Research on nerve cells and the circuits they form. Covers neural mapping, brain development, the striatum, and single-neuron recording.
Researchers create complete map of fruit fly larva brain's learning center, a crucial step towards understanding animal brains. The project could guide scientists in charting connections among neurons in mammals' brains.
Korean researchers have identified the early neuropathic mechanism of polyglutamine brain disease and suggested a way to restore. Dendritic-specific Golgi plays a core role in the early neuropathy of degenerative brain diseases.
A breakthrough method has yielded a trove of neuronal subtypes and gene regulators in the brain, using molecular profiling to detect epigenetic regulation. This discovery opens the door to potentially discovering changes linked to brain disorders and compiling the brain's 'parts list'.
Scientists have identified new subtypes of brain cells in mice and humans using DNA analysis, revealing a complex diversity of neurons. This breakthrough opens the door to understanding how many types of neurons exist, which could lead to improved treatments for brain-related diseases.
Researchers have developed a new way to map differences in brain cells by analyzing chemical modifications in their DNA. The study identified 16 subtypes of neurons in mice and 21 in humans, offering new insights into the diversity of brain cell types and potential for understanding brain development and dysfunction.
Researchers identify FMR1 and ZC3H14 as friend genes, regulating messenger RNA in neurons, affecting learning and memory. Mutant flies and mice display impaired working memory and altered brain development.
A study by Charles Zuker and colleagues has shown that the taste system wires itself through a process of cellular reconnection, allowing flavor information to flow from tongue to brain. The researchers found that specific chemical signals in newborn taste receptor cells can pull the right nerve cell connections towards them.
Researchers at SUNY Downstate aim to develop a breakthrough neuroprosthetic to restore vision by stimulating brain cells with light, avoiding unwanted coactivation of mutually suppressive neurons. The project seeks transformative advances in viral transfection and imaging methodology to improve human medicine.
The NeuroNex Technology Hub aims to create new research capabilities using bioengineering technologies, enabling scientists to manipulate and observe brain circuitry. The center's goals include addressing inequities in access to scientific tools and educating high school students.
The Cornell Neurotechnology NeuroNex Hub will develop new optical imaging tools for noninvasive recording of neural activity in animals, overcoming barriers to deep imaging and whole nervous system visualization. The hub aims to enable biologists to explore complex neuroscience questions, such as animal consciousness.
A team of Rockefeller scientists has identified a specific type of nerve cell, called cholecystokinin (CCK)-expressing neurons, as the site where selective serotonin reuptake inhibitors (SSRIs) initiate their action. This discovery may pave the way for new antidepressants that act more quickly and produce fewer side effects.
Researchers at Rockefeller University have discovered two brain cell populations that regulate appetite and may offer a new path to treating obesity. The study found that activating specific neurons in the dorsal raphe nucleus can suppress hunger and promote weight loss, opening up new avenues for developing effective obesity drugs.
Researchers at the University of Oregon have made significant progress in developing fractal-based retinal implants that could potentially restore vision to people with macular degeneration. The implants use fractal geometry to stimulate retinal neurons, achieving a 90% increase in neuron stimulation while using less voltage.
Scientists coaxed early stage stem cells to create two types of organoids from different brain regions to show how the developing brain maintains proper balance of excitatory and inhibitory neurons. This imbalance has been implicated in neurodevelopmental disorders such as autism and schizophrenia.
Researchers at the Francis Crick Institute have worked out how major players in border formation between tissues keep cells in the right places. They found that ephrins and their Eph receptors trigger signalling inside both cells, stopping them from mixing, and that N-cadherin suppresses repulsion between like cells.
The NIH grant supports collaboration with German researchers to develop a new reprogramming technology that can replace neurons lost through stroke, traumatic brain injury, and brain diseases. The goal is to restore function and potentially lead to new therapies for neurological injuries and diseases.
Researchers at University of California San Diego have identified key brain pathways tied to distinct depressive behaviors. The study found that modifying specific neural connections in mice led to improved behavioral changes, providing insight into the interaction between multiple brain areas in depression.
Researchers discover that blast-induced cavitation in the brain's perineuronal nets can cause neuronal damage. The study sheds light on the effects of blast injuries on the brain and highlights the importance of preventing traumatic brain injuries on the battlefield.
Research reveals that the left habenula is crucial for rapid recovery from fear-induced immobilization in zebrafish larvae. The study also sheds light on the development and function of the habenular region in regulating fear responses, anxiety, and mood.
Researchers at the Francis Crick Institute have uncovered a pathway controlling autophagy, a process that eliminates diseased cell parts. This finding may help prevent diseases like Alzheimer's and Parkinson's by targeting the disposal system.
