Articles tagged with Anatomy
A new study from Texas A&M University reveals that circadian disruptions change the structure of mammary glands, weaken immune defenses, and fuel aggressive breast cancer. Disabling an immune checkpoint molecule called LILRB4 helps restore the immune system's ability to fight back.
Research shows that ants with less protective armor, such as cuticle investment, tend to have larger colony sizes and are more successful in terms of diversification rates. This suggests that complex societies like humans may evolve by sacrificing individual quality for collective power.
Researchers from Institute of Science Tokyo developed 'tubuloids' to capture the slow progression of chronic kidney disease (CKD), replicating key features such as DNA damage, cellular senescence, inflammation, and fibrosis. This realistic platform provides a new way to develop and test treatments for millions globally.
Researchers at the University of Plymouth investigate why drugs used to treat other tumours are ineffective against NF2-related schwannoma and meningioma tumours. They explore repurposing clinically tested cancer drugs to target MDR mechanisms, which may lead to effective therapies for patients with these tumours.
A team of researchers has reconstructed how the cerebellum establishes its connections with the rest of the brain during earliest stages of life. The work describes the phases in which these neural connections emerge, expand, and are refined, offering a comprehensive map of cerebellar projections across the mouse brain.
A study of 101 glioma cases reveals that one-third of patients develop permanent paralysis after surgery. High tumor grade, pre-operative motor deficits, and larger tumor volume are key predictors. The work underscores the importance of careful surgical planning to maximize survival while safeguarding motor function.
Researchers developed a novel bioelectronic material that transforms from a rigid film to a soft, tissue-like interface upon hydration, enabling seamless integration with living tissues. The device, called THIN, has been shown to record biological signals with high fidelity and stability in animal experiments.
Researchers at the University of Plymouth will receive a £2.8 million funding boost to accelerate new treatments for low-grade brain tumors. The center aims to deepen understanding and translate knowledge into life-changing therapies.
Researchers at the University of Plymouth have successfully used transcranial ultrasound stimulation (TUS) to change the function of a deep region of the human brain, specifically the nucleus accumbens. This tiny element is triggered by enjoyable experiences and helps us learn behaviours that lead to rewards.
LMU has secured funding for two large research networks: one on neurovascular diseases and the other on desmosomes. The CRC on neurovascular diseases aims to uncover the causes of these diseases and develop novel therapeutic strategies, while the SFB/Transregio on desmosomes investigates their functions in epithelial barriers.
Researchers created BraDiPho, a 3D atlas of brain connections, combining clinical neuroscience, artificial intelligence, and neuroanatomy. The tool facilitates precise identification of white matter connections, opening up new therapeutic perspectives for neurological diseases.
New research from the Stowers Institute for Medical Research reveals planarian stem cells ignore their nearest neighbors and respond to signals further away in the body. This discovery may help explain the flatworm's extraordinary ability to regenerate and offer clues for developing new ways to replace or repair tissues in humans.
Researchers found that higher SDMA levels, but not ADMA, correlated with weaker blood vessel function in patients with moderate chronic kidney disease. This suggests that measuring SDMA levels may provide a better approach to monitoring vascular function in these patients.
The study found that males have a narrower pelvis, resulting in a more medial starting point for S2AI screws and poorer rod alignment. Researchers aim to tailor treatment to patients' specific anatomy to improve surgical efficiency and outcomes.
Researchers tested a popular evolutionary theory by comparing maternal length and fetal sex in over 100,000 whales. They found that the fetal sex ratio skews female for longer body size, suggesting that female calves benefit more from heritable fitness than males do. The findings contradict the Trivers-Willard hypothesis.
A deep learning model achieved up to 98% accuracy in distinguishing autistic from neurotypical participants, providing clear insights into brain regions most influential to its decisions. The model could benefit autistic people and clinicians by offering accurate and explainable results to inform assessment and support.
A study found that most rodents have thumbnails instead of claws, which helps explain how they thrived in various environments. This discovery suggests that thumbnails provide more manual dexterity than long, sharp claws, enabling rodents to exploit high-energy resources like nuts.
A new study reveals that humans, dogs, and pigs share similar brain responses to vocal sounds and calls from their own species, indicating an evolutionarily ancient mammalian heritage. This discovery sheds light on the deep roots of voice perception and highlights the value of studying companion animals to better understand human biology.
A new study demonstrates the potential to produce cellular spheroids from clinically relevant embryonic stem cells to generate scaffold-free chondrogenic or osteochondrogenic graft tissues. The researchers successfully cultured ES-MSC cellular spheroids, which matured into neocartilage tissues expressing cartilage-associated genes.
