Articles tagged with Bacterial Proteins
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Researchers at the University of Illinois have isolated a protein supercomplex from a bacterial membrane that generates a voltage across the bacterial membrane, enabling efficient ATP production. The study's findings will inform future efforts to obtain the atomic structures of large membrane protein supercomplexes.
Computer simulations show microbeads can significantly reduce or eliminate bacterial infections in burn wounds when combined with debridement. The tiny plastic spheres compete with bacteria for binding sites, physically keeping them from attaching to host cells.
A new study reveals that a type of beneficial bacteria, Bacteroides fragilis, uses the host's immune protein IgA to colonize the gut. The research suggests that IgA fosters colonization of microbiota with beneficial properties during healthy circumstances, while disease states may disrupt this balance.
A Japanese research team has uncovered new molecular details and provided a model explaining how stepwise flagellar assembly occurs in bacteria. The proposed model suggests that subtle changes in the ring's shape determine which proteins are exported to the growing flagellum, enabling its construction.
Researchers found that an immune-system generated molecule called nitric oxide (NO) inhibits the ability of Staphylococcus aureus to transform from a benign colonizing state to its virulent form, producing toxins. NO may play a key role in preventing staph infections by blocking quorum-sensing systems.
A human protein, teneurin, plays a key role in embryonic development and nervous system wiring by binding to other proteins on cell surfaces. Its unique structure, resembling a bacterial toxin, allows it to perform multiple functions through alternative splicing.
Researchers shed light on functional mechanism of ABC exporters, which transport a wide range of molecules out of cells. This understanding could lead to new therapeutic approaches by specifically influencing or inhibiting these processes.
Scientists have gained insight into how soil bacteria sense oxygen levels, which could help develop new treatments for promoting crop growth and tackling disease. The findings focus on the FixL/FixJ protein system in soybean nodule bacteria, essential for nitrogen supply.
Researchers have identified a new class of antibiotics, odilorhabdins, which target bacterial ribosomes and disrupt protein synthesis. The unique compounds have shown potential in treating drug-resistant infections.
Pathogenic bacteria use a unique secretion system to export adhesins, which enable them to adhere to host cells. The study found that the adhesin protein needs to be modified with specific sugars by three enzymes acting in a specific sequence.
Researchers discovered that Vibrio cholerae causes a 200-percent increase in intestinal contractions, expelling native gut bacteria in zebrafish. This finding sheds new light on the bacterium's invasion mechanisms and potentially opens doors to therapies targeting its path.
A University of Maryland researcher has discovered a protein produced by the bacteria that causes Lyme disease, allowing it to evade the body's first immune response. This breakthrough understanding has significant implications for treating tick-borne diseases like Lyme disease, which is increasingly chronic and prevalent.
Researchers found that Shewanella oneidensis bacteria use 'nanowires' to transfer electrons outside their cells, enabling them to survive and thrive in environments with limited oxygen. This discovery could lead to the development of new machines that combine living cells with electronic components.
Researchers have discovered a key member of the SEDS protein family, RodA, which builds bacterial walls. Altering its structure can disrupt this function, making it an attractive target for new antibiotics.
Methanotrophic bacteria have the unique ability to take in copper for use in methane metabolism, a process that also digests the potent greenhouse gas. A Northwestern University study has pinpointed two proteins, MbnB and MbnC, as key players in this process.
Researchers at KU Leuven have identified a protein, LIpA bacteriocin, that targets and kills the deadly Pseudomonas aeruginosa bacteria. The protein's mechanism of action involves binding to the bacterial cell wall protein BamA, effectively shutting it down and allowing the bacteria to die quickly.
A team of EMBL scientists has developed a comprehensive 'cookbook' for growing and studying 96 diverse gut bacterial strains. The research reveals unexpected nutritional preferences and growth characteristics of these bacteria, providing valuable insights into the human gut microbiome.
Researchers from Stanford University have developed a technique called biofilm lithography to create intricate designs with bacterial communities. The method involves shining blue light on bacteria that secrete a sticky protein, resulting in sharp images of patterns such as polka dots and circuits.
Researchers developed a monoclonal antibody targeting BamA in Gram-negative bacteria, inhibiting its function and compromising outer membrane integrity. The treatment shows promise for developing therapeutics against these bacteria.
Researchers created an integrated imaging approach that uses multiple techniques to study Staphylococcus aureus infections. This method revealed new insights into abscesses and the bacteria's response to their environment. The findings have implications for vaccine and therapeutic development, as well as culture-free diagnosis.
