Articles tagged with Alzheimer Disease
Researchers discovered a mechanism to block amyloid-beta fragments in Alzheimer's disease, reducing levels of enzyme BACE-1. A type of nucleic acid found in healthy brains promotes its degradation, offering hope for treatment.
Researchers at Lund University have produced images that predate beta-amyloid plaque formation, contradicting the 'popcorn plaques' theory. The discovery reveals structural changes in the brain and suggests stabilizing beta-amyloid could slow disease progression.
Axon degeneration is a major contributor to neurological diseases. A new study reveals that axons coordinate each other's destruction, creating a ripple effect of neuron death. Blocking this communication can slow degeneration by up to 10 times.
Researchers at Duke University identified a mechanism linking 'jumping genes' to brain cell death in Alzheimer's, potentially leading to new treatments. The study suggests that Alu elements, normally held in check by DNA methylation patterns, can disrupt mitochondrial function and contribute to neurodegeneration.
A new study found that a diabetes drug called amylin improved learning and memory function in AD patients and reduced AD pathology in their brains. The findings suggest a potential blood test for AD using pramlintide.
A study of 1566 community-dwelling Japanese elderly found elevated dementia risks in individuals with fewer remaining teeth. Individuals with 10-19 and no teeth had significantly higher risks compared to those with more teeth.
Researchers found that blocking Keap1 can prevent amyloid-beta peptides damage in mouse nerve cells and shield brain cells from Alzheimer's symptoms. Boosting Nrf2 by blocking its inhibitor has the potential to develop new drugs with fewer side effects for preventing Alzheimer's disease and other neurodegenerative conditions.
NeuroVision is participating in a landmark A4 study to test a new investigational treatment that may reduce beta-amyloid accumulation in the brain. The substudy will use NeuroVision's retinal imaging technology to characterize amyloid imaging findings and assess longitudinal changes.
Researchers at UNIST developed a metal-based substance that hydrolyzes amyloid-β proteins, reducing their toxicity. The cobalt-based complex has the potential to penetrate the brain-vascular barrier and directly interact with the protein in the brain.
Researchers at UCLA School of Nursing found that donepezil, a medication approved for Alzheimer's disease, can accelerate cognitive decline in people with mild cognitive impairment who carry the K-variant of butyrylcholinesterase. Genetic testing is advised to determine if the drug is safe for these patients.
Researchers have discovered that excess glucose damages an enzyme involved in inflammation response, leading to Alzheimer's disease progression. The study found that this 'tipping point' mechanism is critical in understanding how Alzheimer's develops and may lead to new treatments or preventive strategies.
Research finds a strong association between Parkinson's disease and stroke, with a higher incidence of ischemic stroke among those with Parkinson's. This link is similar to that between stroke and Alzheimer's disease.
Alzheimer's patients have different chemical properties in their 'good' cholesterol, which can lead to inflammation and cognitive impairment. The study found a 5.5 times increase of a dysfunctional HDL subfraction and a decreased protein/lipid ratio, associated with reduced brain function.
A study found that people who sleep for over nine hours each night have smaller brain volumes and double the risk of developing dementia in ten years. Early detection of cognitive impairment and dementia can lead to better healthcare decisions and improved quality of life.
A new study called Latino Core aims to learn about the aging process and risk factors for Alzheimer's disease in older Latino adults. The study will enroll over 300 participants and include yearly visits, memory exams, and brain donation to understand the pathophysiology of dementia in this population.
Rhoda Au's e-cognitive health initiative collects data from over 2,200 participants using wearable devices, smartphone apps, and in-home devices to detect subtle changes in daily behavior that may indicate cognitive decline. The goal is to identify early signs of Alzheimer's and dementia, improving diagnosis and treatment options.
A UAlberta study found that AC253 improves memory and learning in mice with Alzheimer's-like symptoms, reducing amyloid levels and inflammation in the brain. Further studies are needed to optimize dosage and effectiveness.
A new AI-based diagnosis technique uses functional and structural brain imaging to identify affected regions in Alzheimer's and Parkinson's patients. The study, published in International Journal of Neural Systems, shows promising results with high accuracy rates.
A large study found that long-term estrogen-based hormone therapy reduced the risk of Alzheimer's disease and improved cognitive function in postmenopausal women. The protective effect may depend on starting hormone therapy at the time of menopause, when neurons are healthy.
A recent study published in Neurology found no association between hormone therapy and the risk of developing Alzheimer's disease. However, women who used hormone therapy for over 10 years showed a reduced risk of Alzheimer's disease compared to non-users.
