Research on nerve cells and the circuits they form. Covers neural mapping, brain development, the striatum, and single-neuron recording.
Researchers at the University of Montreal have identified a key molecule, Pax7, which acts like a pioneer factor to open specific parts of the genome. This discovery provides insight into mechanisms of genome access and has significant implications for our understanding of cell diversification and disease prevention.
Researchers have developed a microfluidic device that emulates the human blood-retinal barrier, allowing for the study of its structure and physiological conditions. The device enables cells to communicate and interact with each other like in a living organ, making it an essential tool for boosting in vitro experimentation.
Researchers at the Buck Institute for Research on Aging have identified a potential therapeutic avenue for Parkinson's disease by clearing senescent astrocytes, which stop dividing and secrete deleterious factors. This approach shows promise in preventing symptoms of the incurable neurological disorder.
Researchers have used a material's persistent photoconductivity to stimulate PC12 neurotypic cells, demonstrating a faster and noninvasive way to influence cellular behavior. The technique, which was shown to increase calcium ion levels within the cells, has the potential to advance research on cellular behavior.
Research at the Santa Fe Institute shows that living systems use collective computation to make decisions, with individuals contributing their own opinions and preferences. The system can produce accurate distributions of power, even in complex environments like primate social groups.
An international team of researchers identified activation of CRH-positive neurons in PVH as sufficient and necessary to induce dietary preference for carbohydrates over fats. The study reveals the role of AMPK and CPT1c in regulating food selection behavior.
A study in mice suggests that West Nile virus infection can lead to persistent neurological problems due to unresolved inflammation. Targeting this inflammation with an arthritis drug may prevent some of these problems with memory.
A new study from the University of Bergen shows that impairment in mitochondria may actually protect the brain in Parkinson's disease. Brain cells with decreased complex I levels are less likely to contain Lewy bodies, abnormal protein-aggregates that characterize Parkinson's disease.
Scientists have developed a new technique to map electrical circuits in the brain with unprecedented accuracy, revealing the detailed architecture of microcircuits. This breakthrough enables researchers to understand how the brain processes complex information and may lead to insights into behavior and sensory processing.
A recent study by University of Utah Health researchers has discovered a novel protein, Arc, that resembles viral proteins and plays a significant role in cell-to-cell communication in the brain. The protein facilitates the transfer of genetic material between neurons, potentially altering our understanding of how memories are formed.
A new study in mice reveals that excess cholesterol may be hindering the repair of fatty protective sheaths around neurons. Researchers found that phagocytes, which ingest debris, had internal organs called lysosomes overwhelmed with cholesterol crystals, reducing their ability to repair myelin.
Exosomes from tick cells can transmit viral proteins and genetic material to vertebrate host cells, enabling the spread of brain-infecting viruses. This discovery suggests that tick-borne Flaviviridae viruses may use exosomes to drive transmission and dissemination within the vertebrate host.
Researchers identified rare genetic variations in Thorase protein associated with schizophrenia, reversed anti-social behavior in mice using perampanel. The study provides preliminary support for Thorase's role in behavioral disorders.
Researchers at UCSB have identified a unique class of gustatory receptor neurons necessary for calcium taste in fruit flies. They found that calcium is sensed as slightly bitter and sour, but its effects on human health are complex, with high levels associated with diseases.
Biomedical engineers have discovered a way to enhance the effectiveness and safety of sonogenetics, emerging techniques that use sound waves to control neuron behavior. By attaching microscopic beads to receptors on cell surfaces, they can produce cell-stretching effects with much less risk of cellular injury.
The primate brain's anterior medial patch uses a combinatorial code to adjust neuron firing rates for face recognition. This coding mechanism is also found in the fruit fly olfactory system.
Researchers developed an antibody selection system to identify therapeutically significant antibodies that induce microglia-like cells. These cells migrated to the brain and exhibited anti-inflammatory properties, reducing brain amyloid deposition in a mouse model of Alzheimer's disease.
Researchers have discovered how cells adapt to stressors by reprogramming their internal signaling networks, which could lead to therapeutics for multiple diseases. The studies focus on cellular mechanisms that protect against cell death and dysfunction, particularly in the context of endoplasmic reticulum stress.
Researchers at Tel Aviv University have identified a novel form of protein aggregation that is both reversible and has positive physiological consequences for cells. This discovery may lead to new treatments for neurodegenerative diseases such as Alzheimer's and Parkinson's.
Scientists discovered a complex color vision circuit in mice involving the M5 cell, which may process color information and lead to new treatments for humans. This finding expands our understanding of color vision and its relationship with other types of vision.
