Articles tagged with Viruses
CSIRO scientists have discovered a long line of viruses emerging from the Hendra virus family, including 15 new paramyxoviruses in animal hosts worldwide. The Australian Animal Health Laboratory holds a collection of all major newly discovered paramyxoviruses.
Researchers followed women with advanced disease to see which HIV variants remain after HAART. They found that R5 viruses can re-emerge as the predominant population following treatment.
Researchers propose a new model of asthma that suggests epithelial cells play a crucial role in the development of the disease. They found that IL-12 p40 production is increased in airway epithelial cells during inflammation and is overactive in people with asthma.
Researchers identify gC1qR as a binding partner for Hepatitis C core protein, allowing the virus to evade immune response and persist in the body. The interaction between gC1qR and core protein may provide new targets for developing therapies to combat chronic hepatitis C.
Researchers found that early antiviral treatment primes the immune system to suppress viral levels without drugs, achieving temporary suppression in several months. Five patients remained off treatment for up to 11 months, maintaining low viral levels.
Chemists at Washington University in St. Louis have created knedel nanoparticles that mimic viruses and show potential for a new direction in gene therapy and other biomedical applications. The nanoparticles can escape detection by the immune system and are designed to behave like viruses, but without the risk of live virus effects.
Researchers found a key cell gene that aids viruses in multiplying by commandeering host cell machinery. This discovery could lead to new therapeutic approaches and antiviral drugs effective against various RNA viruses.
Researchers at Purdue University have solved the structures of two large icosahedral viruses, providing insights into their assembly and potential applications in antiviral agents. The viruses' shells are made up of large building blocks joined primarily in clusters of three, forming stable and highly symmetrical structures.
Researchers at the University of Michigan have identified a key mechanism by which some viruses, including Kaposi's sarcoma-associated herpesvirus, can hide in human cells for extended periods. The study reveals that a protein called LANA binds to host chromosomes, allowing viral DNA to remain dormant until the immune system is weakened.
Researchers have developed a model to study viral evasion and co-option of cellular defense strategies, revealing that persistent infection is achieved by suppressing cell suicide. Physiological changes occur, including slower growth and reduced virus infectivity over time.
Researchers at Thomas Jefferson University and Oxford University have found a promising drug against the hepatitis C virus (HCV), called N-nonyl-DNJ, which inhibits the activity of an important cellular enzyme, glucosidase. This drug may sidestep resistant viruses, a major problem with current treatments.
Researchers have discovered a prehistoric virus in Arctic ice that could potentially re-emerge as the climate warms. The ancient tomato mosaic tobamovirus was found in ice cores dating back 500 to 140,000 years, raising concerns about the possibility of new epidemics.
A new cotton additive with N-halamines effectively kills pathogenic and odor-causing bacteria and viruses. The treatment can be recharged by rinsing treated fabrics in a dilute bleach solution, offering a fast and cost-effective alternative to existing biocidal cottons.
Researchers Mark Young and Trevor Douglas have created a 'molecular cooking pot' using the protein case of a virus, enabling precise delivery of drugs to specific cellular addresses. The discovery has far-reaching implications for medicine, including breast cancer treatment.
Researchers at the University of Pittsburgh found that HIV-1 viral load in semen can fluctuate greatly and does not correspond to viral levels in blood, requiring new testing methods to monitor transmission risk. Testing viral load levels in semen may offer physicians a better way to assess transmission risk and target treatments.
Scientists have found that parts of the protein shell of the common cold virus flap open in a motion called "breathing", which can be stifled by compounds that stop viruses from infecting cells. This discovery could lead to rapid screening methods for antiviral drugs.
Researchers at Washington University School of Medicine discovered that a virus related to mononucleosis and Kaposi's sarcoma can injure arteries in mice, suggesting a possible link between viruses and vascular diseases. The study found lesions resembling early stages of human vascular diseases, including atherosclerosis.
Imperial College researchers are building artificial viruses from DNA, protein, and fat that can bypass the patient's immune system. These artificial viruses have shown great promise for gene therapy in corneal transplants, particularly for children at high risk of graft failure.
Hepatitis A virus is the most severe foodborne viral disease, causing liver damage and debility. Viruses are transmitted through direct or indirect contamination of foods with human feces, highlighting the importance of good hygiene practices in preventing transmission.
Researchers at Johns Hopkins Medicine found a connection between viral infections and immune system B cells producing immunoglobin E, a protein that causes allergic reactions. The study suggests that vaccinating children against mild childhood viral diseases could reduce the incidence of asthma and allergies.