Articles tagged with Neurons
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at the University of Utah discovered that invisible infrared light can activate rat heart cells and toadfish inner-ear cells, sparking potential breakthroughs in cochlear implants for deafness. The study also raises possibilities for optical pacemakers that use infrared signals instead of electrical signals.
A team of researchers at Marshall University has identified and analyzed unique adult animal stem cells that can transform into neurons, which could pave the way for novel therapies for slowly progressing diseases like Parkinson's and multiple sclerosis. The discovery is especially interesting as it involves using readily available and...
Researchers found that eliminating caspase-2 prolongs the life of neurons stressed by pesticide chemicals, a potential therapeutic target for neurodegenerative disorders like Parkinson's and Alzheimer's diseases. Neurons lacking caspase-2 increase autophagy to survive.
A UCSF team has developed a new model for how inherited genes contribute to frontotemporal lobar degeneration, a neurodegenerative disease. The study suggests that progranulin regulates the speed of dying cells being cleared from the brain.
A new study uses optogenetics to precisely identify neural circuits responsible for anxiety, identifying two key pathways in the amygdala region that promote or alleviate anxiety. This breakthrough brings psychiatric professionals closer to understanding anxiety disorders.
Researchers found that signals from cerebrospinal fluid help drive neural development, while elevated CSF protein levels are associated with glioblastoma. The study identifies a potential link between CSF signaling and brain tumor growth, offering new insights into treating this malignant brain tumor.
Research suggests that cerebrospinal fluid contains a complex mix of proteins that change with age, supporting or hindering neural stem cell growth. The protein Insulin-like growth factor 2 (Igf2) strongly correlates with cell division levels.
Deanna Thompson is utilizing NYSTEM funding to study adult neural stem cells for developing new stem cell therapies and research tools. Her research aims to understand how these stem cells proliferate and differentiate into new nerve cells, with potential applications in treating brain injuries, illnesses, and cancers.
The study found that over one-third of genes affected by TDP-43 are involved in the central nervous system. The protein also affects alternative splicing of many genes, including its own RNA message. This loss of regulation leads to more TDP-43 accumulation and neuron damage.
A study published in Cell reveals that lactate from astrocytes plays a crucial role in forming and maintaining long-term memories. The findings have significant implications for treating Alzheimer's disease, dementia, and diabetes.
Researchers found that PARIS protein accumulates in brain cells with mutated parkin gene, leading to decreased PGC-1alpha levels and neurodegeneration. This discovery offers promising new drug targets to slow or stop Parkinson's disease progression.
Researchers found that chronic stimulation of AgRP neurons induces weight gain by increasing food intake, while inhibition inhibits food intake. Stimulating AgRP neurons also triggers intense food seeking behavior.
A recent study published in the Journal of Experimental Medicine found that a specific gene variant can predict the severity of disability after a stroke. The Tp53 gene variant influences cell death and is linked to more severe disability in patients who exclusively express the R variant.
A study led by Academy Research Fellow Eleanor Coffey identifies new players that put the brakes on neuron migration. The results show that JNK1 and SCG10 cooperate to slow down neurons' movement, which is crucial for brain development.
A recent special issue of Neuron examines the complexities of addiction research, highlighting genetic vulnerability, neuronal transmission, and behavioral treatments. The study reveals profound changes in behavior and suggests that therapeutic strategies should focus on reversing cognitive deficits.
Researchers found that a protein called DRP1 triggers a chain reaction causing brain nerve cells to die, but toning it down prevents the chain reaction and keeps those cells alive. The study aims to test whether this protein also protects the brain, potentially delaying disease onset.
Researcher Ron Kopito shows that mutant misfolded protein responsible for Huntington's disease can move from cell to cell, recruiting normal proteins and forming aggregations in each cell it visits. This ability could explain the progression of neurodegenerative diseases like Parkinson's and Alzheimer's through the brain.
Researchers found that a naturally present brain chemical signal, CX3CL1, can suppress microglial activation and reduce inflammation in an animal model of Parkinson's disease. This suggests that the communication between neurons and glial cells may play a role in neurodegeneration.
Cell Press won the PROSE Award for Excellence in Biological & Life Sciences for its 'Article of the Future' format, which offers a personalized reading experience. This award reflects Elsevier's and Cell Press' commitment to evolving scientific publications with new technologies.
Researchers at Stanford University have developed a new technique to trace neural connections in the brain, shedding light on how scent signals are processed. The study found that most nerve pathways heading to higher processing centers originated from one region of the olfactory bulb, explaining how mice direct their innate fear respo...
