Synaptic Efficacy

Inspired by the brain, researchers build smarter, more efficient computer hardware

Discovery shines light on a cascade of events that occurs when toxic tau impacts synapses, suggesting new mechanisms for neurodegeneration

Researchers developed a new tool to track changes in the synaptic proteome over time, correlating changes to synaptic dysregulation and synapse loss. The results suggest that toxic tau oligomers impact postsynaptic structures first, leading to a dynamic cascade of events that contribute to neurodegeneration.

Upgrading brain storage: Quantifying how much information our synapses can hold

Salk scientists develop new method to quantify synaptic features, revealing high precision of plasticity and up to 10 times more storage capacity. The technique uses information theory to analyze synapse pairs from a rat hippocampus, offering a scalable approach for studying brain function.

Eating sea squirts may reverse the signs of ageing, study shows

A new study suggests that supplementing a diet with Ascidiacea, also known as sea squirts, reverses some main signs of aging in animal models. The researchers found that plasmalogens, vital to body processes, decrease with age and contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.