Articles tagged with Bacterial Rna
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Recent research demonstrates that some bacteria use the CRISPR/Cas system to recognize and destroy segments of RNA from invading viruses. This novel approach could provide a new tool for fighting viral infections and offers insights into the complex interactions between bacteria and their environment.
Scientists have developed a systematic approach to discovering unknown DNA modifications, using a combination of bioanalytical chemistry, comparative genomics, and single-molecule real-time sequencing. This approach has led to the discovery of a new epigenetic mark, dADG, which helps bacteria defend their genomes from viral infection.
Researchers found bacteria can recognize and disrupt viruses using a novel RNA-based defense mechanism. This discovery could lead to improved ways to prevent crop diseases and dairy industry infections, and may inspire new gene-editing techniques.
Scientists have found a way to control the sensitivity of coiled protein polymers called R bodies, making them unfurl at higher or lower pH levels. The proteins can burst open 60% of bacterial cells in acidic conditions, offering potential use in delivering molecules inside living systems and targeting biotechnology applications.
Rice University bioengineers have found new techniques for precision genome editing that are more accurate and have fewer off-target errors. The new strategies use biological catalysts capable of cutting DNA called 'engineered nucleases' to maximize on-target gene editing.
Researchers discovered a bacterial immune system that waits until viruses replicate before attacking them, allowing for more efficient defense. This new strategy, called type III CRISPR-Cas, takes up to nine hours to clear infections and has potential applications in biotechnology and medicine.
Two new studies from University of California, Berkeley provide detailed insights into CRISPR-Cas9's molecular basis for accurate DNA targeting. The Cas9 protein appears to have at least three ways to check for correct target DNA before making a cut, ensuring precise genome editing.
A MGH team developed a variant of the SaCas9 enzyme that recognizes a broader range of nucleotide sequences, increasing its targeting range two- to four-fold. This advancement expands the number of genomic sites accessible by CRISPR-Cas9 technology.
A recent study published in PNAS has shed light on the mechanism of action of HigB, a bacterial toxin that contributes to antibiotic resistance. The researchers found that HigB selectively degrades specific mRNAs, leading to the formation of persister cells that are tolerant to antibiotics.
A new study finds that antibiotics create conditions for bacterial demise by stressing their metabolism, leading to oxidative stress that breaks down DNA and other key molecules. This understanding could lead to more effective treatments for patients fighting infections.
Researchers at Berkeley Lab have discovered the structural basis by which bacteria capture and utilize foreign DNA, a crucial step in their adaptive immune system. The study reveals that Cas1 and Cas2 enzymes function as molecular rulers to measure and manipulate foreign DNA.
Trees grown in contaminated soil exhibit enhanced defense mechanisms against pests, as genetic information from other organisms is expressed differently. This phenomenon enables trees to better fend off biotic stresses, potentially revolutionizing phytoremediation processes.
Scientists at ETH Zurich have developed a method to analyze hundreds of metabolites simultaneously in real-time, allowing for rapid analysis of cellular responses to external stimuli. This breakthrough enables the study of complex biological processes and has potential applications in developing new pharmaceutical agents.
A new, rapid testing method could help diagnose febrile infants with accuracy and speed. The innovative approach aims to reduce invasive procedures like lumbar punctures and antibiotic overuse, saving lives and improving treatment outcomes for thousands of young patients worldwide.
Researchers have discovered a new mechanism by which bacteria can develop resistance to antibiotics, called retromutagenesis. This process involves mutations occurring in RNA first, allowing cells to grow and replicate before subsequent DNA mutations can take effect.
Researchers have identified a protein called sigma54 that controls bacterial defenses, including the production of resistant outer coats and defensive structures. Understanding how sigma54 works could lead to the development of new compounds that can kill bacteria, providing a potential solution to antibiotic resistance.
Researchers at the Max Planck Institute developed a method to simultaneously localize bacteria and antibiotic production in environmental samples. Using mass-spectrometric imaging, they visualized the distribution of antibiotics piericidin A1 and B1 across the outer surface of beewolf cocoons.
Research reveals that salicylic acid shapes the microbial community at a plant's root by keeping certain families of bacteria out and letting others in. The hormone also recruits desirable bacterial families, a discovery that could lead to increased plant productivity.
Researchers have discovered a unique process in TB bacteria that uses an additional protein to read DNA, providing a potential new target for antibiotics. This finding could speed up the drug discovery process by allowing scientists to quickly rule out ineffective treatments.
Trees that tolerate soil pollution show improved resistance to biological invasions, with 99% of spidermite RNA found in higher abundance in uncontaminated trees. This discovery implies that polluted plants may prime their defence machinery, enhancing their ability to defend against pests and pathogens.
