Articles tagged with Neurons
Researchers discovered that high doses of antioxidants can disrupt intracellular signaling in neural stem cells, leading to a decrease in their stemness properties. However, treatment with antioxidants improved stem cell function, but only up to a point.
Researchers have identified novel populations of nerve cells that regulate appetite, thermogenesis, and physical activity. Deleting the BDNF gene impairs thermogenesis and causes hyperphagia and severe obesity. The study reveals two distinct types of BDNF neurons with different biological roles.
A new study reveals that fragile X proteins FMRP and FXR2P play a vital role in the maturation of newly formed adult neurons. Mice lacking FXR2P had impaired learning and memory tasks, suggesting potential therapeutic targets for fragile X syndrome and autism. The study's findings also highlight the importance of fostering new nerve ce...
Researchers at Salk Institute found that a low glycemic index diet reduced symptoms of autism in mice, including impaired social interactions and repetitive behaviors. The diet may influence gut bacteria and inflammation, which are linked to the development of autism.
A specialized PET tracer has been developed to visualize the function of nerve cells that lead to neuronal loss and cognitive decline in neurodegenerative diseases. The tracer binds to a transporter of the neurotransmitter acetylcholine, allowing for the quantification of cholinergic neuron loss and its effects on cognition.
Researchers found that female mice are unable to detect male pheromones until they enter the ovulation cycle, where hormones such as progesterone decrease and allow them to sense potential partners. This study highlights the nose's role in making important decisions about behavior influenced by hormonal signals.
A new research team at RI-MUHC has developed a glutamate biosensor platform using revolutionary protein engineering technology Cyto-iGluSnFR. This platform allows for the detection of glutamate levels in brain cells, enabling the screening of millions of chemical compounds to develop new drugs targeting EAATs.
Researchers have identified a key role for microglia in the development of chronic pain, including hyperalgesia and allodynia. Microglia-to-neuron signaling is crucial for these effects, which could lead to new treatments for chronic pain.
Researchers identified the PRDM12 gene essential for pain-sensing neurons in humans, which could lead to the development of new pain treatments. The study found that genetic variants of PRDM12 block the production of pain-sensing neurons, leading to conditions like congenital insensitivity to pain.
Researchers have developed high-throughput techniques to quickly and easily give every cell in a sample a unique genetic barcode, enabling scientists to analyze complex tissues at the single-cell level. This breakthrough allows for deeper understanding of cell diversity and gene expression.
Researchers created a human embryonic stem cell model that allows real-time tracking of cellular behavior during early human development. The study discovered critical molecular cues required for the formation of the neurovascular unit, comprising endothelial cells, smooth muscle cells, and autonomic neurons.
Researchers have identified and corrected defects in diseased cells, restoring normal activity in Cockayne syndrome patients. The study reveals the role of an enzyme, HTRA3 protease, in mitochondrial defects that contribute to premature aging. Therapeutic strategies using HTRA3 inhibitors or antioxidants may soon be tested in patients.
Researchers found that FDA-approved cancer drugs nilotinib or bafetinib can prevent overgrowth of neuron endings associated with Down syndrome and Fragile X syndrome. The study used fruit fly models, showing the drugs did not harm healthy brain development.
A Northwestern University team developed a novel graphene-based ink that can print large, robust 3D structures while preserving the material's unique properties. The ink allows for the creation of flexible and strong scaffolds that can support stem cells and promote differentiation into neuron-like cells.
Researchers discovered that fruit flies use a brain structure called the ellipsoid body to navigate and maintain their bearings. The ellipsoid body cells locked onto visual patterns, allowing the fly to track its orientation in the dark.
Researchers found macrophages accumulate in different parts of the brain during HIV infection, leading to neurological damage. The study provides new insights into the timing and dynamics of white blood cell traffic in the central nervous system.
Amparo Acker-Palmer aims to decipher molecular signaling pathways regulating the neurovascular interface, which could lead to new approaches for treating dementia and mental illness. Her team uses genetically altered mice and zebrafish to visualize dynamic events of cell-to-cell communication at the neurovascular interface.
A study published in Cell reveals the 3D structure of tubulin tyrosine ligase-7 (TTLL7) bound to microtubules, providing insights into how chemical markers influence cell functions. The findings also shed light on how disruptions in these patterns can lead to neurodegenerative disorders.
Researchers have developed a miniature fiber-optic microscope that can penetrate deeply into the brain of a living mouse. This breakthrough technology allows scientists to study brain function in unprecedented detail and has potential human applications in understanding brain disease and developing new treatments.
