Discovery shines light on a cascade of events that occurs when toxic tau impacts synapses, suggesting new mechanisms for neurodegeneration
Researchers developed a new tool to track changes in the synaptic proteome over time, correlating changes to synaptic dysregulation and synapse loss. The results suggest that toxic tau oligomers impact postsynaptic structures first, leading to a dynamic cascade of events that contribute to neurodegeneration.
SourceBuck Institute for Research on Aging·JournalMolecular Neurodegeneration·TypeExperimental study·DateJan 28, 2026