Articles tagged with Parkinsons Disease
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Two proteins, NAP1 and SINTBAD, have been discovered as regulators of mitophagy in cells. This discovery opens a new area of focus for researchers targeting drug therapies to boost mitophagy activity and promote mitochondrial and neuronal health.
Researchers found a blood test to detect alpha-synuclein protein shows promise for diagnosing Parkinson's disease. The study, published in the Journal of Parkinson's Disease, confirmed that the biomarker is highly sensitive and changes over the course of the disease.
Researchers at Weill Cornell Medicine used machine learning to define three subtypes of Parkinson’s disease, each with distinct driver genes and molecular mechanisms. These subtypes may suggest customized treatment strategies for patients, potentially targeting specific drugs such as metformin to slow down progression.
Researchers created a new cortical surface template called 'OpenNeuro Average' that provides greater accuracy and efficiency in analyzing neuroimaging data. The template is based on the geometric shape of the brain and can be used for studies on cognition, clinical neuroscience, autism, and neurodegenerative diseases.
A cross-sectional study of CTE patients found that years of contact sports participation are linked to substantia nigra pathology, leading to parkinsonism. The study suggests that repetitive head impacts may trigger neuropathologic processes in individuals with CTE.
Researchers investigated the relationship between protein aggregation and liquid-liquid phase separation, finding that droplet formation may actually protect against aggregation. The study, led by Paul Scherrer Institute, used over 500 conditions to test the behavior of alpha-synuclein proteins.
A study of 481 deceased athletes found that most developed parkinsonism due to CTE pathology, not classic Parkinson's disease. Researchers identified a link between contact sport participation and severe brain cell death in the brainstem.
Researchers discovered a new genetic cause of inherited Parkinson's disease, the CARS E795V mutation, which affects protein function and leads to neurological symptoms. The study found that this rare mutation is responsible for the condition in nine individuals from four families.
A trial published in The BMJ highlights the need to optimise speech therapy resources for people with Parkinson’s disease. LSVT LOUD is more effective than conventional NHS speech and language therapy or no therapy in improving voice handicap scores.
A major clinical trial led by the University of Nottingham found that LSVT LOUD was more effective at reducing the impact of voice problems in people with Parkinson's disease compared to no speech and language therapy or NHS delivered therapy. The treatment improved communication skills, enabling participants to go out and socialize wi...
A study published in The Journal of Neuroscience found that blocking a protein called Activin A can halt dyskinesia symptoms and effectively erase the brain's 'bad memory' response to certain Parkinson's treatments. This could lead to longer-term use of L-DOPA for patients.
A study published in Radiology found that brain connectivity on MRI scans can predict the progression of brain atrophy in patients with mild Parkinson's disease. The researchers used MRI data to generate a map of the brain's neural connections, which showed potential in predicting gray matter atrophy accumulation over time.
A new study by UCL researchers found that people with anxiety over the age of 50 are at least twice as likely to develop Parkinson's disease. The study, published in the British Journal of General Practice, also identified symptoms such as depression, sleep disturbance, and fatigue as risk factors for developing the condition.
Researchers found that men taking terazosin-type medications had about a 40% lower risk of developing dementia with Lewy bodies compared to those taking tamsulosin or 5-alpha reductase inhibitors. The study suggests that these drugs may have broad potential for treating neurodegenerative conditions.
A team of researchers has developed a simple blood test that uses artificial intelligence (AI) to predict Parkinson's disease up to seven years before the onset of symptoms. The test analyzes a panel of eight blood-based biomarkers with concentrations altered in patients with Parkinson's, providing a diagnosis with 100% accuracy.
Researchers at Johns Hopkins Medicine identified a potentially new biological target involving Aplp1, which drives the spread of Parkinson's disease-causing alpha-synuclein. The findings suggest targeting this interaction with drugs could slow Parkinson's disease progression and other neurodegenerative diseases.
Dorothee Dormann and Edward Lemke propose a new concept to measure the individual risk of getting age-related diseases by analyzing protein clumps in cells. This 'protein aggregation clock' could help diagnose age-related diseases at early stages or identify people at higher risk.
Researchers found a link between gut microbiota and Parkinson's disease, revealing reduced B vitamins and intestinal barrier issues. Treatment with B vitamins could alleviate PD symptoms and slow disease progression.
Researchers at the University of Birmingham discovered a link between dopamine and mentalising abilities in healthy individuals. They found that altering dopamine levels affected participants' ability to accurately attribute mental states, with implications for treating conditions like Parkinson's disease.
Researchers have developed a study using smartwatches to monitor Parkinson's symptoms over time in early-stage patients. The study found significant declines in gait and tremor, as well as changes in speech, with the smartwatch detecting these changes more effectively than traditional tools.
