex interplay between the immune system and bacteria is crucial for preventing autoimmune disorders associated with dysbiosis in the gut.
Researchers discover that P. gingivalis modifies its lipid A structure to evade host defenses and establish chronic infection, leading to persistent systemic low-grade inflammation. This mechanism contributes to the progression of atherosclerosis in blood vessels.
Researchers created nanopyramids made of DNA that can flag and kill bacteria, with a success rate of 65% for Staphylococcus aureus and 48% for Escherichia coli compared to traditional medicine. The innovation offers a new approach to delivering drugs directly into bacterial cells.
Researchers found genetically identical bacteria respond differently to sugars, exhibiting a wide range of behaviors. The study highlights the complexity of bacterial behaviors and their response to environmental conditions.
A new research unit at Goethe University Frankfurt aims to understand the molecular basis of multi-drug resistant Acinetobacter baumannii strains, a common and deadly nosocomial pathogen. The researchers will study the bacterium's biology, infection process, and resistance mechanisms using an interdisciplinary approach.
Researchers at the University of Liverpool discovered a mechanism by which Streptococcus pneumoniae switches from harmless commensal to pathogenic bacterium, triggered by T regulatory cells. This balance is crucial in preventing inflammation and disease.
Researchers discovered that foodborne pathogen Campylobacter jejuni can cause problems in chickens' gut and damage their feet and legs when they walk through contaminated excrement. The bacteria's impact varied among breeds, with one showing significant damage to the gut and developing diarrhea.
Researchers at ETH Zurich have developed a new approach for tuberculosis drugs, inspired by the bacteria-derived antibiotic pyridomycin. The new molecule is more stable and easier to produce synthetically, offering a potential solution to multidrug-resistant strains.
A study published in mBio found that Campylobacter jejuni, a foodborne pathogen, can cause disease in some breeds of chickens. The bacteria were previously thought to be harmless to birds.
Scientists expect progress in developing an effective TB vaccine, with Phase IIa clinical trials underway. The new vaccine aims to activate both killer and helper cells for improved immune response.
A WUSTL scientist has developed a drug delivery system that exploits bacterial siderophores to target specific pathogens, potentially reviving abandoned antibiotics and making it harder for bacteria to develop resistance. The system uses tiny Trojan horses linked to siderophore molecules to smuggle antibiotics into bacterial cells.
Researchers discovered Staphylococcus aureus creates biofilm streamers using a biological glue, which can rapidly clog up medical devices. The bacteria's ability to form these slimy structures is crucial in understanding the mechanism of infections associated with medical devices.
Researchers found that blocking the activation of five genes responsible for transporting fructose-asparagine could be a new strategy to fight Salmonella infections. The nutrient is composed of a sugar and amino acid, and its identification alone is unusual since it has never been discovered as a nutrient for any organism.
Researchers have developed a way to identify isolated pieces of DNA floating outside the bacterial chromosome, which can play important roles in virulence and antibiotic resistance. Extrachromosomal DNA elements, such as phages and plasmids, were found widespread among medically important strains of Staphylococci.
Scientists have determined the three-dimensional structure of a Type VI secretion system export complex in bacteria, offering a potential target for novel antibiotics. The contractile sheath complex functions like a nanosyringe to expel toxins from cells, and its mechanism has been elucidated at sub-nanometer resolution.
Researchers found that blacklegged ticks are almost twice as likely to be infected with two pathogens, Lyme disease and babesiosis. This increases the risk of exposure to multiple diseases, particularly in areas with high incidence of tick-borne illnesses.
Researchers at UEA identified a vulnerable gate in Gram-negative bacteria's outer membrane that prevents the transport of barrier-building blocks, making bacteria susceptible to death. This breakthrough could lead to new generation drugs targeting the protective barrier instead of the bacteria itself.
Researchers at UGA report that Tpl2 plays a key role in directing immune system components, which may lead to new treatments for autoimmune diseases. The study found reduced chemokine receptor activity in mice lacking the enzyme.
Bacteria have been found to use new mechanisms to produce lipids, which can be used for industrial manufacture and pharmaceutical applications. Researchers have identified enzymes that can generate multiple different lipids, including phosphatidylethanolamine and cardiolipin.
A new device can collect and detect Listeria monocytogenes on food industry surfaces in just three to four hours, a significant improvement over current methods that take days. The sensor uses compressed air and water to remove cells before detecting them with an antibody, producing a fluorescent signal.