Scientists at Johns Hopkins used supercomputers to create an atomic scale map of how glutamate binds to a neuron in the brain. The study reveals that glutamate molecules follow specific pathways on the surface of glutamate receptors, with positively charged atoms guiding its negatively charged atoms.
A researcher at Case Western Reserve University is investigating the link between abnormal embryonic brain development and autism. The study aims to understand how cell-signaling defects lead to excessive early brain-cell growth and enlarged neonatal brains, resulting in long-term alterations in brain circuitry.
Research at Kanazawa University identifies FGF signaling as essential for gyri formation in the cerebral cortex, enabling large-scale neuron development and brain functions. The study uses a ferret model to analyze genome-level interactions, revealing the importance of FGF signaling in gyrus formation.
A study at Brown University reveals a previously unknown set of matching barrel structures in the cortex, providing insight into how sensory information is processed. The discovery suggests that layer six may play a greater role than previously realized in communicating with the thalamus.
Researchers have developed a more detailed map of the human brain's cellular diversity, identifying 35 subtypes of neurons and glial cells linked to various brain disorders. The study provides insights into genetic risk factors for diseases like Alzheimer's, Parkinson's, schizophrenia, and bipolar disorder.
A comprehensive atlas of gene expression in human brain cells reveals new insights into autism, intellectual disability, and schizophrenia. The study identifies links between neural stem cell populations and neurodevelopmental disease, opening up new avenues for research.
Scientists develop modified CRISPR-Cas9 technique that alters gene activity without cutting DNA, reversing diseases in mice models. The technique uses adeno-associated viruses to introduce genetic manipulation machinery to cells, promoting expression of target genes without introducing mutations.
A new gene therapy transplantation technique could improve treatment of neurodegenerative diseases by generating genetically engineered microglia-like cells in the brain. This technique has been tested on an experimental model for a metabolic disease and may have future therapeutic applications for other neurodegenerative diseases.
A study found that a cancer medication can improve symptoms of Huntington's disease in mice, including increased mobility and longer lifespan. The drug targets mitochondrial health and protein removal, also relevant to other neurodegenerative disorders.
Researchers have successfully extracted and sequenced the DNA of a single mitochondrion, revealing vastly different sequences between individual mitochondria within a cell. This breakthrough may lead to improved diagnosis and treatment of neurological diseases, such as those caused by accumulated mitochondrial mutations with age.
Researchers at UC Riverside have found a way to access and manipulate taste neurons in the pharynx of common fruit flies, which could help control the spread of mosquito-related illnesses and reduce agricultural losses. This genetic approach offers a new framework for understanding the complexities of insect feeding behaviors.
Researchers at Lobachevsky University are creating a neurochip that can transmit signals to healthy brain cells, potentially replacing damaged areas. The team aims to develop an artificial neural network of 100 nerve cells within three years.
Researchers at the University of Colorado at Boulder are developing a new laser microscopy technique to study the progression of neurodegenerative diseases like Alzheimer's. This technique, which involves shooting pairs of photons deep into brain tissue, may enable earlier diagnosis and better treatment options.
A new study using pluripotent stem cell technology reveals that having too much or too little of the CHRNA7 gene can lead to similar biological effects in brain cells. This discovery sheds light on the mechanisms underlying neuropsychiatric disorders and offers a potential avenue for treatment.
Researchers from TSRI have identified a process in nerve cells called the S-nitrosylation reaction that may contribute to Parkinson's disease. The study found that this reaction can trigger cell death by preventing the proper removal of damaged mitochondria, leading to neuronal damage and death.
Two distinct mechanisms have been identified by which Th17 and Th1 lymphocytes breach the blood-brain barrier in multiple sclerosis, targeting neurons and degrading myelin insulation. Understanding these pathways could lead to development of specific therapies to block immune cell entry.
A study published in Stem Cell Reports reveals that DNA-encoded factors influence the vulnerability of brain cells to Alzheimer's disease. Brain regions with higher Aβ protein levels are more susceptible to damage, while protected areas have a less toxic response.
Diffusion concentrates signal in one place, facilitating cell differentiation in Drosophila embryos. The mechanism amplifies the signal from transcription factors, increasing the likelihood of viable embryos.
Researchers used induced pluripotent stem cells to explore the causes of autism, revealing that abnormalities in astrocytes may contribute to the disorder. Astrocytes play a crucial role in the development and function of the nervous system.
Researchers developed better search algorithms using fruit fly brain's odor classification technique, which assigns similar neural activity patterns to similar odors. The fly-based approach outperformed conventional computer algorithms in sorting data with improved performance.