Dr. Jeetain Mittal's NIH grant will support multiscale computational models investigating phase separation in biology, particularly heterochromatin formation and its role in neurodegenerative diseases. The research aims to elucidate the molecular origins of phase separation using innovative models and methods.
Researchers at University of Dundee uncovered inner relay of a molecular switch that protects the brain against Parkinson's disease. The study provides new potential strategies to develop drugs targeting PINK1 pathway.
Researchers from Mass General Brigham created an algorithm to generate personalized DBS treatment plans based on four major PD symptoms. The algorithm improved patients' symptoms in four of five cases, demonstrating its potential to improve treatment beyond standard-of-care approaches.
Patients with Parkinson's disease exhibiting sympathetic denervation in major salivary glands and the heart tend to have more advanced non-motor symptoms as they age. Autonomic nerve dysfunction may progress independently of nigrostriatal dopaminergic degeneration, suggesting a potential contribution of age to PD progression.
A study led by the University of Turku has identified the brain network responsible for stuttering, which may lead to effective treatments. The research found that stuttering is associated with structural changes in a specific brain network involving the putamen, amygdala, and claustrum.
A study by the University of Turku found that regular caffeine consumption reduces dopamine transporter binding in Parkinson's disease patients, but has no impact on symptoms or motor function. High caffeine intake may also complicate brain imaging results, suggesting a 24-hour caffeine-free period before diagnosis is recommended.
A new study at the University of Copenhagen reveals that urolithin A, a naturally occurring substance in pomegranates, can alleviate memory problems and other consequences of dementia. The substance shows promise in improving brain function by removing damaged mitochondria.
Researchers found that boosting mitochondrial health can combat protein clumping linked to both aging and Alzheimer's. The study identifies a core insoluble proteome enriched with numerous proteins not previously considered, offering new targets for exploration.
FutureNeuro, a leading SFI Research Centre, is expanding its research programme with a focus on diagnostics, therapeutics, and digital health. The centre aims to develop precision diagnostics, future treatments, and systems using real-time health data.
Researchers at Mount Sinai identified genetic connections between inflammatory bowel disease (IBD) and Parkinson’s disease (PD), highlighting potential for joint therapeutic strategies. The study found mutations in the LRRK2 gene as a common element linking both conditions, with implications for innovative treatments.
A region in alpha-synuclein protein aggregates has been identified as a potential therapeutic target to prevent conversion into toxic amyloid fibrils, which accumulate in the brains of people suffering from Parkinson's disease. The discovery opens the door to developing new therapeutic strategies for inactivating these toxic forms.
Researchers at the University of Toronto have found a way to better control the preclinical generation of key neurons depleted in Parkinson's disease. They developed an efficient method for stimulating stem cell differentiation to produce neural cells in the midbrain, which closely resemble dopaminergic neurons of natural origin.
Researchers found a shared triple network of long noncoding RNAs, microRNAs, and messenger RNAs that exacerbates Parkinson's disease symptoms in the context of COVID-19 infection. The study identified key genes and lncRNAs as potential biomarkers for PD diagnosis and progression.
A new study found that genetic variants in lysosomal genes may contribute to the development of Parkinson's disease in individuals exposed to high levels of pesticides. The research suggests a potential gene-environment interaction, where minor changes in these genes can lead to increased disease risk under stress.
Researchers found that older adults tend to conserve energy by modifying their movements under certain circumstances. The findings suggest that the effort costs of reaching are a determining factor in slowing movement with age. This research may lead to new tools for diagnosing diseases, including Parkinson's and multiple sclerosis.
Researchers from the University of Cambridge used AI to identify compounds that block alpha-synuclein aggregation, a key step in treating Parkinson's disease. This breakthrough could lead to faster development of new treatments for the condition, which affects over six million people worldwide.
Scientists at Salk Institute explore the clinical potential of cannabinol (CBN) in treating traumatic brain injury, Alzheimer's disease, and Parkinson's disease. They identify four CBN analogs with improved neuroprotective ability and drug-like efficacy.
Researchers at Van Andel Institute have identified a gene expression pattern, akin to a disease-related fingerprint, in brain cells with Lewy bodies. This finding sheds light on the molecular changes that occur in these cells, which are key pathological hallmarks of Parkinson's disease and some dementias.
Research finds Parkinson's disease alters bodily sensations associated with basic emotions, shifting focus from chest to abdominal area. The study highlights the significance of non-motor symptoms in Parkinson's disease, raising new perspectives for treatment and research.
