Articles tagged with Bacterial Proteins
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Biologists at UCSD have discovered a natural defense mechanism in animal cells to ward off certain types of bacteria that secrete toxins. The discovery could lead to the development of new treatments for bacterial diseases such as pneumonia and strep throat.
Researchers at UT Southwestern Medical Center have refined the description of a bacterial protein that regulates salt and solute flow. By understanding how this protein functions, scientists may be able to design new antimicrobial agents by manipulating its gating mechanism.
Researchers recommend using RIP, a new compound that inhibits bacterial virulence and prevents infection-causing toxins. The discovery has the potential to protect hospitalized patients from deadly staph infections.
Researchers discovered that Salmonella bacteria can alter the lipid composition of a vacuole to avoid destruction by a lysozome, allowing it to survive and replicate rapidly. This remarkable mechanism may lead to new targets for therapeutic strategies to control food poisoning and typhoid fever.
Duke University Medical Center biochemists have successfully engineered a protein that can detect nerve agents like soman and sarin. The proteins could be incorporated into detectors, resembling smoke detectors, to provide early warning and monitor levels.
A new study isolated a compound called dodecenal from fresh cilantro leaves, which is found in salsa, and showed it to be twice as potent as the antibiotic gentamicin at killing Salmonella. The researchers believe that eating more fresh salsa could help prevent foodborne illness.
A new protein, DEFB118, has been discovered in the male reproductive tract and has potent antibacterial activity. It may aid fertilization by protecting sperm from harmful organisms encountered in the female reproductive tract.
Researchers found that bacterial proteins are destroyed by the proteasome within the cytosol during infection, activating the immune system. Bacteria like Listeria avoid recognition by moving within the cytosol, preventing immune activation.
Researchers have identified a key antigen underlying Crohn disease, bacterial flagellin, which triggers an immune response. Studies found high reactivity against specific flagellins in CD patients, but not in controls or ulcerative colitis patients, providing new leads for causal antigens.
Researchers have discovered a molecule called ppGpp that plays a crucial role in regulating bacterial gene expression and survival. When amino acid levels are low, ppGpp accumulates and shuts down protein synthesis, allowing the cell to go dormant until conditions improve.
A research team at the University of Michigan and the University of Texas describes how a resourceful bacterium developed an entirely new way to make disulfide bonds. This breakthrough could have significant implications for disease states like Alzheimer's and cystic fibrosis, as well as biotech applications.
Researchers have unraveled the complete genome sequence of Bdellovibrio bacteriovorus, a predatory bacterium that can degrade complex biopolymers in other bacteria. The study may lead to novel anti-microbial substances and the development of a 'living antibiotic' as a potential therapeutic agent.
A new vaccine formulation uses a bacterial protein called listeriolysin O to boost the immune response against viral diseases. The vaccine has shown promise in preliminary animal studies, with a 100% survival rate in mice infected with a lethal viral strain.
The research team, led by Chi-Huey Wong, discovered a way to make homogeneous pools of glycosylated proteins in E. coli, overcoming previous bottlenecks and challenges. This new method has the potential to be more efficient, scalable, and cost-effective than existing technologies.
Researchers at MCG are studying Campylobacter jejuni to understand its effects on the human body. They aim to develop a vaccine and improve prevention methods for this bacterial infection, which causes bloody diarrhea, fever, and abdominal pain in millions of Americans each year.
Researchers identified a genetic master switch that controls bacterial consumption of chitin, a key component of ocean debris. The discovery sheds light on the process by which bacteria break down tough material and turn it into food, preserving ecological balance in the ocean.
Researchers have successfully created self-assembling nano transistors using DNA, paving the way for large-scale manufacturing of nanoscale electronics. The transistors can be switched on and off by applying voltage to them, making them a promising application in computing technology.
Researchers at SLU have successfully deciphered the molecular structure of recombination protein O (RecO), crucial for accurate genomic DNA replication. This breakthrough may aid pharmaceutical researchers in developing more effective drugs and basic scientists in understanding gene function.
Researchers at UVa and Rockefeller University found that SipA, a Salmonella protein, tethers to actin, allowing bacteria to infect cells. The study's findings may lead to the development of new treatments against severe infections.
Researchers discovered how Salmonella injects proteins into host cells that staple actin molecules together, changing the cell's structure to facilitate bacterial invasion. This complex protein secretion system allows Salmonella to manipulate host cells in unique ways, enabling it to evade immune responses.
