Articles tagged with Parkinsons Disease
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A UNIGE team investigated the destruction of neurons at different times of the day using fruit fly models and found that cellular stress was more deleterious to neurons at night. This suggests that the circadian clock exerts a protective effect on dopaminergic neurons against oxidative stress.
Researchers have discovered a peptide that stabilizes the normal structure of alpha-synuclein protein, preventing misfolding and toxic clumps. This breakthrough could lead to new therapeutic developments for neurodegenerative diseases like Parkinson's.
Researchers identified potential therapeutic targets for Alzheimer's disease and other conditions using a new approach combining AI-driven target identification with protein phase separation analysis. The study provides insights into the role of protein phase separation in human disease and its potential as a therapeutic target.
A recent Cleveland Clinic trial found that augmented reality therapy, such as the Dual-task augmented Reality Treatment (DART), can improve posture and stability in individuals with Parkinson's disease. The digital platform uses a headset to guide exercises and track progress, allowing for more widespread use of physical therapy.
Researchers at Lund University discovered a blood biomarker called DOPA decarboxylase (DCC) that can identify Parkinsonian diseases by measuring elevated levels in the blood, regardless of disease progression
Researchers at Aarhus University have unraveled the mystery of how lipid layers on cell surfaces accelerate Parkinson's disease misfolding. The study reveals that elevated concentrations cause alpha-synuclein to adopt an upright conformation, leading to easier refolding into dangerous aggregates.
A new Northwestern Medicine study reveals that a dysfunction in the neuron's synapses leads to deficits in dopamine and precedes neurodegeneration in Parkinson's disease. The findings suggest targeting dysfunctional synapses before neurons degenerate may represent a better therapeutic strategy.
Prof. Dr. Thomas Gasser has been awarded the Breakthrough Prize in Life Sciences for discovering genetic risk factors for Parkinson's disease. He hopes his findings will lead to treatments targeting molecular causes and prevent or delay the onset of the disease.
Researchers developed a new imaging technique using Bessel beam two-photon microscopy to detect stalling in brain capillaries, which can indicate acute neurological issues. The approach generates clear images of all capillaries every two seconds, providing better temporal resolution and enabling the detection of short stalling events.
A study published in EMBO Molecular Medicine has identified the cellular processes that lead to Parkinson's disease in patients with CHCHD2 gene mutations. The research found that a specific protein, casein kinase 1 epsilon/delta (Csnk1e/d), plays a crucial role in the disease's pathogenesis.
Doctors treating Parkinson's patients need to focus on the emotional and social impacts of stigma, in addition to motor symptoms. Stigma can lead to feelings of loneliness, depression, anxiety, and isolation, which significantly affect quality of life.
A new AI tool assesses motor performance using finger taps, providing rapid and standardized ratings, comparable to expert neurologists. The test outperformed primary care physicians in accuracy, opening doors to evaluating other movement disorders.
Researchers at Tokyo Medical and Dental University found that mutant α-synuclein protein propagates through the brain's lymphatic system in its monomeric state before aggregating, shedding light on Parkinson's disease progression. The study suggests targeting early events may limit disease progression.
A study of medical and genetic data reveals that carrying a particular gene version reduces the risk of Alzheimer's and Parkinson's by over 10% on average. The protective allele, DR4, also correlates with a later onset of symptoms in both diseases.
Researchers have developed a blood test that detects Parkinson's disease by quantifying DNA damage in mitochondrial cells. The test has been shown to identify patients with and without the genetic mutation LRRK2, potentially leading to early diagnosis and targeted therapies.
Performing in a dance company strengthened the dancers' group identity, enabling them to negotiate their personal identity through embodied expression. This novel form of identity negotiation allowed the dancers to rediscover themselves and change their perception of the self.
Research suggests that certain gut problems, such as gastroparesis, dysphagia, and irritable bowel syndrome (IBS), may precede the development of Parkinson's disease. A nationwide medical record network study found a significant association between these conditions and an increased risk of Parkinson's diagnosis.
Scientists at Van Andel Institute have discovered processes that enable the brain to adapt to damage in movement, cognition, and sensory perception circuits. This finding may help optimize current treatments or develop new ones that repair or bypass broken circuits.
A recent NIH-supported study found a significant association between a genetic variant in people of African ancestry and an increased risk of developing Parkinson's disease. The variant, in the GBA1 gene, is associated with a higher risk of 3.5 times for those carrying two copies.
Researchers at Columbia University Irving Medical Center found that a misfolded protein triggers an immune attack in the gut, leading to gastrointestinal symptoms years before brain symptoms appear. The study suggests Parkinson's disease may be an autoimmune disorder and offers hope for early detection and prevention.
