Articles tagged with Bacterial Proteins
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The 'Immune Attack' video game increased teenagers' understanding of cell biology and molecular science, according to a study. Players navigated the microscopic world of immune system proteins and cells to save a patient with bacterial infection, measurably improving their knowledge.
Structural biologists reveal how internalin B dimer activates human receptor Met, allowing Listeria to infect cells. The discovery may lead to therapeutics for improved wound healing and treatment of listeriosis.
A team of scientists has discovered how bacteria defend themselves from viruses and other invaders, unlocking opportunities for targeted antibiotics, gene function studies, and stable bacterial cultures. The CRISPR-Cas system, a dynamic duo of RNA and proteins, recognizes and neutralizes invader RNAs.
Researchers discovered that cells use 'regulated errors' to create resistant proteins against damage, using the amino acid methionine to neutralize reactive oxygen species. This novel non-genetic mechanism allows every protein to get some protection, making it a crucial defense strategy.
Scientists have crystallized a protein that enables beneficial bacteria to bind to the gut lining, interacting with cells and exerting their activity. The discovery opens new avenues of research into gut health and highlights the importance of molecular design in selecting probiotics.
Researchers discovered a new antioxidant system that shields single cysteine residues from oxidative harm, reducing cancer and heart disease risk
Researchers discovered that E. coli has a protein that recognizes the rarer furanose form of galactose, allowing it to exploit this additional nutrient source. This adaptation enables E. coli to grow faster and persist in the gut at the expense of other species.
A dietitian recommends a balanced diet rich in fiber, protein, and low-fat foods to maintain a healthy gut microbiota. Key findings include the importance of monounsaturated fats and adequate protein intake for optimal gut health.
Researchers have identified two new glycoproteins in spider web glue, which can be produced through opposite strands of the same DNA sequence. This discovery paves the way for large-scale production of biobased glues for various applications.
The genomes of two popular E. coli laboratory strains, K-12 and B, have been sequenced for the first time, revealing their genetic similarities and differences. The study provides valuable information on the evolutionary mechanisms that produced these differences and will guide future research in basic molecular biology and genetics.
Researchers at the University of Gothenburg have identified a protein called MUC1 as an important part of the body's defense against Helicobacter pylori. Genetic variations in MUC1 molecules may contribute to why some people are more ill than others with stomach ulcers and stomach cancer.
Bacteria have a novel RNA repair system that adds a methyl group to damaged RNA, making it impossible to cleave the site again. This discovery has implications for protecting cells against ribotoxins and understanding RNA interference in eukaryotes.
Intracellular pathogens like Chlamydia and Legionella exploit host cell biology to escape destruction. Researchers found that SNARE-like proteins expressed by the bacteria inhibit membrane fusion with lysosomes, allowing them to remain in cells.
Researchers at Duke University discovered that some bacteria exhibit bistability, allowing individual cells to respond differently to external commands. This phenomenon enhances the efficiency of synthetic circuits, which could produce proteins, chemicals, or deliver targeted drugs.
Researchers discovered a previously unknown mechanism that aids in the spread of Listeria monocytogenes, a deadly bacterium causing listeriosis and severe illnesses.
Researchers at Weill Cornell Medical College have identified new anti-tuberculosis compounds that inhibit the disease-causing bacteria's mechanism for surviving dormant in infected cells. The findings could lead to drugs that destroy TB in its dormant stage, potentially revolutionizing treatment.
Researchers discovered compounds that disable Mycobacterium tuberculosis' proteasome complex, allowing the bacteria to remain dormant. The inhibitors show high specificity for TB microbes while sparing human cells.
Researchers discovered molecular evidence supporting Darwin's theory of evolution, finding that complex machines evolved through a process of combination and modification of existing proteins. The study provides a blueprint for understanding the evolution of cellular machinery, contradicting Intelligent Design explanations.
Researchers at the University of British Columbia have developed a system that turns harmless bacterium Caulobacter crescentus into a protein production factory, making useful proteins for vaccines and therapeutic purposes. The technology could be used to manufacture HIV-blocking agents cheaply and with minimal expertise.
Manuka honey kills MRSA by destroying key bacterial proteins, including FabI essential for fatty acid biosynthesis. The study suggests manuka honey could be used as a first-line treatment for resistant bacteria infections.