A study has identified CTE pathology in four former soccer players, exceeding the average background rate of CTE found in a previous survey. All six brains also showed signs of Alzheimer's disease, highlighting a potential link between playing football and degenerative brain pathologies.
Researchers call for a shift from animal experiments to human-focused research on Alzheimer's disease and related dementias. Population studies suggest that dietary changes and other modifiable lifestyle factors can reduce the risk of developing dementia.
A study from Lund University found that intestinal bacteria can accelerate the development of Alzheimer's disease in mice. The researchers discovered a direct causal link between gut bacteria and the disease, suggesting that modulating the gut microbiota through diet and probiotics could prevent or delay its onset.
Researchers at Rutgers University found that neurodegenerative diseases like Alzheimer's and Parkinson's may be linked to defective brain cells that dispose of toxic proteins, causing harm to neighboring neurons. The study uses transparent roundworms to understand the process of eliminating toxic cellular substances, revealing a potent...
The study aims to understand the long-term neurologic effects of mild TBI and other deployment-related conditions. It will analyze the impact of TBI on thinking ability, memory, mood, and focus, as well as explore biological factors that influence outcomes.
A recent study published in Journal of the American Geriatrics Society reveals that men are more susceptible to cognitive impairment following hip surgery. Cognitive limitations significantly increase the risk of dying within six months for both men and women, with men being up to five times more likely to die than unimpaired women.
A pilot study conducted by the University of California, Los Angeles, has shown that consuming grapes twice a day for six months can prevent metabolic decline in Alzheimer-related areas of the brain. Participants who followed a grape-enriched diet demonstrated improved attention and memory performance compared to those on a placebo diet.
The project aims to develop inclusive research engagement networks to recruit underrepresented populations into brain health research. Key findings include the development of a sustainable online network to facilitate minority research engagement and knowledge sharing.
A new study by Temple University researchers links glucose deprivation in the brain to cognitive decline and memory impairment in Alzheimer's disease. The study identified p38 as a potential drug target, which could alleviate memory impairments caused by glucose deprivation.
NAP, a fragment of activity-dependent neuroprotective protein, enhances Tau-microtubule interactions to block neurofibrillary tangles in Alzheimer's disease. This stabilizes microtubules and protects biological material transport in nerve cells.
USC-led study finds that older women living in areas with high PM2.5 levels are 81% more at risk for global cognitive decline and 92% more likely to develop dementia, including Alzheimer's disease. Exposure to air pollution particles may accelerate brain aging and promote Alzheimer's disease.
Researchers discovered that abnormality with gatekeeper cells, which surround blood vessels in the brain, leads to neuron deterioration and possible influence on Alzheimer's disease. Pericyte degeneration restricts blood flow and oxygen supply to active areas of the brain.
Research from the University of British Columbia found that a vitamin A deficiency in the womb or early infancy can increase production of amyloid beta and lead to cognitive impairments. Providing supplements after birth may help slow the degenerative brain disease.
Researchers at Tohoku University have developed a new drug, SAK3, that stimulates the release of acetylcholine in the brain and improves cognition. In animal experiments, SAK3 has proven to be safe and well-tolerated, with potential for development into a disease-modifying drug.
A large-scale study led by Dr. Laurent Azoulay found no association between androgen deprivation therapy and an increased risk of Alzheimer's disease in patients with advanced prostate cancer. The study analyzed data from nearly 31,000 men with nonmetastatic prostate cancer over a 27-year period.
Researchers are exploring aerobic exercise as a potential treatment for mild traumatic brain injuries (mTBI) in wounded warriors. The study aims to improve soldiers' quality of life by assessing intensive cardiorespiratory exercise, which may help alleviate symptoms such as migraines and motor problems associated with mTBI.
Certain edible mushrooms have been found to contain bioactive compounds with potential neuroprotective effects, enhancing nerve growth in the brain. The study suggests these mushrooms may help reduce or delay the development of age-related neurodegeneration.
A breakthrough study by Dr. Xinglong Wang has linked ALS and dementias to TDP-43 toxicity in mitochondria, offering new hope for treatment. His team discovered a small-molecule peptide that can reverse symptoms of ALS in mice, paving the way for potential therapeutic approaches.
Researchers at Joslin Diabetes Center found that mice with reduced brain cholesterol suffer neurological damage and behavioral abnormalities. The study suggests that cholesterol may play a role in the development of Alzheimer's disease in people with diabetes.
Researchers discovered that excess tau protein damages brain's GPS, leading to spatial disorientation and cognitive deficits in Alzheimer's disease. The findings may lead to early diagnostic tests and novel targets for treating this common symptom.