Frequent alcohol consumption can lead to the death of stem cells responsible for creating new nerve cells in adult brains. Females are particularly susceptible to this damage, which may help develop new approaches to treating alcoholism.
Researchers at Salk Institute have found that fruit fly brains use an efficient method to perform similarity searches, expanding the dimension of odor information to improve detection. This approach could inform computer algorithms and enhance their ability to find similarities quickly.
Researchers have identified enzymes that regulate the speed of protein cargo trucks on cellular highways, a discovery with implications for spinal cord and nerve injuries as well as neurodegenerative diseases. The study found that these enzymes, TTLL-11 and CCPP-1, work together to control traffic flow on microtubule highways.
Researchers from UW-Madison detail a defined process to make an exact mimic of the human blood-brain barrier in a laboratory dish. This breakthrough allows for more robust exploration of cells and their properties, paving the way for new therapeutic strategies.
A new study published in Nature Medicine finds that sleep-deprived individuals experience slowed-down neuron activity, affecting their ability to process visual information and respond to tasks. This slowdown can lead to lapses in attention and behavior, posing a risk for drowsy driving and other safety hazards.
A Rutgers-led study has shown promise in using inner ear stem cells to reverse deafness, but also poses a risk of increased cell division, which could lead to cancer. The researchers discovered that controlling the chromatin state can reduce unwanted stem cell proliferation.
A UCLA-led study reveals that sleep deprivation affects the ability of brain cells to communicate with each other, leading to mental lapses in memory and visual perception. The researchers discovered that lack of sleep also slows down brain cell activity, causing sluggish cellular activity and performance issues.
Researchers found that gelatin accelerates the healing of the blood-brain barrier after acute brain injury by reducing microglial cell activation and promoting anti-inflammatory responses. This study has significant implications for the development of surgical treatments and brain implants.
Researchers discovered that duck embryos have a high density of rapidly adapting mechanoreceptors, making them more sensitive to touch. This specialization is crucial for ducks' tactile foraging abilities, which differ from those of visual-dependent chickens.
A study found that kisspeptin enhances male sexual attraction and decreases anxiety in male mice by activating specific neurons in the brain. Activation of these neurons increases social interaction and reduces anxiety, while having no effect on copulatory behavior.
Researchers have discovered brain circuitry essential for alertness and brain states in zebra fish and mice, suggesting the human brain is likely similarly wired. The study used a molecular method to identify six suspect circuits composed of distinct populations of neurons that modulate neuronal activity.
A study published in the Journal of Neuroscience suggests that low oxygen levels, not limited blood flow, cause preterm brain cells to fail normal development. This finding opens up opportunities to restore oxygen loss and potentially reduce life-long impacts of preterm brain injury.
Researchers discovered that a blood-clotting protein, fibrinogen, stops adult stem cells from producing myelin, preventing brain cell repair. The study's findings may lead to new treatments for diseases such as MS and other conditions affecting the nervous system.
Researchers found that neurons' firing rates adjust based on option values, leading to adaptive judgments. The brain uses a neural circuit to correct for differences in scale, ensuring maximal payoff and rational decision-making.
Researchers used tiny microscopes on mice's heads to visualize brain activity in living mice, showing how and where instincts are shaped by learning. The results found that social experiences can influence brain responses to other mice and even lead to long-lasting changes in the brain's activity patterns.
Researchers at NUS found that the brain changes the activity of neurons when distracted, but retains information by reorganizing the 'code' used to store it. This discovery could inspire novel artificial neural network architectures and improve our understanding of brain function.
A phase two trial showed improved motor function in children with spastic cerebral palsy who received an infusion of their own umbilical cord blood cells. The improvements were greater than those seen in children receiving lower doses or a placebo, and exceeded expected gains from traditional therapies.
UTHealth researchers identified a key factor in mid-life cell aging that can predict Alzheimer's disease decades before symptoms appear. The study found that mice lacking IL33 gene experienced dementia at age 68, highlighting the potential of this protein as a biomarker for early detection.
Researchers discovered that Zika virus is transmitted from mother to fetus by infected microglia cells, which later develop into the brain's defense system. The finding suggests a potential therapeutic target for reducing Zika transmission and offers hope for preventing devastating neurological damage.
Scientists have identified a novel pathway that protects mitochondria from toxic protein aggregates, reducing cellular energy production. The mitoRQC pathway, involving the cytosolic protein Vms1, regulates aberrant protein fate and maintains cellular homeostasis.