Articles tagged with Bacterial Rna
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A recent NASA study used gene sequencing to detect a vast array of bacteria in clean rooms, including newly discovered species. The findings will aid in improving cleaning and sterilization methods to prevent false-positive results in detecting extraterrestrial life.
Researchers used powerful imaging techniques to study the atomic level interactions between bacteria and antibiotics, revealing a key enzyme structure that enables gene expression. The findings provide insights into potential new antibiotic designs that can prevent bacterial resistance.
Researchers reprogram E. coli to detect and follow specific chemical signals, opening new frontiers in environmental cleanup and drug delivery. The custom chemo-navigational system could be used to target diseased cells while sparing healthy ones.
Researchers found that Photorhabdus produces a special phenoloxidase inhibitor to protect itself against an enzyme used by insects' immune systems. This discovery provides conclusive evidence for a gene-for-gene interaction between the bacterium and the insect, shedding light on insect immune systems.
Researchers found that a single gene in symbiotic bacteria determines aphid thermal tolerance. The gene's mutation affects heat-shock protein production, leading to reduced reproduction and survival in hot conditions. This discovery highlights the critical role of symbiotic bacteria in insect ecology.
Researchers created hairpin-shaped RNA molecules that can differentiate between riboswitches in on and off states. These aptamers could help find new antibiotics by binding to the switches of pathogens, blocking essential protein synthesis.
Researchers at EPFL discovered a new metabolic pathway that helps cells survive bacterial pore-forming toxins. The pathway triggers an inflammatory response and lipid metabolism to repair the cell membrane and protect against further damage.
Researchers have discovered a bacteriophage with a structure similar to human rotavirus, providing new information on the formation of viral particles and genetic distinction. This finding sheds light on the evolutionary origins of viruses, which likely share common ancestors across species.
Scientists from the University of Wisconsin-Madison have made a fundamental discovery about RNA synthesis in E. coli, shedding light on how bacteria regulate gene expression. The study found that a specific region within DNA promoters makes contact with RNA polymerase, but not at promoters for genes involved in ribosomal RNA production.
Evolutionary biologist Jianzhi Zhang discovers parallel evolution of pancreatic enzyme RNASE1 in Asian and African colobine monkeys, showing identical amino acid changes despite separate duplication events. The study reveals a division of labor between old and new genes after duplication.
Researchers at UCSD have discovered how bacterial messenger RNA is unfolded to be read by the cell's protein-making machinery. The study reveals essential factors required for this process and provides insights into developing novel antibiotics targeting these vulnerabilities.
Researchers identified a number of cas genes associated with CRISPR clusters, potentially involved in RNA-processing mechanisms. They propose that all CRISPR inserts are derived from viruses or plasmids, transcribed and silenced via Cas proteins.
Researchers found that cryopyrin is activated by bacterial RNA and essential for the immune response against bacteria. This discovery could lead to a better understanding of autoimmune diseases like rheumatoid arthritis and potentially develop new treatments.
Researchers have discovered several new bacterial species associated with bacterial vaginosis (BV), a common infection in women. The study, published in the New England Journal of Medicine, could lead to improved detection and treatment methods.
Researchers have discovered a new function of RNA in the human immune system, which could lead to the development of new treatments for cancer and single-gene genetic diseases. The study found that certain types of RNA are more likely to trigger an immune response due to their chemical modifications.
New research reveals that rifamycin antibiotics work by removing a crucial magnesium ion from bacterial RNA polymerase, rendering the bacteria non-functional. The study's findings may lead to improved versions of these antibiotics to combat existing resistant strains.
Bacteria require a critical number of individuals, called quorum sensing, to engage in activities like bioluminescence and biofilm formation. Research on Vibrio cholerae and other bacteria aims to develop strategies to prevent disease-causing bacteria from becoming virulent.
Researchers at Yale University have identified a key mechanism behind antibiotic resistance in bacteria. By analyzing the structural changes caused by a single nucleotide mutation, they found that this alteration reduces the ability of antibiotics to bind to ribosomes, allowing resistant bacteria to rapidly cause infections.