Mark Grimes, a UM professor, used new data analysis techniques to study childhood cancer called neuroblastoma. He discovered functional compartmentalization of signaling proteins in cancer cells, which could lead to triggering cell death and improving therapeutic progress.
A new study reveals that protein aggregates accumulate in the proteome of C. elegans as it ages, overwhelming the machinery of protein quality control and impairing cell function. However, long-lived worms deposit surplus proteins in insoluble aggregates enriched with molecular chaperones, which may help maintain healthy aging.
Scientists developed a new model to simulate grid cells in non-Euclidean spaces, revealing heptagonal symmetry on a pseudospherical surface. This finding suggests that the brain may be able to encode non-conventional geometries and abstract spaces.
Researchers found neural crest cells and early pluripotent cells share similar genetic expression patterns, suggesting a subset of blastula cells may have retained activity for pluripotency. This discovery could be useful in regenerative medicine and understanding human diseases.
Researchers have developed a new chemogenetic technique that enables them to switch specific behaviors in mice on and off, demonstrating the control of brain circuits over behavior. This tool, KORD, has the potential to treat diseases such as schizophrenia, depression, and epilepsy by modulating neurons.
Rudolf Jaenisch received the March of Dimes Developmental Biology Prize for establishing the basis of induced pluripotent stem (iPS) cells. His research holds great promise in regenerative medicine, potentially treating human diseases such as sickle-cell anemia and Parkinson's disease.
A study confirms that GM-CSF drives inflammation and neuronal damage in MS, explaining why INF-Beta is effective at reducing MS attacks. The cytokine is also identified as a potential target for new therapies.
Researchers at UC Santa Barbara discover that WDR5 plays a crucial role in the final step of cell division, promoting the disassembly of midbody microtubules and contributing to abscission. The study reveals that WDR5 localizes to the dark zone of the midbody, a previously considered 'junk' structure.
Scientists at Beth Israel Deaconess Medical Center have discovered a long-sought component of the neural network that controls eating, finding that the melanoncortin 4 receptor-regulated circuit inhibits and controls hunger. Activating this circuit reduces feeding in mice and removes feelings of intense hunger.
Neurons, not astrocytes, consume glucose and produce lactate in the brain, according to a groundbreaking study published in Nature Communications. This discovery has significant implications for understanding neurological disorders, such as Alzheimer's and stroke.
A new study reveals that tinnitus is represented differently in the brain compared to normal sounds, and that it may not be just a 'gap' left by hearing damage. The discovery could inform treatments such as neurofeedback and electromagnetic brain stimulation.
Researchers successfully use gene-editing technology to prevent mutated mitochondrial DNA from being passed down to offspring in mice, offering a potential cure for maternally inherited genetic disorders. The approach involves injecting mRNA into mother's oocytes or early embryos and could be easily implemented in IVF clinics worldwide.
Neuroscientists have identified a novel brain circuit responsible for anxiety during nicotine withdrawal, which could lead to new treatments for smokers trying to quit. The study found that a region called the interpeduncular nucleus is activated and causes anxiety, offering a distinct target for dampening affective symptoms.
Researchers at TSRI find that nicotine exposure promotes alcohol dependence in rat models, with those exposed to both nicotine and alcohol showing rapid escalation of drinking behavior and compulsive consumption.
Johns Hopkins researchers have developed a new tool for understanding ALS by transforming skin cells into brain cells affected by the disease. The resulting cell library, now publicly available, will enable scientists to study the disease in greater detail and potentially discover new treatments.
Researchers at Johns Hopkins Medicine found that touch-sensing neurons integrate position and touch information as soon as it reaches the brain, challenging long-held views on how this is done. This integration enables complex sensory processing and informs efforts to improve prosthetic limbs.
Researchers at Caltech discovered that certain bacteria in the gut are essential for producing peripheral serotonin. The study found that mice with normal gut microbes had higher levels of serotonin than those without, and that specific species of bacteria elevated serotonin levels.
A new priority program funded by the German Research Foundation will develop next-generation optogenetic tools with higher light sensitivity. The program aims to expand optogenetics' application in basic research and medicine, particularly for treating vision and hearing impairments, Parkinson's disease, and cardiac diseases.
A study published by the American Academy of Neurology found that people who participated in arts, crafts, and social activities in middle and old age were less likely to develop mild cognitive impairment (MCI) compared to those who did not. Computer use was also associated with a reduced risk of MCI.
A team of researchers has found tiny genetic triggers inside brain cells that regulate appetite and weight. The discovery reveals how a protein called Islet 1 and two small stretches of DNA act as triggers for the Pomc gene, which controls feelings of fullness or hunger.
