Articles tagged with Neurons
A Johns Hopkins team has identified a newly discovered protein called Iduna that protects the brain against stroke and neurologic disorders. The protein works by interrupting a cascade of molecular events that result in cell death, and its presence increases three- to four-fold in preconditioned mouse brain tissue.
A team of researchers at Brown University and India Institute of Technology Kanpur created a scaffold-looking structure consisting of carbon nanofibers that regenerated natural heart tissue cells and neurons. The approach, if successful, would help millions of people suffering from heart attacks.
Researchers found that a steroid hormone called ADIOL moderates inflammation in the brain and may lead to new treatments for patients with neurodegenerative conditions. The discovery could also help predict risk or responses to drugs that mimic its actions.
Researchers found that anticipating feelings of guilt can motivate cooperation, with increased activity in areas processing negative emotions. The study suggests a neural mechanism underlying guilt-aversion-driven cooperation, challenging the 'warm-glow' hypothesis of altruism.
Researchers have discovered that a specific type of T-cell can kill neurons, raising concerns about the potential effectiveness of an MS therapy. The study found that these protective T-cells, which are meant to regulate the immune system, can instead cause autoimmune diseases like MS.
Researchers at the University of Oregon are working on a project to design fractal devices that can be implanted in the eyes to restore vision. These devices will mimic the natural pattern found in the retina and could potentially overcome current limitations in chip technology, which are not compatible with neurons.
A study by Dr. Alexey Terskikh and colleagues found that the SOX2 gene maintains the potential for neural crest stem cells to become neurons in the peripheral nervous system. This discovery could help inform therapies for neurocristopathies, diseases caused by defects in the neural crest or neurons.
Scientists have successfully reversed the toxicity of mutated ALS protein in yeast cells using a human gene. By introducing a 'rescue' protein, they eliminated the deadly effects without sending the toxic protein back to the nucleus. This breakthrough could pave the way for new treatments for the disease.
Researchers at University of California - San Diego School of Medicine and colleagues report a game-changing advance in stem cell science: the creation of long-term, self-renewing neural precursor cells from human embryonic stem cells that can be directed to become many types of neuron. The new process promises to have broad applicatio...
A Gladstone scientist has made two significant stem-cell discoveries, creating powerful new approaches for using stem cells and stem-cell-like technology. Dr. Sheng Ding reveals novel and safer methods for transforming embryonic stem cells into large numbers of brain cells and adult skin cells into neural stem cells.
Researchers identified a step-by-step process involving TET1 and Apobec1 that converts methylated cytosine into hydroxymethylated cytosine, indicating a potential unified mechanism for DNA methylation status change. The discovery has implications for understanding diseases associated with epigenetic abnormality.
A new report links differences in brain structure to political orientation, finding that liberals have larger anterior cingulate cortexes and are better at coping with conflicting information, while conservatives have larger amygdalas and are more sensitive to threats.
Researchers discovered a molecular switch that regulates protein behavior, expanding biomarker possibilities for diagnosing and tracking mental illnesses. The study found a key modification of the Disrupted In Schizophrenia gene (DISC1) governs its functions in new neuron production and neural migration.
Researchers at Duke University and Johns Hopkins University have identified a key brain switch that regulates neuron migration, which may help in early detection of schizophrenia and other conditions. The study suggests that up to 10% of psychiatric illnesses are driven by defects in this switch system.
A study published in Cell Metabolism identifies a previously underappreciated cellular fat storage depot controlled by sterol regulatory element-binding protein 2 (SREBP-2), which plays a crucial role in balancing cellular cholesterol levels and regulating autophagy.
A new study in flies reveals that the sense of smell plays a crucial role in controlling appetite. When flies are starved for hours, their insulin levels drop dramatically, increasing the sensitivity of odor-sensitive neurons.
Researchers at the University of Utah discovered that invisible infrared light can activate rat heart cells and toadfish inner-ear cells, sparking potential breakthroughs in cochlear implants for deafness. The study also raises possibilities for optical pacemakers that use infrared signals instead of electrical signals.
A team of researchers at Marshall University has identified and analyzed unique adult animal stem cells that can transform into neurons, which could pave the way for novel therapies for slowly progressing diseases like Parkinson's and multiple sclerosis. The discovery is especially interesting as it involves using readily available and...
Researchers found that eliminating caspase-2 prolongs the life of neurons stressed by pesticide chemicals, a potential therapeutic target for neurodegenerative disorders like Parkinson's and Alzheimer's diseases. Neurons lacking caspase-2 increase autophagy to survive.
