Articles tagged with Neurons
Researchers at MIT have created a new microscope that can image electrical activity in neurons distributed across the brain, revealing patterns of neural activity from milliseconds. The technique enabled observation of single voltage spikes and rapid bursts of spikes, shedding light on how the brain is activated following a stimulus.
High-frequency brain waves called ripples facilitate long-range neural communication during working memory tasks, suggesting a mechanism for integrating information. The study's findings may also help differentiate healthy cognitive signals from abnormal activity associated with neurological diseases like Alzheimer's or ADHD.
A recent study by Nagoya University researchers found that orexin neurons play a crucial role in regulating motivated behavior. Using novel rat models, they discovered that activity in orexin neurons increases with effort, helping drive motivated behavior.
A new study reveals that the brain plays a crucial role in protecting fertility during heat stress by sending signals to reproductive cells. Researchers discovered an unexpected communication system between the brain and germline cells, showing how animals adjust reproduction when conditions become unfavorable.
Researchers have identified a new type of brain plaque, called mitochondrial plaques, that may emerge at the earliest stages of Alzheimer's disease. These plaques contain high levels of amyloid precursor protein and can directly affect neurons, making them a potential target for new treatments.
Human microglia mature slowly compared to other animals, influencing cognitive abilities and enabling powerful brain functions. The discovery sheds light on what made the human brain unique during evolution.
Michigan State University researchers have created a new research tool to investigate the regenerative biology of zebrafish gut nerves. The tool allows for controlled removal and regeneration of neurons, revealing how neural networks are restored in about nine days. This could lead to better understanding of nerve repair in humans.
A new study published in Nature Communications finds that a protein called saxiphilin can neutralize the potent neurotoxin saxitoxin, preventing and even reversing paralytic shellfish poisoning. The discovery could have important public health implications as saxitoxin accumulates in shellfish and causes poisoning when consumed.
A scoping review suggests astrocytic dysfunction may precede neuronal degeneration in CTE. Astrocytes' dysregulation contributes to the development of CTE's characteristic features through mechanisms including astrogliosis, disrupted waste clearance pathways, and chronic neuroinflammation.
Researchers at Columbia's Zuckerman Institute found that specialist neurons exist but are the exception, not the rule. Most neurons can display a huge diversity of responses and help the brain solve complex tasks.
Researchers at Texas A&M University have found a way to intervene early in traumatic brain injuries using a natural, gut-derived chemical that prevents post-traumatic epilepsy from taking root. The treatment reduced brain inflammation, improved memory and mood, protected brain cells, made seizures both rarer and harder to trigger.
Researchers found that aged mice brains show increased micronuclei, which microglia internalize, leading to changes in morphology and gene expression. This process may contribute to age-associated inflammation and vascular dysfunction.
Researchers at St. Jude Children's Research Hospital discovered that C1 neurons in mice modulate fear and anxiety, with prolonged activation leading to heightened anxiety. Inhibition of these neurons reduced anxiety-like behaviors, suggesting they may be a valuable therapeutic target for anxiety disorders.
Researchers discovered that damaged myelin generates abnormal rhythms in the sleeping brain, linked to disruptions in brain circuit stability. This finding may help design non-invasive approaches to repair myelin during sleep, improving sleep quality in patients with MS and Alzheimer's disease.
A new study finds that human cortical neurons have remarkable computational capabilities, surpassing those of other mammals. The researchers developed a new method to measure the complexity of individual neurons, revealing their sophisticated computing power.
Researchers discovered astrocytes actively preserve long-term memories by regulating Ank2 and BDNF signaling. This finding expands the understanding of how memories are stored in the brain.
Researchers found that local electric fields exert influence on neurons via ephaptic coupling, which helps explain variations in brain activity even within the same task. The study suggests that manipulating these electric fields could be a potential therapeutic approach for improving brain function in disease.
Researchers discovered that a brain protein called Arc helps spread toxic Tau from sick brain cells to healthy ones in mice. This finding suggests that targeting the spread of Tau could be a powerful tool to stop Alzheimer's disease progression. The study also highlights the potential protective role of Arc in early stages of the disease.
Researchers study blind Mexican cavefish to understand how evolution rewires the brain and shapes behavior. They found that cavefish become more active in light, a response believed to help them avoid predators.
Researchers discovered that bilingual brains store concepts in a mental map spanning both languages, allowing for smooth language switching while keeping them distinct. The brain organizes individual words within each language and connects equivalent meanings across languages using a semantic map.