Cell Alerts offers free, instant access to high-impact research articles from top journals like Cell, Neuron, and Current Biology. The app also features upcoming conference listings, enabling easy browsing on-the-go.
Researchers found that Taxol, a cancer drug, can aid in the regeneration of nerve cells after spinal cord injuries. The drug stabilizes microtubules and prevents the production of inhibitory substances in scar tissue, allowing for better nerve cell growth.
USF researchers identified CD45 as a critical component in dampening harmful inflammation in the brain's immune response. The study found that a loss of CD45 led to increased microglial inflammation and neurotoxin accumulation in Alzheimer's mouse models.
Researchers at the University of Calgary have made a breakthrough discovery about how calcium channels regulate neuronal activity. The study reveals that a protein called beta subunit acts as a molecular switch to stabilize or remove calcium channels, controlling excitability in nerve cells.
Researchers from Max Planck Institute for Dynamics and Self-Organization found that the brain's activity patterns are highly chaotic, with information lost at a rate of one bit per active neuron per second. This high deletion rate indicates that the cerebral cortex is tailored to process brief snapshots of sensory input.
Researchers found vasopressin in brain prevents neuronal swelling by maintaining neuron size, contrasting with kidney function. This discovery may aid in treating cerebral edema conditions, such as those caused by brain trauma or infarction.
Researchers at UNC Health Care have discovered a molecule, microRNA-29, that can make brain cells resistant to programmed cell death or apoptosis. This breakthrough could lead to new treatments for neurodegenerative illnesses like Alzheimer's disease and Huntington's disease.
Researchers developed an optogenetic device to control the behavior of Caenorhabditis elegans worms using pulses of blue and green light. They successfully activated or inactivated specific neurons or muscle cells, turning the worm into a virtual biorobot.
A new technique uses inexpensive components from LCD projectors to activate specific neurons and muscles in freely moving worms, allowing for precise control over brain circuits. This advancement in optogenetics enables researchers to explore complex behaviors and functions of these tiny organisms.
Researchers at Stanford have developed a new method that allows them to examine the deep brain's neurons for months, enabling studies on diseases like dementia and cancer. The technique uses tiny glass tubes with microendoscopes to monitor individual cells over prolonged periods.
Researchers found that SIK2 suppressed CREB-mediated gene expression after oxygen and glucose deprivation, increasing neuronal survival in mice lacking SIK2. The SIK2-TORC1-CREB signaling pathway may serve as a potential therapeutic target for promoting neuron survival.
Researchers use vagus nerve stimulation paired with sound tones to retrain the brain and reduce ringing in the ears. After 20 days of treatment, tinnitus disappeared in noise-exposed rats, persisting for up to 3.5 months.
Researchers developed a non-invasive ultra-high-speed microscope to visualize brain activity in real-time, recording the firing of thousands of individual neurons in 3D. This technology could help decipher 'miscommunications' in neuropsychiatric disorders like autism and schizophrenia.
Immune cells called macrophages infiltrate mouse retina after eye injury and dampen inflammation, protecting retinal ganglion cells from death. Macrophage arrival also awakens dormant neural progenitor cells.
Researchers identify a key process leading to brain cell death in Parkinson's disease, offering hope for slowing progression and diagnosis. Blocking this process preserves parkin function and spares neurons.
Scientists have pinpointed the type of cell responsible for brain tumors known as oligodendrogliomas, a category of malignant brain tumors. The tumor originates in and spreads through glial progenitor cells, which are often referred to as 'daughter' cells of stem cells.
Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research found that neural stem cells maintain high levels of reactive oxygen species (ROS) to help regulate normal self-renewal and differentiation. The findings may have significant implications for brain repair and abnormal brain development.
Researchers at the Salk Institute found that slowing mitochondrial function in specific cells can extend the lifespan of an entire organism. The key finding is that a unique signal emanating from damaged mitochondria in nerve or gut cells extends lifespan, while disrupting this signal has no effect.
Researchers have discovered how a malfunctioning gene associated with Lou Gehrig's disease leads to nerve-cell death in mice. The study found that the gene, TDP-43, causes neurons to die when it is bound up outside the nucleus and depletes the cell of normally functioning TDP-43.
Researchers used fruit flies to investigate the function of intestinal neurons, finding that they regulate appetite and adjust water balance during reproduction. Intestinal changes triggered by reproductive hormones may provide a benefit in terms of nutrient absorption but could come at a cost: shorter lifespan.