A study published in Neurology has identified markers of Parkinson's disease in eye scans, detecting the condition up to seven years before clinical presentation. Researchers used AI-powered analysis of retinal images from two large datasets to uncover subtle changes associated with Parkinson's.
Researchers at Lund University have successfully developed temporary, organic electrodes that can be seamlessly integrated into biological systems. This breakthrough enables the possibility of bioelectronics being implanted in and removed from the body without surgery.
Researchers found that rodents exposed to light for the first time in adulthood showed significant plasticity in their brains, challenging previous beliefs about adult brain rigidity. After a month, their brains looked similar to those of healthy controls, with organized visual responses and smaller receptive fields.
Chronic disease medications impair the body's ability to regulate core temperature, increasing the risk of heat-related illness in elderly patients. Exercise and improved fitness levels can help mitigate these effects, but bodily impairments from chemotherapy and medications may limit exercise capacity.
Researchers at Oregon Health & Science University have found that implanting a specific molecule in the brain can effectively reduce alcohol use among chronic heavy drinkers. The study showed a 90% reduction in drinking behavior in nonhuman primates, with the implanted virus permanently increasing dopamine levels and reducing cravings.
Patients with caregivers at higher depression risk experienced poorer quality of life and increased emergency department use. Additional caregiving resources could improve patient outcomes in Parkinson's disease.
Researchers found a significant link between playing tackle football and the risk of parkinsonism or PD diagnosis, even after accounting for known risk factors. Players who played at higher levels of competition experienced increased odds for having a reported diagnosis of PD.
Research suggests football participation is associated with a higher odds of developing parkinsonism or Parkinson's disease. Longer football play duration and intensity are linked to an increased risk of diagnosis, highlighting the potential health risks for athletes involved in contact sports.
Researchers used AI to accurately classify four subtypes of Parkinson's disease from patient-derived stem cells, with one subtype reaching an accuracy of 95%. The study suggests that personalized medicine and targeted drug discovery could be possible using this approach.
A study found that border-associated macrophages play a crucial role in neuroinflammation and neurodegeneration in Parkinson's disease. Deleting MHCII from these cells reduced neuroinflammation, suggesting they are essential for presenting alpha-synuclein antigens to T cells.
Researchers from Shinshu University have developed a novel neuromodulation approach that incorporates gait-combined closed-loop transcranial electrical stimulation, demonstrating significant gait improvements in patients with Parkinson's disease. The treatment showed encouraging results after just ten repetitions, improving speed, gait...
Research shows digital health platforms can deliver personalized nutrition services, decrease burden, and medical expenses. Facilitators include clear communication, training, and social interaction, while barriers include cognitive changes, technology difficulties, and privacy concerns.
Researchers have identified a diverse range of dopamine neurons that control movement, contradicting the long-held assumption that they only respond to rewards. The study sheds new light on Parkinson's disease, which affects motor skills despite the loss of dopamine neurons.
Researchers at Yale University reveal that the LRRK2 gene suppresses activity in lysosomes, microscopic organelles that break down cellular waste. This loss of function may explain the link between LRRK2 and Parkinson's disease, as well as other neurodegenerative conditions.
Mutations in parkin gene break down contacts between lysosomes and mitochondria, disrupting essential metabolite supply to mitochondria. Restoring these contacts may represent a new therapeutic opportunity for Parkinson’s disease.
Researchers have made key discoveries in a new stem cell-based therapy for Parkinson’s disease, using patients’ own cells to replace lost neurons. The approach, called an autologous therapy, has shown promise in reversing symptoms of the disease in rat models and holds potential for clinical trials with improved success rates.
Researchers at Lund University have developed a spinal fluid test to detect Lewy body disease before symptoms emerge. The study found that nearly ten percent of individuals without initial cognitive or motor difficulties had Lewy bodies in their brains, highlighting the potential for early detection and treatment.
Researchers at the University of Montreal found that movement circuits in mice brains are insensitive to dopamine levels, contradicting initial hypotheses. This discovery could lead to new approaches to reduce Parkinson's disease symptoms by identifying mechanisms involved in dopamine secretion.
Researchers have discovered a new mechanism underlying the neuroprotective effects of physical activity on Parkinson's disease. Intensive exercise has been shown to slow disease progression by restoring striatal synaptic plasticity and improving dopamine release, leading to better motor control and visuospatial learning.
Scientists found that cooling or warming the striatum region slows down or speeds up activity patterns, which correlates with rats' timing judgements. This provides evidence for the 'population clock hypothesis', suggesting that brains use decentralized and flexible sense of time.
