Research on nerve cells and the circuits they form. Covers neural mapping, brain development, the striatum, and single-neuron recording.
A new study reveals that protein aggregates accumulate in the proteome of C. elegans as it ages, overwhelming the machinery of protein quality control and impairing cell function. However, long-lived worms deposit surplus proteins in insoluble aggregates enriched with molecular chaperones, which may help maintain healthy aging.
Scientists developed a new model to simulate grid cells in non-Euclidean spaces, revealing heptagonal symmetry on a pseudospherical surface. This finding suggests that the brain may be able to encode non-conventional geometries and abstract spaces.
Researchers found neural crest cells and early pluripotent cells share similar genetic expression patterns, suggesting a subset of blastula cells may have retained activity for pluripotency. This discovery could be useful in regenerative medicine and understanding human diseases.
Researchers have developed a new chemogenetic technique that enables them to switch specific behaviors in mice on and off, demonstrating the control of brain circuits over behavior. This tool, KORD, has the potential to treat diseases such as schizophrenia, depression, and epilepsy by modulating neurons.
Rudolf Jaenisch received the March of Dimes Developmental Biology Prize for establishing the basis of induced pluripotent stem (iPS) cells. His research holds great promise in regenerative medicine, potentially treating human diseases such as sickle-cell anemia and Parkinson's disease.
A study confirms that GM-CSF drives inflammation and neuronal damage in MS, explaining why INF-Beta is effective at reducing MS attacks. The cytokine is also identified as a potential target for new therapies.
Researchers at UC Santa Barbara discover that WDR5 plays a crucial role in the final step of cell division, promoting the disassembly of midbody microtubules and contributing to abscission. The study reveals that WDR5 localizes to the dark zone of the midbody, a previously considered 'junk' structure.
Scientists at Beth Israel Deaconess Medical Center have discovered a long-sought component of the neural network that controls eating, finding that the melanoncortin 4 receptor-regulated circuit inhibits and controls hunger. Activating this circuit reduces feeding in mice and removes feelings of intense hunger.
Neurons, not astrocytes, consume glucose and produce lactate in the brain, according to a groundbreaking study published in Nature Communications. This discovery has significant implications for understanding neurological disorders, such as Alzheimer's and stroke.
A new study reveals that tinnitus is represented differently in the brain compared to normal sounds, and that it may not be just a 'gap' left by hearing damage. The discovery could inform treatments such as neurofeedback and electromagnetic brain stimulation.
Researchers successfully use gene-editing technology to prevent mutated mitochondrial DNA from being passed down to offspring in mice, offering a potential cure for maternally inherited genetic disorders. The approach involves injecting mRNA into mother's oocytes or early embryos and could be easily implemented in IVF clinics worldwide.
Neuroscientists have identified a novel brain circuit responsible for anxiety during nicotine withdrawal, which could lead to new treatments for smokers trying to quit. The study found that a region called the interpeduncular nucleus is activated and causes anxiety, offering a distinct target for dampening affective symptoms.
Researchers at TSRI find that nicotine exposure promotes alcohol dependence in rat models, with those exposed to both nicotine and alcohol showing rapid escalation of drinking behavior and compulsive consumption.
Johns Hopkins researchers have developed a new tool for understanding ALS by transforming skin cells into brain cells affected by the disease. The resulting cell library, now publicly available, will enable scientists to study the disease in greater detail and potentially discover new treatments.
Researchers at Johns Hopkins Medicine found that touch-sensing neurons integrate position and touch information as soon as it reaches the brain, challenging long-held views on how this is done. This integration enables complex sensory processing and informs efforts to improve prosthetic limbs.
Researchers at Caltech discovered that certain bacteria in the gut are essential for producing peripheral serotonin. The study found that mice with normal gut microbes had higher levels of serotonin than those without, and that specific species of bacteria elevated serotonin levels.
A new priority program funded by the German Research Foundation will develop next-generation optogenetic tools with higher light sensitivity. The program aims to expand optogenetics' application in basic research and medicine, particularly for treating vision and hearing impairments, Parkinson's disease, and cardiac diseases.
A study published by the American Academy of Neurology found that people who participated in arts, crafts, and social activities in middle and old age were less likely to develop mild cognitive impairment (MCI) compared to those who did not. Computer use was also associated with a reduced risk of MCI.
A team of researchers has found tiny genetic triggers inside brain cells that regulate appetite and weight. The discovery reveals how a protein called Islet 1 and two small stretches of DNA act as triggers for the Pomc gene, which controls feelings of fullness or hunger.
