Articles tagged with Alzheimer Disease
A randomized controlled study published in Annals of Internal Medicine found that providing information about coronary artery disease risk to patients undergoing genetic testing for Alzheimer's disease improved health behaviors and reduced distress. The study suggests that the disclosure of secondary findings from genomic testing can h...
Researchers have identified PTEN as a key player in Alzheimer's disease, where it drives excessive synaptic plasticity and impairs memory formation. A new study offers a promising approach to prevent this process, using a molecular tool that shields synapses from PTEN recruitment.
The American College of Physicians (ACP) offers guidance on evaluating blood in the urine, emphasizing the importance of referring patients with gross hematuria and confirming heme-positive results. For adults with microscopically confirmed hematuria, urology referral for cystoscopy and imaging is recommended.
Researchers aim to improve measurement methods for amyloid-beta protein production outside the brain, a key area of study for Alzheimer's disease. They plan to develop innovative quantitative proteomics methods to analyze peripheral tissue changes and their relation to brain changes.
Researchers found that higher Omega-3 fatty acid levels enhance the effectiveness of B vitamins in preventing cognitive decline. The study, which included over 250 participants with mild cognitive impairment, suggests that combining B vitamins and fish oil supplements may improve thinking and memory in older adults.
Researchers discover ApoE4's transcriptional effects, targeting genes associated with sirtuins, aging, insulin resistance, inflammation, and amyloid plaques. This finding offers a unified theory of Alzheimer's disease and potential new screening methods for prevention.
A new study developed a comparable test of learning and memory for humans as the one used in mice, addressing limitations in translating results from animals to humans. The virtual version of the Morris water maze was found to show significant impairments in both Alzheimer's disease model mice and early-stage AD patients.
Researchers discovered a distinctive odor signature in mouse models of Alzheimer's disease that appears before significant brain pathology development, suggesting a non-invasive tool for early diagnosis. The odor profile may be related to the presence of an underlying gene rather than actual brain changes.
Two studies by the University of Exeter Medical School shed light on how two parts of the brain's navigation system malfunction in dementia, leading to loss of orientation. The findings suggest that fine navigational detail is not correctly represented in patients with dementia.
A new study finds that traumatic brain injury induces mental impairments using mechanisms linked with Alzheimer's disease, specifically the toxic form of tau protein. The research suggests that TBI may share a common mechanism with neurodegenerative diseases, increasing the risk for dementia and other neurological disorders.
Researchers at Washington University School of Medicine suggest atherosclerosis is driven by processes similar to brain diseases like Alzheimer's and Parkinson's. Protein buildup inside macrophages, facilitated by p62, interferes with their ability to function.
A University of Southampton-led study found that blocking a receptor in the brain responsible for regulating immune cells can prevent cognitive decline and memory loss associated with Alzheimer's disease. The researchers discovered that reducing brain inflammation could halt disease progression.
Researchers found that people with Alzheimer's who had more physical signs of the disease were also more likely to have psychosis. However, when they looked at those whose autopsies confirmed Alzheimer's, psychosis did not correlate with physical evidence of the disease. Instead, it was linked to vascular risk factors and cerebral inju...
Researchers have identified two genetic variants, ABCA7 and MA4A6A, associated with brain atrophy in Alzheimer's disease. The study found that protein levels in the blood produced by these genes could be used as biomarkers for diagnosis and potential treatment.
A $16 million NIH/NINDS grant will fund a seven-year study to create methods for detecting and diagnosing chronic traumatic encephalopathy (CTE) during life. Researchers will examine risk factors, develop clinical criteria, and investigate genetic and head impact exposure risks.
A study published in Nature Medicine found that enhancing proteasome activity with drugs during early stages of Alzheimer's disease may prevent dementia and reduce brain damage. Researchers identified a potential therapeutic target, rolipram, which activates the proteasome system to clear out toxic proteins.
Researchers discover a new treatment approach to neurodegenerative diseases like Alzheimer's, Huntington's and Parkinson's. A drug called rolipram boosts the activity of the proteasome, which clears out toxic proteins from the brain.
Benjamin Wolozin receives award for his research on Alzheimer's disease and neurodegenerative diseases. He has made significant contributions to the current field of understanding these conditions through publications and patents.
Researchers found five genetic loci associated with successful aging, involved in cell senescence, autoimmunity, and Alzheimer's disease. These genes may provide clues about physiological mechanisms for healthy aging and have the potential to improve health outcomes.
A consensus panel of neuropathologists confirms CTE has a distinct pathognomonic signature in the brain, differentiating it from other tauopathies. The criteria define progressive degeneration of brain tissue, including abnormal protein buildup, leading to memory loss and dementia.
