Articles tagged with Bacterial Proteins
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers found that partial degradation of a DNA replication protein is necessary for the survival of Caulobacter crescentus. The energy-dependent protease ClpXP generates specific-sized fragments required for normal growth and DNA repair, challenging previous assumptions about protein digestion in bacteria.
Researchers have discovered how Pseudomonas syringae bacteria use their ice-nucleating proteins to lock water molecules in place and form ice crystals. This process is triggered at warmer-than-normal temperatures, allowing the bacteria to invade plant tissues and seed clouds with precipitation.
Scientists create tiny houses for bacteria using a novel 3D printing technology, enabling precise control over bacterial interactions and growth. The method reveals that certain bacterial communities become more resistant to antibiotics when contained together, providing new insights into infection mechanisms.
Researchers at Ruhr-University Bochum have investigated how plasmas affect bacterial cells, finding that they attack the cell envelope, DNA, and proteins. This discovery could lead to the development of alternative treatments for chronic wounds and root canal disinfection.
The study reveals that membrane proteins use a dynamic, constantly changing state to transport proteins across the outer membrane without requiring energy. This finding provides an exceptional insight into the transport mechanism and has implications for understanding protein folding and transport in bacteria.
Scientists discovered that rare codons near the start of a gene control protein production, allowing for more efficient bacterial reprogramming. This finding could lead to new methods for synthetic biologists to produce drugs and biological devices.
Bacteria use TamA protein to channel protein domains across the outer membrane, overcoming additional barrier for nutrient and toxin transport. This process is crucial for infections by pathogens like Yersinia, Salmonella, and Cholera.
A multidisciplinary team has identified the function of an enzyme and its biochemical pathway in a marine bacterium, using computational methods combined with laboratory techniques. This breakthrough sheds light on protein-coding genes and offers insights into the role of orthologous enzymes in similar pathways.
Researchers found that bacteria deviate from the 'just in time' principle for protein production, adapting dynamically to environmental conditions. They use strategies to optimize protein production, which can be useful in fighting pathogens.
Scientists at Brown University have discovered a novel compound that can kill the TB bacterium by inhibiting ClpP, a cellular enzyme not targeted by any antibacterial drugs. The findings could lead to new treatments for tuberculosis and other infections resistant to traditional antibiotics.
UCI researchers develop a biomimetic infrared camouflage coating using squid protein reflectin, allowing it to mimic the dynamic coloration and reflectance of squid skin. The material can disappear and reappear when visualized with an infrared camera.
Researchers have discovered that the protein Parkin plays a key role in fighting tuberculosis, triggering the destruction of bacteria by immune cells. This finding suggests that strategies already being explored to combat Parkinson's disease may also be effective against tuberculosis.
Scientists have mapped the structure of a protein that helps bacteria evade the immune system. Understanding this protein, called BamA, could lead to new treatments for diseases like gonorrhoea and chanchroid. The discovery brings researchers closer to stopping infection before it takes hold.
Researchers developed an efficient way to target and repair defective genes using a novel technique that simplifies previous methods. This breakthrough enables the potential to repair genetic defects responsible for diseases like breast cancer, Parkinson's, and others, opening doors for meaningful therapeutic applications.
Researchers have discovered a protein in bacteria that delays cell division when food is abundant, enabling cells to grow to the right size. This understanding may be used to design drugs that stop division entirely and kill bacteria.
A study by the NIH found that deleting a protein called Olfm4 improves white blood cells' ability to fight bacteria in mice with chronic granulomatous disease (CGD). This suggests a novel strategy for developing new treatments against common and deadly infections.
A benign crystal protein produced by bacteria could be a safe and inexpensive treatment for parasitic worms in humans. The protein, Cry5B, achieved a 93% elimination of hookworm parasites from infected hamsters.
A new study analyzed dynamical properties in antibiotic resistance enzyme β-lactamase, finding significant evolution across bacterial families without limiting new antibiotic resistance. Minor changes in the enzyme's active site can adapt it to new antibiotics.
Kansas State University researchers have discovered how Enterococcus faecalis, a bacterium causing hospital-associated infections, uses its regulatory system to resist the host's innate immune defense. The team has identified a protein called Eep as a key stress response that can be targeted with novel drug compounds.
A new class of antibiotic has been developed at the University of Adelaide, targeting a specific enzyme critical to bacterial metabolism. The compound, known as a protein inhibitor, binds to and inhibits biotin protein ligase, disrupting bacterial growth.
