Articles tagged with Alzheimer Disease
Scientists from Brandeis University and the Leibniz Institut have created a 3D image of an Alzheimer's peptide aggregate using electron microscopy. The study reveals the spaghetti-like structure of A-beta peptide aggregates, also known as amyloid fibrils.
A new study found that those with at least a high school education spend more years without cognitive loss, including Alzheimer's, Parkinson's, and dementia, but die sooner after the impairment becomes apparent. Those with higher levels of education can expect to live 14.1 more years without cognitive impairment.
Researchers used computer simulations to study the effects of a minor genetic mutation on Alzheimer's disease. The mutation, which affects a protein fragment, alters its shape and increases the likelihood of toxic clumps forming in brain cells.
A randomized clinical trial found that anti-inflammatory drugs celecoxib and naproxen had no effect on cognitive function in older adults with a family history of Alzheimer's disease. In fact, naproxen may have a slightly detrimental effect, according to the study published in Archives of Neurology.
Researchers at Gladstone Institutes have found that modulating enkephalin peptides in the brain may reduce cognitive deficits seen in Alzheimer's disease. Increased levels of preproenkephalin mRNA and enkephalins in brain regions affected by AD were observed, suggesting a potential new therapy target.
A systematic review of 10 studies found a consistent relationship between obesity and an increased risk for dementia, with baseline obesity increasing the risk by 80% on average. Preventing or treating obesity at a younger age could reduce the number of dementia patients by up to 20%.
Research found obesity increases dementia risk by 80%, while being underweight also poses a significant threat. The study, published in Obesity Reviews, analyzed data from over 37,000 people and estimated that 12% of dementia risk can be attributed to obesity.
Researchers found that luteolin and diosmin reduced levels of amyloid-beta, a protein that builds up in the brains of patients with Alzheimer's. The flavonoids work by targeting presenilin-1, a protein linked to the disease.
A study published in Neurology found that long-term use of ibuprofen and other NSAIDs was associated with a lower risk of Alzheimer's disease. The research analyzed data from over 49,000 veterans and showed that people who used ibuprofen for more than five years were 40% less likely to develop dementia.
A significant difference in sleep disturbances was found between Alzheimer patients and their caregivers. Poor sleep quality was linked to various health problems such as depression, daytime sleepiness, and increased risk of obesity, cardiovascular disease, and diabetes.
Researchers at the Salk Institute identified a probable molecular basis for the interaction between diabetes and Alzheimer's disease. The study found that damaged blood vessels in the brain of young diabetic mice suffered from significant memory loss and inflammation before any overt signs of Alzheimer's disease appeared.
Patients with mild Alzheimer's disease showed less decline in functional ability after taking 800mg of tarenflurbil twice daily compared to placebo. The treatment also reduced the pace of decline in global function and activities of daily living scale.
Researchers investigated the potential link between anesthetics and Alzheimer's disease. While desflurane alone did not increase amyloid-beta protein production, it stimulated cellular changes associated with Alzheimer's when combined with low oxygen levels.
Scientists develop novel strategy to inhibit ß-secretase enzyme in Alzheimer's disease by targeting cell membrane RAFTS. The approach demonstrates effective inhibition of amyloid peptide formation with concentrations as low as 100 nM.
Researchers at VIB have identified a molecular link between Alzheimer's disease and the formation of amyloid plaques in the brain. The study suggests that microRNAs may play a role in increasing BACE1 protein, a key component of plaques.
Research finds Pin1, previously thought to help with Alzheimer's, actually worsens frontotemporal dementia due to specific tau mutations. This study suggests alternative therapeutic approaches and proper animal models are needed.
A study of 938 people with Alzheimer's disease found that heavy drinking reduced the age of onset by six to seven years, while heavy smoking reduced it by two and a half years. The combination of both risk factors led to an earlier onset of the disease.
Research found people with high cholesterol levels between 249-500mg are 1.5 times more likely to develop Alzheimer's disease than those with low cholesterol levels under 198mg. High mid-life cholesterol also increased the risk of vascular dementia regardless of other factors.
A study found that people with Alzheimer's disease who took vitamin E lived 26% less likely to die than those who didn't take vitamin E. Vitamin E may be more beneficial when taken with a cholinesterase inhibitor.
