Articles tagged with Bacterial Proteins
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at ETH Zurich have discovered a new agent in fungi that kills bacteria, known as copsin, which has the same effect as traditional antibiotics but belongs to a different class of biochemical substances. The substance was found in the common inky cap mushroom Coprinopsis cinerea and is responsible for its antibiotic effect.
Researchers at UC Berkeley developed a novel protein-based material inspired by nerve cells, showing extreme sensitivity to environment. This discovery could lead to innovative biological sensors, flow valves, and controlled drug release systems.
Researchers identify a bacterial protein that mimics the satiety hormone, leading to variations in food intake. A blood test for this protein could lead to specific treatments for eating disorders, while neutralizing the protein may prevent dysregulation of food intake.
Researchers at The University of Nottingham have shed new light on the interaction between two proteins, laminin receptor (LAMR1) and galectin-3, and the human pathogen Neisseria meningitidis. This study provides critical components that cause the formation of pairs of molecules targeted by the bacterium.
Scientists from Brown University and MIT have discovered new details on how ADEPs bind to the ClpP complex in Mtb, a crucial step towards optimizing these compounds for TB treatment. Novel ADEP analogs show improved binding and activation of ClpP, paving the way for designing new drugs.
Researchers have identified a protein receptor that activates during illness, producing a sugary substance to encourage the growth of protective bacteria and create a healthy microbiota in the gut. This discovery has implications for treating inflammatory bowel disease (IBD) and vulnerable patients.
Researchers at MIT engineered bacteria to produce hybrid materials combining naturally sticky mussel proteins with bacterial curli fibers, creating stronger underwater adhesives. These adhesives were found to bind strongly to various surfaces and are the strongest biologically inspired protein-based adhesives reported to date.
Researchers at Caltech have developed a new tool that uses genetic engineering and light to visualize and map neural networks in living organisms. The tool, which detects changes in membrane voltage, allows for real-time observation of neuronal activity and its effects on behavior.
A Harvard team has created a novel protein engineering system called BIND to engineer bacteria into living foundries for the production of biomaterials with specific functions. The researchers have demonstrated the ability to fuse multiple proteins to create multifunctional biofilms that can be programmed to perform various tasks.
Patients with common variable immunodeficiency (CVID) experience recurrent bacterial infections due to exhausted T cells expressing inhibitory protein PD-1. Rejuvenating these cells through blocking PD-1 may offer protection against bacterial infections, suggesting a potential therapeutic strategy.
Researchers at VIB/VUB have created a detailed three-dimensional image of the pores through which curli building blocks cross the bacterial cell wall, shedding light on biofilm formation. This breakthrough could lead to the development of small molecules that inhibit unwanted biofilm growth and pave the way for new applications in fiel...
Scientists at the University of Rochester have isolated key steps in ribosome formation, a crucial process for bacterial growth. The researchers found that multiple pathways of RNA processing occur simultaneously, suggesting new possibilities for stopping super-bugs.
Researchers have uncovered how bacteria control their growth and division by destroying key proteins through regulated protein degradation, a critical process for bacterial virulence. Understanding this mechanism may lead to the discovery of new antibiotics targeting pathways that allow bacteria to overcome stressful conditions.
Scientists at USC have discovered that bacterial nanowires are not pili, but rather membrane extensions equipped with electron-transfer proteins called cytochromes. This finding challenges the previous understanding of these 'electric bacteria' and opens up new avenues for research on their potential applications in bioelectronic devices.
Researchers at Queen's University Belfast have developed the first innovative antibacterial gel that acts to kill Pseudomonas aeruginosa, staphylococci, and E. coli using natural proteins. The gels target and break down biofilms, a thick jelly-like coating that makes bacteria resistant to current therapies.
Researchers discovered that a specific type of IgG2 antibody protects Pseudomonas aeruginosa by binding to extra-long sugars on the bacterial surface. This protection can lead to reduced antibacterial capacity and worsened disease outcomes in immunized individuals.
Researchers at St. Jude Children's Research Hospital have identified a key enzyme that regulates toxin production in Staphylococcus aureus, a common cause of serious infections. The discovery provides a promising target for developing new antibiotics to combat multi-drug resistant staph and related bacteria.
Researchers at Lund University discovered how Haemophilus influenzae bacteria can share iron with each other, increasing their chances of survival and potentially creating new vaccine targets. This interaction has significant implications for the development of vaccines and treatments for respiratory infections.
