Articles tagged with Alzheimer Disease
Researchers found that Golgi fragmentation accelerates APP trafficking and production of toxic Aβ protein in AD. Rescuing the Golgi by blocking cdk5 or GRASP65 reduces Aβ accumulation, offering a potential therapeutic strategy for slowing Alzheimer's progression.
Carmela Abraham, a professor at Boston University School of Medicine, has received the Massachusetts Neuroscience Consortium Award for her research on multiple sclerosis and the life extension protein Klotho. Her work identifies Klotho as a neuroprotective protein that can benefit animal models of Alzheimer's and multiple sclerosis.
Researchers have successfully created induced neurons that model Alzheimer's disease by starting with fibroblasts taken from skin biopsies. The differentiated cells express normal neuronal markers and proteins associated with the neurodegenerative disorder, including amyloid beta and tau.
A study at Plymouth University is exploring how proteins interact to build up in nerve cells, potentially leading to dementia diseases like Alzheimer's and Parkinson's. The research aims to understand the mechanism behind protein deposits and may one day lead to new therapies for patients with dementia with Lewy bodies.
A new study suggests that changes in brain connections visible on MRI could represent an early sign of Alzheimer's disease. Researchers analyzed 102 patients and found a strong association between increased beta amyloid plaque and decreased white matter strength.
A new compound, ethane-beta-sultam, has been developed to reduce brain cell loss and inflammation caused by binge drinking. This breakthrough could lead to a treatment for Alzheimer's and other neurological diseases that damage the brain.
Recent research suggests that moderate coffee consumption may lower the risk of Alzheimer's disease by up to 20 percent. This protective effect is attributed to compounds such as polyphenols, which are also found in high quantities in coffee.
Researchers found eliminating orexin slowed brain plaque growth and increased sleep time in mice, indicating its potential as an Alzheimer's prevention target. The study also highlights the importance of addressing sleep abnormalities to reduce Alzheimer's risk.
A model inspired by epidemic disease spreading is used to analyze over 700 Amyloid-beta protein imaging datasets, concluding that misfolded protein propagation can be mathematically described. The study identifies genetic and demographic factors influencing this phenomenon in healthy aging and Alzheimer's disease progression.
Veronica Garcia, a UT graduate student, has been awarded a Robert D. Watkins Graduate Research Fellowship to study the molecular mechanisms of Alzheimer's disease and other disorders. The fellowship aims to increase diversity in microbiological sciences research.
The study found that astrocyte hyperactivity is caused by energy carriers like ATP, leading to calcium fluctuations and changes in brain perfusion. The research suggests a novel potential approach for treating Alzheimer's disease by mitigating the hyperactivity of these cells.
Researchers at Temple University discovered that oxygen free radicals bind to a protein receptor in the brain called the thromboxane receptor, transmitting signals that increase amyloid beta and tau production. Blocking this receptor has shown promise in neutralizing Alzheimer's disease symptoms.
Researchers created a three-dimensional model of a single neuron to study its electrical properties. The study found that changes in cell morphology affect hyper-excitability, highlighting a new relationship between cellular dysfunction and structural integrity.
A new neurological disease closely resembling Alzheimer's disease, called primary age-related tauopathy (PART), has been defined and established criteria for diagnosis. PART is characterized by cognitive impairment without amyloid plaques, but with neurofibrillary tangles composed of a protein called tau.
A genetic variant associated with better memory performance was found in a large analysis of genomic data and memory test results from over 14,000 older adults. The researchers discovered that the gene FASTKD2 has not been linked to cognition before, but the G nucleotide variant showed a correlation with improved episodic memory.
The number of Alzheimer's patients is expected to more than double in 40 years, while annual per-person costs will nearly quintuple from $71,000 in 2010. Delaying onset can reduce the prevalence and costs of the disease.
A new study found that anxiety symptoms in individuals with mild cognitive impairment (MCI) increase the risk of a faster decline in cognitive functions and accelerate brain damage, independent of depression. MCI patients with moderate or severe anxiety had a 33%, 78%, and 135% increased risk of Alzheimer's, respectively.
Researchers at University of California, San Diego, have removed the brain area responsible for spatial navigation in rats, showing that other memory abilities remain intact. The study provides insights into Alzheimer's disease and stroke effects on the brain's navigational system.
A new study from the University of Kansas found that neighborhoods that encourage walking for leisure and transportation are associated with improved physical health and cognition in older adults. The research suggests that easy-to-walk communities can help stave off cognitive decline, even in individuals with mild Alzheimer's disease.
Researchers at the University of Copenhagen found that a high-fat diet can postpone signs of brain aging in mice with a defective DNA repair system. This could lead to new treatment possibilities for children with Cockayne syndrome and patients with Alzheimer's and Parkinson's disease.