Researchers identify molecular pathway reducing misfolded proteins implicated in ALS and dementia. Inactivating specific genes can improve mobility in roundworms and human cells, suggesting potential therapeutic value.
Echoes and fluctuations in volume are key cues for judging sound distance, a finding that opens up new possibilities for improving hearing aids and prostheses. Researchers used tiny microphones to record rabbit sounds and simulated modulated noise, measuring neural responses in the midbrain.
A Georgetown University Medical Center study found that brain neurons learn words quickly by tuning to recognize complete words as visual objects, not parts of them. The 'visual word form area' in the left side of the visual cortex remembers how whole words look, facilitating fast reading and helping people with reading difficulties.
Research reveals spinal cord neurons in the dorsal horn use glycine to inhibit pain signals, while also controlling various forms of itch. The discovery offers new insights into the Gate Control Theory and potential therapeutic targets for pain management.
A research team at UCSF has discovered a noncoding RNA molecule called Pnky that can be manipulated to increase the production of neurons from neural stem cells. The study suggests that Pnky may have broad applications in regenerative medicine, including treatments for Alzheimer's disease and Parkinson's disease.
Researchers at the University of Bonn have discovered a new cause of temporal lobe epilepsy: astrocyte uncoupling. This leads to hyperexcitability of neurons and epileptic seizures. The study suggests that inflammation plays a role in uncoupling astrocytes, which can be reversed at an early stage.
Researchers have discovered that the three-dimensional structures of mRNAs determine their stability and efficiency inside cells. This knowledge could help explain minor mutations causing neurodegenerative diseases.
Researchers have identified a group of SCN neurons expressing neuromedin S that are necessary and sufficient for controlling circadian rhythms. The study provides new insights into the mechanisms by which light synchronizes body clock rhythms, offering potential targets for future treatments of diseases related to circadian dysfunction.
The generation of neurons in humans is limited to development, and this process declines with age due to the limited self-renewal of neural stem cells. Therapeutic approaches must focus on maintaining stem cell supply by promoting their self-renewal rate.
Researchers found that neurons in our brains react to time-sensitive information by favoring alternating patterns over repeating ones. This biases can impact medical decision-making and machine learning, highlighting the need for smarter programming and interfaces.
Researchers at Mayo Clinic and collaborators have identified a new class of senolytic drugs that clearly reduce health problems in mice by targeting senescent cells. These treatments aim to limit the effects of aging and extend patient healthspan.
Researchers at Yale University found that Agrp neurons, which control food intake, also initiate repetitive behaviors seen in OCD and anorexia nervosa. These neurons play a crucial role in psychiatric conditions, highlighting the multitasking nature of brain function.
Scientists from Scripps Research Institute found a mechanism causing long-term memory loss due to age by identifying connectivity defects between neurons, preventing the formation of long-term memories. This discovery could lead to ways of rebuilding those connections to improve memory.
Scientists have discovered that abnormal protein amyloid accumulates inside neurons of people as young as 20, which may contribute to Alzheimer's disease. The study found that this early accumulation leads to the formation of toxic clumps that damage and kill neurons.
Researchers at Cold Spring Harbor Laboratory successfully decoded how rats learned to associate specific sounds with rewards, revealing the neural mechanisms underlying auditory learning. The study provides a key insight into how memories are encoded in the brain and may have implications for understanding other sensory systems.
A new study from Harvard T.H. Chan School of Public Health suggests that manipulating the central nervous system's energy-sensing pathway can cause organisms to perceive their cells as in a low-energy state, even if they are eating normally and energy levels are high. This process may offer an alternative to caloric restriction for pro...
Researchers discovered two groups of neurons in the anterior cingulate cortex that play key roles in predicting what another individual will do. The findings could lead to targeted treatments for disorders such as autism and antisocial behavior.
Researchers at Imperial College London discovered that certain sedatives work by 'switching on' neurons in a specific brain region, triggering deep sleep. The findings could lead to targeted remedies for insomnia and more effective anaesthetic drugs.
Researchers at Columbia University find that brain neurons apply Wald's sequential probability ratio test to make simple decisions, just like Alan Turing did with the Enigma code. This neural implementation of the test allows for rapid weighing of probabilities and rational decision-making.
Researchers found the varicella zoster virus in 74% of giant cell arteritis biopsies, suggesting a link between the chicken pox virus and the condition. The study suggests treating giant cell arteritis with a combination of steroids and anti-viral treatment may be effective
Researchers at Yale University found that marijuana activates neurons in the brain that normally suppress appetite, leading to increased hunger. The study provides insights into why people often experience extreme hunger after using cannabis.