Researchers have discovered that populating GI tracts with Bacteroides species producing beta-lactamase enzyme protects good commensal bacteria from antibiotics. This finding suggests a potential new strategy for preserving the gut microbiome during antibiotic treatment.
Researchers discover periodontal bacteria selectively disarm immune system, promoting dysbiosis and bone loss. The study reveals a two-pronged mechanism involving protein receptors C5aR and TLR2, which protects 'bystander' gum bacteria from clearance.
Researchers found YbeY critical for cell fitness, stress tolerance, and ribosome quality control in V. cholerae. It also targets virulence-associated small regulatory RNAs, making the bacterium less harmful.
The WPI team has received a $50,000 grant from the National Science Foundation's Innovation Corps program to explore commercial potential of their new technology. They are engineering surfaces with antimicrobial peptides (AMPs) to prevent infections on catheters, orthopedic implants and other medical devices.
Researchers at UMass Amherst developed a faster method for detecting and separating microbial contamination from food, potentially saving time and expense. The new technique uses magnetically charged beads to quickly remove disease-causing bacteria from liquid samples.
Researchers discovered spirochete-like bacteria in 15-20 million-year-old Dominican Republic amber, which causes Lyme disease. The findings indicate that Lyme disease-causing bacteria have been around for at least 15 million years.
Researchers found that Neisseria meningitidis and gonorrhoeae bacteria can change the structure of their outer proteins to evade the immune system. This discovery could lead to new treatments for bacterial diseases such as meningitis and gonorrhea.
A University of Alberta researcher has developed a paper-based diagnostic tool to detect deadly food-borne pathogens such as E. coli. The device, slightly larger than a postage stamp, is designed to be extremely portable and self-contained, allowing for daily testing on farms in developing countries.
A new class of antimicrobials inhibits biofilm formation and eradicates mature biofilms in Gram-negative and Gram-positive bacteria. The substance, '1018', blocks the stringent stress response mediator (p)ppGPP, preventing its role in biofilm maintenance.
A small molecule peptide destroys biofilms and prevents their formation in various bacteria, including those resistant to antibiotics. The discovery offers a promising strategy to target bacterial biofilms and combat antibiotic-resistant infections.
The OU research team will investigate three specific antibiotic resistant pathogens, focusing on their structural components and physico-chemical properties. The goal is to develop a realistic predictive model that facilitates the design of effective antibiotics capable of penetrating the cell wall of these bacteria.
Researchers at Massachusetts General Hospital discover that pulsed electrical fields can kill resistant bacteria infecting burns, reducing bacterial levels up to 10,000-fold. The technology has the potential to provide a chemical-free way of disinfecting burns and other wound infections.
Research found that disease-causing bacteria like MRSA and E. coli can linger on airplane surfaces for up to a week, surviving environmental conditions and human touch. The study aims to explore effective cleaning and disinfection strategies to reduce the persistence of these pathogens in passenger aircraft cabins.
A laboratory study found that e-cigarette vapor increases the virulence of drug-resistant bacteria like MRSA, making them more resistant to human cells and antibiotics. However, e-cigarettes also decrease the ability of human epithelial cells to kill these bacteria.
Windshield washer fluid has been found to be a source of Legionnaires bacteria, which can cause severe respiratory illness and pneumonia. Nearly 75% of school buses tested in Arizona were contaminated with the bacteria, highlighting the potential for automobile windshield washing systems to transmit deadly infections.
A study published in mBio reveals that humans and companion animals share the same types of MRSA infections, indicating a common population of bacteria. The research suggests that antibiotic usage in animal medicine is shaping the human pathogen, and healthy pets are not likely to pick up MRSA from their human companions.
A breakthrough in diagnostic technology could make it easier to detect pathogenic bacteria, particularly in developing nations. The innovative approach involves hijacking bacterial metabolic machinery to grow polymers that selectively bind to specific bacteria.
Intestinal alkaline phosphatase (IAP) promotes beneficial bacteria growth by blocking ATP's growth-inhibiting action. The study reveals IAP's role in maintaining intestinal microbial balance and its potential as a simple therapy for health problems caused by imbalance.
Scientists investigate Vorarlberger Bergkäse, a regional Austrian cheese, to understand its unique microbiome. The study reveals the presence of halophilic microbe Halomonas on young rinds, which plays an unknown role in cheese-making.
Researchers discovered antibiotic resistance genes in all 71 environments tested, including soil, oceans, and human feces. The most common types of resistance uncovered were efflux pumps and genes conferring resistance to vancomycin, tetracycline, or beta-lactam antibiotics.