A UCSF team has developed a new model for how inherited genes contribute to frontotemporal lobar degeneration, a neurodegenerative disease. The study suggests that progranulin regulates the speed of dying cells being cleared from the brain.
A new study uses optogenetics to precisely identify neural circuits responsible for anxiety, identifying two key pathways in the amygdala region that promote or alleviate anxiety. This breakthrough brings psychiatric professionals closer to understanding anxiety disorders.
Researchers found that signals from cerebrospinal fluid help drive neural development, while elevated CSF protein levels are associated with glioblastoma. The study identifies a potential link between CSF signaling and brain tumor growth, offering new insights into treating this malignant brain tumor.
Research suggests that cerebrospinal fluid contains a complex mix of proteins that change with age, supporting or hindering neural stem cell growth. The protein Insulin-like growth factor 2 (Igf2) strongly correlates with cell division levels.
Deanna Thompson is utilizing NYSTEM funding to study adult neural stem cells for developing new stem cell therapies and research tools. Her research aims to understand how these stem cells proliferate and differentiate into new nerve cells, with potential applications in treating brain injuries, illnesses, and cancers.
The study found that over one-third of genes affected by TDP-43 are involved in the central nervous system. The protein also affects alternative splicing of many genes, including its own RNA message. This loss of regulation leads to more TDP-43 accumulation and neuron damage.
A study published in Cell reveals that lactate from astrocytes plays a crucial role in forming and maintaining long-term memories. The findings have significant implications for treating Alzheimer's disease, dementia, and diabetes.
Researchers found that PARIS protein accumulates in brain cells with mutated parkin gene, leading to decreased PGC-1alpha levels and neurodegeneration. This discovery offers promising new drug targets to slow or stop Parkinson's disease progression.
Researchers found that chronic stimulation of AgRP neurons induces weight gain by increasing food intake, while inhibition inhibits food intake. Stimulating AgRP neurons also triggers intense food seeking behavior.
A recent study published in the Journal of Experimental Medicine found that a specific gene variant can predict the severity of disability after a stroke. The Tp53 gene variant influences cell death and is linked to more severe disability in patients who exclusively express the R variant.
A study led by Academy Research Fellow Eleanor Coffey identifies new players that put the brakes on neuron migration. The results show that JNK1 and SCG10 cooperate to slow down neurons' movement, which is crucial for brain development.
A recent special issue of Neuron examines the complexities of addiction research, highlighting genetic vulnerability, neuronal transmission, and behavioral treatments. The study reveals profound changes in behavior and suggests that therapeutic strategies should focus on reversing cognitive deficits.
Researchers found that a protein called DRP1 triggers a chain reaction causing brain nerve cells to die, but toning it down prevents the chain reaction and keeps those cells alive. The study aims to test whether this protein also protects the brain, potentially delaying disease onset.
Researcher Ron Kopito shows that mutant misfolded protein responsible for Huntington's disease can move from cell to cell, recruiting normal proteins and forming aggregations in each cell it visits. This ability could explain the progression of neurodegenerative diseases like Parkinson's and Alzheimer's through the brain.
Researchers found that a naturally present brain chemical signal, CX3CL1, can suppress microglial activation and reduce inflammation in an animal model of Parkinson's disease. This suggests that the communication between neurons and glial cells may play a role in neurodegeneration.
Cell Press won the PROSE Award for Excellence in Biological & Life Sciences for its 'Article of the Future' format, which offers a personalized reading experience. This award reflects Elsevier's and Cell Press' commitment to evolving scientific publications with new technologies.
Researchers at Stanford University have developed a new technique to trace neural connections in the brain, shedding light on how scent signals are processed. The study found that most nerve pathways heading to higher processing centers originated from one region of the olfactory bulb, explaining how mice direct their innate fear respo...
Cell Alerts offers free, instant access to high-impact research articles from top journals like Cell, Neuron, and Current Biology. The app also features upcoming conference listings, enabling easy browsing on-the-go.
Researchers found that Taxol, a cancer drug, can aid in the regeneration of nerve cells after spinal cord injuries. The drug stabilizes microtubules and prevents the production of inhibitory substances in scar tissue, allowing for better nerve cell growth.
USF researchers identified CD45 as a critical component in dampening harmful inflammation in the brain's immune response. The study found that a loss of CD45 led to increased microglial inflammation and neurotoxin accumulation in Alzheimer's mouse models.
Researchers at the University of Calgary have made a breakthrough discovery about how calcium channels regulate neuronal activity. The study reveals that a protein called beta subunit acts as a molecular switch to stabilize or remove calcium channels, controlling excitability in nerve cells.