Scientists have captured nanoscale movements of ribosomes, revealing a complex four-step ratcheting mechanism that interacts with mRNA and tRNA. This breakthrough could lead to more effective antibiotics and new treatments against devastating diseases like hepatitis C.
Scientists have developed a therapy using genetically engineered Bacteroides ovatus that activates a human growth factor to treat bowel disorders like inflammatory bowel disease. The treatment reduces rectal bleeding, accelerates gut lining healing, and prevents disease onset.
A Princeton-led team has discovered how some antibiotics kill bacteria by jamming the translocator, a protein-producing machine. The researchers also found that a specific protein called YccA protects the translocator from destruction, similar to a human protein of interest in cancer research.
Researchers have identified a key protein, NanA, that allows pneumococcus bacteria to penetrate the brain, leading to meningitis. Removing or modifying this protein can prevent bacterial entry, offering potential new avenues for developing more effective vaccines.
A new study finds that administration of a novel small molecule effectively disrupts quorum sensing in bacteria, protecting animal hosts from infection. The research offers a potential alternative to traditional antibiotics and may lead to more effective treatments for bacterial infections.
A team of scientists used PALM microscopy to show that bacterial membrane proteins can spontaneously form clusters without being actively distributed. The researchers found that random lateral protein diffusion and protein-protein interactions generate complex, ordered patterns in the chemotaxis network.
Researchers aim to understand how colicins penetrate Gram-negative bacteria, potentially leading to new drug delivery methods for diseases. The five-year programme will improve our understanding of biological warfare in bacteria.
Researchers identified a complex of proteins in Arabidopsis that play important roles in recognizing and blocking out invading bacteria. The study provides insights into plants' immune systems and may help protect agricultural crops from diseases.
A team of scientists used fluorescence technique to find a bacterial protein can shift between two stable structures, one active and the other inactive. The discovery sheds light on how proteins regulate cellular activities through shape-shifting.
The study reveals that each bacterial strain presents a unique outer surface protein, rendering current vaccines less effective against new strains. Researchers believe a tip protein-based vaccine strategy could provide better protection.
Research by USGS scientists links estrogen exposure to reduced immune response in largemouth bass, potentially making them more vulnerable to diseases. The study reveals that estrogen blocks production of hepcidin, a hormone that regulates iron and has antimicrobial properties.
Researchers found that interrupting selenoprotein production can halt growth of bacteria such as Clostridium difficile and Treponema denticola. The study uses auranofin, an FDA-approved gold salt compound, to block bacterial growth by altering selenium metabolism.
Bacteria of the Yersinia genus possess a protein thermometer called RovA, which measures temperature and metabolic activity to control infection. RovA activates genes for the infection process in suitable environments, while adapting to life within the host.
A plant MinD protein has been found to rescue the oscillating cell division of E. coli by localizing to its polar regions without oscillation. This finding suggests that the conserved Min proteins between bacteria and plants have different functions.
Researchers found that zinc-coordinated reaction centers have similar physical and chemical properties to magnesium-containing reaction centers. This discovery enables a deeper understanding of photosynthesis structure, function, and evolution.
Researchers identified LXR proteins as a new target in the fight against tuberculosis, providing substantial protection against infection. Additionally, studies revealed that immune cells can destroy AAV-transduced liver cells through CTL recognition, suggesting a potential therapeutic intervention to improve gene therapy success.
Scientists at the University of California, San Diego, have developed a new class of infrared-fluorescent proteins (IFPs) that can be expressed in mammalian cells. These proteins are suitable for whole-body imaging in small animals and may provide a prototype for future studies in animal models.
Scientists have decoded the structure of a needlelike protein complex on Shigella bacteria, essential for infection, revealing new insights into the mechanism of bacterial injection systems that could lead to new drugs.
A single protein called SopB allows Salmonella to invade cells and hijack cellular functions, enabling it to avoid destruction. The study reveals how SopB coaxes cells to mark the protein with ubiquitin, making it recognizable to cellular machinery.
The study reveals the precise orientation of the Fenna-Matthews-Olson (FMO) antenna protein on the membrane, allowing for efficient energy transfer. The 'taco shell' protein plays a crucial role in connecting the peripheral chlorosome antenna complex to the reaction center.
Researchers developed a targeted antibiotic to kill Porphyromonas gingivalis, a cause of gum disease, without harming other beneficial bacteria. This approach aims to provide new treatments for oral diseases and prevent drug resistance.
