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New models predict patterns of brain damage in dementia

Two studies published in Neuron have developed groundbreaking models that predict the landscape of degeneration in various forms of dementia. The models, which focus on structural and functional connectivity networks, suggest that dementias target specific networks of neurons linked by connectivity rather than spatial proximity.

SourceCell Press·JournalNeuron·DateMar 21, 2012

'Computer synapse' analyzed at the nanoscale

Researchers have analyzed the physical and chemical properties of memristors using highly focused x-rays, providing a detailed insight into their behavior. This study is crucial for understanding how memristors work, which will lead to novel applications in semi-autonomous robots and complex electronic circuits.

SourceIOP Publishing·JournalNanotechnology·DateMay 15, 2011

Flipping a switch on neuron activity

Researchers at the University of California and Germany have developed light-sensing modules to attach to neuronal molecules, allowing for real-time study of complex cascades. This breakthrough enables selective activation of individual classes of molecules, paving the way for new treatments for vision impairments.

Trial and error: The brain learns from mistakes

Researchers have identified a protein that corrects errors in the brain's neuronal connections during development. Bone morphogenetic protein 4 (BMP4) helps eliminate incorrect connections, establishing proper specificity in the cerebellum and potentially contributing to neurological disorders like autism.

SourcePLOS·JournalPLOS Biology·DateFeb 8, 2011

Beating the competition

A new connection can significantly enhance the size of a network, according to researchers from Max Planck Institute. By tracing link by link, scientists found that after a certain number of new links, a sudden growth spurt occurs, leading to a dramatic increase in network size.

SourceMax-Planck-Gesellschaft·JournalNature Physics·DateJan 17, 2011

From the brain of a locust

Researchers at Tel Aviv University have made a groundbreaking discovery that mechanical stress is instrumental in several key phenomena in neuronal development. The team used insect cells, including those from the desert locust, to build an in vitro nervous system and observe how neurons form a network.

SourceAmerican Friends of Tel Aviv University·JournalBiophysical Journal·DateNov 29, 2010

Blinking neurons give thoughts away

Researchers successfully used a specialized fluorescent protein to visualize electrical activity in living mice, allowing them to study brain function and behavior in real-time. The 'cameleon' protein enables measurement of action potentials without electrodes, providing insights into neural networks and brain circuitry.

SourceMax-Planck-Gesellschaft·JournalFrontiers in Neural Circuits·DateMay 5, 2010

How nerve cells grow

Researchers have discovered a molecular process that controls the growth of nerve cells, allowing them to form complex extensions for signal transmission. The study highlights the importance of Nedd4-1 enzyme in regulating cytoskeleton structure and ensuring normal dendrite growth.

SourceMax-Planck-Gesellschaft·JournalNeuron·DateFeb 19, 2010

Strictly ballroom analysis

Researchers developed a neural network system to classify music genres, such as cha-cha-cha, jive, and tango, with varying degrees of success. The approach combines the strengths of two existing methods and uses a neural network to analyze beat and tempo, outperforming other classification techniques.

SourceInderscience Publishers·JournalInternational Journal of Intelligent Information and Database Systems·DateAug 26, 2009

Blur's noise and distortion reversed

Researchers develop modified recurrent Hopfield neural network to quickly process images, reducing distortion, noise and blurring. The approach shows significant improvement in image quality by 39-67% and takes half the time of other methods.

SourceInderscience Publishers·JournalInternational Journal of Signal and Imaging Systems Engineering·DateJul 8, 2009

Activation of the prefrontal cortex improves working memory

A study by IDIBAPS reveals that prefrontal cortex activation improves working memory by reinforcing parietal cortex activity, enhancing short-term visual information retention. This innovative view opens up new research avenues, particularly for understanding and treating diseases affecting working memory.

SourceIDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer·JournalProceedings of the National Academy of Sciences·DateApr 1, 2009

Computer simulations explain the limitations of working memory

The study reveals a mechanism in the brain's neuronal network that restricts working memory capacity to two to seven items, with frontal lobes regulating parietal lobe memory capacity. The 'model brain' computations were confirmed using fMRI experiments and suggest improved working memory through increased frontal lobe activation.

SourceKarolinska Institutet·JournalProceedings of the National Academy of Sciences·DateMar 31, 2009

Researchers predict click-through behavior in Web searches

A study by Penn State researchers identified nine factors that can help predict future click-through rates, including number of records in a search and browser type. The positive factors had five effects, while four had negative effects, with user intent having no significant impact on predicting click-throughs.

SourcePenn State·JournalJournal of the American Society for Information Science and Technology·DateMar 11, 2009

Cells with double vision

Researchers found that fly nerve cells can respond to movement in a wider field of vision due to connections with neighboring cells, allowing for more efficient processing of visual information. This challenges the traditional view of single-cell functionality and suggests a more complex network-based approach.

SourceMax-Planck-Gesellschaft·JournalNature Neuroscience·DateFeb 17, 2009

Memory, depression, insomnia -- and worms?

A new study has identified a key molecular sensor in worms that allows them to respond to ultraviolet light, which may provide insights into nerve cell communication and learning. The discovery could potentially lead to new treatments for conditions such as depression and sleep disorders.

SourcePLOS·JournalPLOS Biology·DateAug 4, 2008

New insights into the dynamics of the brain's cortex

A study published in PLOS ONE demonstrates that the spontaneous activity of small neuronal networks in the cortex consists of highly structured patterns rather than random noise. These patterns are shaped by network connectivity and can be used to inform researchers about the underlying anatomy.

SourcePLOS·JournalPLOS ONE·DateMay 13, 2008

Language of a fly proves surprising

A team of researchers discovered that a common fly's motion-sensitive neurons emit spikes very often and precisely, revealing a more complex language than previously thought. This new understanding challenges traditional assumptions about neural networks and could lead to the development of more efficient artificial intelligence.

SourceDOE/Los Alamos National Laboratory·JournalPLOS Computational Biology·DateMar 7, 2008

A balanced memory network

A study published in PLoS Computational Biology found that the number of memories stored in the brain is limited by the number of connections between neurons, not the number of neurons. This means that a typical human brain can store at most about 500 memories, regardless of its size.

SourcePLOS·JournalPLOS Computational Biology·DateSep 6, 2007

Newborn neurons like to hang with the 'in' crowd

Researchers at the Salk Institute found that newborn neurons tend to form connections with mature brain cells, rather than randomly connecting throughout the network. This allows them to compete out older neurons and ensure proper integration into the existing circuitry.

SourceSalk Institute·JournalNature Neuroscience·DateMay 7, 2007

Thinking with the spinal cord?

Researchers have discovered that spinal cord neurons show irregular firing patterns during network activity, similar to the cerebral cortex. This finding enables exploration of how spinal cords generate movements, shedding light on the complex system controlling human motion.

SourceUniversity of Copenhagen·JournalScience·DateJan 23, 2007

Brain on chip

The 'brain-chip' from Martinsried allows biophysicists to visualize the influence of pharmaceutical compounds on neural networks. This breakthrough enables a novel test system for brain and drug research, advancing neurochip prosthetics and neurocomputation.

SourceMax Planck Institute of Biochemistry·JournalJournal of Neurophysiology·DateJun 1, 2006