Articles tagged with Olfactory Receptors
Scientists have identified a gene switch that regulates the choice of odorant receptor genes in olfactory sensory neurons. Regulatory elements in the genome act as on-off switches to determine which gene is chosen for expression.
Researchers found that smell receptors are grouped into distinct sites on the nasal membrane, each engaging most strongly with a particular type of scent. The intensity of reactions is linked to the odor's place on a pleasantness scale, suggesting an organizing principle for our sense of smell.
The Penn team successfully grafted olfactory receptors onto carbon nanotubes, enabling the conversion of chemical signals into electrical signals. This technology has potential applications in pharmaceutical research and could help develop new treatments for diseases by targeting specific GPCRs.
Researchers at Harvard Medical School identified a single compound found in carnivore urine that triggers an instinctual avoidance response in mice and rats, providing crucial tools to study the neural circuitry associated with innate behavior. The discovery reveals a key role for volatile chemicals in predator-rodent interactions.
Researchers have discovered a new compound, VUAA1, that directly stimulates the Orco co-receptor in mosquito odorant receptors, overwhelming the insect's sense of smell. The compound is thousands times more effective than DEET and works against flies, moths, ants, and other insects.
Researchers at Max Planck Institute for Chemical Ecology sequenced the antennal transcriptome of the tobacco hornworm moth, revealing specific proteins involved in olfaction. The study identifies 18 odorant binding proteins and 21 chemosensory proteins, providing new insights into the insect's ability to detect and process odor molecules.
Researchers have discovered that different odorant receptors in mammals exhibit varying degrees of basal activity, driving receptor current fluctuations and firing patterns. This study suggests new information is used by the olfactory system for categorizing odorants, challenging previous understanding of odor coding complexity.
Scientists at Vanderbilt University have identified a second set of olfactory receptors in the malaria mosquito Anopheles gambiae, which responds to key human odorants. This discovery may help explain the effectiveness of DEET repellents and provide new insights into developing more effective lures and controls for malaria.
Researchers have characterized two families of molecular odorant sensors in Anopheles gambiae mosquitoes, which mediate critical behaviors like host location. The discovery suggests that these mosquitoes use multiple olfactory signaling pathways to detect human-derived odors.
Researchers developed an algorithm that enables eNoses to rate novel odors on a scale of pleasantness, achieving high accuracy in predictions, and suggesting a fundamental cross-cultural similarity in odorant pleasantness. The study's findings may lead to new methods for odor screening and environmental monitoring.
A recent study on the zebra finch genome suggests that smell may be involved in bird communication, contrary to earlier assumptions. The research found that around 200 genes can potentially produce functional smell receptors, supporting the idea that some birds rely on their sense of smell.
Researchers at Vanderbilt and Yale universities have successfully transplanted most of the mosquito's 'nose' into frog eggs and fruit flies. The goal is to develop novel ways to inhibit the spread of malaria by targeting specific olfactory receptors.
Researchers have found 27 scent receptors in malaria-transmitting mosquitoes that detect compounds in human sweat. This discovery may lead to the development of new ways to combat malaria by repelling or confusing the mosquitoes. The study's findings could also inform the creation of more effective traps and repellents.
A study by Duke University researchers discovered a commonality in the genetic codes of human sex receptors and those found in other primates. This similarity suggests that varying sensitivity to specific odors may play a role in mate selection, potentially preventing cross-species couplings.
Scientists have found that odor-detecting tools in the nose, specifically MOR23, aid muscle cells' repair process. The receptor regulates cell migration and adhesion to form long fibers, offering potential new treatments for muscular dystrophies.
Young neurobiologist Richard Benton's research on insect odor detection has uncovered unanticipated evolutionary parallels between chemosensation, immune recognition, and synaptic transmission. His findings have significant implications for controlling disease-transmitting insects and understanding the evolution of nervous systems.
Researchers at UC Riverside have identified a novel class of compounds that could pave the way for developing inexpensive and safe mosquito repellents. These odorants, including hexanol and 2,3-butanedione, prevent CO2-sensitive neurons in mosquitoes from functioning.
Researchers compared e-nose sensors with those of the common house fly, finding that fly receptors outperformed MOx sensors in terms of independence and specificity. The findings will help improve the design of electronic noses for various applications.
A new study reveals the source of silkworms' attraction to mulberry leaves is a jasmine-scented chemical called cis-jasmone. The potent attractant triggers a highly tuned olfactory receptor in the silkworms' antennae, guiding them towards the food source.