Scientists used a combination of biochemistry and mass spectrometry to reveal how protein degradation is critical to cell cycle progression and bacterial development. They identified over 100 new candidate substrates of the protease ClpXP, including proteins involved in DNA replication, transcription, and cytoskeletal changes.
Berkeley Lab researchers found that most bacterial genes are regulated by signals unrelated to their function, leading to maladaptive regulation in laboratory settings. Only a small percentage of genes showed adaptive regulation, suggesting that natural responses may not fit the classical all-benefit-and-no-cost model.
Researchers have developed a color sensor method using luminous bacterial proteins to detect pharmaceutical residues and pollutants in water. The method uses a red and green fluorescent dye, with the dyes shining green when present and red when not present, making it suitable for detecting a wide range of substances.
A new study found that the bacterium NI1060 causes gum disease by triggering a normally protective protein called Nod1 to destroy more bone, not just fight infection. This discovery could lead to personalized therapy for dental patients.
A German-American research team identified a sensor protein called MsmS in the microorganism Methanosarcina acetivorans. MsmS may serve as a 'food sensor' to detect energy sources, similar to bacteria but with potential differences in signal transduction systems.
A computational model of E. coli has been developed, enabling researchers to compute the temperature sensitivity of proteins and predict weak points that limit heat tolerance. This study opens up possibilities for creating heat-tolerant microbial strains for industrial applications.
Researchers developed a new screening technique that allows for highly efficient glycoprotein production in bacteria, increasing yields seven times compared to laboratory tests. This breakthrough could lead to more affordable and effective protein-based drugs for diseases like diabetes, cancer, and arthritis.
Scientists discover new antibiotic molecule KKL-35 that targets trans-translation step in bacteria, rendering them incapable of replicating. The compound is 100-fold more effective against Mycobacterium tuberculosis than current therapies.
Researchers found a protective molecular switch in Salmonella Typhimurium that helps the bacteria adapt to hostile environments during infection. This switch, using S-thiolation, may provide insight into fighting systemic illness and could be exploited to develop new treatments.
Researchers have developed a solar-powered nano filter that can remove harmful antibiotics and carcinogens from groundwater at a significantly higher rate than traditional activated carbon filters. The new filter uses two bacterial proteins to absorb 64% of antibiotics, offering an eco-friendly solution to combat antibiotic resistance.
Scientists at Imperial College London have identified four new receptors for the signalling molecule c-di-AMP, which is essential for bacterial growth and division. The discovery provides vital clues for developing new antibiotics targeting these pathways.
Scientists have identified a key gateway to the brain that is affected by alcohol, which could lead to the development of drugs that disrupt this interaction. The breakthrough was made using rare alpine bacteria, and the researchers plan to use mice to study the effects of altering this protein on behavior.
Researchers develop a solar-powered nano filter that can remove 64% of antibiotics from surface waters, compared to 40% by traditional filters. The new filter uses light-driven bacterial proteins to power the absorption process and allows for antibiotic recycling.
Researchers discovered a molecular switch regulating biofilm formation, which could help identify new antibiotics and prevent biofilms from forming. The study sheds light on how bacteria shield themselves in a slimy protective layer to evade attacks.
Scientists have engineered a protein from flesh-eating bacteria to act as a molecular 'superglue' that adheres tightly and resists harsh conditions. This technology has potential applications in diagnostic tests for early detection of cancer cells and other diseases, offering new possibilities for medical breakthroughs.
Researchers at UCSB have discovered a key role for rearrangement hotspots (Rhs) proteins in bacterial intercellular competition. These proteins enable certain bacteria to compete with members of their own species by delivering toxic tips into neighboring cells, leading to cell death.
The study suggests that oil-eating bacteria in the Gulf are more resilient and abundant than previously thought, enabling natural clean-up. The discovery provides new insights into the Gulf's ability to recover from oil spills, potentially reducing the need for heroic measures.
A scissor-like enzyme discovered by UT Southwestern researchers can cut off fatty acids from proteins, disabling the immune system's communication infrastructure and allowing bacteria to grow and survive. This discovery provides insight into severe bacterial infectious diseases and cancer, and may lead to the development of new treatme...
Researchers at UC Davis have identified a key protein pathway that distinguishes between harmless and harmful bacteria. The innate immune system recognizes specific sensing proteins that detect invading pathogens, triggering an alarm response to mobilize immune functions.
Scientists at the University of Pittsburgh School of Medicine identified a biological pathway that triggers excessive inflammation in pneumonia and sepsis, leading to improved lung function and survival in animal models. The team developed small molecules to inhibit this protein, offering hope for new treatments for these conditions.
