Articles tagged with Bacterial Proteins
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Researchers at Yale University describe how Salmonella hijacks cellular mechanisms to infect millions worldwide. A novel bacterial sorting platform attracts and lines up proteins in the right sequence, allowing the bacteria to commandeer host cell functions.
Research suggests that specific bacteria in the placenta during pregnancy may contribute to preterm birth and inflammatory responses. Placentas colonized by bacteria commonly associated with bacterial vaginosis showed elevated pro-inflammatory proteins in newborns, while those colonized by Lactobacillus species had lower levels.
Researchers create genetic sequences never seen in nature and produce substances sustaining life in cells almost as readily as natural proteins. The team's work represents a significant advance in synthetic biology, suggesting the construction of artificial genomes capable of sustaining cell life may be within reach.
A team from the University of Pennsylvania School of Medicine and Utrecht University has deciphered the atomic structure of two key transient enzyme complexes in the human complement system. The findings provide a molecular scaffold for designing novel drug therapeutics by targeting the complex and inhibiting its activation.
Scientists have developed a novel flu vaccine using bacteria, which triggers an immune response without the need for eggs. The study, led by John Treanor, showed that the experimental vaccine worked well in people, with about half of participants responding strongly to just one microgram of the vaccine.
Researchers discovered that bacteria produce unique proteins to inhibit growth and end life of other bacteria, suggesting a primitive form of kin selection. These proteins are acquired through horizontal gene transfer, allowing bacteria to adapt and evolve.
Researchers developed a new approach to vaccination for rotavirus, inducing an immune response in mice and protecting them from infection. The heat-stable vaccine is low-cost and can be delivered as nasal drops or spray, addressing challenges in developing countries.
Researchers discovered a virus component, P19, that can introduce foreign genes into plants without harming them. This technology has potential applications in pharmaceutical development and biotechnology.
Most mutations in Salmonella bacterium lead to very small negative effects on growth rate, similar for non-synonymous and synonymous mutations. The study challenges conventional views on how mutations affect organism survival.
A Purdue University study reveals that Listeria can pass between intestinal cells and trigger a mechanism to increase its ability to enter the cells. This allows the bacteria to cause infection even at low doses.
Scientists at Rice University and Argentina's National University of Rosario identified a key protein in bacteria's response to cold, which acts as a 'measuring stick' tuned to signal temperature drops. The study found that this protein triggers the release of cold-protecting chemicals when its tip is engulfed by the cell membrane.
Scientists discovered a key difference in how TB bacteria and human cells deliver unwanted proteins to their respective recycling factories. This critical difference may help design drugs to disable the bacterial system while leaving normal human protein recycling centers intact.
A team at Scripps Research Institute has detailed the structure of a member of the only remaining class of multidrug resistance transporters. The study, published in Nature, may lead to the development of new antibiotics and improve crop agriculture by reengineering the transporter to help plants grow in soil they can't grow in now.
Researchers aim to create a sustainable water treatment process using moringa seed, which can kill bacteria and remove sediment from water. The system's success depends on optimizing the amount of moringa seed needed to achieve effective water purification without compromising its shelf life.
A new microfluidic chip developed by Taiwanese researchers uses surface enhanced Raman spectroscopy to sort and identify bacteria. The technique creates unique spectral fingerprints for different bacterial species, enabling efficient identification.
Scientists at Scripps Research Institute solved the mystery of protein quality control in eukaryotic organisms, discovering a mechanism that eliminates toxic non-stop proteins. The study reveals that Listerin, conserved across all eukaryotes, tags nascent non-stop proteins with ubiquitin molecules for destruction.
Research reveals that oral bacteria can jailbreak from the mouth into the bloodstream and increase risk of heart disease. Poor dental hygiene allows bacteria like Streptococcus to cause tooth plaque and gum disease, leading to blood clots and cardiovascular problems.
Research found that extracellular proteins require less energy to produce than their cellular counterparts, even though they are lost to the environment. Microbes like E. coli and Pseudomonas syringae have optimized their protein synthesis to reduce energy costs, with over 100 proteins being more economical in nature.
Researchers at the University of Michigan found that bacteria spend more on internal proteins than external ones, conserving resources and improving their competitiveness. This thrifty behavior is linked to protein location and cost, with cheaper amino acids used in internal proteins.
Two studies identify key targets for a new MRSA vaccine, targeting protein A to evade the immune system and clotting factors to disrupt tissue-damaging mechanisms. This approach shows promise in reducing virulence and providing lasting immunity against drug-resistant staph infections.
