Articles tagged with Alzheimer Disease
Researchers created genetically engineered mice with a mutated gene linked to AD, producing 50% more A-beta42 peptide. This discovery may lead to targeted drug treatment for AD by understanding the mechanism of presenilin-1 and APP production.
Researchers found increased enzyme activity in Alzheimer's patients, suggesting a potential factor in disease development. A peptide inhibiting ACTH synthesis and secretion was also identified as a regulator of the body's adaptive response to stress.
A group of scientists agreed upon revised criteria to distinguish different forms of Alzheimer's disease. The new guidelines take into account the distribution of neuritic plaques and neurofibrillary tangles in the brain, providing a more accurate diagnosis and aiding researchers in their understanding of the disease.
Researchers at Case Western Reserve University found that nicotine inhibits the formation of amyloid plaques, a toxic substance in Alzheimer's patients. The study suggests a potential link between nicotine and preventing or slowing down amyloid formation in AD patients.
Research by Dr. Roger Rosenberg and colleagues found that people with one-fourth Cherokee or less ancestry had a lower risk of developing Alzheimer's disease, suggesting a potential protective genetic effect. The study suggests that ancestry may play a role in delaying the development of the disease after age 65.
A genetically-engineered mouse exhibits both behavioral characteristics of Alzheimer's dementia and protein-derived plaques. The oldest mice had significantly higher levels of A-Beta peptides associated with amyloid plaques, raising questions about the relationship between plaques and behavior.
Researchers studying small amphibians have discovered a hormone that can cause brain degeneration, similar to cortisol in humans. The study aims to develop a drug that can block this destructive effect, potentially leading to new treatments for Alzheimer's patients.
A new study finds that first and second generation Japanese-American men living in Hawaii have a higher risk of Alzheimer's disease compared to European-ancestry Americans. The study also notes that rates of vascular dementia remain unchanged in this population.
A new study reveals that a protein called apolipoprotein E (apoE) can protect cultured nerve cells from the damaging effects of oxygen molecules associated with Alzheimer's disease. The apoE protein has different levels of antioxidant activity, with E2 being the most effective.
UT Southwestern Medical Center is testing two new oral medications, propentofylline and SB202026, to alleviate major symptoms of Alzheimer's. These trials aim to improve patient conditions or slow symptom progression.
Researchers at Johns Hopkins Medicine have identified a protein glitch as an early problem in inherited Alzheimer's disease. Presenilin normally cleaves in two, but a disease-causing mutation can prevent this crucial change. This study may lead to new treatments by targeting the point of cleavage with drugs or other interventions.
Researchers at Duke University Medical Center found that testing for a specific gene type can accurately diagnose Alzheimer's disease in most patients. The study showed that 100% of patients with the Alzheimer's susceptibility gene had the disease's telltale neurofibrillary plaques and tangles.
A recent study reveals how Huperzine A, a natural substance derived from a moss used in Chinese folk medicine, inhibits the brain enzyme acetylcholinesterase (AChE) involved in Alzheimer's disease. This specific binding could lead to the development of potent and safe Alzheimer drugs.