Researchers at Harvard University have mapped the neural circuitry of the nose, revealing a seemingly random patchwork of receptors for different scents. Despite striking differences between smells like coffee and peppermint, cells processing similar odors are found in precisely the same location on the olfactory bulb.
Rockefeller University scientists have discovered a new family of ionotropic glutamate receptors in the fly nose, which explains how cells in coeloconic sensilla detect odors. The finding fills a missing piece in the organizational logic of the insect olfactory system and raises questions about their evolutionary origin.
Researchers studied odorant octanal and its shape-changing properties to understand how our sense of smell works. They found that conformationally constrained odorants can alter fragrance mixture odors by muting flexible odorant activity or activating smaller subsets of olfactory sensory neurons.
Researchers at MIT have made a breakthrough in understanding the molecular basis of smell by mass-producing olfactory receptors. This advance could lead to the development of artificial noses for various settings, including medicine and industry. The innovation involves isolating and purifying protein structures using a novel method.
Researchers identified regulatory sequences that act like zip codes, determining where odour receptors are expressed in olfactory neurons. These elements positively and negatively regulate receptor expression, suggesting a broader role in nervous system development.
Researchers at NYU's Center for Developmental Genetics identified a new class of photoreceptors in the retina of fruit flies that co-express two ultraviolet-sensitive rhodopsins. This discovery may have implications for understanding the regulation of color vision and olfactory receptors.
Researchers at Rockefeller University and the University of Tokyo found that insects use fast-acting ion channels to smell odors, a major break with previous understanding. This new strategy allows for direct detection of odor molecules, bypassing complex biological apparatus previously thought to be necessary.
Neuroscientists discover that insulin-like growth factor (IGF) plays a critical role in setting up connections between chemical detectors in the nose and the brain's olfactory centers. IGF joins other molecules known to direct nerve cell growth, making it another tool for wiring up the brain.
Scientists at Rockefeller University have pinpointed DEET's molecular target in insects, showing that the widely used bug repellent acts like a chemical cloak, masking human odors. By targeting specific receptors, DEET confuses mosquitoes and prevents bites.
Research shows that genetic variation plays a significant role in detecting sweat odor, with one gene (OR11H7P) linked to sensitivity. Environmental factors also contribute to individual differences in smell acuity.
Research found that genetic variation affects sensitivity to the smell of sweat, with one gene (OR11H7P) associated with smelling sweat. Environmental factors also play a role in individual differences in olfactory acuity.
A new study reveals that a single gene, OR7D4, plays a crucial role in determining how people perceive the scent of androstenone, a potent ingredient in male body odor. Variants of this gene can make humans perceive androstenone as sweet or unpleasant, with some unable to detect it at all.
Researchers discovered that specific genetic variants of an odor receptor determine how people perceive pleasant or unpleasant odors. The study focused on two sex steroid-derived chemicals and found that different genetic variations led to varying reactions.
A team of scientists has identified an odorant receptor that allows male honey bee drones to detect the presence of a queen up to 60 meters away. The receptor, which can detect the specific pheromone '9-ODA', is expressed in the antennae of male drones and plays a crucial role in their mating rituals.
Researchers found that odorants in spices and fragrances can trigger serotonin release, leading to gastrointestinal reactions. Sacral nerve stimulation has also shown potential for relieving symptoms of idiopathic constipation, with long-term results indicating improved bowel habits and reduced straining.
Researchers at Temple University have developed a new biosensor that uses mammalian olfactory signaling machinery to detect explosives. The biosensor can also potentially be used to screen experimental medications, a crucial step in the development of new drugs.
An interdisciplinary team predicts the scent intensity of lily-of-the-valley fragrance components using a computer model of their olfactory receptors. The study confirms that electronic surface structures determine the interaction between scented molecules and human scent receptors.
Researchers at Max Planck Institute successfully integrated in-vitro synthesized membrane proteins into artificial lipid membranes, overcoming previous difficulties due to protein solubility. This breakthrough enables the creation of biosensors that can detect poisons, explosives, or drugs.
Fruit flies exposed to yeast paste odor did not live as long as calorie-restricted insects without the odor, suggesting that reduced perception plays a role in extending lifespan. The study found that flies with impaired sense of smell lived up to 57% longer and were more stress-resistant.
Researchers found that prolonged exposure to one odorant improves differentiation among related odors and reveals increased response in brain areas. The study suggests that humans naturally learn to identify thousands of different smells through experience-dependent neural plasticity.