Researchers at WashU Medicine have discovered a way to treat urinary tract infections (UTIs) without using antibiotics. By targeting specific sugar-protein interactions, they found that decoy molecules can trick E. coli bacteria into releasing their grip on the bladder and kidneys.
Researchers at Boston University School of Medicine discovered that histatin-5 in saliva stiffens ETEC pili, preventing infection. This finding opens up new avenues for prevention and treatment of enteric infectious diseases.
Researchers found that chlorine bleach is a crucial ingredient in the toxic cocktail used by immune cells to destroy bacteria. The discovery sheds light on how some bacteria outsmart the immune system and how genetic defects can impair it.
Researchers at VIB have devised a novel approach to develop antibacterial drugs using protein aggregation technology, which can effectively target Gram-negative bacteria like E. coli. The technology has shown strong antibacterial activity against these resistant bacteria and will be further explored by biotech company Aelin Therapeutics.
Research explores how gut bacteria respond to common changes in their habitat, revealing that bacterial species can go extinct when environments are altered even slightly. This understanding could lead to the design of targeted probiotics and therapies to make gut microbes more resilient.
Researchers developed the DNA Endonuclease Targeted CRISPR Trans Reporter (DETECTR) system, allowing quick detection of diseases such as HPV using Cas12a. The system involves adding reagents in one reaction and uses isothermal amplification to boost target DNA cuts, resulting in a fluorescent readout.
Researchers at the University of Michigan have discovered a new CRISPR-Cas9 protein, NmeCas9, that can edit both DNA and RNA with high precision. This breakthrough could lead to new therapeutic possibilities for diseases caused by genetic mutations in RNA.
Researchers have developed a new method, DropSynth, to synthesize thousands of genes at once, reducing the cost from $50-$100 to $2 per gene. This breakthrough enables scientists to test hypotheses and analyze large numbers of cells with ease.
A new study has found that the immune system uses a specific balance of T cell types to tolerate beneficial bacteria, while triggering inflammation in pathogenic species. The discovery could lead to new treatments for inflammatory bowel diseases like Crohn's and ulcerative colitis.
Researchers have shed light on the mechanism behind important proteins on N. gonorrhoeae's outer membrane, potentially leading to new antibiotics or a vaccine. The findings suggest that BamE could be a new vaccine target against N. gonorrhoeae.
A study found that Pseudomonas protegens, a soil-dwelling bacterium, releases toxins through its type VI secretion system to protect plants from diseases. The toxins target NAD+, destroying other bacterial species and allowing the plant-protective bacteria to outcompete them.
A Hong Kong Baptist University study found that skin squames from humans contribute to odors in air-conditioning systems by providing a food source for bacteria. The researchers recommend installing filters to capture skin squames, which can help mitigate odor problems.
Researchers at the University of Freiburg have identified a specific position on TatC that can be chemically altered by DCCD, inhibiting contact with the Tat substrate. This finding reveals the mechanism of how TatC and TatB components assemble into an active transporter, creating a cavity for protein insertion.
A new, rapid, and low-cost method for detecting bacteria in water or a food sample has been developed by researchers at the University of Massachusetts Amherst. The technique uses a sensitive and reliable bacteria-detecting chip that can test fresh produce for bacterial loads.
Researchers have identified the structure of a central protein used by archaea to determine direction, revealing significant differences from bacteria. This discovery sheds light on how archaea can adapt to extreme environments and colonize new habitats.
Researchers discovered a new form of antibiotic resistance in pandemic cholera, where the enzyme AlmG modifies lipid A to prevent CAMPs from binding. This unique mechanism offers a new challenge for overcoming increasing antibiotic resistance.
Researchers propose a new term, mapranosis, to describe the interaction between gut microbiota and brain proteins that contributes to neurodegenerative diseases. The process involves amyloid protein misfolding and inflammation in the nervous system.
The recipients are selected based on scientific merit and will present their research during the meeting, receive a travel grant, and be recognized at a reception. The awardees include students and postdoctoral fellows from various institutions.
Researchers developed a model that explains how bacteria adapt to environmental changes, such as temperature and nutrient availability. The study found that the adaptation mechanism is based on a global strategy for redistributing resources, which allows bacteria to survive in fluctuating environments.
Researchers have developed a novel photothermal treatment that leverages the self-activation of certain bacteria to target and kill antibiotic-resistant pathogens. The innovative approach uses a supramolecular radical anion complex that absorbs near-infrared light, generating heat and denaturing proteins in targeted bacteria.