Researchers discovered four linguistic factors indicative of dementia: semantic impairment, acoustic impairment, syntactic impairment, and information impairment. The automated technology provides an objective diagnostic rating for dementia, surpassing the current initial assessment tool used by healthcare professionals.
Scientists at the University of Nottingham have discovered a small molecule called nicotinamide mononucleotide (NMN) that causes a chain reaction of destruction within neuron cell processes. This finding may lead to new therapies for age-related neurodegenerative disorders such as Parkinson's and Alzheimer's disease.
Research published in BMJ Open found that moderate drinking (2-3 units daily) is associated with a lower risk of death among people with early stage Alzheimer's disease. The study analyzed data from 321 participants and found that those who drank moderately had a 77% lowered risk of death compared to those who drank little or no alcohol.
Gut bacteria break down pomegranate polyphenols to produce urolithins, which are anti-inflammatory and neuroprotective compounds. These compounds reduce A\u00e0 fibrillation levels in vitro and increase lifespan of an Alzheimer's roundworm model.
Temple researcher Arthur M. Feldman warns that the newly approved heart drug Entresto may increase patients' risk of Alzheimer's disease and macular degeneration. The drug was approved for heart failure via the FDA's fast-track program, but its cognitive risks have not been fully tested.
Researchers discovered that astrocytes are repelled by amyloid plaques, contrary to previous assumptions. This finding suggests that modifying astrocyte function rather than changing position may be a key response to plaque formation.
A Stanford University study has found that men treated with androgen deprivation therapy for prostate cancer are nearly twice as likely to be diagnosed with Alzheimer's disease. The researchers analyzed electronic medical records of thousands of patients, revealing a significant increase in cognitive decline among those receiving ADT.
A study of medical records found that men taking androgen deprivation therapy for prostate cancer were almost twice as likely to be diagnosed with Alzheimer's disease as those who didn't undergo the therapy. The longer duration of ADT, the greater the risk of Alzheimer's disease.
A Yale-led study finds that individuals with negative beliefs about aging are more likely to develop brain changes associated with Alzheimer's disease. Combatting these negative beliefs could potentially reduce the rising rate of Alzheimer's disease.
NYU Langone will launch the NYU Caregiver Integrated Support and Services Access Program (CISSAP) to offer counseling, support, and services to New York City caregivers. The program aims to improve quality of life and reduce caregiver burden for those caring for individuals with Alzheimer's disease.
A recent study published in Neurology found an association between slow walking speed and amyloid plaques in the brain, which are a hallmark of Alzheimer's disease. The researchers discovered that participants with higher levels of amyloid were more likely to have slower walking speeds.
Researchers have identified a network of nine genes that play a key role in the onset of Alzheimer's Disease. The study found that some genes delay the disease by up to 17 years, while others accelerate its progress.
Researchers found that magnesium-L-threonate alleviated cognitive decline in mouse models of Alzheimer's disease by suppressing Aβ deposition. The study suggests that magnesium ions target APH-1α/1β, inhibiting the aggregation of β-amyloid protein and resulting in improved cognitive function.
Research suggests that low levels of BRCA1 protein in the brain may contribute to dementia. The study found that adding amyloid beta to neurons lowers levels of BRCA1, increasing DNA damage and cognitive decline. Further research is needed to determine whether BRCA1 may be a potential therapeutic target for treating dementia.
Researchers found that BRCA1 depletion impairs brain cell function and contributes to cognitive decline in Alzheimer's disease. The study suggests that therapeutic manipulation of BRCA1 may prevent neuronal damage and cognitive decline in patients with Alzheimer's disease or at risk for the disease.
Researchers at UNSW Australia have identified a new molecular mechanism that contributes to synapse loss in Alzheimer's disease, which occurs early on and precedes nerve cell death. This discovery could lead to earlier diagnosis and new treatments.
A study published in the journal Brain found that amyloid plaques around blood vessels in the brain can disrupt astrocyte function, leading to reduced cerebral blood flow. This could account for symptoms such as memory lapses, impaired decision-making, and personality changes associated with Alzheimer's disease.
A UMD study found that improving fitness through moderate exercise can counteract brain atrophy in older adults with mild cognitive impairment. The study showed increased cortical thickness in both healthy and MCI participants, with greater improvements seen in those with MCI.
A study published in the American Heart Association journal Stroke found that bilingual patients were twice as likely as those who spoke one language to have normal cognitive functions after a stroke. The research also showed that bilinguals performed better on post-stroke tests measuring attention and information retrieval.