A recent study has linked the subthalamic nucleus to attention control, revealing that this brain region also plays a role in thoughts and impulse control. The findings suggest that deep brain stimulation, used to treat Parkinson's disease, may have adverse effects on attentional processes.
Researchers from the University of Cincinnati presented findings on the effectiveness of a two-component enzyme replacement therapy for late-onset Pompe disease. The study showed that patients treated with this regimen experienced improvement or stability in motor function, pulmonary function, and muscle strength. Additionally, experts...
A new hypothesis paper proposes that Parkinson's disease starts in either the brain's smell center or the body's intestinal tract, tied to environmental factors. The study suggests that exposure to pesticides, air pollution, and tainted food may predispose to the disease.
A groundbreaking clinical study demonstrates the potential of fecal microbiota transplantation (FMT) to improve symptoms in patients with Parkinson's disease. After 12 months, participants who received healthy donor stool transplants showed significant improvement in motor symptoms and reduced constipation.
The study found that crowding and salt enhance the aggregation of alpha-synuclein, while also stabilizing the resulting aggregates. The simulations revealed that certain amino acids exist to prevent aggregation and that proteins orient themselves to minimize interactions between these residues.
A Rice University research project aims to provide new insights into biological fibrillar nanostructures with potential implications for the treatment and diagnosis of Alzheimer’s and Parkinson’s diseases.
Researchers discovered Lewy body disease changes in 9% of people over 50 without a clinical diagnosis, suggesting the disease may be more common than thought. Further studies are needed to confirm the results, but early detection is crucial for effective therapies.
Research finds that supplementing propionate suppresses neurodegeneration in animal models of Parkinson's disease by regulating interorgan signalling. Increasing propionate levels rescues transcriptional aberration and enhances energy production, promoting neuronal health without protein aggregate dispersal.
A team of researchers has developed the world's first 3D-printed brain phantom, which can be imaged using dMRI. The brain model is made up of microchannels that mimic nerve cells in the brain, allowing for more accurate analysis and research into neurodegenerative diseases.
A skin biopsy test detects abnormal alpha-synuclein protein in patients with Parkinson's disease, dementia with Lewy bodies, and related disorders. The test showed high accuracy rates, validating its reliability for early diagnosis and clinical drug development.
Researchers at the University of Galway have developed a new method for improving stem cell-based brain repair therapy for Parkinson's disease, which shows promising results in enhancing survival and maturation of cells in the brain. The technique uses a collagen hydrogel to support and protect the cells after transplantation.
A new study by researchers at the University of Minnesota reveals that non-invasive brain stimulation can change a specific brain mechanism related to human behavior. The technique, called transcranial alternating current stimulation, modulates brain activity by shifting when brain cells are active.
A phase 3 trial co-led by a University of Cincinnati researcher found that subcutaneous levodopa delivery through an infusion pump is safe and effective in reducing symptoms for longer periods. The study resulted in almost two hours of additional 'on time' compared to traditional oral medication, paving the way for potential FDA approval.
Cells use autophagy as a recycling system to transport and break down damaged organelles, including mitochondria. A recent study reveals the molecular details of how an enzyme called TBK1 participates in mitophagy, a disease-relevant process linked to Parkinson's disease.
Researchers found that people with Parkinson's disease who experience presence hallucinations overestimate the number of people in a room due to a perceptual disorder. The study used virtual reality and robotics to induce presence hallucinations and measure susceptibility, developing an online test for early detection.
The Federation of European Neuroscience Societies is open to media registration for its 2024 event. Journalists can access the latest research discoveries in neuroscience fields such as dementia, addiction and depression.
Researchers found a correlation between Parkinson's disease and freezing of gait in 20 studies, noting similar brain injury causes both symptoms. Sleep quality deteriorates when dopaminergic medication is stopped, suggesting treatment potential for freezing of gait.
Researchers found that patients with impulse control disorder (ICD) are less affected by the consequences of their actions, particularly when on medication. This suggests that ICD patients may experience positive feelings from taking risky actions based on expectations, rather than processing negative feedback.
Researchers discovered rapid calcium influx into mitochondria upon autophagy induction, coinciding with fluctuations in ER membrane calcium concentrations. Mitochondrial calcium transport may regulate mitophagy velocity, shedding light on disease mechanisms and potential therapeutic avenues for Parkinson's disease.
A small study found that tandem cycling paired with virtual reality improves the physical and emotional well-being of both participants. Care partners also showed significant improvements in resiliency and depression scores after the intervention.
A study has found a strong link between pesticide use and Parkinson's disease in the Rocky Mountain and Great Plains region. The research identified 14 pesticides, including simazine, atrazine, and lindane, that were associated with an increased risk of developing the disease.