A new study by Deniz Erten-Lyons shows that a larger hippocampus in the brain may protect individuals from the effects of Alzheimer's disease. Researchers compared the brains of 12 people with sharp memories to those of 23 individuals diagnosed with Alzheimer's disease, finding a significant difference in hippocampus volume
Researchers identified how toxic protein plaque accumulates in the brain of people with Alzheimer's disease. The study found that endocytosis plays a crucial role in transporting amyloid precursor protein into neurons, leading to A
A long-term study published in Neurology found that men who develop diabetes in mid-life are nearly one-and-a-half times more likely to develop Alzheimer's disease than those without insulin problems. The association was strongest in people without the APOE4 gene, which is known to increase Alzheimer's risk.
A new blood test, NuroPro, measures 59 protein biomarkers to distinguish between Parkinson's, Alzheimer's and other neurodegenerative diseases. The test has been welcomed by researchers but larger studies are needed to confirm its effectiveness.
A new study finds that depression is a risk factor for Alzheimer's disease, rather than an early sign of its underlying pathology. The research, published in Archives of General Psychiatry, found no increase in depressive symptoms before the clinical diagnosis of Alzheimer's disease.
A study by the American Academy of Neurology found that people with a history of depression are more likely to develop Alzheimer's disease than those without one. The risk was particularly high for individuals who experienced depression before age 60, with nearly four times greater likelihood of developing the condition.
Researchers studied 917 older Catholic nuns and found that depressive symptoms did not increase before diagnosis with Alzheimer's disease. Instead, those with more symptoms were more likely to develop the condition, implying depression may be a risk factor for dementia.
An autopsy study of 3,400 individuals found that small vessel damage accounts for 33% of dementia risk, surpassing Alzheimer's and Lewy Body diseases. This discovery underscores the importance of controlling hypertension and diabetes to protect brain health.
A recent study suggests that estrogen reduces oxidative stress caused by mitochondria, increasing energy generation and protecting neurons from damage. This finding sheds light on how to develop effective Alzheimer therapeutics.
A new Alzheimer's vaccine shows promise in clearing beta-amyloid plaques from the brain, but lacks impact on learning and memory impairments. Researchers suggest that a combination of therapies targeting plaque growth and neuron damage may provide better treatment opportunities.
A daily dose of caffeine has been shown to protect the blood-brain barrier from damage caused by high cholesterol, a risk factor for Alzheimer's disease. Caffeine maintains tight junction protein expression, preventing unwanted molecule entry into the central nervous system.
According to the third annual Alzheimer’s Foundation of America ICAN: Investigating Caregivers’ Attitudes and Needs Survey, most 'sandwich caregivers' say their children aged 8-21 are involved in caring for a loved one with Alzheimer's disease. Children assist with tasks such as attending doctors' appointments, feeding, and dressing, w...
Researchers confirm that Pittsburgh Compound-B binds to beta-amyloid deposits found in Alzheimer's brains, enabling definitive diagnosis. The finding aids in early detection and treatment of the disease.
A new study found that human umbilical cord blood cell therapy reduced amyloid-ß plaques by 62% and cerebral amyloid angiopathy by 86% in mice with Alzheimer's-like disease. The treatment targeted the pathogenic inflammatory response associated with CD40-CD40L activity.
Researchers found that human umbilical cord blood cell therapy significantly reduced amyloid-β and β-amyloid plaques in mice with Alzheimer's-like disease. The treatment modulates the immune system by suppressing CD40-CD40L activity, offering potential for targeting inflammatory responses associated with degenerative conditions.
Researchers estimated that one in six women and one in ten men will develop Alzheimer's disease in their lifetime, with a higher lifetime risk for women due to greater lifespan expectancy. The study also found that more than one in three people will experience stroke or dementia by age 80.
Researchers have developed an algorithm to discover communities and substructures in various networks, including genetic networks and social networks. The tool has been applied to identify community structures in co-expressed genes and social networks, and can also be used for sociological research.
Researchers have developed a method using near-infrared light to identify microscopic changes in brain tissue associated with Alzheimer's disease. This technique can potentially detect the disease earlier than current methods, which rely on clinical symptoms or imaging tests.
Researchers at Columbia University Medical Center have identified a process in the brain that may link Alzheimer's disease to stroke. A peptide called p25 is believed to cause an increase in amyloid beta production, which is linked to Alzheimer's.
A UC San Diego researcher has identified a new enzyme target that can reduce the production of beta-amyloid peptides, a hallmark of Alzheimer's disease. By inhibiting this enzyme, the researchers observed improved memory and reduced levels of beta-amyloid protein in mice bred to exhibit Alzheimer's disease symptoms.
Adult offspring of two parents diagnosed with Alzheimer's disease have a significantly increased risk of developing the disease, with 22.6% affected compared to 6-13% in the general population. The age at onset is also younger, with those over 60 having a 31% risk and those over 70 having a 41.8% risk.
