Researchers discovered that one microorganism can live with a bit of ambiguity in its genetic code, synthesizing two different proteins seemingly at random. This finding contradicts a long-held dogma and has implications for future disease therapies, including treating diseases caused by premature stop codons.
SourceUniversity of California - Berkeley·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateDec 1, 2025
A glitch in protein synthesis, known as stop codon readthrough, may affect tumour growth and cancer cell proliferation. The study found that preventing this process can lead to increased degradation of target proteins and a delayed cell cycle, resulting in slower tumour growth.
SourceIndian Institute of Science (IISc)·JournalJournal of Cell Science·DateSep 9, 2024
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Researchers developed a small molecule that reads through premature stop codons in genes, restoring CFTR protein function. The compound, SRI-41315, showed greater readthrough efficiency than its predecessor, SRI-37240, and acted synergistically with G418.
SourceUniversity of Alabama at Birmingham·JournalNature Communications·DateJul 19, 2021
A study found that in species with small populations, chance events take precedence over natural selection, allowing imperfections to creep in. The researchers analyzed the genetic instructions used by cells to make proteins and discovered that less efficient stop codons can increase in frequency due to chance events.
SourceUniversity of Bath·JournalMolecular Biology and Evolution·DateSep 9, 2020
Researchers at Oregon State University developed a gated recurrent neural network to decipher RNA's connections to human health and disease. The model, called mRNN, outperformed existing methods in predicting protein-coding potential and identified special codons that indicate protein synthesis.
SourceOregon State University·JournalNucleic Acids Research·DateJul 20, 2018
A new quality control system in cells has been identified, which recognizes and destroys faulty genetic material by targeting the ribosome and messenger RNA. This discovery could potentially be used to develop new treatments for genetic diseases.
SourceCase Western Reserve University·JournalNature Communications·DateJan 10, 2017
Researchers at the University of Pennsylvania have identified a new mechanism by which RNA molecules are degraded in plants, occurring co-translationally with translation. This process is linked to gene regulation and may play a role in stress response.
SourceUniversity of Pennsylvania·JournalThe Plant Cell·DateOct 13, 2016
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Researchers discovered that antibiotics like gentamicin can cause abnormal proteins to be presented to the immune system, potentially triggering autoimmune disease. This approach, used to treat diseases in genes with truncated proteins, may come with a risk of initiating autoimmunity.
SourceThomas Jefferson University·JournalProceedings of the National Academy of Sciences·DateMar 31, 2014
Researchers successfully modified messenger RNA to override a 'red light' signal, producing a full-length protein instead. This breakthrough may aid treatment strategies for genetic disorders caused by premature stop codons.
SourceUniversity of Rochester Medical Center·JournalNature·DateJun 15, 2011
A recent study has uncovered a natural quality control mechanism in cells that identifies and eliminates faulty messenger RNAs (mRNAs) containing premature stop codons, known as nonsense mutations. The mRNA-binding protein CBP80 plays a critical role in this process, allowing for the development of drug-based gene therapies to combat d...
SourceUniversity of Rochester Medical Center·JournalNature Structural & Molecular Biology·DateOct 25, 2005