Researchers from Max Planck Institute for Dynamics and Self-Organization found that the brain's activity patterns are highly chaotic, with information lost at a rate of one bit per active neuron per second. This high deletion rate indicates that the cerebral cortex is tailored to process brief snapshots of sensory input.
Researchers found vasopressin in brain prevents neuronal swelling by maintaining neuron size, contrasting with kidney function. This discovery may aid in treating cerebral edema conditions, such as those caused by brain trauma or infarction.
Researchers at UNC Health Care have discovered a molecule, microRNA-29, that can make brain cells resistant to programmed cell death or apoptosis. This breakthrough could lead to new treatments for neurodegenerative illnesses like Alzheimer's disease and Huntington's disease.
Researchers developed an optogenetic device to control the behavior of Caenorhabditis elegans worms using pulses of blue and green light. They successfully activated or inactivated specific neurons or muscle cells, turning the worm into a virtual biorobot.
A new technique uses inexpensive components from LCD projectors to activate specific neurons and muscles in freely moving worms, allowing for precise control over brain circuits. This advancement in optogenetics enables researchers to explore complex behaviors and functions of these tiny organisms.
Researchers at Stanford have developed a new method that allows them to examine the deep brain's neurons for months, enabling studies on diseases like dementia and cancer. The technique uses tiny glass tubes with microendoscopes to monitor individual cells over prolonged periods.
Researchers found that SIK2 suppressed CREB-mediated gene expression after oxygen and glucose deprivation, increasing neuronal survival in mice lacking SIK2. The SIK2-TORC1-CREB signaling pathway may serve as a potential therapeutic target for promoting neuron survival.
Researchers use vagus nerve stimulation paired with sound tones to retrain the brain and reduce ringing in the ears. After 20 days of treatment, tinnitus disappeared in noise-exposed rats, persisting for up to 3.5 months.
Researchers developed a non-invasive ultra-high-speed microscope to visualize brain activity in real-time, recording the firing of thousands of individual neurons in 3D. This technology could help decipher 'miscommunications' in neuropsychiatric disorders like autism and schizophrenia.
Immune cells called macrophages infiltrate mouse retina after eye injury and dampen inflammation, protecting retinal ganglion cells from death. Macrophage arrival also awakens dormant neural progenitor cells.
Researchers identify a key process leading to brain cell death in Parkinson's disease, offering hope for slowing progression and diagnosis. Blocking this process preserves parkin function and spares neurons.
Scientists have pinpointed the type of cell responsible for brain tumors known as oligodendrogliomas, a category of malignant brain tumors. The tumor originates in and spreads through glial progenitor cells, which are often referred to as 'daughter' cells of stem cells.
Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research found that neural stem cells maintain high levels of reactive oxygen species (ROS) to help regulate normal self-renewal and differentiation. The findings may have significant implications for brain repair and abnormal brain development.
Researchers at the Salk Institute found that slowing mitochondrial function in specific cells can extend the lifespan of an entire organism. The key finding is that a unique signal emanating from damaged mitochondria in nerve or gut cells extends lifespan, while disrupting this signal has no effect.
Researchers have discovered how a malfunctioning gene associated with Lou Gehrig's disease leads to nerve-cell death in mice. The study found that the gene, TDP-43, causes neurons to die when it is bound up outside the nucleus and depletes the cell of normally functioning TDP-43.
Researchers used fruit flies to investigate the function of intestinal neurons, finding that they regulate appetite and adjust water balance during reproduction. Intestinal changes triggered by reproductive hormones may provide a benefit in terms of nutrient absorption but could come at a cost: shorter lifespan.
Researchers successfully transplanted cord blood-derived cells into a severely brain-injured child, showing improvement after six months. The study found that the cells persisted in the brain hemisphere and improved functional neurological impairment.
Overexpression of PGC-1α significantly improves neurological function in HD-model transgenic mice by reducing htt protein aggregation and oxidative stress. This discovery may lead to therapies targeting PGC-1α function for treating Huntington's disease and related disorders.
A new study reveals that ER stress can lead to the destruction of a protein that regulates calcium signaling in neurons, causing brain damage similar to neurodegenerative diseases. The researchers found that a protective chaperone protein helps maintain the interaction between this protein and calcium signaling.
Researchers at the University of Rochester Medical Center have created a way to isolate pure preparations of neural stem cells directly from human brain tissue. This breakthrough technique saves months of time and labor in the laboratory, allowing scientists to study stem cells in unprecedented detail. The findings suggest that human n...