Researchers used PET imaging with fluorodeoxyglucose (FDG) to classify different types of dementia, achieving over 94% accuracy. The study suggests that early diagnosis using FDG-PET may improve prognosis for patients with mild cognitive impairment and other forms of dementia.
A new study from Washington University in St. Louis found that patients and their caregivers experience a sense of relief upon receiving an Alzheimer's diagnosis, rather than increased anxiety. The study suggests that providing an early diagnosis can allow individuals to make plans for the future, including treatment and preparing for ...
Researchers at USF Health found that Akt protein can influence tau protein, leading to nerve cell death in Alzheimer's disease. The study suggests regulating Akt levels may be beneficial for treating diseases of aging, including cancer and diabetes.
Alzheimer's research reveals that computers can distinguish between brain scans of patients with the disease and healthy individuals or those with other forms of dementia. The accuracy rate is as high as 96%, making it a potentially game-changing tool for early diagnosis and treatment.
Researchers found that transferrin can assemble into worm-like fibrils when dried, exposing iron and potentially causing cell damage. This process may be linked to the deposition of iron in the brain and contribute to neurodegenerative diseases such as Parkinson's, Alzheimer's, and Huntington's.
Researchers have discovered a moss protein that may play a crucial role in preventing Alzheimer's disease. The study found that the moss protein has an evolutionary conserved function with human presenilin, suggesting that it may provide clues to its primary role in mammalian systems.
Researchers used advanced imaging to examine brain tissue in mouse models of Alzheimer's disease, finding that amyloid plaques can develop in as little as a day and neuronal changes appear soon afterwards. The study provides new insights into the timing of brain changes associated with Alzheimer's dementia.
A study found that individuals with fewer years of education are more likely to have a delayed realization of cognitive problems that could be Alzheimer's disease. Patients with lower education levels were also more severely impaired on their first visit, suggesting they may only seek medical attention after symptoms become unbearable.
A new study by Rhode Island Hospital and Brown University found that individuals with early Alzheimer's disease experience more accidents and perform poorly on road tests compared to drivers without cognitive impairment. However, some individuals with very mild dementia can continue to drive safely for extended periods.
Researchers engineered mice to overexpress ABCA1, reducing amyloid deposition in the brain, a hallmark of Alzheimer's disease. This study provides new insights into the disease's pathophysiology and potential therapeutic targets.
Researchers have discovered that increasing lipid associated with apoE in the brain may decrease amyloid deposition in Alzheimer's patients. Meanwhile, a new study found that neutralizing IL-22 prevents psoriasis-like disease in mice, suggesting a potential approach to treating this chronic condition. Additionally, scientists have deve...
Researchers at Mayo Clinic Jacksonville have identified three genes on chromosome 10 associated with Alzheimer's disease. Blood levels of amyloid beta proteins were significantly elevated in asymptomatic young individuals from extended families, indicating a substantial genetic risk factor.
Increasing levels of a protein called ABCA1 sharply reduced buildup of brain plaques characteristic of Alzheimer's disease in mice. Altering the brain's use of lipids may provide a new approach to treating the condition. The study highlights a promising target for potential Alzheimer's therapies.
A study of 929 Catholic clergy members found no link between statin use and reduced risk of Alzheimer's disease. No association was also found between statins and slowed cognitive decline among older adults.
International brain aging expert Peter Whitehouse questions current approaches to Alzheimer's diagnosis and treatment, suggesting that AD represents our culture's attempt to make sense of natural brain aging. The book offers practical advice and information on how to maintain cognitive vitality and a sense of fulfillment as we age.
Researchers found that omega-3 fatty acid DHA increases LR11 production, protecting against Alzheimer's disease. Low levels of LR11 lead to toxic plaques associated with the disease.
A four-year study found that walking and moderate exercise significantly lowered the risk of developing vascular dementia in people over 65. Participants who exerted more energy through physical activities like walking, gardening, or house work had a 27% lower risk compared to those with less energy expenditure.
VIB researchers find certain brain lipids destabilize fibrils, leading to toxic protofibril formation and memory loss in mice. This discovery opens new avenues for medicines against Alzheimer's disease.
Research findings suggest a significant association between high blood pressure and the development of mild cognitive impairment. Approximately 9.9 out of every 1,000 elderly individuals without dementia develop this condition yearly, with 10-12% progressing to Alzheimer's disease each year.
Researchers found that high sugar consumption led to obesity, insulin resistance, and cognitive decline in mice. The study highlights the potential link between sugary drinks and Alzheimer's disease, a finding that could have significant implications for human health.