Articles tagged with Viruses
A randomized clinical trial of 345 patients with mild-to-moderate COVID-19 found that viral load and symptom rebound were common after a standard 5-day course of antiviral treatment. Prolonging treatment duration may help reduce COVID-19 rebound
Researchers discover that certain bacteria can evade the immune system by circumventing antibody coating, leading to severe inflammation. The study identifies IgG2 as a key player in this process, providing potential biomarkers and targets for new treatments.
A computational model of the more than 26 million atoms in a DNA-packed viral capsid has expanded our understanding of virus structure and DNA dynamics. The study found that the DNA formed switchback loops as it was pushed into the capsid, similar to how DNA is organized in eukaryotic cells.
A novel antibody constant region variant (REW) extends plasma half-life and improves biodistribution, allowing for both invasive and non-invasive delivery. The REW technology also enhances the complement system, providing enhanced ability to kill cancer cells and bacteria.
A study by Texas A&M University found that only 9% of older Americans had been vaccinated against RSV prior to this fall and winter. The study also revealed that men were more likely to be vaccinated than women, and those who were vaccinated had higher levels of concern about the disease.
Researchers found that faulty mtDNA replication causes mitochondria to leak genetic material, triggering an immune response and leading to disease. By targeting this process, doctors may develop therapies to prevent harmful inflammation.
Researchers found that KSHV manipulates human enzymes CDK6 and CAD to reshape cellular metabolism and proliferation, leading to tumor formation. Inhibiting this process with existing FDA-approved breast cancer drugs reduced viral replication and shrunk tumors in preclinical models.
Researchers at Martin-Luther-Universität Halle-Wittenberg developed novel RNA- or DNA-based substances that reliably fight off viral infections in plants. The new approach uses antisense oligonucleotides to target specific viral RNA molecules, achieving an impressive up to 90% success rate against a common virus.
Researchers found that microbial viruses carry special genetic elements for controlling methane processes, called auxiliary metabolic genes (AMGs). The study suggests that viral contributions to methane cycling are underestimated and deserve more attention.
A UC Riverside-led study has devised a way to make large quantities of the Membrane protein, which plays a crucial role in how SARS-CoV-2 acquires its spherical structure. The researchers found that when the M protein interacts with the membrane, it coaxes the membrane to curve, leading to the virus's characteristic shape.
A recent study by Pusan National University scientists discovered the crucial role of PKM gene and EPHA2 pathway in HNSCC development. The research highlights the importance of HPV infection status in shaping the tumor microenvironment, enabling precision medicine for targeted treatment.
Researchers found that e-liquids containing propylene glycol and vegetable glycerin enhance COVID-19 infection, while those with benzoic acid prevent it. Vapers are advised to quit or switch to e-liquids with acidic pH for better protection.
Researchers at ISTA have discovered the composition of poxviral cores, a key factor in their infectivity. The study's findings could lead to the development of new therapeutics targeting the viral core.
A University of Edinburgh-led research team traced the lineage of 743 RNA virus species to track their evolution and identify those most likely to emerge and spread rapidly in humans. The findings show that viruses that can spread within human populations typically evolve separately from strictly zoonotic viruses.
Researchers have discovered a novel RNA viral genome from thermoacidophilic microbes in hot springs, revealing a previously overlooked third RNA virus kingdom. The discovery sheds light on the diversity and evolution of RNA viruses and their potential roles in high-temperature environments.
A new surface technology has been developed that reduces viruses' infection ability by 96% using mechanical methods. The surface, made of silicon with tiny spikes, damages the structure of viruses when they come into contact with it.
Early data from Luxembourg's national immunisation campaign against severe respiratory syncytial virus (RSV) in 2023 showed a decline in hospitalisations, especially among infants under six months old. The authors attributed this to the administration of a monoclonal antibody, nirsevimab, shortly after birth. Additionally, the mean age...
Researchers analyzed ancient fecal samples to assess what details of the ancient people's lives could be ascertained from these samples. The study found DNA fragments of human betaherpesvirus 5, adenovirus F, and other viral and bacterial genetic material from thousands of years ago.
Researchers found that hepatitis E virus (HEV) mutations made treatment with individual drugs less effective, highlighting the need for combination therapies. The study's findings also provide insights into the evolutionary dynamics of HEV, paving the way for next-generation antiviral treatments.
Researchers discovered a connection between hepatitis B and C viruses and multiple myeloma, finding that antiviral treatment can improve outcomes. The study suggests that early detection of these infections may lead to better treatment and survival rates for patients with this cancer.