Researchers discovered a neural circuit in mice that enhances social dominance, boosting chances of becoming an alpha male during aggressive encounters. Stimulating this circuit increased the mouse's winning rate to 90% without affecting motor performance or anxiety levels.
A team of researchers has created behavior anatomy maps in fruit flies to understand how specific brain circuits generate aggression, wing extension, or grooming behaviors. The data will help neurobiologists assign behaviors to neurons and study brain circuits.
Researchers used machine learning to track 400,000 fruit flies' behaviors over 225 days and matched specific behaviors to different groups of neurons. The resulting brain-wide atlas offers insight into fly neural circuitry and could inform understanding of human behavior.
Rice University engineers are building a flat microscope to monitor and stimulate neurons on the surface of the brain. The goal is to provide an alternate path for sight and sound to be delivered directly to the brain, compensating for loss of vision or hearing.
A recent study found that mice who lost their sense of smell gained less weight on a high-fat diet compared to those with normal smell. The researchers used gene therapy to temporarily destroy olfactory neurons, and the smell-deficient mice rapidly burned calories by up-regulating their sympathetic nervous system.
Researchers discovered that pain neurons produce CGRP, a neuropeptide that inhibits osteoclast and cytokine production, to suppress fungal inflammation. The study found that Jdp2 transcription factor is necessary for this immunosuppression and that pain neurons are more potent at producing CGRP in response to β-glucan than LPS.
Researchers pinpointed the brain's dorsolateral prefrontal cortex as responsible for credit assignment, a mechanism that enables learning from success. The study used non-human primates to demonstrate the cortex's role in linking causes and effects.
Researchers at Stanford University developed a new tool to efficiently slice cells in half, enabling faster and more standardized study of single-cell wound repair. The 'cellular guillotine' cuts Stentor cells up to 200 times faster than previous methods with similar survival rates.
Researchers developed an algorithm to capture neural activity within mouse brain tissue, enabling them to track hundreds of individual neurons in a single recording. The technique, combined with light field microscopy, allows for real-time monitoring and alteration of stimuli based on brain activity.
Researchers at Lund University have developed a method to produce diseased, aging brain cells on a large scale in a cell culture dish. This enables experiments that were previously not possible, opening up research areas linked to new drug testing, accurate disease models, and earlier diagnostics.
A new study from the Monell Center has identified novel genes and molecular pathways involved in shaping a taste cell's function, potentially allowing for the treatment of taste disorders or fine-tuning of taste perception. The research also sheds light on how taste stem cells develop into different types of mature taste cells.
Researchers found that artificial viruses can infect brain cells and surrounding tissues beyond the injection site, influencing the immune response. The study's findings could improve the selection of suitable viral 'gene transporters' for custom therapies, offering a glimmer of hope for patients with Alzheimer's and Parkinson's.
Duke University researchers have identified a potential new mechanism for Parkinson's disease, suggesting that misfolded alpha-synuclein protein spreads from gut endocrine cells to the brain. This finding could lead to earlier diagnosis and development of therapies targeting the protein.
A new UCL and University of Nottingham study found that most neurons in the brain's auditory cortex detect sound location relative to the head, but some track the actual position in the world. The researchers monitored ferrets while they moved around a small arena surrounded by speakers, using electrodes and LEDs to track movement.
Researchers at Beth Israel Deaconess Medical Center identify a pathway by which neurons driving hunger influence distant areas of the brain involved in decision-making. They found that visual cues associated with food trigger activation of specific neurons in the insular cortex, particularly in hungry mice.
A new study from Newcastle University shows that the exact time of neuron development and its position in the brain are key to forming neural connections. This understanding can lead to better diagnosis and treatment of developmental diseases like schizophrenia, autism, and ADHD.
A study using brain scans found that feelings of empathy involve distinct brain activity patterns, with empathic care overlapping with value and reward systems and empathic distress linked to mirroring systems. The researchers discovered consistent patterns across individuals, predicting emotions based on brain activity.
Neuroscientists propose using nonlinear message-passing and probabilistic models to simulate real-world conditions in the brain. This approach aims to better understand the brain's ability to perform approximate probabilistic inference.
Researchers discovered that a small group of hypothalamus neurons, called POMC, modulate the amount of insulin produced by the pancreas. The study reveals new molecular mechanisms involved in this connection and highlights the importance of mitochondrial dynamics in glucose sensing and insulin release control.
A new mathematical framework developed by Tatyana Sharpee and colleagues provides a theoretical understanding of how different cell types divide work among themselves. This framework could help explain greater efficiency and reliability in cell function, as well as the impact of disease when division of labor is not effective.