Researchers at PhageTech identified phage-derived antimicrobial proteins that inhibit bacterial growth and kill bacteria in diverse ways. The company's technology platform has led to the discovery of novel bacterial targets essential to bacterial growth, which are being screened for small molecule compounds as potential new antibiotics.
Researchers at Purdue University have captured the clearest image yet of the T4 virus's docking bay, a complex structure that allows it to infect its host. This breakthrough could lead to new strategies for stopping viral infections and developing novel antibiotics.
Researchers at Scripps Research Institute identify a single protein called Trif that associates with different receptors to detect pathogens, triggering immune reactions. The protein could be a potential target for intervening in diseases like sepsis.
Researchers discovered Trif, a critical transducer protein in the innate immune system, which mediates signals from both bacterial and viral infections. The protein's role sparks inflammation, making it an attractive target for drugs designed to combat runaway inflammation characteristic of infectious diseases.
Researchers identified a previously unknown protein family, chaplins A-H, essential for S. coelicolor's aerial hyphae formation. Exogenous application of chaplin proteins restores aerial growth in streptomycetes lacking specific genes.
Researchers have discovered that heat shock proteins from deep ocean vent microbes can increase the sensitivity of DNA tests by up to ten times. These unique proteins also enable genetically modified bacteria to survive at higher temperatures.
Research found that two proteins, IL-1 and TNF-alpha, work together to overcome pneumonia. Inhibiting one protein can lead to death in mice with bacterial pneumonia. Cytokines play a crucial role in the immune response by recruiting white blood cells to fight invading bacteria.
Researchers have discovered how bacteria evade antibiotics by exploiting a protein complex with a diverse binding site. The findings may lead to the development of new antibiotics that can bypass this pump, allowing drugs to kill bacteria. Alternative strategies, such as disabling the pump, are also being explored.
Duke University biochemists create sensor proteins that can specifically detect TNT and other chemicals, opening doors for medical and environmental applications. The researchers' computational design method narrows down possible structures to reasonable numbers with days' worth of calculations.
Scientists identified a genetic key to TB bacteria survival in lung cells, revealing that SecA2 protein is crucial for virulence and secreting antioxidant molecules. This finding may aid treatment development and has implications for other disease-causing bacteria.
Cecropin A alters bacterial gene regulation, challenging conventional thinking on its mechanism of action. The insect antibiotic's ability to evade resistance raises hope for new therapeutic agents.
Researchers have discovered a novel protein, Ang4, produced by Paneth cells in the intestinal lining that can kill certain types of gut microbes. This finding suggests that Ang4 may play a crucial role in maintaining gut health and preventing infection.
Scientists have created a completely autonomous organism that uses 21 amino acids, enabling site-specific incorporation of novel amino acids into proteins. This breakthrough expands the genetic code's capabilities and paves the way for innovative medical research and protein modification technologies.
Researchers successfully expanded the genetic code of E. coli bacteria, creating a self-sufficient organism that can produce new amino acids on its own. The breakthrough could lead to enhanced function in organisms and provide answers to questions about why life settled on 20 natural amino acids.
Researchers discovered that sirtuins, a family of proteins controlling cellular respiration, may play a crucial role in extending lifespan. Sirtuins modify an enzyme to convert acetate into acetyl-CoA, a key component of energy production.
Scientists have developed a novel system to manufacture glycosylated proteins in E. coli, enabling the production of complex human proteins like Factor VIII and erythropoietin. This breakthrough opens up new avenues for research and industry applications.
Researchers reveal the role of chaperone proteins in fiber assembly, leading to potential breakthroughs in treating urinary tract infections. The study provides insight into how disease-causing bacteria build and secrete proteins that enable them to cause disease.
Researchers at the University of Illinois Chicago have isolated a protein from bacteria that kills cancer cells without causing harm. The protein, azurin, was tested in mice with human melanomas and showed significant tumor shrinkage, with no deaths or adverse reactions.
Researchers discovered that ion channels in bacteria allow them to withstand stomach acid by enabling an electrical shunt. This finding suggests a similar mechanism exists in human cells, potentially related to maintaining acidic conditions within endosomes.
Researchers have developed a gene therapy technique that integrates DNA without using viral vectors, inserting the DNA at known locations. The technique successfully integrated a gene coding for Factor IX into mouse DNA, making 12 times more protein than control mice.
