Articles tagged with Excitatory Synapses
Research identifies aberrant ERBB4 expression in excitatory neurons as an early driver of Alzheimer's disease pathologies, including neuronal hyperactivity, synapse loss, and cognitive decline. Manipulating ERBB4 expression in mouse models reveals its role in driving disease features, including reactive gliosis and amyloid buildup.
A study published in Science Advances reveals that an autism-linked mutation disrupts brain circuits responsible for erasing fear memories, leading to PTSD-like symptoms. By reactivating specific neurons, researchers were able to reverse the behavioral and physiological abnormalities.
A new study reveals that maternal immune activation can alter hippocampal neuron excitability in newborn rats, with implications for neurodevelopmental disorders. Prenatal inflammation has been linked to conditions like autism, schizophrenia, and depression, and may underlie their increased risk.
Scientists have identified a novel molecular mechanism underlying brain cell communication, regulating excitatory synapse maturation and contributing to anxiety disorders. The study reveals the TrkC-PTPσ complex governs synaptic protein phosphorylation, leading to abnormal synapse organization and behavioral defects in mice.
Researchers at Colorado State University used human stem cells to study synaptic connections in the brain, focusing on GABAergic synapses. They found that Gephyrin promotes autonomous assembly of these synapses, which can develop independently of neuronal communication. This understanding could lead to new treatments for neurological d...
A new study published in eNeuro explores the intricate interplay between brain regions involved in nicotine's effects on the human brain. Researchers discovered that the medial habenula experiences fluctuations in activity based on factors such as dosage and sex, highlighting a nuanced relationship.
A newly developed labeling method allows for visualization of intraregional synaptic connections between inhibitory interneurons and excitatory engram cells. Researchers have identified the role of inhibitory interneurons in memory expression, suggesting that they suppress fear expression by inhibiting fear engram cells.
A groundbreaking review paper reveals the importance of GABA tone, the amount of GABA that regulates continuous signaling in the brain. The study identifies key mechanisms and functions, including astrocytes' role in regulating GABA tone and its impact on cognitive processes.
A KAIST research team has identified excessive astrocyte-mediated synapse removal as the cause of mental diseases induced by childhood abuse trauma. This mechanism is linked to stress hormones and can lead to abnormal neural networks and complex behavioral abnormalities.
The gene LRRC4 regulates synapse formation, stability and excitatory transmission, playing a crucial role in learning, memory formation and storage. It also has key implications in neuronal disorders and aggressive brain and spinal cord cancer.
Researchers developed a new method to target diseased neurons using light, changing their long-term behavior. The approach uses light-sensitive enzymes to create insulating or conductive coatings on cell membranes, tuning excitability in neurons.
Dr. Jayaraman's team will analyze glutamate receptors involved in learning and memory processes, shedding light on pathologies of learning disabilities, epilepsy, and other neurological issues.
Research in rats suggests that hormonal contraceptives may alter the developing prefrontal cortex, increasing stress hormone production and disrupting signal transmission. The study's findings have implications for understanding the impact of birth control on teenage behavior and mood.
Researchers at Colorado State University have found a way to alter the type of synapses between brain cells using enzymes. This breakthrough could lead to new treatments for brain disorders caused by faulty synaptic information processing and exchange.
A team at the University of Tokyo discovered that syntaxin protein plays a vital role in storing memory in the nervous system, influencing the migratory behavior of nematodes. The study found that altering syntaxin can lead to reversed behavior, allowing worms to choose whether to approach or avoid salt concentrations.
A new study suggests that supplementing a diet with Ascidiacea, also known as sea squirts, reverses some main signs of aging in animal models. The researchers found that plasmalogens, vital to body processes, decrease with age and contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.
Researchers at MIT's Picower Institute identified the gene and protein CPG15 that enables brain cells to select permanent synapses based on experience-driven neural activity. Without CPG15, mice exhibit slower learning and reliance on circuit architectures that haven't been refined by experience.