Researchers identified a crucial part of the photoreceptor responsible for light-dependent gene expression in Arabidopsis thaliana. This finding has significant implications for agriculture, enabling the development of crops that can thrive in diverse environments with increased crop density.
Researchers used computer simulations to study the dynamics of efflux pumps in bacteria, which create drug resistance. Understanding how these pumps work could lead to finding ways to deactivate them, potentially making antibiotics effective again against life-threatening diseases.
Researchers at Caltech have created bacteria that can produce chemical compounds with boron-carbon bonds, a breakthrough in synthetic biology. The findings could lead to more economical and environmentally friendly ways to manufacture pharmaceuticals and other products.
Mycobacteria use virulence factors to transmit TB-causing disease, infecting 1/3 of the world's population. The bacteria can sense molecular machine transport, adjusting protein levels accordingly.
A team of scientists at Université de Montréal developed a novel strategy to block the transfer of antibiotic-resistant genes by binding molecules that target the TraE protein. This approach has the potential to reduce the spread of resistance genes, preserving the potency of antibiotics and improving human health.
Researchers use cryo-EM to visualize the molecular interface between flagellin and NAIP5, revealing how bacteria are recognized by the immune system. The study found that flagellin is in contact with six different parts of NAIP5, providing new insights into potential strategies for protection from pathogens.
The mouse immune system uses six different ways to identify invading bacteria, scanning the bacterial protein in detail. This effective immune response helps understand why certain bacteria can evade detection.
Researchers at UC Davis have created a method to produce all 34 proteins required for mRNA translation in the correct proportions within a single mixed culture. This breakthrough enables rapid and high-purity reconstitution of cellular reactions, making it useful for various applications such as disease diagnosis and drug development.
Researchers elucidate torque generation mechanism of flagellar motor in Bacillus subtilis using high-speed atomic force microscopy and mutational analysis. The study finds that sodium ions drive the assembly and activation of flagellar motor, regardless of its composition.
Killer cells use a methodical approach to destroy bacterial invaders, inflicting oxidative damage and targeting critical proteins with the deadly enzyme granzyme B. The discovery offers new insights into how immune systems combat bacteria, potentially leading to the development of new antimicrobial drugs.
A Wayne State University research team has received a $1.85 million NIH grant to investigate non-Shine-Dalgarno translation initiation in bacteria. The goal is to identify new antibiotic targets effective against pathogens lacking Shine-Dalgarno sites.
University of Michigan researchers found that killer T cells use a multi-pronged attack to kill bacteria, targeting multiple processes. This discovery could lead to the development of new medications or repurposing of existing drugs to combat antibiotic-resistant pathogens.
Researchers at Rutgers University have identified a protein complex called TldD that activates the antibiotic microcin B17 by removing its protective coating. This discovery could lead to the development of new antibacterial agents and drugs to combat toxins.
Researchers led by Yasu Morita at UMass Amherst have characterized a protein involved in producing a glycolipid compound critical for TB-causing Mycobacterium to become infectious. The discovery provides insight into the disease's mechanisms and potential new drug targets.
A recent study published in Cell reveals a new mechanism in the gut microbiome that regulates pro- and anti-inflammatory cells, potentially preventing inflammatory bowel disease. The research also suggests that changes in the gut microbiome can increase the risk of other autoimmune disorders.
A team of researchers from Instituto de Medicina Molecular used a pioneer method to modify proteins involved in infectious diseases. They identified a novel molecular mechanism that protects pathogenic bacteria from oxidative processes.
Bacteria self-organize to form a golden shell around their colony using gold nanoparticles, creating a functional pressure sensor. The researchers controlled the size and shape of the device by altering the growth environment, demonstrating a proof-of-principle for fabricating structured materials.
Researchers have identified a key protein, MgtE, that plays a crucial role in signaling bacteria to form clusters, or biofilms, in the lungs of cystic fibrosis patients. The study reveals how fluctuations in magnesium levels influence MgtE activity, providing new insights into the development of chronic pneumonia.
Researchers at John Innes Centre developed an advanced analysis method to study bacterial signalling, enabling a comprehensive 'signalling map' for the key protein Hfq. This approach integrates data from multiple experiments, increasing our capacity to understand plant and human diseases.
Researchers at the University of Groningen have identified a novel mechanism that targets hibernating ribosomes, making bacteria resistant to antibiotics. The mechanism involves a single protein, HPF±ong, which can dimerize and inhibit protein synthesis.