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Synthetic biology reveals the secrets of life without oxygen

Anaerobic bacteria have survived for ages in oxygen-free niches, influencing human health and environment. The 'AnoxyGen' project aims to unlock their biosynthetic potential using molecular and synthetic biology tools.

SourceLeibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute -·DateJul 12, 2024
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Mass General Brigham researchers uncover metabolic secrets of anaerobes and identify new strategies to treat c. difficile infections

The study found that Clostridioides difficile uses fermentation to rapidly colonize the gut and identified critical pathways converged on a metabolic integration point to produce amino acid alanine, driving bacterial growth. The findings provide new targets for small molecule drugs to counter C. difficile colonization and infection.

SourceMass General Brigham·JournalNature Chemical Biology·TypeObservational study·DateMar 9, 2023

Discovery of new microscopic species expands the tree of life

Scientists have discovered several rare microorganisms, including Legendrea loyezae and Lacerus, which were previously unknown to science. The discovery expands our understanding of the tree of life and highlights the importance of microscopic life.

SourceBournemouth University·JournalProtist·TypeObservational study·DateSep 29, 2022