Taking slightly longer to smell an odor can lead to more accurate identification, a discovery that sheds light on the brain's olfactory processing. The study, published in Neuron, reveals a clear relationship between sampling time and accuracy, implications for understanding human olfaction.
A comprehensive study published in Cell reveals that inhibitory responses are widespread among odor receptors, and most receptors are inhibited by at least one odor. The research also shows that individual receptors range along a continuum from narrowly tuned to broadly tuned to odorants.
Olfactory sensory neurons expressing the MOR23 odor receptor responded differently to lyral concentrations and reaction times varied between 500 milliseconds and five seconds. The study adds a new layer to understanding the olfactory system's response to odors, suggesting finer-tuned responses in the brain.
A Yale University research project aims to reduce malaria transmission by identifying effective odor cues that attract or repel mosquitoes. The team will test these odors in simulated natural situations and eventually distribute them to African villages for practical tests.
The study found that individual odors stimulate a small subset of neurons across a large area in the cortex. Different odorants exhibit similar patterns of activation, but with partial overlaps. This suggests a complex logic to the way information is mapped onto the cortex.
Scientists have discovered a gene responsible for an insect's sense of smell, which is highly conserved across four different species, including pests that target crops and human health. This finding could lead to the development of new pesticides and disease-controlling insect repellents by targeting the insects' sense of smell.
Researchers discovered two proteins that chaperone odorant receptors to the surface of olfactory nerves in mice, enabling them to match nearly 1,000 different mouse odorant receptors with specific chemicals. This breakthrough opens up new possibilities for understanding the mechanisms underlying our sense of smell.
Research reveals that human olfactory receptor hOR17-4 is expressed on both human sperm cells and olfactory neurons, suggesting a dual capacity for chemosensory functions. This discovery has implications for understanding fertility defects associated with olfactory receptor-dependent chemotaxis in sperm.
Researchers found that a specific smell receptor, Or83b, is crucial for insects' sense of smell, allowing it to detect human hosts. Blocking this gene could lead to the development of more effective insect repellents.
Researchers at Yale University have created a detailed map of the relationship between odor receptors and neurons in fruit flies. The study reveals that different receptors respond to varying numbers of odors and can even be inhibited by certain smells, providing valuable insights into the human olfactory system.
The study established four principles of olfactory system development: without sensory activity there is no full maturation, a sensitive period influences organization maturation, sensitive periods occur at different times for different receptors, and glomeruli may be innervated by multiple nerves during early development.
Olfactory sensory neurons can adapt to odorant stimulation, but the ability to enhance long-term survival after stimulation has been unclear. Researchers found that odorants stimulate the Erk/MAP kinase/CREB pathway, leading to cell survival and dynamic long-term adjustment to sensory information.
Researchers refute vibration theory by finding shape of odor molecules crucial for distinct smells. The study's results support the prevailing 'shape theory', which suggests that chemical shape is the primary factor in determining a substance's scent.
Researchers successfully cloned mice from olfactory cell nuclei, demonstrating totipotent development and normal brain function. The study expands understanding of neuronal diversity and offers insights into reprogramming mature cells.
Scientists at Vanderbilt University have verified that female Anopheles mosquitoes contain receptors responding to one of the chemical compounds found in human sweat. This discovery may lead to better ways to repel deadly insects and uncover additional chemicals that either attract or repel them.
Researchers discovered that human sperm cells have a receptor for chemo-attraction, which triggers movement towards elevated concentrations of a sperm-attracting substance called bourgeonal. This finding suggests that sperm may be able to 'smell' their way to the egg.
A study found that 54% of human olfactory receptor genes are impaired, compared to 28-36% in other primates. The decline of the sense of smell likely occurred within an 'evolutionary moment' 3-5 million years ago.
Scientists propose a new mechanism for passing information through cell membranes via a shuttlecock motion involving metalloproteins. This theory explains why dietary zinc deficiencies lead to a loss of smell and has significant implications for understanding the sense of smell.
Researchers at UC Berkeley have found that the adult brain has more capabilities to change than previously thought. By exposing non-detectors to a specific odor, they showed that both nostrils can learn to detect it, suggesting a central component in the brain is involved in olfactory learning.
The Odor Index is a new tool that relates the concentration of odorants to human perception, providing a comparative scale for measuring odors. The technology has shown significant reductions in odors in wastewater treatment plants and other industries.
Researchers at Vanderbilt University have identified four genes in the Anopheles gambiae mosquito that code for odorant receptors similar to those found in fruit flies. These genes are only expressed in the antennae and maxillary palps, indicating that mosquitoes use a conserved chemosensory system to track human body odor.