The National Institutes of Health (NIH) has provided $26 million in funding to continue and expand the DIAN-TU trial, a large-scale clinical trial aimed at identifying drugs to stop or slow Alzheimer's disease. The trial is focused on dominantly inherited forms of Alzheimer's disease and will test two treatments in patients with inheri...
Research on Alzheimer's disease and other neurological conditions may eventually lead to ways to prevent memory loss, learning disabilities, and devastating symptoms. Significant progress continues to be made with advancements in detecting neurodegeneration and predicting cognitive decline.
A new blood test has been developed to diagnose early onset Alzheimer's disease, detecting changes in the brain two decades before symptoms appear. The test shows high accuracy in predicting AD risk and has the potential to improve treatment options.
Elderly men with self-reported sleep disturbances are at a higher risk of developing Alzheimer's disease. A 40-year follow-up period revealed that late-life sleep disturbances significantly increase the risk. Regular good sleep habits may support brain health and reduce the risk of Alzheimer's disease.
The Alzheimer's Association has awarded research grants to investigate non-drug treatments for Alzheimer's disease, including exercise and cognitive stimulation interventions. These studies aim to lower the risk of cognitive decline and dementia in older adults.
Researchers found that reduced levels of SNX27 protein lead to increased beta-amyloid production and brain plaques, a hallmark of Alzheimer's disease. Adding new copies of the SNX27 gene can repair memory deficits in Down syndrome mice.
A new animal study found that a walnut-enriched diet improved learning skills, memory, and reduced anxiety in mice. The researchers suggest that walnuts' high antioxidant content may protect the brain from degeneration typical of Alzheimer's disease.
Researchers have developed a method to deliver drugs more effectively for Alzheimer's and Parkinson's using micro and nanoparticles. Encapsulated growth factors have been found to be much more effective than traditional oral medications in animal trials, improving symptoms and healing damaged zones.
The European College of Neuropsychopharmacology awards Dick Swaab with the 2014 ECNP Media Award for his book 'We are our Brains'. The award recognises outstanding contributions to destigmatising disorders of the brain. Swaab's work aims to promote a better understanding of brain function and its impact on mental health.
A study followed 800 women for nearly 40 years and found that those with neurotic tendencies were more likely to develop dementia conditions. The research suggests that long periods of stress can increase the risk of Alzheimer's disease, with shy women experiencing the highest increase in risk.
A study found higher orexin levels in patients with moderate-to-severe Alzheimer's disease compared to controls. This association was also observed in relation to total tau protein levels and cognitive impairment, highlighting the potential link between orexinergic system dysregulation and AD progression.
Researchers have identified a novel gene, MGST3, that regulates hippocampus size in both mice and humans, linked to neurodegenerative diseases like Alzheimer's. The discovery provides another biomarker for identifying those at greatest risk of developing the condition.
Researchers distinguish different types of beta-amyloid aggregates and find that those with 20 to 100 units are most toxic, leading to neuronal death. The study provides evidence for the hypothesis that intermediate aggregates cause neuronal death.
A nearly 40-year-long study found that middle-aged women experiencing anxiety, jealousy, and moodiness are at a higher risk of developing Alzheimer's disease. Women who scored highest on neuroticism tests had double the risk of dementia, with those who were both easily distressed and withdrawn having the highest risk.
Researchers at Gladstone Institutes found that progranulin deficiency can increase amyloid-beta plaque formation, neuroinflammation, and cognitive dysfunction in a mouse model of Alzheimer's disease. Increasing progranulin levels via gene therapy effectively prevented these abnormalities and protected against cell death.
Researchers show that Alzheimer's patients experience sustained states of sadness and happiness despite little or no recollection of movie clips. The study highlights the importance of caregivers' actions on patients' emotional state, suggesting simple techniques can improve quality of life.
A study published in Neurology found that people who notice their memory slipping may be on to something, with 56% of participants reporting changes in their memory. The study suggests a significant window of opportunity for intervention before diagnosable problems show up, approximately 12 years after initial complaints began.
Researchers at Mayo Clinic have discovered a defect in the Wnt signaling pathway that contributes to both overproduction of toxic protein and loss of communication between neurons in Alzheimer's patients. Targeting this specific defect with drugs may rejuvenate or rescue the pathway, potentially preventing or treating Alzheimer's disease.
Researchers studied adults with Down syndrome to understand the role of amyloid-β protein in memory and cognitive function. Contrary to expectations, many individuals with elevated amyloid-β levels did not exhibit negative consequences, highlighting the complexity of Alzheimer's disease.
A new experimental PET tracer effectively diagnoses chronic traumatic encephalopathy (CTE) while patients are still alive. The technology differentiates CTE from other forms of dementia, enabling estimates of prevalence and risk. This breakthrough improves diagnosis and treatment for athletes and others exposed to repeated head trauma.