Researchers identify molecular pathway reducing misfolded proteins implicated in ALS and dementia. Inactivating specific genes can improve mobility in roundworms and human cells, suggesting potential therapeutic value.
Echoes and fluctuations in volume are key cues for judging sound distance, a finding that opens up new possibilities for improving hearing aids and prostheses. Researchers used tiny microphones to record rabbit sounds and simulated modulated noise, measuring neural responses in the midbrain.
A Georgetown University Medical Center study found that brain neurons learn words quickly by tuning to recognize complete words as visual objects, not parts of them. The 'visual word form area' in the left side of the visual cortex remembers how whole words look, facilitating fast reading and helping people with reading difficulties.
Research reveals spinal cord neurons in the dorsal horn use glycine to inhibit pain signals, while also controlling various forms of itch. The discovery offers new insights into the Gate Control Theory and potential therapeutic targets for pain management.
A research team at UCSF has discovered a noncoding RNA molecule called Pnky that can be manipulated to increase the production of neurons from neural stem cells. The study suggests that Pnky may have broad applications in regenerative medicine, including treatments for Alzheimer's disease and Parkinson's disease.
Researchers at the University of Bonn have discovered a new cause of temporal lobe epilepsy: astrocyte uncoupling. This leads to hyperexcitability of neurons and epileptic seizures. The study suggests that inflammation plays a role in uncoupling astrocytes, which can be reversed at an early stage.
Researchers have discovered that the three-dimensional structures of mRNAs determine their stability and efficiency inside cells. This knowledge could help explain minor mutations causing neurodegenerative diseases.
Researchers have identified a group of SCN neurons expressing neuromedin S that are necessary and sufficient for controlling circadian rhythms. The study provides new insights into the mechanisms by which light synchronizes body clock rhythms, offering potential targets for future treatments of diseases related to circadian dysfunction.
The generation of neurons in humans is limited to development, and this process declines with age due to the limited self-renewal of neural stem cells. Therapeutic approaches must focus on maintaining stem cell supply by promoting their self-renewal rate.
Researchers found that neurons in our brains react to time-sensitive information by favoring alternating patterns over repeating ones. This biases can impact medical decision-making and machine learning, highlighting the need for smarter programming and interfaces.
Researchers at Mayo Clinic and collaborators have identified a new class of senolytic drugs that clearly reduce health problems in mice by targeting senescent cells. These treatments aim to limit the effects of aging and extend patient healthspan.
Researchers at Yale University found that Agrp neurons, which control food intake, also initiate repetitive behaviors seen in OCD and anorexia nervosa. These neurons play a crucial role in psychiatric conditions, highlighting the multitasking nature of brain function.
Scientists from Scripps Research Institute found a mechanism causing long-term memory loss due to age by identifying connectivity defects between neurons, preventing the formation of long-term memories. This discovery could lead to ways of rebuilding those connections to improve memory.
Scientists have discovered that abnormal protein amyloid accumulates inside neurons of people as young as 20, which may contribute to Alzheimer's disease. The study found that this early accumulation leads to the formation of toxic clumps that damage and kill neurons.
Researchers at Cold Spring Harbor Laboratory successfully decoded how rats learned to associate specific sounds with rewards, revealing the neural mechanisms underlying auditory learning. The study provides a key insight into how memories are encoded in the brain and may have implications for understanding other sensory systems.
A new study from Harvard T.H. Chan School of Public Health suggests that manipulating the central nervous system's energy-sensing pathway can cause organisms to perceive their cells as in a low-energy state, even if they are eating normally and energy levels are high. This process may offer an alternative to caloric restriction for pro...
Researchers discovered two groups of neurons in the anterior cingulate cortex that play key roles in predicting what another individual will do. The findings could lead to targeted treatments for disorders such as autism and antisocial behavior.
Researchers at Imperial College London discovered that certain sedatives work by 'switching on' neurons in a specific brain region, triggering deep sleep. The findings could lead to targeted remedies for insomnia and more effective anaesthetic drugs.
Researchers at Columbia University find that brain neurons apply Wald's sequential probability ratio test to make simple decisions, just like Alan Turing did with the Enigma code. This neural implementation of the test allows for rapid weighing of probabilities and rational decision-making.
Researchers found the varicella zoster virus in 74% of giant cell arteritis biopsies, suggesting a link between the chicken pox virus and the condition. The study suggests treating giant cell arteritis with a combination of steroids and anti-viral treatment may be effective
Researchers at Yale University found that marijuana activates neurons in the brain that normally suppress appetite, leading to increased hunger. The study provides insights into why people often experience extreme hunger after using cannabis.