Mass General Brigham researchers have made key improvements to Parkinson's disease cell therapies by using regulatory T cells to supplement neuronal cell therapy. The study shows that co-transplanting regulatory T cells with dopaminergic neurons increases survival and improves behavior recovery in rodent models.
EPFL researchers have created a novel biosensor, ImmunoSEIRA, to detect misfolded protein biomarkers linked to Parkinson's and Alzheimer's diseases. The sensor employs AI-powered neural networks for disease stage quantification and features gold nanorod arrays with antibodies for specific protein detection.
A new study found critical gaps and disparities in access to Parkinson's disease care among Medicare beneficiaries. Only 9% of people with Parkinson's disease receive care from movement disorder specialists.
Scientists at Rockefeller University identified distinct RNA changes in the brains of deceased patients with Parkinson's disease, which were also found in their living counterparts' blood. These changes are associated with various clinical symptoms, such as dementia and levodopa-induced dyskinesia.
Research leaders collaborate with organizations and regulators to develop digital tools for Parkinson's clinical trials. The Digital Drug Development Tools initiative accelerates the regulatory endorsement of these tools, enabling more objective and patient-centered measures.
A new study describes an engineered approach that makes protein aggregates amenable to spatial manipulations in both budding yeast and human cells. This system allows for the export of protein aggregates from cells, potentially protecting mother cells from toxicity and contributing to a better understanding of neurodegenerative diseases.
A team of researchers from WEHI has solved a long-standing mystery about how the protein Optineurin recognises and removes damaged mitochondria. The discovery provides new insights into the Parkinson's disease pathway and could potentially lead to new treatments for the condition.
A new evidence-based framework proposes integrating palliative care into neurology teams to address the total pain of neurologic illness, including psychological, social, and spiritual distress. This approach aims to screen for and prevent suffering by incorporating a palliative care model from day one.
A recent Finnish register-based study found no association between inhaled beta-2 agonist use and reduced risk of Parkinson's disease. Accumulation of alpha-synuclein protein is a key factor in the disease. The study controlled for age, sex, and comorbidities to rule out confounding factors.
Scientists at the Stowers Institute for Medical Research have uncovered the structure of the first step in amyloid formation for Huntington's disease. The team proposes a new method for treating not only Huntington's but potentially dozens of other amyloid-associated diseases by preventing the initial, rate-limiting step from occurring.
Researchers found that reduced brain wave strength is linked to cognitive dysfunction in PD patients, suggesting EEG as a diagnostic tool. The study aims to improve diagnosis and develop targeted therapies for cognitive symptoms.
A powerful new stem cell technique has enabled large-scale studies of the relationship between human genetics and biology, accelerating research and potential personalized treatments.
A new observational study published in BMJ Open found that long Covid can have a devastating effect on daily lives, with fatigue impacting social activities, work, and relationships. The study's findings suggest that long Covid can leave people with worse fatigue and quality of life than some cancers.
A new study found that combining conventional speech therapy with singing can improve voice problems in individuals with Parkinson's disease. The tele-rehabilitation program showed significant improvements in voice intensity and Voice Handicap Index scores, suggesting a more effective treatment approach.
Researchers used mouse genetics to determine if brain or spinal cord causes dystonia, finding that spinal cord is responsible. Spinal cord dysfunction leads to signs of dystonia similar to those seen in humans, providing a new target for treatment.
Researchers found that progesterone can protect nerve cells from dying in people with Parkinson's disease. The study suggests that a balanced diet and steroid hormone-based therapeutic approaches could help slow down or stop the progression of neurodegenerative diseases.
The study used transcranial photobiomodulation (tPBM) to stimulate the prefrontal cortex, a region involved in cognitive function. The results showed that tPBM modulated hemodynamic and metabolic activities in a wavelength- and site-specific manner.
A recent study has identified 53 pesticides linked to an increased risk of Parkinson's disease, with exposure to multiple chemicals combined being more toxic than any single pesticide. The researchers also found that specific pesticides can directly harm dopamine neurons, a key finding for the development of new therapeutic strategies.
Research shows that bursts of electrical stimulation can modify activity in the subthalamic nucleus, influencing human behavior and potentially treating neurological disorders like Parkinson's disease. The study suggests a new approach to restore healthy brain function in people with these conditions.
Researchers at Brown University have developed a new imaging technique to track changes in blood vessels in the brains of mice, which could lead to early detection of neurodegenerative diseases. The method uses advanced imaging techniques and AI algorithms to identify biomarkers that may predict disease onset.