Engineers have created a prototype for real-time listeria bacterial contamination detection, aiming to detect levels as low as one bacteria in a 25-gram sample. The device utilizes nanobrushes that select and capture specific bacteria, mimicking the mechanism used by the Hawaiian bobtail squid's cilia.
Scientists at UC Berkeley have identified over 35 new groups of bacteria, revealing a diverse radiation that challenges the traditional three-domain view of life. These microbes are tiny, with some as small as 400 nanometers across, and have unique features such as small genomes and unusual ribosomes.
University of Pittsburgh scientist Alexander Deiters has developed a new method for controlling gene editing using light, enabling more precise and controlled manipulation of genes. This approach may eliminate 'off-target effects' and enable genetic studies with unprecedented resolution.
Researchers at Rockefeller University have cracked the code of a fundamental process bacteria use to defend themselves against invaders. The type III CRISPR-Cas system targets both viral DNA and RNA, preventing viruses from copying themselves and infecting more bacteria.
Emory scientists have adapted the CRISPR genetic defense system to target the RNA of the hepatitis C virus in human cells. This approach could potentially prevent viral infections and has implications for biotechnology applications, including the prevention of viral infections in transgenic animals and plants.
Researchers at Tel Aviv University and the Weizmann Institute of Science have discovered a precise mechanism used by bacteria to defend themselves against invading viruses. The CRISPR-Cas system is adaptive, allowing bacteria to 'memorize' viral DNA and launch targeted attacks in future encounters.
Researchers at the University of Colorado School of Medicine have discovered an RNA structure-based signal that bridges evolutionary divergence between bacteria and eukaryotes, enabling protein synthesis. This finding challenges long-held assumptions about the molecular signals initiating protein synthesis in these distinct life forms.
A SLU scientist has discovered an evolutionary mechanism used by bacteria to evade antibiotics like azithromycin. The discovery reveals a universal stalling mechanism, suggesting a way to improve existing drugs' effectiveness against antibiotic-resistant strains.
Researchers found that gut microbiota affects mucus barrier properties in mice, with different microbial compositions leading to varying levels of protection against bacterial invasion. The study suggests that a well-developed inner mucus layer is crucial for overall health and highlights the importance of the gut microbiota composition.
Researchers boosted bacteria's ability to produce isopentenol, a compound with desirable gasoline properties, by identifying and overexpressing genes that improve tolerance to solvent stress. The findings suggest a promising approach to developing a bacterial strain that can yield industrial quantities of renewable bio-gasoline.
Researchers have developed a technique that uses the bacteria's own CRISPR-Cas system to turn off specific genes or sets of genes, creating a powerful tool for future research on genetics. This approach allows researchers to better understand the role of individual genes and identify gene sets associated with problems such as multidrug...
Researchers have identified a protein receptor that activates during illness, producing a sugary substance to encourage the growth of protective bacteria and create a healthy microbiota in the gut. This discovery has implications for treating inflammatory bowel disease (IBD) and vulnerable patients.
Researchers at UTSA's South Texas Center for Emerging Infectious Diseases have discovered a regulatory thermometer in Vibrio cholerae bacteria that controls the expression of virulence factors leading to cholera. The discovery could lead to new therapeutic strategies against this deadly disease.
Researchers use CRISPR genome-editing system to target specific genes conferring antibiotic resistance, resulting in 99% killing of resistant bacteria. CombiGEM technology rapidly identifies genetic combinations that sensitize bacteria to different antibiotics.
Researchers identify how bacteria prioritize instructions and create a 'shredder' enzyme that destroys old messages. By targeting this enzyme with antibiotics, deadly bacterial infections may be killed, providing new hope for treating human illnesses.
Researchers have developed a molecule that can silence the NDM-1 resistance gene in bacteria, restoring susceptibility to carbapenem antibiotics. This approach could be a viable strategy for treating resistant infections.
Scientists at the University of Rochester have isolated key steps in ribosome formation, a crucial process for bacterial growth. The researchers found that multiple pathways of RNA processing occur simultaneously, suggesting new possibilities for stopping super-bugs.
Scientists discovered that Listeria uses RNA molecules to fine-tune protein production, allowing it to evade the immune system and resist antibiotics. By understanding this mechanism, researchers can develop targeted treatments to combat the life-threatening bacteria.
Researchers have better understood how bacteria can protect itself from harm, using X-ray crystallography to visualize the molecular machinery known as Cascade. The unique ladder-like structure allows RNA to scan DNA more efficiently than a double-helix structure, enabling faster recognition and destruction of viral invaders.
Researchers using supercomputers at TACC analyzed bacterial communities for gum disease, diabetes, and Crohn's disease. They found that these microbes adjust their metabolism in response to disease, suggesting new ways to prevent or reverse the conditions.
