Articles tagged with Bacterial Pathogens
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A WSU researcher is studying the ecological factors behind antibiotic resistance in 30 Tanzanian villages, looking at genes, landscapes, and pathways. The project aims to understand how ecological components contribute to the problem and inform policies in the US.
Scientists have confirmed the existence of a new tick-borne disease in Switzerland, neoehrlichiosis, which has infected eight patients with severe symptoms. A DNA test has been developed to detect the infection quickly, allowing for timely treatment.
Researchers found eight different tetracycline resistance genes among US honeybees, but only two or three in honeybees from countries with banned antibiotic use. This suggests that the use of antibiotics may have weakened honeybee wellbeing and reduced their ability to fight off other diseases.
Researchers at UTHealth have developed a new technique to test 15 times more bacterial genes than previous years, uncovering potential roles in infection. The study could lead to vaccine candidates, better diagnostic tools, and targeted drug intervention.
Researchers at Columbia University Irving Medical Center have developed a groundbreaking mouse model of typhoid fever, enabling the study and creation of more effective vaccines. The mouse model uses toll-like receptors to combat the infection, with promising results in immunizing mice against Salmonella typhi.
Researchers have developed a mouse model of typhoid fever, allowing for more effective vaccine development against the deadly pathogen. The model shows human-like symptoms and responds positively to immunization.
A combination of six naturally occurring bacteria eradicates a highly contagious form of Clostridium difficile, a cause of bloating, diarrhea, and over 2,000 UK deaths in 2011. Faecal transplantation resolves symptoms and contagiousness, but the new approach aims to reduce antibiotic use.
Researchers at the University of Illinois have developed a new approach to inhibit the transfer of antibiotic-resistance genes in Streptococcus pneumoniae. By targeting a protein called CSP, they found that artificial versions of this protein can block gene transfer and reduce the infectious capacity of the bacteria.
Researchers at Simon Fraser University have discovered a Trojan horse-like mechanism that enables antibiotics to deliver directly into a bacterial cell. The method uses pilus filaments to transport antibiotics into bacteria, offering a new approach to treat deadly bacterial infections like cholera and Pseudomonas aeruginosa.
Researchers have designed a complex logic circuit using bacterial genes, enabling synthetic bacteria to monitor and respond to their environments. The circuit consists of four sensors and three two-input AND gates, allowing the bacteria to perform tasks such as detecting cancer indicators and releasing tumor-killing factors.
Researchers at VCU School of Medicine have identified the key and door of a bacterium responsible for tick-transmitted diseases, which could lead to the development of a single vaccine protecting against multiple bacteria. The study focuses on the protein OmpA, which mediates infection in host cells.
Researchers at the University of Washington examined the pathogen Pseudomonas aeruginosa, which colonizes in cystic fibrosis patients. They found that certain cells called cheater cells share public goods without releasing them, leading to destabilization of cooperation and potential new strategies for infection control.
A new diagnostic and antibiotic discovery tool has been developed using multicolored probes targeting cell wall synthesis in bacteria. This method enables fine spatiotemporal tracking of cell wall dynamics and will broadly impact basic and applied research on bacterial growth and control.
UCI researchers found that chronic kidney disease changes the composition of intestinal bacterial microbes, leading to uremic toxins and nutritional abnormalities. Study leader Dr. N.D. Vaziri suggests improving gut microbes through diet and dialysis may improve patient well-being.
Researchers have developed a new class of antibiotics that disarm pathogens instead of killing them, effectively treating antibiotic-resistant infections. By blocking the synthesis of endotoxin, a toxic product shed by bacteria, these antibiotics prevent inflammation and protect against potentially lethal infections.
Research identifies distinct microbial communities in healthy and cystic fibrosis patient lungs, suggesting beneficial microbes contribute to health. The findings suggest a potential new approach to treating cystic fibrosis, including probiotic therapies.
Researchers describe experiments exploring multi-drug tolerance, a phenomenon that allows bacteria to outwit antibiotics. By analyzing HipA protein's structure and biochemical components, they gained insight into how this mechanism enables bacterial dormancy.
A study published in Nature reveals that people with type 2 diabetes have a high level of pathogens in their intestines, which can increase resistance to certain medicines. The research also identifies biological indicators that could be used for faster and earlier diagnosis of the disease.
Researchers at the University of California, Berkeley have identified a germ-killing power in the eyes' keratin protein, which can effectively combat bacteria such as Streptococcus pyogenes and Pseudomonas aeruginosa. The synthetic molecules derived from this protein show promise as low-cost therapeutics against various infections.
Researchers at MU developed a technique using bacteriophages to selectively kill harmful bacteria in water treatment facilities. This method could save taxpayers money by reducing cleaning costs and has potential applications against deadly antibiotic-resistant bacteria.
