Anaerobic bacteria have survived for ages in oxygen-free niches, influencing human health and environment. The 'AnoxyGen' project aims to unlock their biosynthetic potential using molecular and synthetic biology tools.
The study found that Clostridioides difficile uses fermentation to rapidly colonize the gut and identified critical pathways converged on a metabolic integration point to produce amino acid alanine, driving bacterial growth. The findings provide new targets for small molecule drugs to counter C. difficile colonization and infection.
Scientists have discovered several rare microorganisms, including Legendrea loyezae and Lacerus, which were previously unknown to science. The discovery expands our understanding of the tree of life and highlights the importance of microscopic life.