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Mass General Brigham researchers uncover metabolic secrets of anaerobes and identify new strategies to treat c. difficile infections

The study found that Clostridioides difficile uses fermentation to rapidly colonize the gut and identified critical pathways converged on a metabolic integration point to produce amino acid alanine, driving bacterial growth. The findings provide new targets for small molecule drugs to counter C. difficile colonization and infection.

SourceMass General Brigham·JournalNature Chemical Biology·TypeObservational study·DateMar 9, 2023