Researchers reveal that beneficial root bacteria, like Bacillus subtilis, suppress plant immunity to control the relationship, boosting growth through nitrogen conversion. This complex interaction raises questions about the benefits and drawbacks of these symbiotic relationships.
Researchers at Oregon State University found that overgrown algae can bring unwanted pathogens, choke off oxygen, and disrupt helpful bacteria on coral reefs. The study reveals a 'slippery slope to slime' where increased algae growth leads to decreased coral growth rates and altered bacterial communities.
Researchers have developed a novel method to directly detect bacterial protein secretion, shedding light on the virulence mechanisms of pathogens like tuberculosis. The technique has significant implications for understanding disease progression and identifying potential therapeutic targets.
A study found that high antibody levels for Porphyromonas gingivalis were associated with a two-fold risk of pancreatic cancer, while high levels of antibodies for commensal oral bacteria were linked to a 45-percent lower risk. The study strengthens the suggestion that oral bacteria may be indicators of pancreatic cancer risk.
Researchers have found identical strains of antibiotic-resistant Campylobacter coli in both antibiotic-free and conventionally raised pigs. The study suggests that the environment plays a key role in the persistence of these resistant pathogens, regardless of antimicrobial usage by pork producers.
A new X-ray study reveals that persister cells are regulated by toxins produced by the bacteria themselves, allowing them to enter a dormant state. This understanding can lead to the development of treatments that block toxin function and production, potentially improving outcomes in life-threatening diseases.
Researchers at University at Buffalo have discovered a novel set of genes essential for the growth of potentially lethal, drug-resistant bacteria A. baumannii. The study reveals multiple new drug targets for this human infection and suggests that laboratory conditions may not be ideal for identifying antimicrobial drug targets.
Researchers at Case Western Reserve University have developed novel antivirulence drugs that block toxin production in bacteria, rendering them harmless. The discovery has the potential to combat antibiotic-resistant infections like MRSA and strep.
Bacteria use a reversible switching mechanism to adapt to environments lacking oxygen, revealing a new 'antioxidant' pathway for repairing damaged proteins. This discovery has implications for the development of new antibiotics and our understanding of iron-sulfur cluster proteins in various cellular processes.
Researchers found that a few marine microbes produce natural antibiotics that protect their populations from competitors and neighboring populations. This cooperative behavior, where some individuals act as protectors of the many, is a surprising example of social organization in microbial populations.
Scientists have identified a new signaling system in bacteria that enables them to produce an appendage, swim away, and inhibit biofilm formation. This discovery could lead to understanding how to break up harmful bacterial biofilms on teeth or medical devices.
Studies on California and deer mice reveal that lifetime monogamy leads to reduced bacterial diversity and a less diverse gene pool for immunity, whereas promiscuity correlates with increased bacterial diversity and genetic variation. This suggests that social behavior influences immune system function.
Researchers found at least seven shared antibiotic-resistance genes between soil bacteria and disease-causing pathogens, suggesting recent gene transfers. The discovery highlights the potential for environmental bacteria to contribute to human health risks.
Researchers at Tel Aviv University have developed a treatment for coral infected with White Plague disease, a deadly bacterium that causes 9% of Favia favus corals to die. The treatment uses viruses that infect bacteria, providing a breakthrough in developing regionalized treatments.
Researchers found that antibiotic concentrations set by regulators are high enough to slow fermentation, allowing pathogens like Salmonella and E. coli to proliferate. Boosting lactic-acid-producing bacteria survival can help mitigate the issue.
Researchers at the University of Delaware found that beneficial bacteria in soil can signal plants' stomata to close, preventing disease infection. This discovery highlights the potential for probiotics to bolster plant immunity naturally.
Researchers propose that certain dietary fats encourage the growth of harmful bacteria, leading to low-level inflammation and chronic disease. Unsaturated fats, like omega-3 fatty acids, have strong antimicrobial properties, weakening bacterial cell membranes.
Researchers at Université de Montréal have discovered a novel strategy to combat antibiotic-resistant superbugs by targeting virulence factors. By removing these proteins, the body's immune system can eliminate the bacteria, making them harmless.
William Hanage, a renowned expert in infectious disease epidemiology, has received the 2012 ICAAC Young Investigator Award from the American Society for Microbiology. His research focuses on understanding the factors behind the response of bacterial populations to antimicrobials and vaccines.
Researchers at UEA applied strategic thinking from insurance companies to understand how animals and plants recruit beneficial bacteria, revealing the importance of 'screening out' bad bacteria and ' screening in' good ones. The breakthrough brings scientists closer to understanding the human body's relationship with bacteria.
Researchers at University of Wisconsin-Madison have identified small molecule chemicals that can disrupt quorum sensing in Acinetobacter baumanni, a pathogenic bacterium responsible for deadly hospital-acquired infections. The compounds may potentially be used to limit the virulence of the bacteria and prevent biofilm formation.