Researchers have identified the DegU protein as crucial for bacterial decision-making in biofilms. This protein enables individual bacteria to switch between different physiological processes, such as movement and biofilm production, in response to environmental conditions.
Researchers at the University of Michigan discovered a tiny protein called HdeA that protects disease-causing bacteria from stomach acid. This protein unfolds and becomes more flexible in response to acid, but unlike other proteins, it activates when unfolded, allowing it to bind and adapt to damaged proteins.
Researchers at the University of Bath are part of a €3 million Europe-wide collaboration to pioneer new, safer anti-bacterial plastics and coatings. The team has developed compounds effective against MRSA and other hospital bacterial infections, with the goal of incorporating them into various materials.
Researchers developed an onsite method to quickly diagnose tuberculosis and distinguish drug-resistant strains from treatable ones. The method uses bacteriophages with a green fluorescence protein to provide rapid and relatively cheap diagnosis in rural African areas.
Researchers have discovered how Shewanella bacteria 'breathe' toxic metals, converting them into non-toxic forms. This process could potentially clean up contaminated nuclear waste sites by utilizing the bacteria's ability to extract energy from metal oxides.
Researchers at Kansas State University collaborated with Epitopix LLC to develop the US' first vaccine against E. coli O157 in beef cattle. The vaccine has been granted conditional approval by the USDA and is expected to help reduce cattle shedding of the pathogen.
Researchers at Ohio State University discovered that cells have a second chance to correct errors in protein production, which could lead to new insights into neurodegenerative disorders and the development of targeted antibiotics. This discovery gives scientists a better understanding of the mechanism behind protein synthesis mistakes.
Researchers at the University of Leeds have discovered that proteins fold incorrectly many times before forming the correct structure, with amino acids central to function causing misfolding. The study, which looked at the Im7 protein, has huge implications for understanding protein sequences and disease balance.
New research shows individual COPD exacerbations increase repeat likelihood, driving disease progression. Patients may be 'brittle' during a subsequent eight-week period, requiring close monitoring and follow-up to prevent further exacerbations.
Researchers discovered how meningitis bacteria use a protein to disguise themselves as human cells, evading the immune system. This finding could lead to improved vaccines against meningitis B, which accounts for most UK cases. The bacterial protein can be modified to generate a stronger immune response.
Scientists at Caltech have discovered self-regulating molecular 'transformers' that control the delivery of proteins to their correct locations within cells. The research could lead to novel treatments for diseases resulting from flaws in protein delivery and the development of new types of antibiotics.
Scientists at Lawrence Berkeley National Laboratory create a novel technique to precisely modify recombinant proteins by introducing aldehyde tags. This breakthrough enables the labeling of therapeutic proteins in mammalian cells, paving the way for targeted treatments and improved pharmaceuticals.
Researchers developed a mathematical model to evaluate the efficiency of bacterial protein production, finding that optimal efficiency requires seven genes for ribosome production. The model accurately predicted how E. coli adapts to disruptions in production workflow.
Researchers at the University of Texas M. D. Anderson Cancer Center have discovered how E. coli bacteria can resist antibiotics by inducing a dormant state through the HipA protein kinase. By studying the molecular details of HipA's role in multidrug tolerance, the team has identified potential targets for new therapies.
A new family of antibacterial agents has been identified in the freshwater animal Hydra, which shows promise in combating drug-resistant bacteria. The protein hydramacin-1, found in Hydra, exhibits broad-spectrum antibacterial activity against Gram-positive and Gram-negative bacteria.
A new nasal spray vaccine has shown promising results in protecting against botulism, a deadly bacterium that can cause paralysis and death. The vaccine uses a gene therapy approach to prime the immune system against a key toxin, offering a safer alternative to existing vaccines.
Researchers at St. Jude Children's Research Hospital have discovered a more effective treatment for secondary pneumonia following influenza, using antibiotics like clindamycin and azithromycin. These treatments inhibit protein synthesis, reducing inflammation and improving survival rates in mice infected with both conditions.
Scientists at Johns Hopkins Medicine found that the ribosome recognizes and corrects errors during protein synthesis. The discovery reveals a critical 'proofreading step' in protein production, showcasing the cell's strict adherence to high-fidelity synthesis.
A computational method predicts bacterial protein interactions with remarkable accuracy, identifying critical residues that bind directly with other proteins. This breakthrough enables the development of new antibiotics targeting specific protein interactions vital to pathogenic bacteria survival.