Researchers at Rice University and Baylor College of Medicine have discovered that bilingual brains preserve a shared overall geometric organization despite tuning themselves differently for each language. This 'shared semantic geometry' allows individuals to effortlessly translate thoughts between languages without confusion.
Researchers at Kyoto University found that neurons sustain DNA breaks during cortex formation, but a quick repair mechanism prevents harm. The study reveals that this damage is a normal part of brain development and may contribute to individuality and neurodevelopmental diseases.
A team of researchers from Hiroshima University has identified a unique molecule, GPR3, that rapidly responds to upstream signals and induces downstream signaling in neurons. This discovery sheds light on the early stages of neuronal development and its dysregulation in neurological disorders.
Researchers have published the first complete connectome of a fruit fly brain and 'spinal cord', allowing for the study of how neural circuits control complex behaviors. The open-source resource is poised to propel neuroscience research by providing insights into basic principles of nervous system interactions.
Researchers have discovered a previously unrecognized class of hairs in mice and a specialized population of touch-sensitive neurons that connect to them. The team found that these neurons play a crucial role in transmitting mechanical itch sensations, which are characteristic of chronic skin inflammation patients. Further studies sugg...
Researchers at the University of Michigan have discovered a new way to understand neurons and their connectivity by studying fruit flies. This breakthrough simplifies future studies on neurobiology and decision-making in mammals, including humans.
A new framework, criticome, integrates experience until age 25, reframing autism, schizophrenia, depression, and trauma as developmental disorders. The study suggests that screen-saturated childhoods may produce adult dysfunction, highlighting the importance of early experience in brain development.
Scientists have identified dopamine as a key player in mediating stress-induced courtship suppression in male Drosophila fruit flies. The duration of stress exposure significantly influenced the persistence of suppressed courtship behavior, highlighting the importance of dopamine signaling in this process.
Researchers suggest targeting upstream metabolic nodes to regulate mTORC1 signaling and autophagy defects in neurodegenerative diseases. Acetyl-CoA production modulation and p300 acetylation activity regulation may also hold therapeutic promise.
Researchers at NIH have discovered key intracellular signaling processes involved in the weight-loss effects of semaglutide, a GLP-1 drug. The findings may help extend treatment duration and reduce plateaus experienced by patients.
Researchers studied how hibernation affects the visual brain of squirrels, finding that certain neurons undergo quick structural changes during deep sleep and arousal stages. These changes reverse within hours after waking and have no lasting effects on neuron structure six months after hibernation.
A recent study by Dr. Walaa Oweis and Prof. Eran Meshorer found that protein clumps in the brain may actually be protecting neurons from stress, acting as a vital quarantine system.
A new study reveals that ALS unfolds through a domino-like sequence of events starting with an early breakdown in motor neurons, followed by a damaging inflammatory response. The findings suggest that targeting these immune signatures could slow down disease progression.
Researchers at MIT's Picower Institute have identified key properties that influence how neurons respond to visual stimuli, including distance from the soma and local clustering. These findings provide insight into how brain circuits process information and may shed light on neural disorders.
Researchers develop machine learning analysis method SPERRFY that combines datasets on brain region connections and gene activity. The study finds a 'GPS' system of genes that predict which brain regions are connected, supporting the chemoaffinity theory and offering new avenues for research into brain development and disease.
A research team at the University of Zurich has developed a new gene editing approach that correctly treats the genetic mutation causing hereditary epilepsy in mice. The therapy improves communication between nerve cells, reduces febrile seizures, and increases survival rates.
A new technology called LinCx allows scientists to create new electrical connections between carefully chosen neurons, enabling selective changes in brain circuit function. This approach enables bypassing broken brain connections and may be used to treat neurological disorders.
A novel antibody, NG101, accelerates the regeneration of damaged spinal cord tissue by neutralizing a protein that blocks nerve fiber growth. This therapy enables new nerve fibers to form functional connections, allowing patients to become more independent and potentially recover arm and hand function.
Researchers discovered that genes linked to neuronal communication are also altered in immune cells of patients with depression, reinforcing the systemic nature of the disease. This finding paves the way for developing blood tests to identify and diagnose depression, as well as new treatment approaches targeting inflammation.
University of Missouri researchers develop organic transistors that process information like biological neural networks, boosting brain-like computing and potentially leading to more energy-efficient artificial intelligence. The approach could lead to significant improvements in tasks such as pattern recognition and decision-making.
A review from Florida Atlantic University links obesity to Alzheimer's disease through disruptions in metabolism, highlighting the importance of mitochondrial function and gut-brain axis balance. Early detection and whole-body prevention may become possible through monitoring metabolic health.