Researchers found drug-resistant Staphylococcus aureus in 36 chimpanzees (58% of tested), with nearly 10% showing multi-drug resistance. The risk of acquiring novel pathogens from humans poses a significant threat to wild apes, echoing worst-case scenarios in U.S. hospitals.
Researchers demonstrate that bacteria can form antibiotic-resistant clumps in a short time, even in a flowing liquid such as the blood, leading to severe infections. These clumps persist even when two different types of antibiotics are added, suggesting that sticking together protects the floating bacteria from the drugs' effects.
Scientists at the University of Nottingham have developed new polymers resistant to bacterial attachment, reducing biofilm formation and infection rates. The breakthrough could lead to a significant reduction in hospital infections and medical device failures, with initial results showing up to 96.7% reduction in bacteria.
Researchers develop SPAdes, a new algorithm to sequence genomes from single cells, enabling analysis of 'dark matter' bacteria and human pathogens. The breakthrough could lead to early detection of cancer progression by monitoring normal cells before they turn malignant.
A new disinfectant, Akwaton, has been shown to effectively destroy bacterial spores at extremely low concentrations. This is a significant improvement over existing chemical compounds that require higher concentrations and can be harmful to humans.
The study found that Shigella sonnei, a bacterium previously thought to be more common in developing countries, is now spreading globally due to its high levels of drug resistance. The researchers suggest that vaccine development will be crucial in controlling the disease.
Researchers have discovered that plants like Arabidopsis select a specific bacterial community from the diverse microbial ecosystem in the soil, with Actinobacteria, Proteobacteria and Bacteroidetes phyla being preferred. This community is dependent on soil type and plant genotype, and plays a crucial role in plant health.
At the annual meeting of crystallographers, researchers presented groundbreaking studies on X-ray laser technology, deep-sea bacteria's pressure tolerance, and molecular mechanisms underlying bacterial resistance to antibiotics. The discoveries have significant implications for fields such as medicine, genomics, and material science.
The UGA team created a single-step method to rapidly detect viruses, bacteria, and chemical contaminants using nanotechnology. They successfully detected compounds in highly diluted samples and mixtures with dyes, suggesting the technology can be used for food, blood, saliva, and urine testing.
Researchers explore the role of Lactobacillus reuteri in protecting against foodborne infection, finding that its antimicrobial substance reuterin can protect intestinal epithelial cells from Salmonella infection. The study's results suggest the efficacy of using probiotic bacteria or their derivatives in future therapies.
A study published in Nature reveals that the HVEM molecule plays a critical role in protecting against bacterial infections, including E. coli and pneumococcus, by acting as a border guard to signal the immune system to respond. The discovery provides a potential new therapeutic target for preventing and treating bacterial infections.
Scientists studied Agrobacterium tumefaciens, a rod-shaped soil bacterium responsible for crown gall disease in plants. They discovered that the bacterium maintains its linear chromosome through an enzyme called TelA, which forms hairpin loops to protect it.
Researchers discovered that E. coli uses yersiniabactin to steal copper from host cells, allowing the bacteria to grow and reproduce. This finding could lead to new treatments for serious urinary tract infections. By blocking this thievery with a drug, patients' chances of fighting off infections may significantly improve.
Michigan State University researchers discovered how bacteria flip a DNA switch to transform from harmless microbes to deadly insecticides. The bacteria, bioluminescent insect pathogens, reside in the intestines of worms and aid their survival, but can rapidly grow and produce toxins when the worms infest insects.
Researchers discovered that mice without NLRP6 receptor protein are better protected against bacterial infections and can more easily remove bacteria. This finding opens up a new therapeutic track for treating bacterial infections beyond antibiotics.
Biochemist Alejandro Heuck maps molecular structure of needle-like tool used by bacteria to drill holes in mammalian cell walls. Researchers aim to identify new targets for developing drugs and treatments against diseases caused by bubonic plague, dysentery, food poisoning, and sepsis.
A new test, RapidChek SELECTTM Salmonella, detects Salmonella Typhi shedding in stool with a 10-fold to 1000-fold improvement over traditional methods. This technology assesses the degree and duration of shedding after immunization, ensuring vaccine efficacy and community safety.
Researchers have identified a novel mechanism by which Bartonella bacteria manipulate host cell signaling, prolonging cell lifespan and contributing to chronic infection persistence. The study reveals the role of protein BepA in binding adenylyl cyclase, leading to increased cAMP production and preventing host cell death.
A team of scientists from Washington University in St. Louis has identified the eastern gray squirrel as a major animal reservoir for tick-borne diseases, including ehrlichioses and STARI. The study uses a new assay to detect species-level tick blood meals, confirming the presence of gray squirrel DNA in infected ticks.