A new computational method has uncovered closely related, previously indistinguishable bacteria living in different parts of the human mouth. The study provides high taxonomic resolution of bacterial communities, revealing distinct bacteria in saliva, tongue, gums, plaque, and tonsils with unique properties.
Scientists applied a new oligotyping technique to analyze the human oral microbiome, identifying over 300 oligotypes and discovering closely related species with distinct habitat distributions. This approach provides deep insight into the microbial communities in health and disease.
Researchers at the University of Utah found that multiple silent mutations greatly impact protein translation, with some causing a five-fold decrease in speed. The study also reveals that codon context matters, altering translation efficiency by up to 30-fold.
Researchers found YbeY critical for cell fitness, stress tolerance, and ribosome quality control in V. cholerae. It also targets virulence-associated small regulatory RNAs, making the bacterium less harmful.
Researchers have identified six natural-products derivatives that can inhibit oral biofilm formation and quorum sensing in three indigenous oral Gram-positive bacteria. These compounds, structurally similar to S-ribosyl homocysteine, reduce bioluminescence in a Vibrio harveyi QS reporter, indicating inhibition of AI-2 based QS.
Researchers at North Carolina State University have developed a novel approach to eliminate specific strains of bacteria using the CRISPR-Cas system. This method has shown promise in lab tests, eliminating targeted bacteria without affecting good bacteria and demonstrating precision in targeting different species.
Researchers found that HrpA is essential for Lyme disease transmission and tick survival, enabling the bacterium to regulate its RNA and survive in mammalian hosts. The discovery provides significant insights into the complex life cycle of Borrelia burgdorferi and potential targets for future treatments.
The University of Chicago researchers will investigate 102 hypothetical genes from plague and brucellosis bacteria using cross-disciplinary approaches. This research aims to assign functions to these genes, which could inform studies across species with similar genes.
Researchers found that partial degradation of a DNA replication protein is necessary for the survival of Caulobacter crescentus. The energy-dependent protease ClpXP generates specific-sized fragments required for normal growth and DNA repair, challenging previous assumptions about protein digestion in bacteria.
Researchers have developed PPMOs, which target specific genes in bacteria, offering a more precise and effective alternative to antibiotics. In animal studies, PPMOs showed significant control of certain strains of Acinetobacter, a bacterium resistant to many antibiotics.
E. coli bacteria produce at most six times more heat than needed to meet thermodynamic constraints, suggesting they could grow faster and still obey the second law of thermodynamics. This finding has implications for synthetic biology applications and may support the hypothesis that RNA evolved before DNA.
A team of Spanish researchers has sequenced the global deep ocean genome using over 2,000 samples of microorganisms collected from the Atlantic, Indian, and Pacific Oceans. This groundbreaking study reveals a vast unknown species of microorganisms with intense biological activity.
Scientists discover new antibiotic molecule KKL-35 that targets trans-translation step in bacteria, rendering them incapable of replicating. The compound is 100-fold more effective against Mycobacterium tuberculosis than current therapies.
Researchers found that Shigella uses a biological 'RNA thermometer' to monitor its environment and produce the necessary protein for survival. At body temperature, the thermometer melts away, allowing the bacterium to synthesize the ShuA protein needed for iron acquisition.
Researchers at the University of Southern Denmark have made a groundbreaking discovery about bacterial biofilm formation, a major contributor to complicated infections. The study found that small RNA molecules play a crucial role in determining whether bacteria form biofilms or swim, offering new avenues for treating such infections.
Researchers at Helmholtz Centre for Infection Research identify diverse CRISPR-Cas gene variants, opening possibilities for targeted genetic manipulation and medical applications. These newly discovered gene variations can be used to develop novel therapies, including gene editing.
Researchers at Helmholtz Institute for Pharmaceutical Research Saarland have discovered a new peptide that inhibits bacterial RNA polymerase, preventing DNA-to-RNA transcription. The peptide, P07, shows promise as a potential new antibiotic with a unique mechanism of action that does not lead to cross-resistance.
Researchers have discovered a new type of molecular motor that moves DNA through cells without rotational motion. The discovery challenges previous understanding and paves the way for practical machines and devices in nanotechnology.
A new study reveals that certain viruses, known as bacteriophages, can hijack the immune systems of bacteria to overcome their defenses. This discovery has significant implications for phage therapy, which could potentially treat bacterial infections resistant to antibiotics.
Research found that stressed bacteria can spontaneously develop resistance to rifampicin, a commonly used antibiotic. This discovery has significant implications for the evolution of antibiotic resistance and may impact treatment options for serious bacterial infections such as tuberculosis and leprosy.