A Stanford-led study found that astrocytes, once thought to be supporting cells, can become toxic and destroy nerve cells, driving many neurodegenerative diseases. The discovery has profound implications for treating these diseases by blocking or countering the toxin secreted by harmful astrocytes.
The Harrington Discovery Institute has selected three 2016 partnership scholars to support groundbreaking research in Alzheimer's disease and blindness. The scholars will receive funding and expert pharmaceutical guidance to advance their discoveries into new medicines.
A recent study found that benzodiazepines and related drugs are associated with a 20% higher risk of stroke among persons with Alzheimer's disease. The association is stronger for ischemic strokes than hemorrhagic strokes. Cardiovascular risk factors did not explain the link.
The new guidelines provide a revised conceptual model of VCI and its subtypes, aiming to clarify diagnosis and facilitate collaboration among researchers. The study's findings have the potential to speed up research in this vital area and bring much-needed help to people with vascular cognitive impairment.
New research found that concussions accelerate brain atrophy and cognitive decline in people with a genetic risk for Alzheimer's disease. The study, published in the journal Brain, suggests that even mild traumatic brain injuries may increase the risk of developing neurodegenerative diseases.
USP9 gene may provide new starting point for developing active ingredients to treat Alzheimer's disease. The researchers found that USP9 has an indirect influence on tau protein, which is believed to play a significant role in the onset of Alzheimer's disease.
Antidepressant use nearly doubles hip fracture risk among community-dwelling elderly with Alzheimer's, highest risk seen at the start of treatment. The association remains elevated even after adjusting for other fall and fracture risks.
A new review article suggests that protein aggregation inside aging neurons sets off inflammatory responses, which can lead to neurodegenerative diseases like Alzheimer's. Therapies targeting protein removal and prevention of inflammation hold potential to prevent or treat these conditions.
A recent study published in Cell Reports reveals that microglia turnover is 10 times faster than previously thought, allowing for multiple renewal cycles throughout a person's life. This groundbreaking finding has significant implications for understanding the role of microglia in neurodegenerative diseases like Alzheimer's.
A new study published in the American Journal of Clinical Nutrition found that a high-cholesterol diet or frequent consumption of eggs do not increase the risk of memory disorders. In fact, egg consumption was associated with better cognitive performance in certain tests.
Researchers found that chemicals extracted from prickly pear and brown seaweed improve cellular and animal models of neurodegenerative proteinopathies. The study suggests these substances may target pathways affected by multiple neurodegenerative conditions.
Researchers have discovered a potential new treatment for Alzheimer's disease by inhibiting the 12/15-lipoxygenase enzyme, which is elevated in patients with the condition. The study found that this inhibitor reverses cognitive decline and neuropathology in an AD mouse model, even after symptoms have already developed.
A randomized, Phase III study will enroll 600 people with suboptimal diets to evaluate the effects of a specific diet on cognitive abilities and brain health. The MIND diet, which includes foods like fish, berries, nuts, and leafy greens, aims to improve brain health by developing new dietary guidelines.
Researchers have discovered two new molecules, AVN-211 and AVN-322, that show high therapeutic potential in treating Alzheimer's disease. These compounds have demonstrated improved memory function and reduced cognitive dysfunction in lab animals.
A team of Vanderbilt researchers has cleared a major hurdle in their quest to develop an Alzheimer's treatment, with the FDA approving its first human trial. The investigational drug aims to target major pathologies of the disease and selectively activate a key receptor in the brain.
Researchers confirm the use of a simple sniff test as a supplementary tool for diagnosing mild cognitive impairment and Alzheimer's dementia. The study found that combining the sniff test with a standard cognitive assessment significantly improved diagnostic accuracy, particularly in identifying people at high risk of worsening.
Scientists have detailed the structure of TREM2, a molecule implicated in Alzheimer's and other neurodegenerative diseases. The study shows that certain mutations alter the surface or internal structure of TREM2, leading to impaired function and neurodegeneration.
Researchers discovered that two M1-selective medications reversed memory deficits and extended the lifespan of mice with neurodegenerative disease. The findings support the concept that more specific drugs can be effective in treating cognitive symptoms.
A new class of drugs targeting a specific protein receptor has shown promising results in improving cognitive function and extending the life-span of terminally ill mice with neurodegeneration. The study provides hope for developing effective treatments to alleviate symptoms and slow disease progression in Alzheimer's patients.
A 20-year study found that men taking a sauna 4-7 times a week were 66% less likely to be diagnosed with dementia. The study also showed a significant reduction in the risk of Alzheimer's disease.