Researchers have established apple snails as a system to study eye regeneration, which may hold the key for restoring vision due to damage and disease. The team discovered that the snail eye is anatomically similar to humans and can regrow itself, with genes such as pax6 playing a crucial role in development.
Scientists reconstructed the brain, heart, and fins of a 400-million-year-old fish called Norselaspis glacialis. The study found that its acute senses and powerful heart evolved well before jaws and teeth, suggesting a fast-swimming lifestyle was key to evading predators.
The University of Bath conducted the largest growth and maturation study in world football, evaluating over 1,000 academy players in Scotland. The study found a strong bias toward early-developing players, raising questions about current selection and development practices.
A new treatment for corneal scarring is being developed by University of Houston optometry researcher Tarsis G. Ferreira. The treatment uses a natural protein called decorin to block scarring and unwanted blood vessel growth, offering hope for people with injured corneas.
Researchers reanalyzed the coelacanth's skull musculature and found that only 13% of previously identified evolutionary muscle novelties were accurate. The study also identified nine new evolutionary transformations related to feeding and respiration, revealing a more similar anatomy to cartilaginous fish and tetrapods.
Laminin-411 protein and its derived peptide A4G47 exhibit pro-myelinating activity in oligodendrocytes, promoting myelin sheath formation. This discovery advances understanding of myelin sheath formation and potential applications for treating demyelinating diseases.
A study published in Journal of the Mechanical Behavior of Biomedical Materials found that wrinkled skin is caused by its tendency to buckle under pressure due to age-related changes in its mechanical properties. As people age, their skin becomes more prone to wrinkles as it stretches and contracts in different directions.
A novel fluorescent probe, SLY, has been developed to precisely identify hepatocellular carcinoma tissue using sialylated glycans on the cell surface. The probe outperforms conventional methods by clearly distinguishing tumor margins within liver tissues.
Researchers compared CECS and EES techniques for treating giant and irregular pituitary tumors. The study found that CECS resulted in a higher gross tumor removal rate (66%) and lower postoperative bleeding rates compared to EES.
A study published in Chinese Neurosurgical Journal found that the Neuroform Atlas stent-assisted coiling procedure is safe and effective for treating intracranial aneurysms in arteries less than 2.5 mm in diameter, with favorable outcomes and low postoperative complication rates.
A team led by L. Mahadevan found that young anacondas can execute a quick, one-off skating movement called the 'S-start' due to their physical attributes. This movement is similar to sidewinding and could inspire new robotic systems.
A new study shows that a simple blood test taken in the first trimester of pregnancy can accurately identify women at risk of developing preeclampsia five months before clinical diagnosis. The test uses cell-free RNA, or cfRNA, to capture subtle molecular signals from multiple maternal tissues.
Researchers found that chipmunks' skulls became larger but teeth shorter due to increased human food availability. Voles' auditory bullae decreased in size possibly to dampen environmental noise. These changes demonstrate the profound impact of humans on wildlife and their environment.
Researchers from Binghamton University confirm the long-held 'urban myth' that saltwater dries out skin, increasing tissue stiffness and stress. A simple solution to alleviate tightness is taking a shower after coming out of the ocean.
Researchers uncover how RUNX2 regulates cranial base growth by controlling chondrocyte differentiation, proliferation, and organization. The study provides fundamental insights into the complex interplay between RUNX2 and FGFR3, shedding light on novel therapeutic targets for craniofacial defects.
Researchers used a premature aging mouse model to study the effects of age and sex on osteocyte networks and bone structure. Aged PolgA mice showed accelerated skeletal aging, reduced osteocyte connectivity, and increased frailty, with males exhibiting more pronounced changes.
Researchers discovered that the brain's retrosplenial cortex (RSC) encodes competing navigation hypotheses in distinct neural activity patterns. These patterns allow animals to choose the correct path despite ambiguity, and can be used to compute how to reach a reward.
Researchers found that carotid artery plaques can undergo changes over time, becoming more complex and increasing the risk of internal bleeding. This study emphasizes the importance of ongoing plaque monitoring and proactive risk factor management to prevent stroke.
A joint research team from POSTECH and Hanyang University developed a personalized stimulation control mechanism using evoked compound action potential feedback mechanisms to treat urinary disorders. This technology enables precise adjustment of tibial nerve stimulation in real-time, based on individual nerve responses, improving patie...
Researchers created first complete genetic activity map of a branching worm, revealing how it controls reproduction across its multiple body branches. The study highlights the unique genetic toolkit and challenges understanding of animal bodies' organization.