A study by Karen Lloyd reveals that archaea slowly eat tiny bits of protein, implications for understanding bare minimum conditions to support life. The finding provides clues about the absolute minimum conditions required to sustain life and the global carbon cycle.
Scientists have retrieved four seabed archaeal cells and mapped their genome, revealing they live on protein degradation. This breakthrough opens up new knowledge for microbiologists, allowing them to study individual microorganisms directly from nature.
A clinical isolate of E. coli resistant to carbapenems has been studied, revealing four genetic mutations that enable the bacteria to survive and multiply despite the presence of antibiotics. These mutations involve changes to membrane proteins, regulatory proteins, and a multidrug efflux pump.
Researchers at the University of Pennsylvania have developed a nanotube-based diagnostic device that can detect Lyme disease bacteria in the blood, potentially leading to earlier diagnosis and treatment. The device uses laboratory-produced antibodies to bind to proteins from the organism, providing an electronic read-out of its presence.
Researchers have made a breakthrough in creating 'bio-batteries' by discovering that bacteria can produce an electric current when touching a mineral surface. This allows for the direct transfer of electrical charge through bacterial cell membranes, paving the way for efficient microbial fuel cells.
A new study suggests that flagellin plays a crucial role in activating the body's natural defenses against urinary tract infections (UTIs). The research found that motile Escherichia coli isolates activate NF-κB signaling pathways, indicating a key role for flagellin in up-regulating host innate defences.
Researchers at Rice University have found a way to divide and modify enzymes to create a genetic logic gate, which can be used to mimic digital circuitry. The discovery could lead to the development of diagnostic systems that look for signs of disease and gene therapies in one step.
The genome of extremophile red alga Galdieria sulphuraria reveals horizontal gene transfer from bacteria, allowing it to survive battery acid and toxic metals. This discovery provides new insights into evolution and potential applications in biotechnology.
Researchers have discovered how two proteins shelter each other to ensure smooth and safe cell division, a process crucial for growth and response to environmental changes. By understanding these molecular mechanisms, scientists may uncover new clues for understanding diseases like cancer.
A recent UCLA study reveals that certain bacteria, including those causing tuberculosis, can pretend to be viruses when infecting humans. This allows them to hijack the immune response and hide out inside cells. The findings may also explain how viral infections like the flu make us more susceptible to bacterial infections like pneumonia.
New research reveals how primitive cells could have replicated without crucial structures, shedding light on the earliest forms of cellular life. Genetic changes required for L-form growth identified, including increased fatty acid production and imbalance between surface area and volume.
Researchers at the University of Southampton have identified a potential new target for meningitis B vaccination, offering hope for universal protection. The discovery focuses on the Adhesin Complex Protein (ACP), which stimulates the production of antibodies that kill bacteria, providing protection against multiple MenB strains.
Researchers have successfully revived ancient enzymes that enable antibiotic-resistant bacteria to thrive. The 2-3 billion-year-old proteins were reconstructed and studied for their stability, structure, and function, offering insights into the evolution of antibiotic resistance.
Researchers found that superbugs like E. coli require a balance between two proteins, RbfA and KsgA, to produce proteins. Disrupting this balance could potentially kill the bacteria without harming humans.
Vanderbilt investigators have identified the structural features of calprotectin's two metal binding sites and demonstrated that manganese binding is key to its antibacterial action. The study could guide efforts to develop novel antibacterials that limit a microbe's access to metals.
Researchers at Ruhr-University Bochum have discovered a metabolic pathway for hydrogen production in green algae under stress conditions, even in the dark. This discovery provides new insights into the production of hydrogen gas and its potential application in sustainable energy solutions.
Researchers discovered a novel charge zipper principle used by membrane proteins to form functional units, allowing them to be immersed into hydrophobic cell membranes. The mechanism involves the assembly of amino acids with positive or negative charges, forming an uncharged ring that lines the TatA pore.
Researchers discovered that the protein transport system in chloroplasts of higher plants evolved from a bacterial system, with Physcomitrella patens serving as an intermediate stage. The moss has both old and new components of the SRP system, guiding proteins to their place of work in the cell membrane.
Researchers identified the mechanism by which Staphylococcus aureus colonizes nasal passages, finding that Clumping factor B (ClfB) binds to skin protein loricrin with high affinity. This interaction is crucial for successful colonization and opens new avenues for developing therapeutic strategies.
Researchers at Arizona State University have fabricated an artificial protein and examined its effects on living cells, revealing a peculiar set of adaptations including filamentation, ATP depletion, and the formation of endoliposomes. These findings may lead to the development of novel therapeutic agents.