Researchers successfully transplanted cord blood-derived cells into a severely brain-injured child, showing improvement after six months. The study found that the cells persisted in the brain hemisphere and improved functional neurological impairment.
Overexpression of PGC-1α significantly improves neurological function in HD-model transgenic mice by reducing htt protein aggregation and oxidative stress. This discovery may lead to therapies targeting PGC-1α function for treating Huntington's disease and related disorders.
A new study reveals that ER stress can lead to the destruction of a protein that regulates calcium signaling in neurons, causing brain damage similar to neurodegenerative diseases. The researchers found that a protective chaperone protein helps maintain the interaction between this protein and calcium signaling.
Researchers at the University of Rochester Medical Center have created a way to isolate pure preparations of neural stem cells directly from human brain tissue. This breakthrough technique saves months of time and labor in the laboratory, allowing scientists to study stem cells in unprecedented detail. The findings suggest that human n...
Researchers found that dynamic Hsp27 regulation is crucial for clearing abnormal tau protein and preventing neurofibrillary tangles. Effective Hsp27 switching promotes tau recycling in healthy nerve cells and clears brain abnormalities.
A new study reveals how diabetes disrupts brain cholesterol synthesis, leading to neurologic complications such as depression and increased Alzheimer's disease risk. Insulin therapy restores normal cholesterol production in the brain.
Scientists at St. Jude Children's Research Hospital identified a signaling pathway regulating neuronal departure from the brain niche, crucial for brain architecture formation and associated with epilepsy and mental retardation. The findings also provide insight into mechanisms in epithelial tissues.
Researchers at MIT and Harvard discovered that the brain assigns gender to faces based on location, challenging a long-held neuroscience principle. The study found that when people view computer-generated faces without other distinguishing features, patterns of biases emerge based on where the face appears on the screen.
Researchers at USC College have made a groundbreaking discovery about sour flavors, revealing that protons from acids directly activate taste cells. This finding has important implications for understanding how different tastes interact and may lead to practical applications in cooking and food industry.
Researchers found that a mutation in the MeCP2 gene leads to the mobilization of L1 retrotransposons in brain cells, reshuffling their genomes and possibly contributing to the symptoms of Rett syndrome. This discovery sheds light on the complexity of molecular events underlying psychiatric disorders such as autism and schizophrenia.
University of Illinois researchers developed microsensors that can track individual cells' masses and divisions over time. They found that cells grow faster as they grow heavier, rather than at a fixed rate throughout the cell cycle. The sensors also allow for imaging and tracking of cellular processes in conjunction with changes in mass.
Researchers at the Salk Institute found that fisetin slows the onset of motor problems and delays death in three models of Huntington's disease. The study suggests that fisetin may be able to slow down the progression of the disease in humans, improving quality of life for those affected.
Researchers at Duke University Medical Center discovered a novel feedback mechanism controlled by the Zif protein that regulates the balance of brain stem cells. This discovery has implications for understanding neural stem cell self-renewal and may lead to new therapies against brain tumors and diseases.
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Researchers identified a common pain gene across species, including humans, which is linked to synesthesia and acts primarily in the brain, not peripheral nerves. The discovery opens up new avenues for understanding pain and developing more effective treatments.
Neurobiologists have identified specific types of neurons in the amygdala that process fear inputs and regulate subsequent fear responses. These circuits play a key role in the generalization of fear, allowing it to become divorced from its original situation, and may provide new targets for treating phobias and anxiety disorders.
Scientists at Caltech have identified a delicate balance in the brain that controls fear output from the amygdala. Two neural subtypes act like a seesaw to regulate fear levels, with PKCδ+ neurons forming one end and inhibiting outflow from the region.
Researchers studied zebra finch brain activity while singing to understand the neural basis of syntax and timing in songbird communication. The study found that specific neurons fire at precise moments to produce a musical-like sequence, similar to human speech.
Researchers applied transcranial direct current stimulation to the parietal lobe, improving participants' ability to learn artificial numbers and processing relationships between them. The treatment had a lasting impact of up to 6 months, with potential implications for individuals with moderate to severe numerical disabilities.
Researchers have solved some of the mysteries of the zebrafish's neural circuit that underlies its vision. By analyzing the brain activity of retinal cells, they found that large visual stimuli are filtered out to prevent overreacting, while small moving objects activate the output neurons efficiently.