Researchers discovered a common pathway critical for Salmonella's ability to cause disease and resist antibiotics. Mutant strains exhibited abnormalities under stressful conditions, highlighting the importance of stress response mechanisms.
Scientists at NIH identify novel Staphylococcus aureus toxin LukGH, which destroys human immune cells and increases MRSA severity. The toxin is secreted into the environment, forming pores in neutrophils that lead to their destruction.
Scientists have identified a promising target for a strategic hit in bacteria that could help halt reproduction and reduce the spread of infections. The research, led by Dr. Antonio J. Martín-Galiano and professor José M. Andreu, maps out a protein called FtsZ, which is crucial for bacterial cell division.
Researchers at Loyola Medicine have discovered protein acetylation, a common molecular reaction in bacteria that affects protein function and gene regulation. This finding has significant implications for understanding bacterial physiology and developing new drugs to combat harmful bacteria.
A study led by Universitat Autonoma de Barcelona researchers reveals a new mechanism controlling bacterial swarming and its interaction with the DNA repair system. The discovery could lead to designing new strategies to increase antibiotic sensitivity in pathogenic bacteria.
Researchers found that GroEL and GroES proteins play a critical role in increasing the maximum temperature for E. coli growth. The study shows a 16-fold increase in GroE levels, indicating a uniquely important role in mitigating protein folding damage.
Researchers at UCR are developing genetically engineered bacteria to kill mosquito larvae, making it ten times more effective than current products. The new bacterial strain is environmentally safe and has built-in resistance management properties, potentially leading to a commercially available product in 3-5 years.
Scientists have discovered a group of four proteins responsible for generating Helicobacter pylori's characteristic curvature, enabling its survival in the acidic stomach environment. Laboratory-engineered mutant strains lacking these proteins fail to twist properly and are unable to colonize the stomach.
Plectasin disrupts the forming of the cell wall in bacteria, preventing division and ultimately leading to bacterial death. Despite its potential, the authors caution that no permanent solution exists to antibiotic resistance.
Queen's University biochemistry professor Zongchao Jia and post-doctoral student Jimin Zheng discovered a unique protein switch in bacteria, allowing them to adapt to low-nutrient environments. This breakthrough could lead to the development of molecules that can kill bacteria in water, reducing contamination risks.
A study published in the Journal of Experimental Medicine suggests that boosting interleukin-10 levels can protect against lethal E. coli K1 infection without antibiotic side effects. Researchers seek to determine its safety and efficacy in human infants infected with the bacterium.
Researchers have developed a new method to study the metabolic functions of microbial communities, identifying key species and interactions in complex decomposition processes. The Protein-SIP technique measures carbon flux accurately, revealing food chains within microbial communities.
Scientists studied Mycobacterium tuberculosis proteasome structure and assembly to understand its role in pathogen survival. This knowledge could aid in developing anti-TB drugs by preventing proteasome maturation.
The study provides strong evidence that the NBD dimer does not fully dissociate in each gating cycle, proposing a new gating model for CFTR with two distinct cycles. This advancement sheds light on the chloride channel's behavior and may lead to improved treatments for cystic fibrosis patients.
Researchers find that combining certain antibiotics can halt bacterial evolution and favor non-resistant strains, potentially reversing the trend of antibiotic resistance. This approach could lead to identifying novel drug combinations that hinder resistance development without compromising effectiveness.
A new switch has been discovered that enables Salmonella bacteria to sabotage host cells, allowing it to replicate and establish an infection. This finding could lead to the development of drugs to combat Salmonella-related diseases.
Bacteria have a CRISPR defence system that can be passed down to future generations, providing immunity against viral attacks. This system could be exploited to give bacteria 'flu jabs' to protect them against real-world threats, increasing industrial productivity and reducing costs.
A Johns Hopkins team identified a class of chemical compounds that selectively slow down a tuberculosis protein's activity and block TB growth. The MetAP inhibitors have the potential to enhance existing therapy by targeting an essential enzyme in the bacteria's survival.
Rival bacterial colonies use a toxic protein called sibling lethal factor to outcompete each other for limited nutrients. The protein kills cells at the edge of a colony closest to a competing group, creating a lopsided growth pattern and preserving scarce resources.
The RECAN project developed novel fluorochrome dyes bound to monoclonal antibodies, enabling improved diagnosis of leukaemia and rheumatic diseases. The project also produced recombinant proteins for immunisation and created a range of specific monoclonal and polyclonal antibodies with great commercial potential.