New research from Binghamton University reveals that the topography patterns of wrinkled fingers remain constant after multiple immersions. The study found that blood vessels beneath the skin contract and move in relation to other vessels, resulting in consistent wrinkles.
Researchers discovered neuroestrogen's role in regulating food intake and hunger. Neuroestrogen enhances the brain's responsiveness to leptin, a hormone that helps regulate hunger.
Researchers compared feathers and bodies of flightless birds and their flying relatives, finding that some features change relatively quickly. The study sheds light on evolution of complex traits that lose original function, and could help reveal which fossil birds were flightless.
A fossil therapsid was found in Mallorca with a skull hole for the jaw muscle and structures that evolved into mammals' middle ear bones. The discovery changes scientists' understanding of when therapsids evolved and tells us about where we come from.
Researchers have introduced DSFN to improve the speed and accuracy of diagnoses of retinal disorders. This AI-powered medical imaging technique combines retina images with vascular distribution information to accurately locate the fovea in complex clinical scenarios, enabling doctors to detect early signs of ocular diseases.
A new study finds that the ancient bird Longipteryx ate fruits, contrary to previous hypotheses that it feasted on fish or insects. The discovery was made by analyzing fossilized seeds in the bird's stomach, which suggest a mixed diet including fruits and possibly insects when they were not available.
Researchers studied the anatomy of mudskippers to understand their adaptations to life on land. They found that the fish's muscles in the pectoral fins are bigger and that some bone-connecting tendons were replaced by fascia tissue, providing stability and strength for walking.
A newly discovered fossil, Gaiasia jennyae, reveals a giant salamander-like creature that was a top predator in the ice age before dinosaurs. The creature's unique features, including its toilet seat-shaped head and interlocking jaws, suggest it was an ambush predator.
The e-COL+ project aims to capture and reconstruct France's natural history collections in 3D, covering nearly 6% of the world's total natural specimens. The project will provide modern equipment, create a comprehensive dataset of 3D models, and build AI tools to improve model reconstruction.
Researchers have identified a novel target downstream of parathyroid hormone signaling that suppresses bone formation. Gprc5a negatively regulates osteoblast proliferation and differentiation by partially suppressing BMP signaling, potentially increasing teriparatide effectiveness in non-responding patients.
Researchers found cyclin D1 expression in patients with penile cancer (PC) is associated with clinical and histopathological features. Patients with cyclin D1 expression had lower disease-free survival compared to the cyclin D1-negative group.
Researchers discovered lemurs possess an additional pair of vocal folds, which they believe is responsible for enriching their vocal repertoire and allowing them to exaggerate their size. This adaptation may have provided a selective advantage in competition for territory or mates.
A new reconstruction of the 375-million-year-old fossil fish Tiktaalik reveals that its ribs likely attached to its pelvis, enabling support of the body and potentially leading to the evolution of walking. This discovery provides insights into the major evolutionary transition from fish to four-limbed vertebrates.
Researchers have solved the long-standing question of what triggers the alarm response in fish by identifying two distinct chemical signals: Daniol sulphate and Ostariopterin. These substances convey separate pieces of information that must be detected simultaneously to trigger a flight-or-freeze response.
Researchers from Pusan National University discovered a link between diabetes and periodontitis, showing pro-inflammatory cytokines rise in classical monocytes. The study highlights the systemic impact of these conditions on immune regulation and suggests a potential therapeutic target to reduce diabetes risk.
Scientists discovered a common trait among flying birds, including the number of primary feathers, to determine their evolutionary history. The finding provides clues about dinosaur flight and may inform debates on its origins.
A study found that migratory bats are sensitive to the angle of magnetic inclination and use it for navigation. The soprano pipistrelle bat species calibrated its internal compass at sunset, taking into account both the horizontal component and inclination of the Earth's magnetic field.
Researchers studied over 100 noctilionoid bat species, finding that different dietary types drove modifications in tooth number, size, shape, and position. For instance, fruit-eating bats have shorter jaws with reduced middle premolars, while nectar-feeders have longer jaws with room for more teeth.
Researchers from Binghamton University found that collagen fibers in skin become more tightly packed together, leading to increased stiffness and tissue hardness. This study sheds light on the biological mechanisms behind sun-induced skin changes.
Researchers updated their protein localization prediction model, MULocDeep, to provide more targeted predictions for biological discoveries. The tool helps researchers design more effective experiments and advance scientific discoveries related to drug development and treating diseases like epilepsy.
A new study found that marathon running causes significant damage to extrinsic foot muscles, while intrinsic muscles are less affected. The research suggests that marathon runners can take steps to prevent injuries by prioritizing recovery and muscle fatigue management.