Researchers uncover role of glia in ALS pathogenesis, finding altered functioning of TDP-43 protein and MYC factor responsible for abnormality. The study provides new anchors to understand clinical heterogeneity of ALS and suggests potential biomarkers for diagnosis and monitoring.
Andrea H. Brand, a NYU Grossman School of Medicine professor, was elected for her research on nervous system development and gene regulation. Eero P. Simoncelli, a Center for Neural Science director, was recognized for his work on brain representation and sensory processing in humans and machines.
Scientists have discovered a protective brain pathway that preserves dopamine-producing neurons and reduces degeneration in female models with Parkinson's disease. The study suggests that strengthening this pathway could help slow the progression of the disease, offering new potential for treatment.
Researchers discovered that interictal epileptiform discharges (IEDs) occur in a predictable pattern, unfolding sequentially in individual neurons. Nearly 80% of IED-involving neurons are also involved in language and perception, suggesting the brain blips can derail cognition.
Researchers at UCSF discovered that single-celled organism Stentor learns through modifying existing proteins with calcium signaling, which is similar to the mechanism used by animal neurons. This finding suggests that learning may be a fundamental feature of life and could have evolved before the emergence of brains.
Researchers found that the hippocampal CA3 network starts out dense but becomes sparser and more refined as animals mature, following a pruning model. This suggests an initially exuberant connectivity allows for efficient integration of visual, smell, and sound information.
Researchers from the Salk Institute found that astrocytes play a crucial role in fragile X syndrome symptoms. Correcting dysregulations in star-shaped brain cells improved some symptoms, including reduced seizures and restored molecular balances in a mouse model of FXS. The study validates the importance of studying astrocytes in FXS r...
Researchers identify specific chemicals that trigger neural activity in nematodes when they detect certain bacteria, leading to changes in feeding behavior and avoiding harmful pathogens. The study sheds light on fundamental mechanisms of how neurons interact with bacteria, paving the way for potential therapeutic interventions.
Engineers at Northwestern University developed artificial neurons that generate realistic electrical signals to activate living brain cells. This breakthrough paves the way for brain-machine interfaces and neuroprosthetics, as well as more efficient brain-like computing systems.
Researchers develop molecular tool called SynTrogo, which enables selective dismantling of synaptic connections in brain circuits. By harnessing astrocytes, the system reduces synapse number while strengthening remaining connections, leading to enhanced long-term potentiation and improved memory.
Researchers developed a nasal spray that reversibly reduces brain inflammation, restores cellular power plants, and improves memory. The treatment bypasses the brain's protective shield through intranasal delivery, suppressing chronic inflammation and promoting successful brain aging.
A new study suggests that many animal communication signals, including those from insects, birds, mammals, and fish, repeat at nearly the same tempo of 2 hertz. This common tempo may reflect a shared biological constraint, enabling brains to detect signals more easily and process communication more efficiently.
Researchers at MIT's Picower Institute mapped the neural circuits that enable C. elegans worms to navigate towards attractive odors and avoid unappealing ones. The study revealed a specific sequence of neural activation, involving key neurons and the neuromodulator tyramine.
Research reveals inflammation in the GI tract changes how nerves are arranged, affecting intestinal muscle contractions. A protective stress response pathway helps neurons survive, preserving their structure and potentially offering a way to curtail persistent symptoms associated with IBD.
A new framework for brain-computer interfaces is proposed using single-neuron recordings, integrating clinical advances with existing technologies. The framework enables two closed-loop strategies: adaptive neural feedback systems and adaptive neuromodulation systems, facilitating the study of memory processing and concept cells.
A secondary analysis of the ANGEL-ASPECT trial found EVT to be beneficial for patients with anterior-circulation LVO and a large ischemic core and absent-to-moderate white matter lesions. In contrast, those with severe WMLs showed less pronounced benefits, suggesting uncertainty about EVT's efficacy in this subgroup.
Researchers confirmed core predictions of Hubel and Wiesel's model by analyzing signal transmission at individual synapses between the thalamus and visual cortex. They found that orientation selectivity emerges through cortical circuits, resolving a long-standing controversy in neuroscience.
A new study uses optogenetics to control specific communication pathways in the common marmoset brain, offering a clearer view of complex behavior and brain disorders. This method enables researchers to manipulate individual long-range brain circuits with greater precision than before.
Researchers at Nagoya University found that a brief spike in testosterone after birth causes muscle-wasting disease to develop decades later. Treating the disease at birth significantly reduced nerve cell breakdown in adult mice.