A subset of CD4+ 'helper' T cells helps fight cytomegalovirus infection and reduces the chances of transmission. The late-rising T cells expand long after the initial response has died down, gathering in high numbers in the salivary gland.
Researchers discovered a gene expression signature that differentiates between symptomatic and asymptomatic infections, as well as positive and negative individuals. The study reveals complex interactions between viruses and the human body, with influenza leading to greater changes in gene expression.
Research finds that people with higher HIV viral loads have higher recombination rates, enabling the virus to diversify and evade the immune system. This study contributes to a deeper understanding of how recombination drives HIV evolution.
The Pirola variant of SARS-CoV-2 has rediscovered an entry pathway into lung cells that was previously used by earlier variants, which may promote the development of pneumonia. The virus uses the cellular enzyme TMPRSS2 for entry and is resistant to most therapeutic antibodies.
Researchers at Washington University School of Medicine discovered a decoy molecule that protects against the potentially deadly brain infection. The study advanced understanding of viral protein and receptor interactions, laying a foundation for treatments and vaccines.
VirCapSeq-VERT, a next-generation sequencing-based screening and surveillance system, can detect any virus that can potentially infect humans with greater sensitivity and speed than other NGS platforms. The technology achieved clinical sensitivity of 99 percent and 100 percent clinical specificity in a validation study.
Multiple sclerosis affects over 2.8 million worldwide, and EU funding will investigate viral infections like EBV as potential causes and co-factors. The BEHIND-MS consortium aims to develop new cell models to test hypotheses on the disease's development.
Commercially available NPBI-based air purifiers significantly reduced airborne virus infectivity, eliminating up to 99.98% of COVID-19, flu and RSV viruses in real-world concentrations.
A study by Max Planck Institute for Marine Microbiology reveals that extracellular vesicles are the primary mechanism for genetic information exchange in the ocean. This discovery challenges traditional views on horizontal gene transfer and highlights the importance of EVs in microbial ecosystems.
Scientists at the La Jolla Institute for Immunology have uncovered a group of T cells known as mucosal-associated invariant T (MAIT) cells. These cells can recognize the same markers whether they come from humans or mice, opening up new possibilities for treating infectious diseases and improving cancer immunotherapies. The study also ...
Scientists have discovered that willow bark extract has a broad-spectrum antiviral effect against both enveloped and non-enveloped viruses, including coronaviruses and enteroviruses. The extract works by attacking the surface of the virus, preventing it from entering cells and reproducing.
Researchers at Xi'an Jiaotong-Liverpool University have developed a sensitive and robust pH sensor that can detect pH variation in just a few microliters of samples. The new sensor uses novel materials and methods to overcome the current method's limitations, which are not sensitive enough or fragile for commercial-scale use.
Research out of Osaka University reveals that many Japanese people continue to wear masks for socio-psychological reasons, including relief and norm. The study found correlations between mask usage motivations and actual mask usage before and after the government downgraded COVID-19's legal status.
Researchers found that higher ventilation rates do not necessarily prevent the spread of airborne diseases in cruise ship cabins. The ideal ventilation strategy involves medium flow rates during occupancy and increased airflow after evacuation to minimize droplet spreading.
The Cumming Global Centre for Pandemic Therapeutics is offering global grants of up to $200,000 per annum for three years to develop novel therapeutics for pathogens of pandemic potential. Researchers are invited to submit expressions of interest for Round Two of the Foundation Grants program.
A new study found that Zika virus infection during pregnancy slows fetal growth and affects how infants interact with their mothers in the first month of life. The study also suggests that reducing viral load may be beneficial for infant development.
Researchers at Gwangju Institute of Science and Technology (GIST) have developed a deep learning-based biosensing platform called DeepGT, which can accurately quantify nanoscale bioparticles, including viruses. The platform harnesses the advantages of Gires-Tournois biosensors and AI to refine visual artifacts and extract relevant info...
Recent study on Drosophila melanogaster museum specimens shows that Northern European populations gave way to well-connected fly populations across the continent. The analysis also highlights genes that may have helped this species adapt to novel climates, viruses, and insecticides.
Researchers at Tulane University discovered that prior exposure to Cytomegalovirus (CMV) significantly reduces the risk of birth defects and miscarriage during pregnancy. The study found that pre-existing immunity effectively limits transmission and protects against associated birth defects.
Researchers at Utrecht University have uncovered a sophisticated mechanism by which coronavirus spike proteins can be activated for cell entry. Sugar binding induces opening of the spike protein and exposure of the receptor binding domain, required for subsequent entry steps.