Researchers discovered that direction-selective ganglion cells in the retina sense their owner's motion through space by detecting radial optical flow. This allows the brain to integrate information from visual and vestibular systems to sense rotation and maintain image stabilization.
Researchers at Salk Institute developed a new protocol to derive astrocytes from human stem cells, which could provide breakthroughs for treatments of stroke, Alzheimer's and psychiatric disorders. The method allows for faster and more effective production of astrocytes, enabling researchers to model neurological disorders in a dish.
Scientists at the University of Geneva found that a protein called Sara plays a crucial role in guiding endosomes to differentiate between cells, a process essential for fly hair development. Mutant flies without Sara have naked backs, highlighting the significance of this mechanism in cancer tumour formation.
A Georgia State University researcher has received a $7.7 million federal grant to develop three-dimensional human brain models called organoids for studying West Nile and Zika virus infections. The study aims to understand the differences between these two neurotropic viruses, which have distinct disease effects in humans.
Researchers at Caltech have discovered that sour-sensing taste cells play a crucial role in detecting water on the tongue. The study found that these cells are responsible for sensing water through a pathway also used for basic tastes, such as salt and sugar. This finding challenges current understanding of how mammals detect water.
A new study reveals that microglial cells are essential for normal brain function, and impaired TREM2 gene expression can lead to devastating consequences. The researchers found that mutations in the TREM2 gene disrupt microglial function, leading to impaired phagocytosis and catastrophic effects on energy metabolism.
A new study published in Nature Communications identifies specific neurons in the Lateral Prefrontal Cortex that encode perceived and memorized information. The researchers found that these neurons can signal whether a representation is real or imaginary, which may help treat disorders like schizophrenia.
Scientists have discovered a simple code for facial identity in the primate brain, allowing them to reconstruct faces from neural activity. By analyzing electrical signals from specific nerve cells, researchers can create a multidimensional face space and decode additional faces.
Researchers at Rice University have developed a new technique that reduces computational overhead for deep learning by up to 95% using hashing, a tried-and-true data-indexing method. The technique blends locality-sensitive hashing and sparse backpropagation to achieve significant savings in energy and time.
MIT researchers create temporally interfering (TI) stimulation, a new technique that stimulates neurons in the brain without implants. This method uses low-frequency electrical signals to target specific areas of the brain, offering new possibilities for brain research and potential treatments for conditions like Parkinson's disease.
Georgia State neuroscientists rewired the brain of one species to have the connections of another, finding distinct neural circuits underlying swimming behavior in two closely related sea slugs. The study's results suggest that behaviors can be conserved while their neural basis shifts over evolution.
Researchers discovered a new GPCR, substance P neurokinin 1 receptor (NK1R), that signals from the inside of neurons to sustain excitation and transmit pain. Targeting NK1R internalization alleviated pain in rats using modified compounds, offering prolonged pain relief.
Researchers have discovered a key connection between circadian clocks in the brain and peripheral organs, revealing how they synchronize their rhythms. The study found that a specific neuropeptide pathway enables communication between the central clock in the brain and peripheral clocks in organs like the prothoracic gland.
Researchers have discovered that neural crest cells colonize the spleen during embryogenesis and persist into adulthood, displaying markers indicating a glial lineage. These cells are arranged anatomically adjacent to blood vessels, pericytes, and nerves, suggesting an astrocyte-like phenotype.
A recent study by Dr. John Peever has found a link between REM sleep disorders and neurodegenerative diseases such as Parkinson's Disease and Lewy bodies dementia. The research suggests that sleep disorders may be an early warning sign for these conditions, which can appear up to 15 years later.
Researchers have identified a neural circuit in flies that updates its internal compass based on the insect's own movements, allowing it to track turns and navigate in the dark. This mechanism is similar to what has been suggested to exist in larger mammalian brains, including humans.
Researchers at Janelia Research Campus have discovered how fruit flies use a specialized nerve cell system to navigate their environment, involving the activation and suppression of neighboring neurons. The discovery sheds light on the fly's internal picture of the outside world and its cognitive processes.
Researchers at Massachusetts General Hospital discovered how a potential treatment for Huntington disease produces its effects, but found impaired NRF2-mediated activity in neural stem cells from HD patients. This limits the therapeutic potential of NRF2 signaling.
Researchers have discovered how the enteric nervous system, a complex network of nerve cells in the gut, is formed during mouse development. The study reveals that individual progenitor cells produce specific types of cells, which form overlapping columns and exhibit synchronized activity.
Scientists developed an automated approach to track neurons in the brain of freely crawling worms, enabling researchers to correlate neural activity with specific movements and behaviors. The new algorithm, dubbed Neuron Registration Vector Encoding, improves upon previous methods by assigning a unique identity to each neuron it detects.