The ribosome recycling factor plays a crucial role in protein synthesis by disassembling the ribosomal complex after protein completion. Researchers believe RRF could be targeted for new antibiotic development to combat bacterial resistance.
The partnership aims to advance biomedical research through collaboration between biologists and mathematicians/scientists. The new awards will support projects in areas such as disease modeling, HIV dynamics, and bioinformatics.
Researchers at the Max Planck Institute of Biophysics have determined the first structure of the SecYEG protein translocation machinery from Escherichia coli. The structure provides a detailed view of the complex, which binds and transports secretory and membrane proteins.
A recent study has found that exposure to bacteria significantly increases the expression of genes involved in immune response, reducing the risk of developing allergies in children who grow up on farms. This discovery highlights the potential benefits of living on a farm for children's immune system development.
Scientists at The Wistar Institute identified key segments of an insect-derived antimicrobial peptide that kill bacteria and prevent mammalian cell entry. The research team confirmed the peptide's binding site on a bacterial protein target, opening up possibilities for novel antibiotic design and universal drug delivery.
Researchers have discovered how certain sugars on the surface of H. pylori bacteria help the immune system fight infection, but also make it worse. The findings provide new prospects for developing a vaccine against this virulent bug that causes ulcers and stomach cancer.
Researchers discover that Staph's toxic shock toxin inhibits production of other toxic proteins, leading to reduced disease severity. This breakthrough understanding sheds light on the complex ways Staph causes life-threatening infections.
Researchers at the University of Washington discovered that fluid forces in the human body help invasive bacteria, such as E. coli, thrive and adhere to surfaces. This finding has significant medical implications, including the potential for improved biomedical device safety and a better understanding of urinary tract infections.
Researchers at Cornell University and Argonne National Laboratory have solved the structure of a key bacterial quorum-sensing protein, which could lead to new treatments for biofilm-related diseases. The discovery may also enable the design of targeted therapies to prevent harmful bacteria from forming biofilms.
A new technique uses ESR to measure distances between atoms in proteins, revealing the overall structure of a molecule. This method is particularly useful for studying larger protein assemblies and membrane-embedded proteins, which are challenging to study using traditional methods.
Researchers identified iron as a key factor in axillary bacterial growth and developed an iron-chelating compound, DTPA, to inhibit bacterial growth. Combining DTPA with butylated hydroxytoluene (BHT) showed significant deodorancy benefits by limiting the bacteria's access to iron.
Researchers create custom-built antimicrobial agents using polymers and oligomers inspired by natural defense peptides. The new approach focuses on overall shape rather than specific chemistry, offering a novel solution for combating bacterial infections.
Researchers found bacterial proteins cause autoimmune disorders in APS patients by mimicking endogenous host proteins. High-affinity antibodies against these proteins were pathogenic and induced symptoms similar to APS. The study raises concerns about vaccine risks, particularly the tetanus toxoid protein.
Researchers found diseased gums release higher levels of bacterial pro-inflammatory components, which can travel to organs like the heart and cause harm. The study supports earlier findings suggesting periodontal disease may trigger cardiovascular disease through oral bacterial components.
Researchers have determined the three-dimensional structure of the chloride ion channel using x-ray crystallography, resolving a long-standing biochemical puzzle. The discovery provides insights into how nature arranges proteins to stabilize anions like chloride inside cell membranes.
Infants and adults are susceptible to bacterial meningitis-induced CNS cell death, leading to severe neurological outcomes. Researchers investigated the underlying mechanisms of this devastating condition, shedding light on potential therapeutic targets for treatment and prevention.
Researchers discovered a link between the CFTR gene and increased susceptibility to respiratory infections in cystic fibrosis. They found that altered CFTR can change the internal chemistry of lung cells, making them more attractive to certain bacteria.
Researchers at Weizmann Institute and Max-Planck Research Units create crystals capturing individual complexes formed between bacterial ribosomes and antibiotics, revealing how these drugs shut off protein production. The findings may improve treatment strategies of existing drugs and lead to rational drug design.
A recent study published in Journal of Nutrition found that human intestinal cells with excess iron are more susceptible to bacterial infection. The researchers suggest that fortifying foods with high doses of iron may be causing other health problems and recommend a revision of the standard policy of iron fortification.
A new study found that patients with periodontal disease have higher levels of C-reactive protein, a marker of inflammation associated with cardiovascular risks. The study suggests a possible link between oral bacteria and heart disease, emphasizing the importance of maintaining good gum health.