The US Department of Agriculture has developed a new lentil variety called Essex, which boasts high seed yields and nitrogen-fixing properties. This development is expected to enhance the nutritional value of lentils for consumers while also improving soil fertility for subsequent wheat crops.
MIT researchers use high-speed atomic force microscopy to image bacteria in real-time, revealing a two-step process for AMP-induced cell death. The technique allows scientists to study living cells and gain insights into how bacteria become resistant to antimicrobial peptides.
Rachel J. Dutton received the Raymond W. Sarber Award for her research on disulfide bond formation pathways across bacterial genomes. Her discovery of an alternative VKOR homologue in Mycobacterium tuberculosis has implications for understanding bacterial protein stability and anticoagulant resistance.
A study published in Plant Biotechnology Journal found that algae can produce human therapeutic proteins such as VEGF, HMGB1, and fibronectin at levels comparable to mammalian cell cultures. This could significantly reduce the cost of expensive treatments for diseases like Multiple Sclerosis and Type 1 diabetes.
Cyanobacteria build miniature factories inside themselves that turn carbon into fuel, with spatial organization improving efficiency. The discovery may help create designer bacteria for producing carbon-neutral fuels like biodiesel and hydrogen.
Researchers are exploring the use of synthetic biology to enable corn plants to fix their own nitrogen, eliminating the need for fertilizers. This technology has the potential to increase crop yields while reducing environmental degradation and promoting sustainable agriculture.
Wolf-Watz recognized for seminal work on Yersinia host-pathogen interaction and international collaborations that advanced microbiological sciences. His proposal of type III protein secretion systems as unique injectors of proteins into host cells has been critical to understanding host-pathogen interactions.
Researchers have discovered a Bt protein that is highly effective at curing intestinal parasitic roundworm infections in humans. The Cry5B protein produced by the Bt bacterium is three times better than tribendimidine and shows promise as an alternative to existing treatments.
Scientists at Emory University School of Medicine discovered a set of bacteria-killing proteins that recognize human blood type molecules on bacterial surfaces. These proteins, galectin-4 and galectin-8, can kill certain strains of E.coli within minutes.
Researchers at Dartmouth College have discovered a protein structure controlling Vibrio cholerae's virulent nature. A fatty acid found within the protein appears to inhibit its function, preventing the bacteria from causing life-threatening diarrhea.
Researchers have discovered the bacterial protein VpsT as the key player in biofilm formation by Vibrio bacteria. This breakthrough provides new opportunities to disrupt biofilm creation and combat enteric disease, with potential applications for therapeutic interventions.
Researchers found that only 16% and 9% of Helicobacter pylori strains expressed the hopE and hopV genes, respectively, despite detection rates being much higher. This suggests a mechanism for the bacteria to evade the immune system.
Dr. Kim Orth's pioneering work focuses on mechanisms bacteria use to cause disease, expanding the frontiers of chemistry through innovative research. Her discoveries have important implications in medicine, especially in understanding and treating infectious diseases.
Scientists at EMBL discovered membrane-coat proteins in bacteria from the PVC superphylum, which could aid in understanding eukaryotic cell evolution and structure. These findings provide molecular evidence that coat proteins shape eukaryotic endomembrane systems in prokaryotes.
Researchers at Florida Institute of Technology are awarded a four-year, $1.024 million NIH grant to continue their studies on cell growth regulation and its implications for human health. The funding will support the development of novel inhibitors that could be used to combat antibiotic-resistant bacterial diseases and treat cancer.
Researchers at UNC have discovered a single calcium atom controls bacterial motility required for infection. By blocking this site, the bacteria can't move, stopping its ability to establish infections like meningitis. The finding identifies a key step in bacterial infection and could lead to new drug targets.
Researchers found that HdeA lets go of unfolded proteins gradually, allowing them to refold instead of clumping together. This unique mechanism allows HdeA to harness energy from the environment, making it a more efficient chaperone.
Researchers have identified two new glycoproteins in spider web glue that can be used to develop a new generation of biobased adhesives. These proteins are produced from opposite strands of the same DNA sequence, making them a promising material for large-scale production and various applications.
Scientists applied physics techniques to study bacteria's survival strategies, gaining insights into human decision making. The study found that bacteria's game theory decision making process is more advanced than the Prisoner's Dilemma, enabling them to weigh pros and cons in complex environments.
Researchers at the University of Michigan have discovered a way to stabilize proteins by linking their stability to antibiotic resistance in bacteria. This method enables easy selection for stabilizing mutations, rendering proteins more resistant to unfolding and increasing their practical utility.