Researchers identified PUCH, a novel enzyme that produces small molecules called piRNAs to detect and prevent parasitic DNA from replicating in our genomes. This discovery sheds light on how our immune system works and may have implications for understanding innate immunity.
Researchers found that soil viruses exhibit dynamic and changing behavior after dry soils are watered, with a diverse range of virus types and minimal turnover. This suggests that viruses may play a more nuanced role in shaping bacterial communities and ecosystems than previously thought.
A study by Charité and Leibniz-IZW found that reducing biodiversity in rainforests leads to an increase in virus prevalence among mosquito species. This is because resilient species thrive in disturbed habitats, carrying viruses with them. The research reveals the importance of biodiversity in understanding infectious disease dynamics.
Researchers found that reducing biodiversity harms mosquito species, leading to more resilient species and increased virus prevalence. The study suggests that a decrease in biodiversity can lead to an increase in the spread of viruses carried by mosquitoes.
Researchers launch EU-funded initiative to uncover EBV's role in MS, aiming to find underlying mechanism and develop antiviral treatments. The project seeks to improve disease course or stop progression, with potential for preventive strategies like vaccination.
New research reveals that the Deformed wing virus DWV-A originated in Asia, contradicting previous European origins. The study found that Varroa mites transmitted the virus to European honey bees after their introduction to Asia, leading to widespread infections and colony declines.
Researchers found that a subset of HIV-infected cells produce viral RNA and proteins during anti-retroviral therapy, which may impact patients' immune responses. The study suggests that these non-functional viral pieces can stimulate an immune response, potentially leading to inflammation and negative consequences for treated individuals.
A Europe-wide study found associations between climatic factors and the occurrence of pathogens in birds and bats, with temperature increasing the risk of avian flu virus and malaria parasites. Rainfall had both positive and negative effects on pathogen prevalence, increasing the risk of certain viruses and bacteria.
Scientists have identified a molecule that effectively inhibits heparanase activity related to the herpes simplex virus, reducing its spread on human cells. The discovery is an important step towards developing a non-toxic heparanase inhibitor for clinical use.
Researchers developed a self-decontaminating fabric that kills coronaviruses in under 5 seconds using Joule heating. The material can handle hundreds of uses with minimal waste, transforming the way personal protective equipment is made and used.
Researchers have developed a new approach to treating herpes by inhibiting an enzyme that releases newly formed virus particles from infected cells. The inhibitors, made of oligosaccharides, significantly reduce the spread of the virus and may also impede cancer metastasis.
Researchers developed a model explaining why bat-borne viruses cause higher case fatality rates in humans compared to other zoonoses; life history and immunology play key roles.
RSV virus remains infectious on surfaces for up to seven days, emphasizing the need for regular disinfection. Effective hand sanitizers with at least 30% alcohol content can inactivate the virus.
Researchers developed an automated viral plaque assay method combining time-lapse holographic imaging and deep learning to greatly reduce detection time. This technique can aid in developing new vaccines and antiviral drugs by expediting the testing process, allowing for faster response times to virus-induced health emergencies.
University of Louisville researchers have received a five-year, $11.7 million National Institutes of Health grant to investigate the connection between microorganisms and disease. The study will focus on various chronic conditions, including Alzheimer's disease, heart disease, diabetes, periodontitis, and colorectal cancer.
Researchers found stable antibodies in 800-year-old medieval human teeth that can still recognize viral proteins, allowing them to study the history of infectious human diseases. This discovery expands the field of palaeoproteomics and may enable experts to analyze how human antibody responses developed over time.
A recent study published in Cell Host and Microbe reveals how flaviviruses hijack human cells to promote replication. The discovery of KAT5γ's critical role in viral replication paves the way for designing inhibitory molecules to stop viral replication.
City of Hope will conduct Phase 1 clinical trials for novel cell and gene therapy treatments for patients with HIV, acute myeloid leukemia, and severe aplastic anemia. A CAR T therapy for HIV is also being developed to potentially target other diseases.
Researchers have developed novel molecules that target the membrane of viruses, rather than their proteins, offering a promising new approach for treating infectious diseases. The molecules, inspired by natural peptides, disrupt the protective layers of enveloped viruses like Zika and chikungunya, while sparing human cells.
Researchers investigated the inactivation efficacy of different UV wavelengths against SARS-CoV-2 Omicron variants, finding similar inactivation properties across various wavelengths. The study highlights the potential of far-UVC light as a safe germicidal option for mitigating airborne virus transmission.