A new study reveals that Alzheimer's patients' healthcare costs increase significantly even before a diagnosis, primarily driven by hospital care and medication. The cost difference stabilizes two years after diagnosis, with AD patients having twice the healthcare costs of non-AD patients.
A novel mouse study finds that modulating the brain's stress circuitry with a CRF-antagonist significantly prevents Alzheimer's disease neuropathology and cognitive impairment. The treatment reduced amyloid plaque generation and cellular damage, suggesting a potential therapeutic approach for AD prevention.
Researchers discovered that the protein APP forms spherical structures in the nucleus, affecting gene activity and neurotransmitter modulation. This finding may lead to new therapies for Alzheimer's disease by inhibiting neurotransmitter activity.
Researchers at Oxford University found that apathetic individuals showed more activity in the pre-motor cortex when making decisions, despite being less likely to accept effortful choices. This suggests that biology, not attitude, may be the root cause of apathy in some people.
A team of researchers discovered a molecular mechanism responsible for familial amyloidosis and other life-threatening diseases, including Alzheimer's and Parkinson's. They found that specific mutations can alter the protein's structure, leading to abnormal clumping and organ damage.
Research finds men carrying ApoE4 gene suffer more tiny brain bleeds and memory loss than women with similar diagnoses. The study provides new insights into the effects of ApoE4 on Alzheimer's disease in humans.
Researchers are developing a simple, inexpensive blood test that can detect the risk of Alzheimer's disease in individuals with Down syndrome. The test aims to identify people who will develop the disease before cognitive symptoms appear.
A possible solution to the inflammatory side effects of Alzheimer's immunotherapy has been discovered by researchers from the University of Southampton. They engineered three new antibodies that preserved immunotherapeutic activity while reducing inflammation.
A $9.4 million grant is being used to test a transdermal nicotine patch for improving memory loss in older adults with mild cognitive impairment (MCI). MCI affects millions of people worldwide and is the stage between normal aging and dementia when others notice mild memory problems.
A study published in Neurology found that raloxifene, an estrogen-like drug, had no demonstrated benefit on memory and thinking skills for women with mild to moderate Alzheimer's disease. The results suggest that the drug may not be effective as a treatment for this condition.
Researchers propose that Alzheimer's disease is a collection of diseases stemming from similar molecular mechanisms. They identified a key protein, cyclophilin B, responsible for its manifestation in distinct neurodegenerative disorders. This study aims to develop novel therapies tailored to individual disease subtypes.
A new study finds that the APOE epsilon 4 allele is associated with an increased risk of late-life depression, even after controlling for Alzheimer's disease. The presence of this allele predicts future depression in older adults, highlighting its potential as a marker for prevention and early detection.
A study found that long-term aerobic exercise can prevent structural deterioration associated with old age in mice, improving blood-brain barrier function and reducing inflammation. Exercise was particularly beneficial for animals lacking the Apoe gene, a major genetic risk factor for Alzheimer's disease.
Researchers have found that transplanted human umbilical cord blood cells migrate to brain tissue and remain active for up to 30 days, without promoting tumor growth. The study suggests that these cells may confer therapeutic effects through modulation of the inflammatory response associated with Alzheimer's disease.
A UCI study found that circadian rhythm-altering sleep disruptions similar to jet lag can promote memory problems and chemical alterations in the brain. The researchers suggest that good sleep habits may be crucial for maximizing good memory.
A University of Sussex study reveals that rehearsing information immediately after being given it strengthens memory, as the posterior cingulate region of the brain activates when laying down and rehearsing a memory. This area integrates episodic details into knowledge and understanding, making memories resistant to forgetting.
A study published in Nature Communications reveals a mechanism by which the pathologic version of tau protein spreads from neuron to neuron in the brain, contributing to Alzheimer's disease progression. This process involves the release and uptake of high-molecular-weight, soluble tau proteins that are studded with phosphate molecules.
Young adults with genetically increased Alzheimer's risk show altered activation patterns in the entorhinal cortex, a key region for spatial navigation. This alteration may contribute to the development of Alzheimer's dementia in the long term.
A recent study has found that plaques associated with dementia can disrupt the spread of slow waves in the brain during sleep, impairing memory consolidation. Researchers were able to decode this defect at the molecular level and alleviate it with medication, showing potential for a new treatment approach.
Young adults with a genetic risk of Alzheimer's disease showed reduced grid cell functioning and abnormal spatial navigation when navigating a virtual maze. This could be an early biomarker for the disease, suggesting that early intervention may be effective.
Research suggests that antidepressants like SSRIs and NRI can improve motor recovery and aphasia treatment in stroke patients. However, more studies with well-designed methodologies are required to establish the usefulness of these medications as adjuvants to rehabilitation.