A promising new approach to treat multiple sclerosis has been discovered by scientists at the Centre for Addiction and Mental Health. They identified a previously unknown change in the spinal cord related to MS and developed a peptide that disrupts this change, leading to major improvements in neurological functioning.
Researchers discovered that brain's grid cells are anchored to one wall and rotated by a specific angle (7.5 degrees) to minimize symmetry and errors in navigation. The rotation is necessary to ensure accurate mapping of environments, even when landmarks are far apart.
Researchers at Temple University will examine how cocaine and HIV-1 interact to cause brain impairment in patients infected with HIV-1. The study aims to determine where to focus potential treatments to disrupt this damaging pathway.
Researchers found that umbilical cord cells activate the Akt signaling pathway, leading to increased expression of antioxidant genes like Prdx5, which reduces inflammation and promotes neural cell survival. This study suggests that umbilical cord cell therapy could be a promising treatment for stroke and other brain injuries.
Human stem cells have been shown to repair damage caused by radiation therapy for brain cancer in rats, regaining cognitive and motor functions lost after treatment. The study uses human embryonic stem cells or induced pluripotent stem cells to replace damaged oligodendrocyte progenitor cells.
SuperAgers, aged 80+, have distinct brain signatures with a thicker cortex, fewer tangles linked to Alzheimer's, and a higher supply of neurons related to social intelligence.
Researchers found that activation of cholinergic neurons in brain stem structures induced REM sleep in animal models. The findings provide a better understanding of brain mechanisms controlling different sleep states, essential for treating sleep disorders.
Researchers at Vanderbilt University have discovered a new reset button for the brain's master biological clock, which can be stimulated using light to alter sleep patterns. This finding has the potential to lead to new treatments for conditions like seasonal affective disorder and reduce adverse health effects of night shifts.
A new study by the University of Wisconsin-Madison Waisman Center has made significant progress in understanding the role of human astrocytes in neurodegenerative diseases such as ALS and spinal cord injuries. Astrocytes, a type of glial cell, have been found to play a crucial role in neuronal survival and proper nervous system signaling.
Gene expression in neurons is crucial for memory formation. After fear conditioning, researchers found altered gene expression in the auditory thalamus and cortex regions of the brain.
Researchers have discovered a neural circuit that controls compulsive sugar consumption in mice without affecting normal feeding behavior, providing a potential target for treating compulsive overeating. The study reveals a distinct subset of neurons responsible for mediating food-seeking behavior and responding to reward consumption.
Scientists have visualized protein degradation in intact nerve cells for the first time, shedding light on how proteasomes remove defective proteins. The study reveals that only a minority of proteasomes are actively degrading proteins in quiescent cells.
A recent study by OIST researchers used chemogenetic inhibition to suppress neuronal activity in zebra finches, showing that the arcopallium region controls song composition but not order or timing. This precise technique provides a detailed understanding of how unique neurons coordinate vocalization.
Researchers at Columbia University Irving Medical Center have identified the brain's on-off switch for thirst, revealing two types of neurons that drive and suppress the sensation. The study uses optogenetics to activate specific neuron populations in the subfornical organ, leading to increased drinking behavior in mice.
Scientists have discovered a novel mechanism that helps cells respond to oxidative stress, a major cause of Parkinson's and Alzheimer's diseases. The new mechanism involves a protein modification called ubiquitination, which stabilizes ribosome function and promotes protein synthesis.
A team of scientists has identified a brain circuit in mice that regulates thirst, with two distinct cell types working together to maintain fluid balance. The study found that activating one set of cells triggers drinking behavior, while silencing the other population suppresses thirst.
Researchers have visualized protein degradation in intact nerve cells for the first time, using electron cryo-tomography to distinguish single proteasomes within the cell. The study reveals that only a minority of proteasomes are actively degrading proteins, with most remaining idle.
A study by McGill University scientists found that high salt intake affects brain circuits, preventing the inhibition of neurons that release vasopressin and leading to increased blood pressure. The research suggests that limiting dietary salt may help mitigate hypertension.
Research by UC San Francisco scientists reveals that estrogen-producing neurons play a crucial role in regulating aggression in mice, affecting both male and female behavior. The study found that eliminating these neurons slowed response times to threats and reduced aggression in males, while females showed similar changes in maternal ...
A team of researchers at Cold Spring Harbor Laboratory has identified a new pathway that controls fear memories and behavior in the mouse brain. The discovery, published in Nature, reveals that the paraventricular nucleus of the thalamus plays a critical role in regulating fear learning and memory.