Researchers at the University of Delaware have identified a protein called HSP70 that helps stabilize NOD2, a key protein involved in Crohn's disease. This finding provides a possible pathway for developing an effective therapy for the inflammatory bowel disease.
Researchers at Kansas State University have found that bacteria can acquire iron from the environment using tiny protein loops on their surface. These protein loops are similar to fingers and can open or close to grab iron molecules, allowing the bacteria to establish an infection.
Researchers have identified a protein called MurJ that is essential to the survival of E. coli bacteria, making it a potential new target for antibiotics. Inhibiting MurJ would require getting past just one of the two membranes, making it an attractive new target in the age of resistant pathogens.
Researchers at Johns Hopkins University deciphered the inner workings of YiiP, a protein that prevents zinc toxicity in bacteria. The study reveals how protons drive the transport of zinc ions across cell membranes, shedding light on potential targets for modulating ZnT proteins and treating type 2 diabetes.
Scientists have determined the three-dimensional structure of a Type VI secretion system export complex in bacteria, offering a potential target for novel antibiotics. The contractile sheath complex functions like a nanosyringe to expel toxins from cells, and its mechanism has been elucidated at sub-nanometer resolution.
During the acute phase of H. pylori infection, the bacteria undergo accelerated evolution, accumulating mutations at a rate 30-50 times faster than during the chronic phase. This allows them to evade recognition by the immune system and survive, eventually establishing a chronic infection.
Researchers at Duke University have identified a key protein that drives DNA copying in plasmids responsible for antibiotic resistance in staphylococcus bacteria. By understanding how this protein works, scientists may develop new ways to prevent the spread of antibiotic-resistant plasmids.
Researchers found YbeY critical for cell fitness, stress tolerance, and ribosome quality control in V. cholerae. It also targets virulence-associated small regulatory RNAs, making the bacterium less harmful.
Researchers at UC Riverside discovered that a bacterial protein in aphid saliva, GroEL, induces immune responses in plants. This finding could lead to the development of durable resistance against aphid attacks in crops.
Researchers found that Neisseria meningitidis and gonorrhoeae bacteria can change the structure of their outer proteins to evade the immune system. This discovery could lead to new treatments for bacterial diseases such as meningitis and gonorrhea.
Researchers discover protein toxic to nematodes, protecting fungus and plant roots from parasites. The toxin docks on modified sugar structures, paving the way for novel vaccines against parasites and pathogenic germs.
A study published in Cell Reports reveals that a specific protein, EIIAGlc, is essential for Salmonella's ability to inject toxins into host cells and manipulate host processes. The discovery opens up new avenues for developing targeted treatments against life-threatening Salmonella infections.
Researchers found that galectins recognize and kill bacteria with similar carbohydrate coatings, filling gaps in immune defenses. This discovery could lead to the development of new antibiotics for treating certain bacterial infections.
The study reveals that chaperones, like GroEL and GroES, use a high-speed origami-like mechanism to accelerate protein folding. This process, which was previously thought to be energetically unfavorable, is now understood to be a favorable reaction, allowing proteins to fold faster than they are produced.
Scientists identified two proteins on fetal membranes that help the body's immune cells recognize and fight GBS bacteria. The study found a genetic risk factor for premature birth in fetuses lacking one of these proteins, highlighting the importance of GBS-siglec crosstalk on placental membranes.
Scientists at the University of York studied how Staphylococcus aureus attaches to human blood proteins fibronectin and fibrinogen. The research reveals how binding of these proteins cooperates to cause life-threatening infections, including infective endocarditis.
Researchers at the University of Missouri identified a molecular signal that invites bacterial attack in plants. This discovery could lead to natural defenses against harmful bacteria in food-producing plants.
Researchers at DRI found that certain bacteria can consume and convert left-handed amino acids into right-handed forms, which would otherwise be toxic to plants and animals. This discovery suggests that these bacteria play a crucial role in detoxifying the environment by consuming D-amino acids produced through geochemical transformation.
Novel proteins in gonorrhea bacteria may offer a way to attack the survival and spread of the disease. These proteins are essential for growth and survival, making them a promising target for vaccine development or new drug treatments.
Infectious disease specialists at Johns Hopkins Children's Center identified a protein called NOD2 that regulates the body's immune response to CMV. The findings offer a new explanation for severe CMV infections in patients with Crohn's disease and may lead to vaccine development.
Research finds that protein TG2 enables bacteria Porphyromonas gingivalis to adhere to cells, and blocking its associations prevents bacterial adhesion. The study provides insight into a potential target for preventing gum disease.