A new lab technique has identified high levels of pathogens in a hospital therapy pool, with
A recent study by Washington University researchers used a molecular survey to detect Mycobacterium avium in the lungs of nine lifeguards who developed hypersensitivity pneumonitis after exposure to pool water. The bacterium, known for its resistance to disinfection, was found at high levels in air samples taken near the pool.
A large multicohort study of HAART-naive patients found significant reductions in AIDS incidence and opportunistic events, with greater declines for viral etiologies.
Researchers have developed a miniaturized lab that can detect HIV and bacteria in saliva using a portable oral swab kit. The device analyzes samples quickly and accurately, making it useful for rapid response situations such as bioterrorism incidents or emergency room emergencies.
A Yale University study identified a tick gut receptor used by spirochete bacteria to colonize ticks, which the bacteria use to survive. Blocking this receptor disrupts the bacteria's life cycle, opening up new strategies for improving Lyme disease diagnosis and treatment.
Researchers couple bacterial life with theophylline production, which breaks down caffeine slowly in plants. The goal is to create coffee plants low in caffeine using these engineered bacteria.
Researchers at Yale University have identified a cooperative RNA switch in nature, which responds to various target compounds and regulates metabolic processes. This discovery supports the theory of an RNA World, where RNA molecules served a central role in early life.
Researchers found that DksA is crucial for regulating gene expression in bacteria, enabling them to survive and resist antibiotics. By targeting this protein, scientists may develop novel antibacterial drugs that reduce resistance.
Researchers at Rutgers University have discovered a molecule that uniquely blocks a key bacterial enzyme, RNA polymerase, starving it and killing bacteria. The discovery sets the stage for developing novel antibacterial drug designs and could lead to applications beyond drug design.
Researchers have discovered a molecule called ppGpp that plays a crucial role in regulating bacterial gene expression and survival. When amino acid levels are low, ppGpp accumulates and shuts down protein synthesis, allowing the cell to go dormant until conditions improve.
A new transcript-based cloning technique enables scientists to identify specific genes in a matter of months, reducing the process from years. The technique was used to isolate and identify a gene in Medicago truncatula that plays a crucial role in nitrogen fixation.
Cumbre Inc. and University of Wisconsin-Madison researchers have published data on a new class of bacterial RNA polymerase inhibitors with major breakthrough potential, offering a powerful tool to study gene expression mechanisms and developing new antibiotics against bacterial pathogens.
A new class of compounds called CBR703 series inhibit RNA polymerase, a key enzyme in gene expression, and hinder the ability of bacteria to perform crucial catalytic functions. The compounds render RNA polymerase useless by binding to a specific place on the enzyme.
Rockefeller University scientists have discovered how transcription begins in bacteria, a crucial step for developing new antibiotics. The structure of the RNA polymerase holoenzyme reveals a novel protein-protein interaction that regulates transcription initiation.
Researchers at Stanford University have developed nanocircles that can shut down specific genes in living bacteria, paving the way for potential use in genetic therapy. The study demonstrates that nanocircles can act as a Trojan horse to target and inhibit disease-causing genes.
Researchers have discovered a bacterial protein called anti-TRAP (AT) that participates in regulating tryptophan production. The newly discovered protein helps Bacillus bacteria control the production of tryptophan, one of the building blocks of most proteins in humans.
Researchers have discovered a way to link specific microbes to the oxidation of methane in anoxic marine sediments using molecular and stable isotope techniques. This partnership between archaea and sulfate-reducing bacteria extracts energy from methane, removing nearly 80% of the methane in marine sediments.
A Purdue University study reveals that a virus uses six RNAs to create a motor that transports DNA, facilitating the development of nanoscale devices. The research also improves scientists' understanding of how cells transport large molecules through membranes.
Researchers at Johns Hopkins University discovered that RNA- and DNA-binding proteins have the same shape, a configuration of three coils called alpha helices. This similarity suggests that the protein could be an ancient ancestral form of other proteins crucial to embryonic development.
A team of scientists led by Jennifer Doudna solved the 3D structure of a large portion of an RNA enzyme, revealing its ability to trigger cell activity and potentially provide the first method for genetic reproduction. This breakthrough could help design new drugs to fight lethal viruses and repair genetic errors.