Researchers found that bexarotene reduces amyloid-beta levels in late-stage Alzheimer's mice but increases them in early stages. This study suggests a personalized treatment approach for APOE4 carriers, who may benefit from short-term treatment in later disease stages.
A recent study by University of California, Berkeley researchers has found evidence of neural compensation in individuals with beta-amyloid deposits, a hallmark of Alzheimer's disease. This discovery could help explain how some older adults maintain normal cognitive function despite the presence of these deposits.
Researchers at Tel Aviv University have discovered a new way to preserve the flexibility and resilience of the brain, targeting areas affected by Alzheimer's disease. The breakthrough involves stabilizing microtubules, which provide a cellular skeleton for nerve cells, promoting neuroplasticity.
A large case-control study found that long-term benzodiazepine use is associated with an increased risk of Alzheimer's disease. The study suggests that the strongest association was seen with long-acting benzodiazepines, emphasizing the need for careful balance between benefits and risks in elderly patients.
Researchers successfully harness a mouse's immune system to remove toxic proteins in the brain associated with Alzheimer's disease. The treatment approach, which stimulates the natural immune system, showed promise in reducing amyloid beta plaques and tau tangles.
A recent study found that APOE ε4 and APOC1 H2 gene polymorphisms are associated with increased risk of cognitive decline in Chinese patients with late-onset Alzheimer's disease. The findings suggest a potential genetic link between these genes and cognitive impairment progression in this population.
Researchers found that APOE genotype influences the diagnostic accuracy of CSF biomarkers, particularly beta-amyloid 42 (Aβ42), in diagnosing Alzheimer's disease. In contrast, the APOE gene had no effect on Aβ42 levels in younger individuals.
A new study published in the American Journal of Alzheimer's Disease and Other Dementias found that mindfulness training can brighten outlooks on life for both individuals with memory loss and their caregivers. The training eased depression, improved sleep quality, and enhanced overall quality of life.
Scientists have found that punicalagin, a polyphenol in pomegranate, can inhibit neuro-inflammation in brain cells. The compound may help slow the development of diseases like Alzheimer's and Parkinson's by reducing inflammation.
Researchers have developed a recombinant adenovirus expressing Aβ-ABAD decoy peptide, which increases superoxide dismutase activity and decreases oxidative stress markers in PC12 cells. This study suggests that rAAV/ABAD-DP-6His may be a potential therapeutic strategy for Alzheimer's disease.
A study found that elderly individuals with Alzheimer's disease have fewer inhibitory neurons, leading to fragmented sleep. The researchers discovered a correlation between the number of remaining ventrolateral preoptic neurons and sleep fragmentation, highlighting a potential link between aging and sleep disorders.
Researchers at Brigham and Women's Hospital discovered that early changes in brain DNA methylation are involved in Alzheimer's disease. The study found correlations between methylation levels and Alzheimer's disease in specific genes, suggesting a potential role for epigenomic modifications in disease susceptibility.
Researchers have discovered strong evidence that epigenetic changes play a role in Alzheimer's disease, with specific DNA modifications linked to neuropathology. The study provides potential hope for understanding the mechanisms involved in dementia and highlights the importance of epigenetics research.
Researchers found that Yizhijiannao granule inhibits neuronal apoptosis, reducing tau phosphorylation and neuroinflammation in Alzheimer's disease. The study identified multiple proteins involved in regulating amyloid beta production, oxidative stress, and neuronal survival.
A study found that altered brain activity, measured by PET scans, is associated with impaired daily living activities in individuals with mild cognitive impairment and dementia. The researchers identified changes in frontal and temporal areas of the brain linked to memory and decision-making.
Researchers found a 40-year-old man with no apolipoprotein E had normal cognitive function despite being at high risk for Alzheimer's. The study suggests reducing apoE levels may be beneficial in treating neurodegenerative disorders like AD.
A recent study published in the medical journal Neurology has confirmed a substantial link between vitamin D deficiency and an increased risk of dementia and Alzheimer's disease in older adults. The research found that participants with severe vitamin D deficiency were more than twice as likely to develop dementia and Alzheimer's disease.
A study published in Neurology found that low vitamin D levels double the risk of developing dementia and Alzheimer's disease in older people. Researchers analyzed blood levels of vitamin D and found a significant association between low vitamin D levels and increased dementia risk.
Researchers at Yale School of Medicine have discovered a new drug compound, TC-2153, that inhibits the negative effects of STEP protein, which is key to regulating learning and memory in Alzheimer's disease. Decreasing STEP levels reversed cognitive deficits in mice, suggesting a potential therapeutic approach for treating the condition.
Researchers at Yale University have discovered a new drug compound, TC-2153, that inhibits the negative effects of STEP protein and reverses cognitive deficits in Alzheimer's disease. The compound was found to improve cognitive function in mice, suggesting a potential therapeutic avenue for treating the disease.