A bacterial infection can alter a key protein in the lungs, leading to acute lung injury. Researchers have identified a therapeutic target using human lung cells and 3D modeling, proposing a biological shield to protect the protein.
A new sensor can measure antibiotic levels in blood with high sensitivity, enabling individualized treatment and reducing potential toxic effects. This development has the potential to improve clinical regimes and combination therapies.
Scientists discovered that polyphosphate, an ancient chemical present in all living creatures, plays a crucial role in protein folding and can substitute for complex chaperone proteins. This breakthrough could lead to new strategies for treating protein folding diseases like Alzheimer's and Parkinson's.
Researchers at Lawrence Livermore National Laboratory have characterized two novel proteins from the tularemia bacteria Francisella tularensis that may contribute to its virulence. These proteins, REP24 and REP34, are responsible for induction of rapid encystment in amoebae, which allows the bacteria to survive unfavorable conditions.
Researchers at TUM have developed two new mechanisms of action that can permanently deactivate ClpP proteases, essential for bacterial survival. The newly discovered inhibitors target the protein's structure and function, potentially leading to more effective treatment options.
Researchers at The Scripps Research Institute found a protein, Protein M, that attaches to antibodies and prevents them from binding to their target, helping bacteria evade the immune response. This discovery could lead to new antibacterial therapies and tools for research and drug development.
A study by researchers at the University of California, Irvine found that interleukin-22 enhances the growth of dangerous bacteria like Salmonella while curbing the growth of healthy gut bacteria. This unexpected finding suggests that a protective immune response can actually aid the growth of harmful pathogens.
Researchers discovered a genetic mechanism controlling the production of a large spike-like protein on staph bacteria that prevents clumping and reduces disease-causing ability. The study suggests targeting clumping behavior for therapy, potentially reducing staph infections.
Researchers developed a NIST cell membrane model to detect bacterial vaginosis (BV) at low concentrations. The model revealed the presence of BV-causing bacteria by detecting protein toxin VLY in real-time, with improved sensitivity and speed compared to current methods.
Researchers have developed a new class of antibiotics called acyldepsipeptides (ADEPs) that kill bacteria in a unique way by altering protein degradation pathways. By modifying the ADEP molecule's structure to make it more rigid, they increased its potency up to 1,200 times that of the naturally occurring molecule.
Bacteria use molecular groups called hemes to transfer electrons through tiny protein-based wires. The researchers found that evolution has set the protein up so that when electrons have a strong drive to hop, heme stepping stones are less tightly connected, and when the drive is low, they are more closely connected.
Researchers at Florida State University have made groundbreaking findings on a bacteriophage that infects nitrogen-fixing bacteria. The study reveals novel details about the virus's DNA and physical structure, shedding light on how it invades and impacts bacteria.
Researchers at Hebrew University have discovered how persistent bacteria survive antibiotic treatment by disrupting the chemical messaging process. This understanding could lead to improved therapies in the future.
Researchers at Kansas State University are exploring how E. coli proteins block the host's innate immune system, which is critical for infection prevention. Understanding this mechanism may lead to new therapeutics for autoimmune diseases and cancer.
Tel Aviv University researchers have discovered a protein that kills bacteria, potentially offering a new antibiotic substitute. The protein, produced by a virus that attacks bacteria, impedes cell division in E. coli and causes cells to elongate and die.
A new model from Uppsala University predicts how bacteria can rapidly adapt to environmental changes through smart regulation of gene expression. The study shows the ultimate limit for bacterial protein level adjustments in response to changing environments.
Researchers discovered a mechanism behind VapC20 toxin in M. tuberculosis, which destroys the bacteria's protein factory by cleaving a key location. This discovery could lead to new ways of treating pathogenic bacteria by impairing their cytotoxin use.
Researchers discovered that anthrax toxin can hide out in human cells for days, avoiding detection by the immune system and cellular machinery. The findings explain why antibiotics are often ineffective against anthrax infections, making it a lingering threat.
Researchers have determined the atomic resolution structure of a bacterial nanowire protein, revealing its shape and form suggest ways for electrons to shuttle along the wire. The study's findings could lead to new applications such as bacterial fuel cells, carbon cycling, and biocomputers.
Bacteria and other organisms use proteins to quickly adapt to changing environments by regulating gene expression. A new study reveals how transcription factors bind to DNA and glide along the spiral path in search of binding sites.
Researchers at the University of Adelaide and The University of Queensland discovered that zinc 'jams shut' a protein transporter in deadly bacteria, preventing manganese uptake. This finding opens the way for designing antibacterial agents to target essential transporters.